Kim Powell

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple

Journal article  |  2020  |  Brain Research Bulletin

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a..

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy.

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien

Journal article  |  2019  |  Progress in Neurobiology

We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-mo..

The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies

Naomi Dvir, Muhammad S Javaid, Nigel C Jones, Kim L Powell, Patrick Kwan, Terence J O'Brien, Ana Antonic-Baker

Journal article  |  2019  |  Systematic Reviews

BACKGROUND: Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It af..

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Wai Lam Leung, Pablo Casillas-Espinosa, Pragati Sharma, Piero Perucca, Kim Powell, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Epilepsia

Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance

Michael CH Li, Terence J O'Brien, Marian Todaro, Kim L Powell

Journal article  |  2019  |  Epilepsia

There is growing evidence that cardiac dysfunction in patients with chronic epilepsy could play a pathogenic role in sudden unexpe..

Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien

Journal article  |  2019  |  Epilepsia

OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

Kim L Powell, Xavier Fitzgerald, Claire Shallue, Valentina Jovanovska, Matthias Klugmann, Georg von Jonquieres, Terence J O'Brien, Margaret J Morris

Journal article  |  2018  |  Neurobiology of Disease

Ca(V)3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons

Stuart M Cain, John R Tyson, Hyun-Beom Choi, Rebecca Ko, Paulo JC Lin, Jeffrey M LeDue, Kim L Powell, Louis-Philippe Bernier, Ravi L Rungta, Yi Yang, Pieter R Cullis, Terence J O'Brien, Brian A MacVicar, Terrance P Snutch

Journal article  |  2018  |  Epilepsia

Delayed myelination and neurodevelopment in male seizure-prone versus seizure-resistant rats

Pragati Sharma, Kim L Powell, Mary E Wlodek, Terence J O'Brien, Krista L Gilby

Journal article  |  2018  |  Epilepsia

Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains

Pragati Sharma, David K Wright, Leigh A Johnston, Kim L Powell, Mary E Wlodek, Sandy R Shultz, Terence J O'Brien, Krista L Gilby

Journal article  |  2017  |  Neurobiology of Disease

Evaluating whole genome sequence data from the Genetic Absence Epilepsy Rat from Strasbourg and its related non-epileptic strain

Pablo M Casillas-Espinosa, Kim L Powell, Mingfu Zhu, C Ryan Campbell, Jessica M Maia, Zhong Ren, Nigel C Jones, Terence J O'Brien, Slave Petrovski

Journal article  |  2017  |  PLOS ONE

INHIBITION OF MICROGLIAL ACTIVATION WITH MINOCYCLINE AT THE INTRATHECAL LEVEL ATTENUATES SYMPATHOEXCITATORY AND PROARRHYTHMOGENIC CHANGES IN RATS WITH CHRONIC TEMPORAL LOBE EPILEPSY

Amol M Bhandare, Komal Kapoor, Kim L Powell, Emma Braine, Pablo Casillas-Espinosa, Terence J O'Brien, Melissa MJ Farnham, Paul M Pilowsky

Journal article  |  2017  |  Neuroscience

The pathophysiology of cardiac dysfunction in epilepsy

Krishnan Ravindran, Kim L Powell, Marian Todaro, Terence J O'Brien

Journal article  |  2016  |  Epilepsy Research

Interleukin-1 beta has trophic effects in microglia and its release is mediated by P2X7R pore

Mastura Monif, Christopher A Reid, Kim L Powell, Katherine J Drummond, Terrence J O'Brien, David A Williams

Journal article  |  2016  |  Journal of Neuroinflammation

In response: LQT, HCN, and epilepsy model

Kim L Powell, Terence J O'Brien

Journal article  |  2015  |  Epilepsia

Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model

Pablo Miguel Casillas-Espinosa, Ashleigh Hicks, Amy Jeffreys, Terrance P Snutch, Terence J O'Brien, Kim L Powell

Journal article  |  2015  |  PLOS ONE

Neuroanatomical and neurodevelopmental white matter differences between rat strains with differing vulnerability to epileptogenes

P Sharma, ME Wlodek, KL Powell, TJ O'Brien

Conference Proceedings  |  2015  |  JOURNAL OF NEUROCHEMISTRY

Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg

Kim L Powell, Howard Tang, Caroline Ng, Isabelle Guillemain, Gabriel Dieuset, Gabi Dezsi, Nihan Carcak, Filiz Onat, Benoit Martin, Terence J O'Brien, Antoine Depaulis, Nigel C Jones

Journal article  |  2014  |  Epilepsia

The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy

Nihan Carcak, Thomas Zheng, Idrish Ali, Ahmad Abdullah, Chris French, Kim L Powell, Nigel C Jones, Leena van Raay, Gil Rind, Filiz Onat, Terence J O'Brien

Journal article  |  2014  |  Epilepsia

Low threshold T-type calcium channels as targets for novel epilepsy treatments

Kim L Powell, Stuart M Cain, Terrance P Snutch, Terence J O'Brien

Journal article  |  2014  |  British Journal of Pharmacology

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

Kim L Powell, Nigel C Jones, Jeremy T Kennard, Caroline Ng, Vijay Urmaliya, Shannen Lau, Adora Tran, Thomas Zheng, Ezgi Ozturk, Gabi Dezsi, Ika Megatia, Lea M Delbridge, Didier Pinault, Christopher A Reid, Paul J White, Terence J O'Brien

Journal article  |  2014  |  Epilepsia

Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?

Kim L Powell, Katarzyna Lukasiuk, Terence J O'Brien, Asla Pitkanen

Book Chapter  |  2014  |  Advances in Experimental Medicine and Biology

Long-Term Valproate Treatment Increases Brain Neuropeptide Y Expression and Decreases Seizure Expression in a Genetic Rat Model of Absence Epilepsy

Johanna Elms, Kim L Powell, Leena van Raay, Stefanie Dedeurwaerdere, Terence J O'Brien, Margaret J Morris

Journal article  |  2013  |  PLoS One

Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

Gabi Dezsi, Ezgi Ozturk, Davor Stanic, Kim L Powell, Hal Blumenfeld, Terence J O'Brien, Nigel C Jones

Journal article  |  2013  |  Epilepsia

Ethosuximide reduces epileptogenesis and behavioural comorbidity in the GAERS model of genetic generalised epilepsy

G Dezsi, E Ozturk, D Stanic, KL Powell, H Blumenfeld, TJ O'Brien, ND JONES

Journal article  |  2013  |  Epilepsia

Regulators of synaptic transmission: Roles in the pathogenesis and treatment of epilepsy

Pablo M Casillas-Espinosa, Kim L Powell, Terence J O'Brien

Journal article  |  2012  |  Epilepsia

THE PRESENCE OF THE CAV3.2 R1584P MUTATION IS ASSOCIATED WITH RESISTANCE TO KINDLING INDUCED CHANGE IN THE TRN NEURON FIRING PATTERN

N Carcak, T Zheng, NC Jones, L Van Raay, K Powell, F Onat, TJ O'Brien

Conference Proceedings  |  2012  |  EPILEPSIA

Glutamate is associated with a higher risk of seizures in patients with gliomas

Tanya I Yuen, Andrew P Morokoff, Andrew Bjorksten, Giovanna D'Abaco, Lucy Paradiso, Sue Finch, Daniel Wong, Christopher A Reid, Kim L Powell, Kate J Drummond, Mark A Rosenthal, Andrew H Kaye, Terence J O'Brien

Journal article  |  2012  |  Neurology

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

Elizabeth Tringham, Kim L Powell, Stuart M Cain, Kristy Kuplast, Janette Mezeyova, Manjula Weerapura, Cyrus Eduljee, Xinpo Jiang, Paula Smith, Jerrie-Lynn Morrison, Nigel C Jones, Emma Braine, Gil Rind, Molly Fee-Maki, David Parker, Hassan Pajouhesh, Manjeet Parmar, Terence J O'Brien, Terrance P Snutch

Journal article  |  2012  |  Science Translational Medicine

Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures

Nigel C Jones, Terence J O'Brien, Kim L Powell

Journal article  |  2011  |  Neuroscience Letters

Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg

JTT Kennard, R Barmanray, S Sampurno, E Ozturk, CA Reid, L Paradiso, GM D'Abaco, AH Kaye, SJ Foote, TJ O'Brien, KL Powell

Journal article  |  2011  |  Neurobiology of Disease

THE GAERS CA(V)3.2 T-TYPE CALCIUM CHANNEL MUTATION (GCM) AFFECTS RELATIVE EXPRESSION OF THE CHANNEL SPLICE VARIANTS

Caroline Ng, JR Tyson, KL Powell, SM Cain, CA Reid, TP Snutch, TJ O'Brien

Conference Proceedings  |  2009  |  EPILEPSIA

ALTERED GLUTAMATE TRANSPORER EXPRESSION AND INCREASED GLUTAMATE LEVELS IN TUMORS ARE SPECIFICALLY ASSOCIATED WITH TUMOR ASSOCIATED SEIZURES

T O'Brien, T Yuen, A Morokoff, A Bjorksten, G D'Abaco, K Powell, C Reid, K Drummond, M Rosenthal, L Paradiso, A Kaye

Conference Proceedings  |  2009  |  EPILEPSIA

Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1

Brendan EL Adams, Christopher A Reid, Damian Myers, Caroline Ng, Kim Powell, A Marie Phillips, Thomas Zheng, Terence J O'Brien, David A Williams

Journal article  |  2009  |  Experimental Neurology

The P2X(7) Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X(7)R Pore

Mastura Monif, Christopher A Reid, Kim L Powell, Megan L Smart, David A Williams

Journal article  |  2009  |  Journal of Neuroscience

A Ca(v)3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy

Kim L Powell, Stuart M Cain, Caroline Ng, Shreerang Sirdesai, Laurence S David, Mervyn Kyi, Esperanza Garcia, John R Tyson, Christopher A Reid, Melanie Bahlo, Simon J Foote, Terrance P Snutch, Terence J O'Brien

Journal article  |  2009  |  Journal of Neuroscience

Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats

Kim L Powell, Caroline Ng, Terence J O'Brien, Sheng Hong Xu, David A Williams, Simon J Foote, Christopher A Reid

Journal article  |  2008  |  Epilepsia

Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin

KL Powell, M Kyi, CA Reid, L Paradiso, GM D'Abaco, AH Kaye, SJ Foote, TJ O'Brien

Journal article  |  2008  |  Neurobiology of Disease

A CAV3.2 T-TYPE CALCIUM CHANNEL POINT MUTATION HAS SPLICE VARIANT-SPECIFIC EFFECTS ON FUNCTION AND SEGREGATES WITH SEIZURE EXPRESSION IN A POLYGENIC RAT MODEL OF ABSENCE EPILEPSY

Caroline Ng, Kim L Powell, SM Cain, S Sirdesai, LS David, M Kyi, E Garcia, J Tyson, Christopher A Reid, M Bahlo, SJ Foote, TP Snutch, TJ O'Brien

Conference Proceedings  |  2008  |  EPILEPSIA

BRAIN AND HEART LINKS: ALTERATIONS IN CARDIAC FUNCTION AND HCN CHANNEL EXPRESSION IN GENETIC ABSENCE EPILEPSY RATS FROM STRASBOURG

Ika Megatia, NC Jones, Didier Pinault, Terence J O'Brien, Kim L Powell

Conference Proceedings  |  2008  |  EPILEPSIA

A novel mutation in the rat Ca(v)3.2 T-type Ca2 channel CACNA1H gene increases absence seizure expression

Kim L Powell, S Sirdesai, M Kyi, C Ng, E Garcia, CA Reid, D Pinault, SJ Foote, TP Snutch, TJ O'Brien

Conference Proceedings  |  2007  |  EPILEPSIA

H-4 histamine receptor

K Powell

Journal article  |  2007

H-3 histamine receptor

K Powell

Journal article  |  2007

Histamine receptors

K Powell

Journal article  |  2007

H-2 histamine receptor

K Powell

Journal article  |  2007

H-1 histamine receptor

K Powell

Journal article  |  2007

Changes in HCN expression in the hippocampus are not critical to limbic epileptogenesis: Contrasting results in two animal models

Kim L Powell, Caroline Ng, Sheng-Hong Xu, Terence J O'Brien, David A Williams, Chris A Reid

Conference Proceedings  |  2006  |  EPILEPSIA

Deletion of guanine nucleotide binding protein alpha(z) subunit in mice induces a gene dose dependent tolerance to morphine

KJ Leck, SE Bartlett, MT Smith, D Megirian, J Holgate, KL Powell, KI Matthaei, IA Hendry

Journal article  |  2004  |  Neuropharmacology

Molecular evolution of V(H)9 germline genes isolated from DBA, BALB, 129 and C57BL mouse strains and sublines

P Zylstra, A Franklin, KA Hassan, KL Powell, EJ Steele, RV Blanden

Journal article  |  2003  |  Immunogenetics

G(Z alpha) deficient mice: enzyme levels in the autonomic nervous system, neuronal survival and effect of genetic background

KL Powell, KI Matthaei, K Heydon, IA Hendry

Journal article  |  2002  |  International Journal of Developmental Neuroscience

Targeted disruption of the mouse G(Z)-alpha gene: A role for G(Z) in platelet function?

KL Kelleher, KI Matthael, IA Hendry

Journal article  |  2001  |  Thrombosis and Haemostasis

A one-step quantitative reverse transcription polymerase chain reaction procedure

KL Kelleher, KJ Leck, IA Hendry, KI Matthaei

Journal article  |  2001  |  Brain Research Protocols

Hypertolerance to morphine in G(z alpha)-deficient mice

IA Hendry, KL Kelleher, SE Bartlett, KJ Leck, AJ Reynolds, K Heydon, A Mellick, D Megirian, KI Matthaei

Journal article  |  2000  |  Brain Research

Developmental expression of messenger RNA levels of the alpha subunit of the GTP-binding protein, G(z), in the mouse nervous system

KL Kelleher, KI Matthaei, KJ Leck, IA Hendry

Journal article  |  1998  |  Developmental Brain Research

Increased neurite outgrowth of cultured rat dorsal root ganglion cells following transection or inhibition of axonal transport of the sciatic nerve

DM White, K Mansfield, K Kelleher

Journal article  |  1996  |  Neuroscience Letters