Laura Mackay

Intratumoral CD8 T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer.

Balaji Virassamy, Franco Caramia, Peter Savas, Sneha Sant, Jianan Wang, Susan N Christo, Ann Byrne, Kylie Clarke, Emmaline Brown, Zhi Ling Teo, Bianca von Scheidt, David Freestone, Luke C Gandolfo, Karsten Weber, Julia Teply-Szymanski, Ran Li, Stephen J Luen, Carsten Denkert, Sibylle Loibl, Olivia Lucas, et al.

Journal article  |  2023  |  Cancer Cell

CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (TRM) cell phenotype are associated with favorable prognosis i..

Tissue-resident memory T (T-RM) cells: Front-line workers of the immune system

Maleika Osman, Simone LL Park, Laura KK Mackay

Journal article  |  2023  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-resident memory T (TRM ) cells play a vital role in local immune protection against infection and cancer. The location of T..

Unconventional haircare

Hui-Fern Koay, Laura K Mackay

Journal article  |  2023  |  NATURE IMMUNOLOGY

Australian Donation and Transplantation Biobank: A Research Biobank Integrated Within a Deceased Organ and Tissue Donation Program

Varun J Sharma, Graham Starkey, Rohit D'Costa, Fiona James, Effie Mouhtouris, Lisa Davis, Boa Zhong Wang, Angela Vago, Jaishankar Raman, Laura K Mackay, Helen Opdam, Robert Jones, M Lindsay Grayson, Dominique E Martin, Claire L Gordon

Journal article  |  2023  |  TRANSPLANTATION DIRECT

UNLABELLED: We aimed to facilitate the donation of tissue samples for research by establishing a centralized system integrated in ..

Study protocol: Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR)

Fiona James, Michelle SY Goh, Effie Mouhtouris, Sara Vogrin, Kyra YL Chua, Natasha E Holmes, Andrew Awad, Ana-Maria Copaescu, Joseph F De Luca, Celia Zubrinich, Douglas Gin, Heather Cleland, Abby Douglas, Johannes S Kern, Constance H Katelaris, Francis Thien, Sara Barnes, James Yun, Winnie Tong, William B Smith, et al.

Journal article  |  2022  |  BMJ OPEN

INTRODUCTION: Severe cutaneous adverse reactions (SCAR) are a group of T cell-mediated hypersensitivities associated with signific..

Runx3 drives a CD8( ) T cell tissue residency program that is absent in CD4( ) T cells

Raissa Fonseca, Thomas N Burn, Luke C Gandolfo, Sapna Devi, Simone L Park, Andreas Obers, Maximilien Evrard, Susan N Christo, Frank A Buquicchio, Caleb A Lareau, Keely M McDonald, Sarah K Sandford, Natasha M Zamudio, Nagela G Zanluqui, Ali Zaid, Terence P Speed, Ansuman T Satpathy, Scott N Mueller, Francis R Carbone, Laura K Mackay

Journal article  |  2022  |  NATURE IMMUNOLOGY

Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription fac..

Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface

Joon Keit Loi, Yannick O Alexandre, Kirthana Senthil, Dominik Schienstock, Sarah Sandford, Sapna Devi, Susan N Christo, Laura K Mackay, Holly R Chinnery, Peregrine B Osborne, Laura E Downie, Erica K Sloan, Scott N Mueller

Journal article  |  2022  |  CELL REPORTS

The eye is considered immune privileged such that immune responses are dampened to protect vision. As the most anterior compartmen..

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

Wuji Zhang, Brendon Y Chua, Kevin J Selva, Lukasz Kedzierski, Thomas M Ashhurst, Ebene R Haycroft, Suzanne K Shoffner-Beck, Luca Hensen, David F Boyd, Fiona James, Effie Mouhtouris, Jason C Kwong, Kyra YL Chua, George Drewett, Ana Copaescu, Julie E Dobson, Louise C Rowntree, Jennifer R Habel, Lilith F Allen, Hui-Fern Koay, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral a..

Unlocking autofluorescence in the era of full spectrum analysis: Implications for immunophenotype discovery projects

Vanta J Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K Mackay, Axel Kallies, Jose A Villadangos, Hamish EG McWilliam, Alexis Perez-Gonzalez

Journal article  |  2022  |  CYTOMETRY PART A

Understanding the complex elements affecting signal resolution in cytometry is key for quality experimental design and data. In th..

ICOS-play: dressing T cells for residency

Simone LL Park, Susan NN Christo, Laura KK Mackay

Journal article  |  2022  |  TRENDS IN IMMUNOLOGY

Efficient generation of tissue-resident memory T (TRM) cells is essential for long-lived immune protection in barrier tissues. Pen..