Dr Needham is head of the Hearing Neurosciences laboratory and a Senior Research Fellow in the Department of Surgery (Otolaryngology), based at the Royal Victorian Eye & Ear Hospital in East Melbourne. In 2017 she joined the HEARing CRC, as Project Leader of Interface Optimisation and Assessment.
Her research interests and publications span the fields of neurophysiology, ion channels, optical neural stimulation, auditory physiology, stem cells, cochlear implants and hearing preservation strategies.
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Lex33965 - Improving The Spatial Selectivity Of Cochlear Implants Using Light-Based Stimul..
Electrode impedance changes after implantation of a dexamethasone-eluting intracochlear ar..
Neuronal Injury In Noise-Induced Hearing Loss: Are Acid-Sensing Ion Channels Responsible?
Displaying the 10 most recent projects by Karina Needham.
Internal Research Grant
Displaying the 33 most recent scholarly works by Karina Needham.
Thermal damage threshold of neurons during infrared stimulation
WGA Brown, K Needham, JM Begeng, AC Thompson, BA Nayagam, T Kameneva, PR Stoddart
Journal article | 2020 | Biomedical Optics Express
In infrared neural stimulation (INS), laser-evoked thermal transients are used to generate small depolarising currents in neurons...
Electrode impedance changes after implantation of a dexamethasone-eluting intracochlear array.
Karina Needham, Dimitra Stathopoulos, Carrie Newbold, Jason Leavens, Frank Risi, Shahram Manouchehri, Irfan Durmo, Robert Cowan
Journal article | 2020 | Cochlear Implants International
Postoperative inflammation and the formation of fibrotic tissue around the intracochlear electrode array are often held responsibl..
Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency-an in vitro study
William L Hart, Rachael T Richardson, Tatiana Kameneva, Alex C Thompson, Andrew K Wise, James B Fallon, Paul R Stoddart, Karina Needham
Journal article | 2020 | Journal of Neural Engineering
OBJECTIVE: The performance of neuroprostheses, including cochlear and retinal implants, is currently constrained by the spatial re..
Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices
Tomoko Hyakumura, Stuart McDougall, Sue Finch, Karina Needham, Mirella Dottori, Bryony A Nayagam
Journal article | 2019 | Stem Cells International
Stem cells have been touted as a source of potential replacement neurons for inner ear degeneration for almost two decades now; ye..
Protecting against electrode insertion trauma using dexamethasone.
Scott Chambers, Carrie Newbold, Dimitra Stathopoulos, Karina Needham, Chris Miller, Frank Risi, Ya Lang Enke, Godofredo Timbol, Robert Cowan
Journal article | 2019 | Cochlear Implants International
OBJECTIVE: To compare the benefits of a dexamethasone-eluting array for hearing preservation and cochlear histopathology in low tr..
Enriched retinal ganglion cells derived from human embryonic stem cells
Katherine P Gill, Sandy SC Hung, Alexei Sharov, Camden Y Lo, Karina Needham, Grace E Lidgerwood, Stacey Jackson, Duncan E Crombie, Bryony A Nayagam, Anthony L Cook, Alex W Hewitt, Alice Pebay, Raymond CB Wong
Journal article | 2016 | SCIENTIFIC REPORTS
Directing human induced pluripotent stem cells into a neurosensory lineage for auditory neuron replacement.
Niliksha Gunewardene, Nicole Van Bergen, Duncan Crombie, Karina Needham, Mirella Dottori, Bryony A Nayagam
Journal article | 2014 | BioResearch Open Access
Emerging therapies for sensorineural hearing loss include replacing damaged auditory neurons (ANs) using stem cells. Ultimately, i..
Functional Characterization of Friedreich Ataxia iPS-Derived Neuronal Progenitors and Their Integration in the Adult Brain
Matthew J Bird, Karina Needham, Ann E Frazier, Jorien van Rooijen, Jessie Leung, Shelley Hough, Mark Denham, Matthew E Thornton, Clare L Parish, Bryony A Nayagam, Martin Pera, David R Thorburn, Lachlan H Thompson, Mirella Dottori
Journal article | 2014 | PLoS One
Whole cell patch clamp for investigating the mechanisms of infrared neural stimulation.
William GA Brown, Karina Needham, Bryony A Nayagam, Paul R Stoddart
Journal article | 2013 | Journal of visualized experiments : JoVE
It has been demonstrated in recent years that pulsed, infrared laser light can be used to elicit electrical responses in neural ti..
Honours, Awards and Fellowships
Senior Otolaryngology/Allied Specialties Wagstaff Fellow
Early Career Researcher Grant Scheme
Melbourne Research Scholarship
Dean's Honours List (BSc Honours)
Association for Research in Otolaryngology
Australian Neuroscience Society
PhD (Auditory Neuroscience)
University of Melbourne
Bachelor of Science (Hons)
University of Melbourne