Shenna Langenbach

Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer

Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart

Journal article  |  2021  |  CANCERS

Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target th..

Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways

Asres Berhan, Trudi Harris, Jade Jaffar, Fernando Jativa, Shenna Langenbach, Ingrid Loennstedt, Monther Alhamdoosh, Milica Ng, Peter Lee, Glen Westall, Nick Wilson, Michael Wilson, Alastair G Stewart

Journal article  |  2020  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathological changes in the biomechanical environment are implicated in the progression of idiopathic pulmonary fibrosis (IPF). St..

An Automated Quantitative Method to Analyze Immunohistochemistry and Immunocytochemistry Images

Yongcheng Jin, Kexin Shi, Xumei Gao, Shenna Y Langenbach, Meina Li, Trudi Harris, Alastair G Stewart

Journal article  |  2020  |  Journal of Engineering and Science in Medical Diagnostics and Therapy

AbstractImmunohistochemistry (IHC) plays an important role in target protein analysis. However, many researchers analyze IHC image..

Integrin alpha 7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells

Chun Ming Teoh, Sheryl SL Tan, ShennaY Langenbach, Amanda H Wong, Dorothy HJ Cheong, John KC Tam, Chih Sheng New, Thai Tran

Journal article  |  2019  |  SCIENTIFIC REPORTS

Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contra..

PHOSPHOLIPASE D-DEPENDENT INHIBITION OF THE NUCLEAR HORMONE RECEPTOR GR BY (LYSO) PHOSPHATIDIC ACID

M Li, Y Xia, T Harris, S Langenbach, Q Chen, A Stewart

Conference Proceedings  |  2019  |  RESPIROLOGY

A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-beta 1 in Steroid-Resistant Airway Diseases

Meina Li, Christine R Keenan, Guillermo Lopez-Campos, Jonathan E Mangum, Qianyu Chen, Danica Prodanovic, Yuxiu C Xia, Shenna Y Langenbach, Trudi Harris, Vinzenz Hofferek, Gavin E Reid, Alastair G Stewart

Journal article  |  2019  |  ISCIENCE

Impaired therapeutic responses to anti-inflammatory glucocorticoids (GC) in chronic respiratory diseases are partly attributable t..

Casein Kinase 1 delta/epsilon Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-beta in Pulmonary Fibrosis

Christine R Keenan, Shenna Y Langenbach, Fernando Jativa, Trudi Harris, Meina Li, Qianyu Chen, Yuxiu Xia, Bryan Gao, Michael J Schuliga, Jade Jaffar, Danica Prodanovic, Yan Tu, Asres Berhan, Peter VS Lee, Glen P Westall, Alastair G Stewart

Journal article  |  2018  |  FRONTIERS IN PHARMACOLOGY

Transforming growth factor-beta (TGF-β) is a major mediator of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). H..

TOLL-LIKE RECEPTORS IN VIRUS-INDUCED STEROID RESISTANCE IN BRONCHIAL EPITHELIAL CELLS

Y Xia, A Radwan, S Langenbach, R Gualano, A Stewart

Conference Proceedings  |  2018  |  RESPIROLOGY

CASEIN KINASE 1DELTA/EPSILON: A NOVEL PATHWAY SENSITIZING GLUCOCORTICOID ACTIVITY

M Li, C Keenan, Y Xia, S Langenbach, T Harris, A Stewart

Conference Proceedings  |  2018  |  RESPIROLOGY

Cortisol limits selected actions of synthetic glucocorticoids in the airway epithelium

Danica Prodanovic, Christine R Keenan, Shenna Langenbach, Meina Li, Qianyu Chen, Michael J Lew, Alastair G Stewart

Journal article  |  2018  |  FASEB JOURNAL

Cortisol, a physiologic glucocorticoid (GC), is essential for growth and differentiation of the airway epithelium. Epithelial func..