Theo Mantamadiotis

Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment

Samuel S Widodo, Marija Dinevska, Lucero Cuzcano, Michael Papanicolaou, Thomas R Cox, Stanley S Stylli, Theo Mantamadiotis

Journal article  |  2023  |  Advances in Cancer Biology - Metastasis

Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression.

Sarah A Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis, Katharine J Drummond

Journal article  |  2023  |  BMC Cancer

BACKGROUND: A subset of meningiomas progress in histopathological grade but drivers of progression are poorly understood. We aimed..

Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization

Marija Dinevska, Samuel S Widodo, Liam Furst, Lucero Cuzcano, Yitong Fang, Stefano Mangiola, Paul J Neeson, Phillip K Darcy, Robert G Ramsay, Ryan Hutchinson, Fabienne MacKay, Michael Christie, Stanley S Stylli, Theo Mantamadiotis

Journal article  |  2022  |  CELLULAR ONCOLOGY

PURPOSE: Tumor cells thrive by adapting to the signals in their microenvironment. To adapt, cancer cells activate signaling and tr..

Advances in CAR T cell immunotherapy for paediatric brain tumours

Padmashree Rao, Liam Furst, Deborah Meyran, Chelsea Mayoh, Paul J Neeson, Rachael Terry, Dong-Anh Khuong-Quang, Theo Mantamadiotis, Paul G Ekert

Journal article  |  2022  |  FRONTIERS IN ONCOLOGY

Brain tumours are the most common solid tumour in children and the leading cause of cancer related death in children. Current trea..

Repurposing FDA-approved drugs as inhibitors of therapy-induced invadopodia activity in glioblastoma cells

Dylan Jones, Clarissa A Whitehead, Marija Dinevska, Samuel S Widodo, Liam M Furst, Andrew P Morokoff, Andrew H Kaye, Katharine J Drummond, Theo Mantamadiotis, Stanley S Stylli

Journal article  |  2022  |  MOLECULAR AND CELLULAR BIOCHEMISTRY

Glioblastoma (GBM) is the most prevalent primary central nervous system tumour in adults. The lethality of GBM lies in its highly ..

Identification and isolation of slow-cycling glioma stem cells

Liam Furst, Ryan J Atkins, Marija Dinevska, Stanley S Stylli, Niall M Corcoran, Christopher M Hovens, Theo Mantamadiotis

Book Chapter  |  2022  |  Methods in Cell Biology

Cancer stem cells are defined as low-abundance, quiescent cells and are considered a major cellular source of tumor recurrence fol..

The renin-angiotensin system in central nervous system tumors and degenerative diseases

Simon Haron, Ethan J Kilmister, Paul F Davis, Stanley S Stylli, Theo Mantamadiotis, Andrew H Kaye, Sean R Hall, Swee T Tan, Agadha C Wickremesekera

Journal article  |  2021  |  FRONTIERS IN BIOSCIENCE-LANDMARK

Despite their differences, central nervous system (CNS) tumors and degenerative diseases share important molecular mechanisms unde..

LSC - 2021 - cAMP response element-binding protein mediates immune-evasion of KRAS-mutant lung adenocarcinoma

Georgia A Giotopoulou, Giannoula Ntaliarda, A Marazioti, Ioannis Lilis, N Spiropoulou, F Kalogianni, E Tourkochristou, Ioanna Giopanou, Magda Spella, M Iliopoulou, A Korfiati, K Theofilatos, S Mavroudi, Theo Mantamadiotis, Torsten Goldmann, S Marwitz, GT Stathopoulos

Conference Proceedings  |  2021  |  Lung cancer

IL-10 in glioma

Samuel S Widodo, Marija Dinevska, Liam M Furst, Stanley S Stylli, Theo Mantamadiotis

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

The prognosis for patients with glioblastoma (GBM), the most common and malignant type of primary brain tumour, is very poor, desp..

The Renin-Angiotensin System in the Tumor Microenvironment of Glioblastoma

Michael O'Rawe, Ethan J Kilmister, Theo Mantamadiotis, Andrew H Kaye, Swee T Tan, Agadha C Wickremesekera

Journal article  |  2021  |  CANCERS

Glioblastoma (GB) is an aggressive primary brain tumor. Despite intensive research over the past 50 years, little advance has been..