Kim Powell

Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability

Rahel Feleke, Dana Jazayeri, Maya Abouzeid, Kim L Powell, Prashant K Srivastava, Terence J O'Brien, Nigel C Jones, Michael R Johnson

Journal article  |  2022  |  BRAIN

Prenatal exposure to the anti-seizure medication sodium valproate (VPA) is associated with an increased risk of adverse postnatal ..

Changes in cardiac ion channels and cardiac structure in post-status epilepticus models of epilepsy

Zining Liu, Flavia Gomes, Peravina Thergarajan, Shobi Sivathamboo, Kim Powell, Piero Perucca, Idrish Ali, Nigel Jones, Pablo Casillas-Espinosa, Terence O'Brien

Conference Proceedings  |  2021  |  EPILEPSIA

Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy

Kim L Powell, Zining Liu, Claire L Curl, Antonia JA Raaijmakers, Pragati Sharma, Emma L Braine, Flavia M Gomes, Shobi Sivathamboo, Vaughan G Macefield, Pablo M Casillas-Espinosa, Nigel C Jones, Lea M Delbridge, Terence J O'Brien

Journal article  |  2021  |  NEUROBIOLOGY OF DISEASE

OBJECTIVE: This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilept..

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells

Matthew Drill, Kim L Powell, Liyen Katrina Kan, Nigel C Jones, Terence J O'Brien, John A Hamilton, Mastura Monif

Journal article  |  2020  |  SCIENTIFIC REPORTS

Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12–15 months. The P2X receptor 7 (P2X7..

A rat model of valproate teratogenicity from chronic oral treatment during pregnancy

Dana Jazayeri, Emma Braine, Stuart McDonald, Sebastian Dworkin, Kim L Powell, Karen Griggs, Frank JE Vajda, Terence J O'Brien, Nigel C Jones

Journal article  |  2020  |  EPILEPSIA

OBJECTIVE: Sodium valproate (VPA), the most effective antiepileptic drug for patients with genetic generalized epilepsy (GGE), is ..

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple

Journal article  |  2020  |  BRAIN RESEARCH BULLETIN

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a..

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien

Journal article  |  2019  |  PROGRESS IN NEUROBIOLOGY

We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-mo..

The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies

Naomi Dvir, Muhammad S Javaid, Nigel C Jones, Kim L Powell, Patrick Kwan, Terence J O'Brien, Ana Antonic-Baker

Journal article  |  2019  |  SYSTEMATIC REVIEWS

BACKGROUND: Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It af..

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Wai Lam Leung, Pablo Casillas-Espinosa, Pragati Sharma, Piero Perucca, Kim Powell, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  EPILEPSIA

Epidemiological data and gene association studies suggest a genetic predisposition to developing epilepsy after an acquired brain ..

Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance

Michael CH Li, Terence J O'Brien, Marian Todaro, Kim L Powell

Journal article  |  2019  |  EPILEPSIA

There is growing evidence that cardiac dysfunction in patients with chronic epilepsy could play a pathogenic role in sudden unexpe..