Laura Downie

Interventions for myopia control in children: a living systematic review and network meta-analysis.

John G Lawrenson, Rakhee Shah, Byki Huntjens, Laura E Downie, Gianni Virgili, Rohit Dhakal, Pavan K Verkicharla, Dongfeng Li, Sonia Mavi, Ashleigh Kernohan, Tianjing Li, Jeffrey J Walline

Journal article  |  2023  |  Cochrane Database Syst Rev

BACKGROUND: Myopia is a common refractive error, where elongation of the eyeball causes distant objects to appear blurred. The inc..

Topical Decorin Reduces Corneal Inflammation and Imparts Neuroprotection in a Mouse Model of Benzalkonium Chloride-induced Corneal Neuropathy.

Mengliang Wu, Laura E Downie, Lisa J Hill, Holly R Chinnery

Journal article  |  2023  |  Invest Ophthalmol Vis Sci

PURPOSE: We evaluated the neuroprotective and immunomodulatory effects of topical decorin in a murine model of benzalkonium chlori..

Omega-3 polyunsaturated fatty acids and corneal nerve health: Current evidence and future directions

Alexis Ceecee Britten-Jones, Jennifer P Craig, Laura E Downie

Journal article  |  2022  |  OCULAR SURFACE

Corneal nerves play a key role in maintaining ocular surface integrity. Corneal nerve damage, from local or systemic conditions, c..

Clinical Registries in Dry Eye Disease: A Systematic Review

Pauline Khoo, Laura E Downie, Fiona Stapleton, Saaeha Rauz, Vincent Daien, Francisco Arnalich, David Mingo, Stephanie L Watson

Journal article  |  2022  |  CORNEA

PURPOSE: The objective of this study was to undertake a systematic review of the literature reporting on clinical registries in dr..

Is critical flicker-fusion frequency a valid measure of visual fatigue? A post-hoc analysis of a double-masked randomised controlled trial

Sumeer Singh, Laura EE Downie, Andrew JJ Anderson

Journal article  |  2022  |  OPHTHALMIC AND PHYSIOLOGICAL OPTICS

PURPOSE: Critical flicker-fusion frequency (CFF) has been used in clinical studies as a measure of visual fatigue. We examine the ..

Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

Mengliang Wu, Lisa J Hill, Laura E Downie, Holly R Chinnery

Journal article  |  2022  |  PROGRESS IN RETINAL AND EYE RESEARCH

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with their important roles in the mainte..

Interventions for the Management of Computer Vision Syndrome A Systematic Review and Meta-analysis

Sumeer Singh, Myra B McGuinness, Andrew J Anderson, Laura E Downie

Journal article  |  2022  |  OPHTHALMOLOGY

TOPIC: To evaluate the efficacy and safety of interventions for treating eye strain related to computer use relative to placebo or..

Association between systemic omega-3 polyunsaturated fatty acid levels, and corneal nerve structure and function

Alexis Ceecee Britten-Jones, Jennifer P Craig, Andrew J Anderson, Laura E Downie

Journal article  |  2022  |  EYE

BACKGROUND: Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have anti-inf..

Topographical Distribution and Phenotype of Resident Meibomian Gland Orifice Immune Cells (MOICs) in Mice and the Effects of Topical Benzalkonium Chloride (BAK)

Ching Yi Wu, Mengliang Wu, Xin Huang, Ben J Gu, Carole Maldonado-Codina, Philip B Morgan, Laura E Downie, Holly R Chinnery

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Meibomian gland orifices (MGOs) are located along the eyelid margin and secrete meibum into the tear film. The profile of resident..

Knowledge, views and experiences of Australian optometrists in relation to ocular stem cell therapies

Maria Cabrera-Aguas, Laura E Downie, Megan M Munsie, Nick Di Girolamo, Michael O'Connor, Stephanie L Watson

Journal article  |  2022  |  CLINICAL AND EXPERIMENTAL OPTOMETRY

CLINICAL RELEVANCE: Findings from this study examining Australian optometrists' insights into ocular stem cell (SC) therapies have..