Kim Powell

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells

Matthew Drill, Kim L Powell, Liyen Katrina Kan, Nigel C Jones, Terence J O'Brien, John A Hamilton, Mastura Monif

Journal article  |  2020  |  Scientific Reports

Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12-15 months. The P2X receptor 7 (P2X7..

A rat model of valproate teratogenicity from chronic oral treatment during pregnancy

Dana Jazayeri, Emma Braine, Stuart McDonald, Sebastian Dworkin, Kim L Powell, Karen Griggs, Frank JE Vajda, Terence J O'Brien, Nigel C Jones

Journal article  |  2020  |  Epilepsia

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple

Journal article  |  2020  |  Brain Research Bulletin

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a..

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien

Journal article  |  2019  |  Progress in Neurobiology

We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-mo..

The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies

Naomi Dvir, Muhammad S Javaid, Nigel C Jones, Kim L Powell, Patrick Kwan, Terence J O'Brien, Ana Antonic-Baker

Journal article  |  2019  |  Systematic Reviews

BACKGROUND: Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It af..

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Wai Lam Leung, Pablo Casillas-Espinosa, Pragati Sharma, Piero Perucca, Kim Powell, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Epilepsia

Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance

Michael CH Li, Terence J O'Brien, Marian Todaro, Kim L Powell

Journal article  |  2019  |  Epilepsia

There is growing evidence that cardiac dysfunction in patients with chronic epilepsy could play a pathogenic role in sudden unexpe..

Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien

Journal article  |  2019  |  Epilepsia

OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

Kim L Powell, Xavier Fitzgerald, Claire Shallue, Valentina Jovanovska, Matthias Klugmann, Georg von Jonquieres, Terence J O'Brien, Margaret J Morris

Journal article  |  2018  |  Neurobiology of Disease

Delayed myelination and neurodevelopment in male seizure-prone versus seizure-resistant rats

Pragati Sharma, Kim L Powell, Mary E Wlodek, Terence J O'Brien, Krista L Gilby

Journal article  |  2018  |  Epilepsia