Professor John Prins is an active clinician-scientist, a key opinion leader in diabetes and endocrinology in Australia and sits on numerous national and international scientific, clinical and educational committees and boards for the National Health and Medical Research Council (NHMRC), non-government organisations and industry.Professor Prins undertook his clinical training in endocrinology in Brisbane and then completed a PhD in adipose tissue biology at The University of Queensland (UQ). Then followed a postdoctoral research appointment at the University of Cambridge, UK, based at Addenbrooke’s Hospital.
He returned to Brisbane in 1998 after being awarded a Wellcome International Senior Research Fellowship.In 2004 he was Founder/Director of the UQ Centre for Diabetes and Endocrine Research, one of the most prominent and successful groups on the Princess Alexandra Hospital campus, which merged with the UQ Centre for Immunology and Cancer Research (CICR) in January 2007 to form the UQ Diamantina Institute. In 2009 Professor Prins was appointed CEO/Director of Mater Research. He was also Professor of Endocrinology at UQ and is a Senior Staff Endocrinologist at the Princess Alexandra Hospital.In 2018 Prof Prins was appointed Head of the Melbourne Medical School and Professor of Medicine at the University of Melbourne. He also has part-time clinical appointments in Endocrinology at the Royal Melbourne Hospital, Goulbourne Valley Health and Rumbalara.Professor Prins has substantial commercialisation experience, holds four international patents and was founder and scientific director of a spin-out biotech company—Adipogen Pty Ltd. He sits on numerous Australian and Global Pharmaceutical Scientific & Clinical Advisory Boards. His current corporate roles include directorships of Metro South Hospital and Health Service ($2.6b) and the Centre for Eye Research Australia. Professor Prins is actively involved in undergraduate and post-graduate teaching and training and has ongoing research interests in obesity, diabetes and intellectual disability. His current research focus is early-stage drug development in Type 2 Diabetes and in Non-Alcoholic Fatty Liver Disease. His research has attracted substantial government, NGO and Industry funding. He has published over 150 papers with over 11,000 citations and has an H index of 48 (Web of Science).
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The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Os..
Diabetes screen during tuberculosis contact investigations highlights opportunity for new ..
Uniting emergency and inpatient clinicians across the ED-inpatient interface: The last fro..
Displaying the 184 most recent scholarly works by John Prins.
Sex Differences in the Risk of Barrett Esophagus Associated With the Metabolic Effects of Obesity.
Bradley J Kendall, Graeme A Macdonald, Johannes B Prins, Suzanne O'Brien, Aaron P Thrift, David C Whiteman, undefined Study of Digestive Health
Journal article | 2019 | Journal of Clinical Gastroenterology
GOAL: The goal of this study was to determine if there is an association between the insulin-insulin-like growth factor axis, the ..
The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans
Nicole Cesana-Nigro, Sahar Keshvari, Johanna L Barclay, Jane Sorbello, John W Upham, Helen Benham, Stephen T Anderson, Natasha Steiger, Johannes B Prins, Warrick J Inder
Journal article | 2019 | Clinical Endocrinology
OBJECTIVE: Thrombospondin-1 (TSP1), a matricellular protein, and Osteocalcin (OCN), a noncollagenous protein secreted by osteoblas..
Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups
Blanca Restrepo, Leanie Kleynhans, Alejandra B Salinas, Bassent Abdelbary, Happy Tshivhula, Genesis P Aguillon-Duran, Carine Kunsevi-Kilola, Gloria Salinas, Kim Stanley, Stephanus T Malherbe, Elizna Maasdorp, Moncerrato Garcia-Viveros, Ilze Louw, Esperanza M Garcia-Oropesa, Juan Carlos Lopez-Alvarenga, John B Prins, Gerhard Walzl, Larry S Schlesinger, Katharina Ronacher
Journal article | 2018 | Tuberculosis
Intensity of early correction of hyperglycaemia and outcome of critically ill patients with diabetic ketoacidosis
Johan Martensson, Michael Bailey, Balasubramanian Venkatesh, David Pilcher, Adam Deane, Yasmine Ali Abdelhamid, Marco Crisman, Brij Verma, Christopher MacIsaac, Geoffrey Wigmore, Yahya Shehabi, Takafumi Suzuki, Craig French, Neil Orford, Nima Kakho, Johannes Prins, Elif I Ekinci, Rinaldo Bellomo
Journal article | 2017 | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
The temporal profile of adiponectin in healthy human subjects: a comparison with additional inflammatory and endocrine markers
Katherine Robinson, Anand Krishnan, Karthik Venkatesh, Mark Jones, Emeline Tocquer, Diane Bruneau, Jeff Grice, Jeremy Cohen, John Prins, Bala Venkatesh
Conference Proceedings | 2017 | CLINICAL ENDOCRINOLOGY
Living well after breast cancer randomized controlled trial protocol: evaluating a telephone-delivered weight loss intervention versus usual care in women following treatment for breast cancer
Marina M Reeves, Caroline O Terranova, Jane M Erickson, Jennifer R Job, Denise SK Brookes, Nicole McCarthy, Ingrid J Hickman, Sheleigh P Lawler, Brianna S Fjeldsoe, Genevieve N Healy, Elisabeth AH Winkler, Monika Janda, J Lennert Veerman, Robert S Ware, Johannes B Prins, Theo Vos, Wendy Demark-Wahnefried, Elizabeth G Eakin
Journal article | 2016 | BMC Cancer
Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease
Ilaria Croci, Nuala M Byrne, Veronique S Chachay, Andrew P Hills, Andrew D Clouston, Trisha M O'Moore-Sullivan, Johannes B Prins, Graeme A Macdonald, Ingrid J Hickman
Journal article | 2016 | World Journal of Hepatology
Identification of carboxypeptidase X (CPX)-1 as a positive regulator of adipogenesis
Yu-Hee Kim, Johanna L Barclay, Jingjing He, Xiao Luo, Hayley M O'Neill, Sahar Keshvari, Julie A Webster, Choaping Ng, Louise J Hutley, Johannes B Prins, Jonathan P Whitehead
Journal article | 2016 | The FASEB Journal
Thrombospondin-1 is a glucocorticoid responsive protein and potential biomarker of glucocorticoid activity
Johanna L Barclay, Carolyn J Petersons, Sahar Keshvari, Jane Sorbello, Brenda L Mangelsdorf, Campbell H Thompson, Johannes B Prins, Morton G Burt, Jonathan P Whitehead, Warrick Inder
Conference Proceedings | 2016 | CLINICAL ENDOCRINOLOGY
Thrombospondin-1 is a glucocorticoid responsive protein in humans
Johanna L Barclay, Carolyn J Petersons, Sahar Keshvari, Jane Sorbello, Brenda L Mangelsdorf, Campbell H Thompson, Johannes B Prins, Morton G Burt, Jonathan P Whitehead, Warrick J Inder
Journal article | 2016 | European Journal of Endocrinology
Effect of 1-h moderate-intensity aerobic exercise on intramyocellular lipids in obese men before and after a lifestyle intervention
Stephanie Ipavec-Levasseur, Ilaria Croci, Stephane Choquette, Nuala M Byrne, Gary Cowin, Trisha M O'Moore-Sullivan, Johannes B Prins, Ingrid J Hickman
Journal article | 2015 | Applied Physiology, Nutrition, and Metabolism
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress
Sumaira Z Hasnain, Danielle J Borg, Brooke E Harcourt, Hui Tong, Yonghua H Sheng, Choa Ping Ng, Indrajit Das, Ran Wang, Alice C-H Chen, Thomas Loudovaris, Thomas W Kay, Helen E Thomas, Jonathan P Whitehead, Josephine M Forbes, Johannes B Prins, Michael A McGuckin
Journal article | 2014 | Nature Medicine
Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease
Veronique S Chachay, Graeme A Macdonald, Jennifer H Martin, Jonathan P Whitehead, Trisha M O'Moore-Sullivan, Paul Lee, Michael Franklin, Kerenaftali Klein, Paul J Taylor, Maree Ferguson, Jeff S Coombes, Gethin P Thomas, Gary J Cowin, Carl MJ Kirkpatrick, Johannes B Prins, Ingrid J Hickman
Journal article | 2014 | Clinical Gastroenterology and Hepatology
Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs
Fiona M Keane, Tsun-Wen Yao, Stefanie Seelk, Margaret G Gall, Sumaiya Chowdhury, Sarah E Poplawski, Jack H Lai, Youhua Li, Wengen Wu, Penny Farrell, Ana Julia Vieira de Ribeiro, Brenna Osborne, Denise MT Yu, Devanshi Seth, Khairunnessa Rahman, Paul Haber, A Kemal Topaloglu, Chuanmin Wang, Sally Thomson, Annemarie Hennessy, et al.
Journal article | 2014 | FEBS Open Bio
Whole-body substrate metabolism is associated with disease severity in patients with non-alcoholic fatty liver disease
Ilaria Croci, Nuala M Byrne, Stephane Choquette, Andrew P Hills, Veronique S Chachay, Andrew D Clouston, Trisha M O'Moore-Sullivan, Graeme A Macdonald, Johannes B Prins, Ingrid J Hickman
Journal article | 2013 | Gut
Investigating the clinical effect of resveratrol in non-alcoholic fatty liver disease: A randomised, double blind, placebo-controlled trial
VS Chachay, JH Martin, JB Prins, JP Whitehead, TM O'Moore-Sullivan, P Lee, M Franklin, K Klein, PJ Taylor, M Ferguson, JS Coombes, GP Thomas, GJ Cowin, CMJ Kirkpatrick, GA Macdonald, IJ Hickman
Conference Proceedings | 2013 | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin?
Olivia RL Wright, Ingrid J Hickman, William G Petchey, Clair M Sullivan, Cynthia Ong, Felicity J Rose, Choaping Ng, Johannes B Prins, Jonathan P Whitehead, Trisha M O'Moore-Sullivan
Journal article | 2013 | Canadian Journal of Physiology and Pharmacology
An Inhibitor of Phospholipase A(2) Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats
Abishek Iyer, Junxian Lim, Hemant Poudyal, Robert C Reid, Jacky Y Suen, Julie Webster, Johannes B Prins, Jonathan P Whitehead, David P Fairlie, Lindsay Brown
Journal article | 2012 | Diabetes
Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors
Xiao Luo, Louise J Hutley, Julie A Webster, Yu-Hee Kim, Dong-Fang Liu, Felicity S Newell, Charlotte H Widberg, Anthony Bachmann, Nigel Turner, Carsten Schmitz-Peiffer, Johannes B Prins, Gong-She Yang, Jonathan P Whitehead
Journal article | 2012 | Diabetes
Exercise prescription for patients with type 2 diabetes and pre-diabetes: A position statement from Exercise and Sport Science Australia
Matthew D Hordern, David W Dunstan, Johannes B Prins, Michael K Baker, Maria A Fiatarone Singh, Jeff S Coombes
Journal article | 2012 | Journal of Science and Medicine in Sport
The Effect of a High-Fat Meal on Postprandial Arterial Stiffness in Men with Obesity and Type 2 Diabetes
LK Phillips, JM Peake, X Zhang, IJ Hickman, O Kolade, JW Sacre, BE Huang, P Simpson, SH Li, JP Whitehead, JE Sharman, JH Martin, JB Prins
Journal article | 2010 | The Journal of Clinical Endocrinology & Metabolism
Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation
Ayanthi A Richards, Michelle L Colgrave, Jialiang Zhang, Julie Webster, Fiona Simpson, Elaine Preston, Donna Wilks, Kyle L Hoehn, Matthew Stephenson, Graeme A Macdonald, John B Prins, Gregory J Cooney, Aimin Xu, Jonathan P Whitehead
Journal article | 2010 | Molecular Endocrinology
The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with Chronic Kidney Disease: a randomised controlled trial
William G Petchey, Ingrid J Hickman, Emma Duncan, Johannes B Prins, Carmel M Hawley, David W Johnson, Katherine Barraclough, Nicole M Isbel
Journal article | 2009 | BMC Nephrology
Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity
Hua Su, Jennifer H Gunter, Melissa de Vries, Tim Connor, Stephen Wanyonyi, Felicity S Newell, David Segal, Juan Carlos Molero, Ofer Reizes, Johannes B Prins, Louise J Hutley, Ken Walder, Jonathan P Whitehead
Journal article | 2009 | Biochemical and Biophysical Research Communications
Patients with type 2 diabetes have exaggerated brachial and central exercise blood pressure: Relation to left ventricular relative wall thickness
James A Scott, Jeff S Coombes, Johannes B Prins, Rodel L Leano, Thomas H Marwick, James E Sharman
Journal article | 2008 | American Journal of Hypertension
Should patients with type 2 diabetes and raised liver enzymes be referred for further evaluation of liver disease?
Ingrid J Hickman, Anthony J Russell, Johannes B Prins, Graeme A Macdonald
Journal article | 2008 | Diabetes Research and Clinical Practice
Raised liver enzymes are common in type 2 diabetes (T2DM) but often considered benign. Non-alcoholic fatty liver was the cause in ..
Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes
Zia UA Mollah, Saparna Pai, Craig Moore, Brendan J O'Sullivan, Matthew J Harrison, Judy Peng, Karen Phillips, Johannes B Prins, John Cardinal, Ranjeny Thomas
Journal article | 2008 | The Journal of Immunology
Metabolic syndrome in severe chronic kidney disease: Prevalence, predictors, prognostic significance and effects of risk factor modification
David W Johnson, Kirsten Armstrong, Scott B Campbell, David W Mudge, Carmel M Hawley, Jeff S Coombes, Johannes B Prins, Nicole M Isbel
Journal article | 2007 | Nephrology
Effect of weight loss due to lifestyle intervention on subclinical cardiovascular dysfunction in obesity (body mass index > 30 kg/m(2))
Chiew Y Wong, Nuala M Byrne, Trisha O'Moore-Sullivan, Andrew P Hills, Johannes B Prins, Thomas H Marwick
Journal article | 2006 | The American Journal of Cardiology
Relative adrenal insufficiency in sepsis: match point or deuce?
Bala Venkatesh, John Prins, David Torpy, Marianne Chapman, Chris Joyce, D Jamie Cooper, Jeremy Cohen, Ingrid Hickman, Daryl Jones, Alicia Higgins
Journal article | 2006 | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
Cardiorespiratory fitness is related to physical inactivity, metabolic risk factors, and atherosclerotic burden in glucose-intolerant renal transplant recipients
Kirsten Armstrong, Dhrubo Rakhit, Leanne Jeffriess, David Johnson, Rodel Leano, John Prins, Luke Garske, Thomas Marwick, Nicole Isbel
Journal article | 2006 | Clinical Journal of the American Society of Nephrology
Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: Evidence for regulation of multimerization by alterations in posttranslational modifications
Ayanthi A Richards, Tim Stephens, Hayley K Charlton, Alun Jones, Graeme A MacDonald, Johannes B Prins, Jonathan P Whitehead
Journal article | 2006 | Molecular Endocrinology
Cardiorespiratory fitness is related to physical inactivity, metabolic syndrome and atherosclerotic burden in glucose-intolerant renal transplant recipients
K Armstrong, D Rakhit, R Pidcock, L Orazio, J Prins, L Jeffriess, T Marwick, D Johnson, N Isbel
Conference Proceedings | 2006 | IMMUNOLOGY AND CELL BIOLOGY
Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum - A potential mechanism for olanzapine-induced insulin resistance in patients with schizophrenia
Ayanthi A Richards, Ingrid J Hickman, Amy Y-H Wang, Amanda L Jones, Felicity Newell, Bryan J Mowry, Jonathan P Whitehead, Johannes B Prins, Graeme A Macdonald
Journal article | 2006 | Journal of Clinical Psychopharmacology
TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue--influence of BMI and adipose distribution.
Manuela Good, Felicity M Newell, Larisa M Haupt, Jonathan P Whitehead, Louise J Hutley, Johannes B Prins
Journal article | 2006 | Diabetes and Vascular Disease Research
Tumour necrosis factor (TNF)alpha is implicated in the relationship between obesity and insulin resistance/ type 2 diabetes. In an..
Clinical variables add incremental value to fasting blood glucose in predicting a positive glucose tolerance test in established renal transplant recipients.
K Armstrong, AM Elliott, J Prins, E Beller, S Campbell, C Hawley, D Johnson, N Isbel
Conference Proceedings | 2005 | AMERICAN JOURNAL OF TRANSPLANTATION
A report of a national mutation testing service for the MEN1 gene: clinical presentations and implications for mutation testing
JW Cardinal, L Bergman, N Hayward, A Sweet, J Warner, L Marks, D Learoyd, T Dwight, B Robinson, M Epstein, M Smith, BT Teh, DP Cameron, JB Prins
Journal article | 2005 | Journal of Medical Genetics
Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications
J Warner, M Epstein, A Sweet, D Singh, J Burgess, S Stranks, P Hill, D Perry-Keene, D Learoyd, B Robinson, P Birdsey, E Mackenzie, BT Teh, JB Prins, J Cardinal
Journal article | 2004 | Journal of Medical Genetics
The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
PJ Meunier, C Roux, E Seeman, S Ortolani, JE Badurski, TD Spector, J Cannata, A Balogh, EM Lemmel, S Pors-Nielsen, R Rizzoli, HK Genant, JY Reginster, J Graham, KW Ng, R Prince, J Prins, E Seeman, J Wark, JY Reginster, et al.
Journal article | 2004 | New England Journal of Medicine
Glucose uptake and insulin action in human adipose tissue--influence of BMI, anatomical depot and body fat distribution.
M Stolic, A Russell, L Hutley, G Fielding, J Hay, G MacDonald, J Whitehead, J Prins
Journal article | 2002 | International Journal of Obesity
OBJECTIVE: To examine and compare in vitro basal and insulin-stimulated glucose uptake in human omental and subcutaneous adipose t..
Human adipose tissue endothelial cells promote preadipocyte proliferation.
LJ Hutley, AC Herington, W Shurety, C Cheung, DA Vesey, DP Cameron, JB Prins
Journal article | 2001 | American Journal of Physiology-Endocrinology and Metabolism
Adipogenesis is preceded by development of a microvascular network, and optimal functioning of adipose tissue as an energy store a..
Potentiation of glucose uptake, in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: Evidence for selectivity in the downstream responses to PPAR gamma activation
C Nugent, JB Prins, JP Whitehead, D Savage, JM Wentworth, VK Chatterjee, S O'Rahilly
Journal article | 2001 | Molecular Endocrinology
Arachidonic acid stimulates glucose uptake in 3T3-L1 adipocytes by increasing GLUT1 and GLUT4 levels at the plasma membrane - Evidence for involvement of lipoxygenase metabolites and peroxisome proliferator-activated receptor gamma
C Nugent, JB Prins, JP Whitehead, JM Wentworth, VKK Chatterjee, S O'Rahilly
Journal article | 2001 | Journal of Biological Chemistry
Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II
JB Prins, EC Ledgerwood, P Ameloot, P Vandenabeele, PR Faraco, NA Bright, S O'Rahilly, JR Bradley
Conference Proceedings | 1998 | Bioscience Reports
Tumour necrosis factor induced autophagy and mitochondrial morphological abnormalities are mediated by TNFR-I and/or TNFR-II and do not invariably lead to cell death.
J Prins, E Ledgerwood, P Ameloot, P Vandenabeele, P Faraco, N Bright, S O'Rahilly, J Bradley
Journal article | 1998 | Biochemical Society Transactions
Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes.
JE Digby, CT Montague, CP Sewter, L Sanders, WO Wilkison, S O'Rahilly, JB Prins
Journal article | 1998 | Diabetes
Thiazolidinediones (TZDs) are a novel class of insulin-sensitizing agents used in the treatment of NIDDM and are potent agonists f..
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation
M Adams, CT Montague, JB Prins, JC Holder, SA Smith, L Sanders, JE Digby, CP Sewter, MA Lazar, VKK Chatterjee, S O'Rahilly
Journal article | 1997 | Journal of Clinical Investigation
Tumor necrosis factor-alpha induces apoptosis of human adipose cells.
JB Prins, CU Niesler, CM Winterford, NA Bright, K Siddle, S O'Rahilly, NI Walker, DP Cameron
Journal article | 1997 | Diabetes
Tumor necrosis factor-alpha (TNF-alpha) production by adipocytes is elevated in obesity, as shown by increased adipose tissue TNF-..
Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes.
SE Ozanne, BT Nave, CL Wang, PR Shepherd, J Prins, GD Smith
Journal article | 1997 | American Journal of Physiology-Endocrinology and Metabolism
Insulin action on adipocytes was studied in the offspring of mothers who had been fed either a control (20% protein) or a low (8%)..
Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.
CT Montague, JB Prins, L Sanders, JE Digby, S O'Rahilly
Journal article | 1997 | Diabetes
Obese subjects with excess intra-abdominal fat deposition suffer greater adverse metabolic consequences than do similarly overweig..
Honours, Awards and Fellowships
FAHMS - Fellow of the Australasian Academy of Health Science
FRACP - Fellow of the Royal Australasian College of Physicians
Head Of School
Melbourne Medical School
Doctor of Philosophy (Medicine)
University of Queensland
Bachelor of Medicine, Bachelor of Surgery
The University of Queensland