Karina Needham

Thermal damage threshold of neurons during infrared stimulation

WGA Brown, K Needham, JM Begeng, AC Thompson, BA Nayagam, T Kameneva, PR Stoddart

Journal article  |  2020  |  Biomedical Optics Express

In infrared neural stimulation (INS), laser-evoked thermal transients are used to generate small depolarising currents in neurons...

Electrode impedance changes after implantation of a dexamethasone-eluting intracochlear array.

Karina Needham, Dimitra Stathopoulos, Carrie Newbold, Jason Leavens, Frank Risi, Shahram Manouchehri, Irfan Durmo, Robert Cowan

Journal article  |  2020  |  Cochlear Implants International

Postoperative inflammation and the formation of fibrotic tissue around the intracochlear electrode array are often held responsibl..

Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency-an in vitro study

William L Hart, Rachael T Richardson, Tatiana Kameneva, Alex C Thompson, Andrew K Wise, James B Fallon, Paul R Stoddart, Karina Needham

Journal article  |  2020  |  Journal of Neural Engineering

OBJECTIVE: The performance of neuroprostheses, including cochlear and retinal implants, is currently constrained by the spatial re..

Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices

Tomoko Hyakumura, Stuart McDougall, Sue Finch, Karina Needham, Mirella Dottori, Bryony A Nayagam

Journal article  |  2019  |  Stem Cells International

Stem cells have been touted as a source of potential replacement neurons for inner ear degeneration for almost two decades now; ye..

Protecting against electrode insertion trauma using dexamethasone.

Scott Chambers, Carrie Newbold, Dimitra Stathopoulos, Karina Needham, Chris Miller, Frank Risi, Ya Lang Enke, Godofredo Timbol, Robert Cowan

Journal article  |  2019  |  Cochlear Implants International

OBJECTIVE: To compare the benefits of a dexamethasone-eluting array for hearing preservation and cochlear histopathology in low tr..

Stimulation of Primary Auditory Neurons Mediated by Near-Infrared Excitation of Gold Nanorods

Chiara Paviolo, Karina Needham, William GA Brown, Jiawey Yong, Paul R Stoddart

Book Chapter  |  2018  |  Neuromethods

Time-dependent activity of primary auditory neurons in the presence of neurotrophins and antibiotics

Helen Q Cai, Lisa N Gillespie, Tess Wright, William GA Brown, Ricki Minter, Bryony A Nayagam, Stephen J O'Leary, Karina Needham

Journal article  |  2017  |  Hearing Research

Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss

Rachael T Richardson, Alexander C Thompson, Andrew K Wise, Karina Needham

Journal article  |  2017  |  Expert Opinion on Biological Therapy

Enriched retinal ganglion cells derived from human embryonic stem cells

Katherine P Gill, Sandy SC Hung, Alexei Sharov, Camden Y Lo, Karina Needham, Grace E Lidgerwood, Stacey Jackson, Duncan E Crombie, Bryony A Nayagam, Anthony L Cook, Alex W Hewitt, Alice Pebay, Raymond CB Wong

Journal article  |  2016  |  SCIENTIFIC REPORTS

Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3

Tess Wright, Lisa N Gillespie, Stephen J O'Leary, Karina Needham

Journal article  |  2016  |  Scientific Reports

Gold-Nanorod-Assisted Near-Infrared Stimulation of Primary Auditory Neurons

Jiawey Yong, Karina Needham, William GA Brown, Bryony A Nayagam, Sally L McArthur, Aimin Yu, Paul R Stoddart

Journal article  |  2014  |  Advanced Healthcare Materials

Directing human induced pluripotent stem cells into a neurosensory lineage for auditory neuron replacement.

Niliksha Gunewardene, Nicole Van Bergen, Duncan Crombie, Karina Needham, Mirella Dottori, Bryony A Nayagam

Journal article  |  2014  |  BioResearch Open Access

Emerging therapies for sensorineural hearing loss include replacing damaged auditory neurons (ANs) using stem cells. Ultimately, i..

Functional Characterization of Friedreich Ataxia iPS-Derived Neuronal Progenitors and Their Integration in the Adult Brain

Matthew J Bird, Karina Needham, Ann E Frazier, Jorien van Rooijen, Jessie Leung, Shelley Hough, Mark Denham, Matthew E Thornton, Clare L Parish, Bryony A Nayagam, Martin Pera, David R Thorburn, Lachlan H Thompson, Mirella Dottori

Journal article  |  2014  |  PLoS One

Electropermeabilization of Adherent Cells with Cochlear Implant Electrical Stimulation in vitro

Carrie Newbold, Andrew Farrington, Lawson Peters, Robert Cowan, Karina Needham

Journal article  |  2014  |  Audiology and Neurotology

Electrophysiological properties of neurosensory progenitors derived from human embryonic stem cells

Karina Needham, Tomoko Hyakumura, Niliksha Gunewardene, Mirella Dottori, Bryony A Nayagam

Journal article  |  2014  |  STEM CELL RESEARCH

Whole cell patch clamp for investigating the mechanisms of infrared neural stimulation.

William GA Brown, Karina Needham, Bryony A Nayagam, Paul R Stoddart

Journal article  |  2013  |  Journal of visualized experiments : JoVE

It has been demonstrated in recent years that pulsed, infrared laser light can be used to elicit electrical responses in neural ti..

Whole Cell Patch Clamp for Investigating the Mechanisms of Infrared Neural Stimulation

William GA Brown, Karina Needham, Bryony A Nayagam, Paul R Stoddart

Journal article  |  2013  |  Journal of Visualized Experiments

An In Vitro Model of Developmental Synaptogenesis Using Cocultures of Human Neural Progenitors and Cochlear Explants

Bryony A Nayagam, Albert S Edge, Karina Needham, Tomoko Hyakumura, Jessie Leung, David AX Nayagam, Mirella Dottori

Journal article  |  2013  |  Stem Cells and Development

Whole cell patch clamp for investigating the mechanisms of infrared neural stimulation

WGA Brown, K Needham, BA Nayagam, PR Stoddart

Journal article  |  2013  |  Journal of visualized experiments : JoVE

Dark-field Microspectroscopic Analysis of Gold Nanorods in Spiral Ganglion Neurons

J Yong, WGA Brown, K Needham, BA Nayagam, A Yu, SL McArthur, PR Stoddart

Conference Proceedings  |  2013  |  Micro/Nano Materials, Devices, and Systems

Challenges for stem cells to functionally repair the damaged auditory nerve

Karina Needham, Ricki L Minter, Robert K Shepherd, Bryony A Nayagam

Journal article  |  2013  |  EXPERT OPINION ON BIOLOGICAL THERAPY

Combined application of brain-derived neurotrophic factor and neurotrophin-3 and its impact on spiral ganglion neuron firing properties and hyperpolarization-activated currents

Karina Needham, Bryony A Nayagam, Ricki L Minter, Stephen J O'Leary

Journal article  |  2012  |  Hearing Research

Identification of endocrine cells of the stomach that express acid-sensitive background potassium (K(2P)9.1/TASK3) channels

Karina Needham, Louise Pontell, Billie Hunne, Michelle Thacker, Damian McHugh, John B Furness

Journal article  |  2010  |  Journal of Molecular Histology

Identification of subunits of voltage-gated calcium channels and actions of pregabalin on intrinsic primary afferent neurons in the guinea-pig ileum

K Needham, R Bron, B Hunne, TV Nguyen, K Turner, M Nash, JB Furness

Journal article  |  2010  |  Neurogastroenterology and Motility

Measuring hyperpolarisation-activated currents in dissociated spiral ganglion neurons

KN Needham, BN Nayagam, RLM Minter, SJO O'Leary

Conference Proceedings  |  2010  |  The Art, Science and future of Otorhinolaryngology: Frontiers 2010

Synaptic responses in cochlear nucleus neurons evoked by activation of the olivocochlear system

WHAM Mulders, AG Paolini, K Needham, D Robertson

Journal article  |  2009  |  Hearing Research

Evidence that task1 channels contribute to the background current in Ah/type 11 neurons of the guinea-pig intestine

H Matsuyama, TV Nguyen, B Hunne, M Thacker, K Needham, D McHugh, JB Furness

Journal article  |  2008  |  Neuroscience

The commissural pathway and cochlear nucleus bushy neurons: An in vivo intracellular investigation

Karina Needham, Antonio G Paolini

Journal article  |  2007  |  Brain Research

Neural timing, inhibition and the nature of stellate cell interaction in the ventral cochlear nucleus

Karina Needham, Antonio G Paolini

Journal article  |  2006  |  Hearing Research

Balanced inhibition and excitation underlies spike firing regularity in ventral cochlear nucleus chopper neurons

AG Paolini, JC Clarey, K Needham, GM Clark

Journal article  |  2005  |  European Journal of Neuroscience

Fast inhibition alters first spike timing in auditory brainstem neurons

AG Paolini, JC Clarey, K Needham, GM Clark

Journal article  |  2004  |  Journal of Neurophysiology

Fast inhibition underlies the transmission of auditory information between cochlear nuclei

K Needham, AG Paolini

Journal article  |  2003  |  Journal of Neuroscience

Olivocochlear collaterals evoke excitatory effects in onset neurones of the rat cochlear nucleus

WHAM Mulders, AG Paolini, K Needham, D Robertson

Journal article  |  2003  |  Hearing Research