Paul Cameron

Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART

Charline Bacchus-Souffan, Mark Fitch, Jori Symons, Mohamed Abdel-Mohsen, Daniel B Reeves, Rebecca Hoh, Mars Stone, Joseph Hiatt, Peggy Kim, Abha Chopra, Haelee Ahn, Vanessa A York, Daniel L Cameron, Frederick M Hecht, Jeffrey N Martin, Steven A Yukl, Simon Mallal, Paul U Cameron, Steven G Deeks, Joshua T Schiffer, et al.

Journal article  |  2021  |  PLOS PATHOGENS

The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well c..

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4( ) T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained

Michael Roche, Carolin Tumpach, Jori Symons, Matthew Gartner, Jenny L Anderson, Gabriela Khoury, Kieran Cashin, Paul U Cameron, Melissa J Churchill, Steven G Deeks, Paul R Gorry, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF VIROLOGY

HIV can persist in people living with HIV (PLWH) on antiretroviral therapy (ART) in multiple CD4+ T cell subsets, including naive ..

Combination Immune Checkpoint Blockade to Reverse HIV Latency

Renee M Van der Sluis, Nitasha A Kumar, Rachel D Pascoe, Jennifer M Zerbato, Vanessa A Evans, Ashanti I Dantanarayana, Jenny L Anderson, Rafick P Sekaly, Remi Fromentin, Nicolas Chomont, Paul U Cameron, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD..

Human Immunodeficiency Virus (HIV)-Infected CCR6( ) Rectal CD4( ) T Cells and HIV Persistence On Antiretroviral Therapy

Jenny L Anderson, Gabriela Khoury, Remi Fromentin, Ajantha Solomon, Nicolas Chomont, Elizabeth Sinclair, Jeffrey M Milush, Wendy Hartogensis, Peter Bacchetti, Michael Roche, Carolin Tumpach, Matthew Gartner, Matthew C Pitman, Christine Lorrie Epling, Rebecca Hoh, Frederick M Hecht, Ma Somsouk, Paul U Cameron, Steven G Deeks, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Identifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral t..

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

Renee M Van der Sluis, Jennifer M Zerbato, Jake W Rhodes, Rachel D Pascoe, Ajantha Solomon, Nitasha A Kumar, Ashanti I Dantanarayana, Surekha Tennakoon, Jeremy Dufloo, James McMahon, Judy J Chang, Vanessa A Evans, Paul J Hertzog, Martin R Jakobsen, Andrew N Harman, Sharon R Lewin, Paul U Cameron

Journal article  |  2020  |  PLOS PATHOGENS

HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus per..

Influenza-specific IgG1( ) memory B-cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency

Gemma E Hartley, Emily SJ Edwards, Julian J Bosco, Samar Ojaimi, Robert G Stirling, Paul U Cameron, Katie Flanagan, Magdalena Plebanski, Philip Mark Hogarth, Robyn E O'Hehir, Menno C Zelm

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Background: Annual influenza vaccination is recommended to all individuals over 6 months of age, including predominantly antibody ..

Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency

Youry Kim, Paul U Cameron, Sharon R Lewin, Jenny L Anderson

Journal article  |  2019  |  JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

INTRODUCTION: HIV latency can be established in vitro following direct infection of a resting CD4+ T cell (pre-activation latency)..

Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells

Emily SJ Edwards, Julian J Bosco, Pei M Aui, Robert G Stirling, Paul U Cameron, Josh Chatelier, Fiona Hore-Lacy, Robyn E O'Hehir, Menno C van Zelm

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Background: Patients with predominantly antibody deficiency (PAD) suffer from severe and recurrent infections that require lifelon..

Quantification of T-Cell and B-Cell Replication History in Aging, Immunodeficiency, and Newborn Screening

Ruud HJ Verstegen, Pei M Aui, Eliza Watson, Samuel De Jong, Sophinus JW Bartol, Julian J Bosco, Paul U Cameron, Robert G Stirling, Esther de Vries, Jacques JM van Dongen, Menno C van Zelm

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Quantification of T-cell receptor excision circles (TRECs) has impacted on human T-cell research, but interpretations on T-cell re..

Identification of HIV transmitting CD11c human epidermal dendritic cells.

Kirstie M Bertram, Rachel A Botting, Heeva Baharlou, Jake W Rhodes, Hafsa Rana, J Dinny Graham, Ellis Patrick, James Fletcher, Toby M Plasto, Naomi R Truong, Caroline Royle, Chloe M Doyle, Orion Tong, Najla Nasr, Laith Barnouti, Mark P Kohout, Andrew J Brooks, Michael P Wines, Peter Haertsch, Jake Lim, et al.

Journal article  |  2019  |  Nat Commun

Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. He..