Gavin Reid

Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli

Dezerae Cox, Angelique R Ormsby, Gavin E Reid, Danny M Hatters

Journal article  |  2022  |  NPJ SYSTEMS BIOLOGY AND APPLICATIONS

The correct spatio-temporal organization of the proteome is essential for cellular homeostasis. However, a detailed mechanistic un..

Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease

Richard G Lee, Shanti Balasubramaniam, Maike Stentenbach, Tom Kralj, Timothy McCubbin, Benjamin Padman, Janine Smith, Lisa G Riley, Archana Priyadarshi, Liuyu Peng, Madison R Nuske, Richard Webster, Ken Peacock, Philip Roberts, Zornitza Stark, Gabrielle Lemire, Yoko A Ito, Kym M Boycott, Michael T Geraghty, Jan Bert Klinken, et al.

Journal article  |  2022  |  HUMAN MOLECULAR GENETICS

Mitochondrial diseases are a group of inherited diseases with highly varied and complex clinical presentations. Here, we report fo..

Toxicity of heroin laced with synthetic opioid β-U10 and etizolam

Matthew Di Rago, Jared Castle, Kerryn Crump, Linda Glowacki, Jennifer Shumann, Shaun Greene, Gavin E Reid, Dimitri Gerostamoulos

Journal article  |  2022  |  Toxicologie Analytique et Clinique

Illicit heroin can be substituted or adulterated with New Psychoactive Substances (NPS) including highly potent fentanyl-type subs..

Reprogrammed Lipid Metabolism and the Lipid-Associated Hallmarks of Colorectal Cancer

Timothy Salita, Yepy H Rustam, Dmitri Mouradov, Oliver M Sieber, Gavin E Reid

Journal article  |  2022  |  CANCERS

Lipids have diverse structures, with multifarious regulatory functions in membrane homeostasis and bioenergetic metabolism, in med..

Trace residue identification, characterization, and longitudinal monitoring of the novel synthetic opioid beta-U10, from discarded drug paraphernalia

Henry West, John L Fitzgerald, Katherine L Hopkins, Michael G Leeming, Matthew DiRago, Dimitri Gerostamoulos, Nicolas Clark, Paul Dietze, Jonathan M White, James Ziogas, Gavin E Reid

Journal article  |  2022  |  DRUG TESTING AND ANALYSIS

Empirical data regarding dynamic alterations in illicit drug supply markets in response to the COVID-19 pandemic, including the po..

A Census of Hsp70-Mediated Proteome Solubility Changes upon Recovery from Heat Stress

Xiaojing Sui, Dezerae Cox, Shuai Nie, Gavin E Reid, Danny M Hatters

Journal article  |  2022  |  JOURNAL OF PROTEOME RESEARCH

Eukaryotic cells respond to heat shock through several regulatory processes including upregulation of stress responsive chaperones..

Hidden information on protein function in censuses of proteome foldedness

Dezerae Cox, Ching-Seng Ang, Nadinath B Nillegoda, Gavin E Reid, Danny M Hatters

Journal article  |  2022  |  NATURE COMMUNICATIONS

Methods that assay protein foldedness with proteomics have generated censuses of apparent protein folding stabilities in biologica..

Multi-omics approach characterises CRLS1 deficiency, a novel mitochondrial disorder

Shanti Balasubramaniam, Richard G Lee, Benjamin Padman, Kym M Boycott, Michael T Geraghty, Rebecca Walsh, Sasha Ferdinandusse, Oliver Rackham, Frédéric M Vaz, Tony Rosciolli, Gavin E Reid, Janice Fletcher, Aleksandra Filipovska

Journal article  |  2022  |  Pathology

Multi-Omic Analysis to Characterize Metabolic Adaptation of the E. coli Lipidome in Response to Environmental Stress

Thomas Kralj, Madison Nuske, Vinzenz Hofferek, Marc-Antoine Sani, Tzong-Hsien Lee, Frances Separovic, Marie-Isabel Aguilar, Gavin E Reid

Journal article  |  2022  |  METABOLITES

As an adaptive survival response to exogenous stress, bacteria undergo dynamic remodelling of their lipid metabolism pathways to a..

Extracellular vesicular lipids as biomarkers for the diagnosis of Alzheimer’s disease

Huaqi Su, Yepy H Rustam, Colin L Masters, Enes Makalic, Catriona McLean, Andrew F Hill, Kevin J Barnham, Gavin E Reid, Laura J Vella

Journal article  |  2021  |  Alzheimer's & Dementia

An increasing number of studies have revealed that dysregulated lipid homeostasis is associated with the pathological processes th..