Karina Needham

Response of primary auditory neurons to stimulation with infrared light in vitro

William GA Brown, Karina Needham, James M Begeng, Alexander C Thompson, Bryony A Nayagam, Tatiana Kameneva, Paul R Stoddart

Journal article  |  2021  |  JOURNAL OF NEURAL ENGINEERING

Objective.Infrared light can be used to modulate the activity of neuronal cells through thermally-evoked capacitive currents and t..

Laminin coated diamond electrodes for neural stimulation

Md Kabir Uddin Sikder, Wei Tong, Hitesh Pingle, Peter Kingshott, Karina Needham, Mohit N Shivdasani, James B Fallon, Peter Seligman, Michael R Ibbotson, Steven Prawer, David J Garrett

Journal article  |  2021  |  MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

The performance of many implantable neural stimulation devices is degraded due to the loss of neurons around the electrodes by the..

Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation

Alex C Thompson, Andrew K Wise, William L Hart, Karina Needham, James B Fallon, Niliksha Gunewardene, Paul R Stoddart, Rachael T Richardson

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: Compared to electrical stimulation, optogenetic stimulation has the potential to improve the spatial precision of neura..

Comparison of electrode impedance measures between a dexamethasone-eluting and standard Cochlear (TM) Contour Advance (R) electrode in adult cochlear implant recipients

Robert Briggs, Stephen O'Leary, Catherine Birman, Kerrie Plant, Ruth English, Pamela Dawson, Frank Risi, Jason Gavrilis, Karina Needham, Robert Cowan

Journal article  |  2020  |  HEARING RESEARCH

OBJECTIVE: To compare the difference in electrode impedance across discrete time points to 24 months post-activation for two group..

Thermal damage threshold of neurons during infrared stimulation

WGA Brown, K Needham, JM Begeng, AC Thompson, BA Nayagam, T Kameneva, PR Stoddart

Journal article  |  2020  |  Biomedical Optics Express

In infrared neural stimulation (INS), laser-evoked thermal transients are used to generate small depolarising currents in neurons...

Electrode impedance changes after implantation of a dexamethasone-eluting intracochlear array

Karina Needham, Dimitra Stathopoulos, Carrie Newbold, Jason Leavens, Frank Risi, Shahram Manouchehri, Irfan Durmo, Robert Cowan

Journal article  |  2020  |  COCHLEAR IMPLANTS INTERNATIONAL

Postoperative inflammation and the formation of fibrotic tissue around the intracochlear electrode array are often held responsibl..

Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency-an in vitro study

William L Hart, Rachael T Richardson, Tatiana Kameneva, Alex C Thompson, Andrew K Wise, James B Fallon, Paul R Stoddart, Karina Needham

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: The performance of neuroprostheses, including cochlear and retinal implants, is currently constrained by the spatial re..

Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices

Tomoko Hyakumura, Stuart McDougall, Sue Finch, Karina Needham, Mirella Dottori, Bryony A Nayagam

Journal article  |  2019  |  Stem Cells International

Stem cells have been touted as a source of potential replacement neurons for inner ear degeneration for almost two decades now; ye..

Protecting against electrode insertion trauma using dexamethasone

Scott Chambers, Carrie Newbold, Dimitra Stathopoulos, Karina Needham, Chris Miller, Frank Risi, Ya Lang Enke, Godofredo Timbol, Robert Cowan

Journal article  |  2019  |  COCHLEAR IMPLANTS INTERNATIONAL

OBJECTIVE: To compare the benefits of a dexamethasone-eluting array for hearing preservation and cochlear histopathology in low tr..

Stimulation of Primary Auditory Neurons Mediated by Near-Infrared Excitation of Gold Nanorods

Chiara Paviolo, Karina Needham, William GA Brown, Jiawey Yong, Paul R Stoddart

Book Chapter  |  2018  |  Neuromethods

Neural stimulation plays an important role in achieving therapeutic interactions with both the central and peripheral nervous syst..