Kim Powell

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells

Matthew Drill, Kim L Powell, Liyen Katrina Kan, Nigel C Jones, Terence J O'Brien, John A Hamilton, Mastura Monif

Journal article  |  2020  |  Scientific Reports

Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12–15 months. The P2X receptor 7 (P2X7..

A rat model of valproate teratogenicity from chronic oral treatment during pregnancy

Dana Jazayeri, Emma Braine, Stuart McDonald, Sebastian Dworkin, Kim L Powell, Karen Griggs, Frank JE Vajda, Terence J O'Brien, Nigel C Jones

Journal article  |  2020  |  Epilepsia

OBJECTIVE: Sodium valproate (VPA), the most effective antiepileptic drug for patients with genetic generalized epilepsy (GGE), is ..

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple

Journal article  |  2020  |  Brain Research Bulletin

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a..

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien

Journal article  |  2019  |  Progress in Neurobiology

We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-mo..

The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies

Naomi Dvir, Muhammad S Javaid, Nigel C Jones, Kim L Powell, Patrick Kwan, Terence J O'Brien, Ana Antonic-Baker

Journal article  |  2019  |  Systematic Reviews

BACKGROUND: Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It af..

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Wai Lam Leung, Pablo Casillas-Espinosa, Pragati Sharma, Piero Perucca, Kim Powell, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Epilepsia

Epidemiological data and gene association studies suggest a genetic predisposition to developing epilepsy after an acquired brain ..

Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance

Michael CH Li, Terence J O'Brien, Marian Todaro, Kim L Powell

Journal article  |  2019  |  Epilepsia

There is growing evidence that cardiac dysfunction in patients with chronic epilepsy could play a pathogenic role in sudden unexpe..

Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien

Journal article  |  2019  |  Epilepsia

OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

Kim L Powell, Xavier Fitzgerald, Claire Shallue, Valentina Jovanovska, Matthias Klugmann, Georg von Jonquieres, Terence J O'Brien, Margaret J Morris

Journal article  |  2018  |  Neurobiology of Disease

Neuropeptide Y (NPY) is an important 36 amino acid peptide that is abundantly expressed in the mammalian CNS and is known to be an..

Delayed myelination and neurodevelopment in male seizure-prone versus seizure-resistant rats

Pragati Sharma, Kim L Powell, Mary E Wlodek, Terence J O'Brien, Krista L Gilby

Journal article  |  2018  |  Epilepsia

OBJECTIVE: Aberrant myelination and developmental delay have been reported in epilepsy. However, it is unclear whether these are l..