Helen Abud

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

Ian Y Luk, Laura J Jenkins, Kael L Schoffer, Irvin Ng, Janson WT Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D Burrows, Robin L Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F Richardson, Oliver M Sieber, Yang Liao, Jennifer K Mooi, Natalia Vukelic, Camilla M Reehorst, Shoukat Afshar-Sterle, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnin..

INPP4B promotes PI3K alpha-dependent late endosome formation and Wnt/beta-catenin signaling in breast cancer

Samuel J Rodgers, Lisa M Ooms, Viola MJ Oorschot, Ralf B Schittenhelm, Elizabeth Nguyen, Sabryn A Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J Eramo, Absorn Sriratana, Clare G Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E Abud, Georg Ramm, Antonella Papa, Andrew M Ellisdon, Roger J Daly, Catriona A McLean, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast..

PtdIns(3,4,5)P-3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

Nuthasuda Srijakotre, Heng-jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E Abud, Kurt I Anderson, Heidi CE Welch, Tony Tiganis, Paul Timpson, Catriona A McLean, Lisa M Ooms, Christina A Mitchell

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rac-GEF, P-Rex1, activates Rac1 signaling downstream of G protein-coupled receptors and PI3K. Increased P-Rex1 expression prom..

Mesenchymal niche-derived Neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium

jacqueline Donoghue, Thierry Jarde

Journal article  |  2020  |  Cell Stem Cell

Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key component of organoid growth media y..

'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'

Diana J Micati, Karthika Radhakrishnan, Julia C Young, Ewa Rajpert-De Meyts, Gary R Hime, Helen E Abud, Kate L Loveland

Journal article  |  2020  |  ANDROLOGY

BACKGROUND: Snail transcription factors mediate key cellular transitions in many developmental processes, including spermatogenesi..

A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells

Christian M Nefzger, Thierry Jarde, Fernando J Rossello, Katja Horvay, Anja S Knaupp, David R Powell, Joseph Chen, Helen E Abud, Jose M Polo

Journal article  |  2016  |  STEM CELL REPORTS

The isolation of pure populations of mouse intestinal stem cells (ISCs) is essential to facilitate functional studies of tissue ho..

Genome-Wide ENU Mutagenesis in Combination with High Density SNP Analysis and Exome Sequencing Provides Rapid Identification of Novel Mouse Models of Developmental Disease

Georgina Caruana, Peter G Farlie, Adam H Hart, Stefan Bagheri-Fam, Megan J Wallace, Michael S Dobbie, Christopher T Gordon, Kerry A Miller, Belinda Whittle, Helen E Abud, Ruth M Arkell, Timothy J Cole, Vincent R Harley, Ian M Smyth, John F Bertram

Journal article  |  2013  |  PLOS ONE

BACKGROUND: Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linki..

Wnt Signaling Regulates Snai1 Expression and Cellular Localization in the Mouse Intestinal Epithelial Stem Cell Niche

Katja Horvay, Franca Casagranda, Agnes Gany, Gary R Hime, Helen E Abud

Journal article  |  2011  |  STEM CELLS AND DEVELOPMENT

Snail genes are transcriptional repressors well known to play important roles in epithelial to mesenchymal transitions during both..

Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/beta-Catenin Pathway In Vivo

Michael Buchert, Dimitris Athineos, Helen E Abud, Zoe D Burke, Maree C Faux, Michael S Samuel, Andrew G Jarnicki, Catherine E Winbanks, Ian P Newton, Valerie S Meniel, Hiromu Suzuki, Steven A Stacker, Inke S Nathke, David Tosh, Joerg Huelsken, Alan R Clarke, Joan K Heath, Owen J Sansom, Matthias Ernst

Journal article  |  2010  |  PLOS GENETICS

Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascr..

Differential requirement for beta-catenin in epithelial and fiber cells during lens development

Sarah Cain, Gemma Martinez, Maria I Kokkinos, Kirsty Turner, Robert J Richardson, Helen E Abud, Joerg Huelsken, Michael L Robinson, Robb U de Iongh

Journal article  |  2008  |  DEVELOPMENTAL BIOLOGY

Recent studies implicate Wnt/beta-catenin signaling in lens differentiation (Stump, R. J., et al., 2003. A role for Wnt/beta-caten..