Paul Cameron

Memory CD4( ) T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency

Thomas A Rasmussen, Jennifer M Zerbato, Ajantha Rhodes, Carolin Tumpach, Ashanti Dantanarayana, James H McMahon, Jillian SY Lau, J Judy Chang, Celine Gubser, Wendy Brown, Rebecca Hoh, Melissa Krone, Rachel Pascoe, Chris Y Chiu, Michael Bramhall, Hyun Jae Lee, Ashraful Haque, Remi Fromentin, Nicolas Chomont, Jeffrey Milush, et al.

Journal article  |  2022  |  CELL REPORTS MEDICINE

Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4+ T cell activation and may prom..

Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue

Zuwena A Richardson, Claire Deleage, Candani SA Tutuka, Marzena Walkiewicz, Perla M Del Rio-Estrada, Rachel D Pascoe, Vanessa A Evans, Gustavo Reyesteran, Michael Gonzales, Samuel Roberts-Thomson, Mauricio Gonzalez-Navarro, Fernanda Torres-Ruiz, Jacob D Estes, Sharon R Lewin, Paul U Cameron

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGICAL METHODS

The main barrier to a cure for HIV is the persistence of long-lived and proliferating latently infected CD4+ T-cells despite antir..

Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy

Chris Y Chiu, Judy J Chang, Ashanti Dantanarayana, Ajantha Solomon, Vanessa A Evans, Rachel Pascoe, Celine Gubser, Lydie Trautman, Remi Fromentin, Nicolas Chomont, James H McMahon, Paul U Cameron, Thomas A Rasmussen, Sharon R Lewin

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune che..

Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART

Charline Bacchus-Souffan, Mark Fitch, Jori Symons, Mohamed Abdel-Mohsen, Daniel B Reeves, Rebecca Hoh, Mars Stone, Joseph Hiatt, Peggy Kim, Abha Chopra, Haelee Ahn, Vanessa A York, Daniel L Cameron, Frederick M Hecht, Jeffrey N Martin, Steven A Yukl, Simon Mallal, Paul U Cameron, Steven G Deeks, Joshua T Schiffer, et al.

Journal article  |  2021  |  PLOS PATHOGENS

The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well c..

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4( ) T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained

Michael Roche, Carolin Tumpach, Jori Symons, Matthew Gartner, Jenny L Anderson, Gabriela Khoury, Kieran Cashin, Paul U Cameron, Melissa J Churchill, Steven G Deeks, Paul R Gorry, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF VIROLOGY

HIV can persist in people living with HIV (PLWH) on antiretroviral therapy (ART) in multiple CD4+ T cell subsets, including naive ..

Combination Immune Checkpoint Blockade to Reverse HIV Latency

Renee M Van der Sluis, Nitasha A Kumar, Rachel D Pascoe, Jennifer M Zerbato, Vanessa A Evans, Ashanti I Dantanarayana, Jenny L Anderson, Rafick P Sekaly, Remi Fromentin, Nicolas Chomont, Paul U Cameron, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD..

Human Immunodeficiency Virus (HIV)-Infected CCR6( ) Rectal CD4( ) T Cells and HIV Persistence On Antiretroviral Therapy

Jenny L Anderson, Gabriela Khoury, Remi Fromentin, Ajantha Solomon, Nicolas Chomont, Elizabeth Sinclair, Jeffrey M Milush, Wendy Hartogensis, Peter Bacchetti, Michael Roche, Carolin Tumpach, Matthew Gartner, Matthew C Pitman, Christine Lorrie Epling, Rebecca Hoh, Frederick M Hecht, Ma Somsouk, Paul U Cameron, Steven G Deeks, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Identifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral t..

Immunophenotyping of B-Cell AND T-CELL ABNORMALITIES IN PID USING EUROFLOW-BASED PANELS

Emily SJ Edwards, Julian J Bosco, Pei M Aui, Robert G Stirling, Paul U Cameron, Josh Chatelier, Fiona Hore-Lacy, Robyn E O’Hehir, Menno C van Zelm

Journal article  |  2020  |  Pathology

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

Renee M Van der Sluis, Jennifer M Zerbato, Jake W Rhodes, Rachel D Pascoe, Ajantha Solomon, Nitasha A Kumar, Ashanti I Dantanarayana, Surekha Tennakoon, Jeremy Dufloo, James McMahon, Judy J Chang, Vanessa A Evans, Paul J Hertzog, Martin R Jakobsen, Andrew N Harman, Sharon R Lewin, Paul U Cameron

Journal article  |  2020  |  PLOS PATHOGENS

HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus per..

Influenza-specific IgG1( ) memory B-cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency

Gemma E Hartley, Emily SJ Edwards, Julian J Bosco, Samar Ojaimi, Robert G Stirling, Paul U Cameron, Katie Flanagan, Magdalena Plebanski, Philip Mark Hogarth, Robyn E O'Hehir, Menno C Zelm

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

BACKGROUND: Annual influenza vaccination is recommended to all individuals over 6 months of age, including predominantly antibody ..