Jamie Craig

Cardiovascular Disease Predicts Structural and Functional Progression in Early Glaucoma.

Henry Marshall, Sean Mullany, Ayub Qassim, Owen Siggs, Mark Hassall, Bronwyn Ridge, Thi Nguyen, Mona Awadalla, Nicholas H Andrew, Paul R Healey, Ashish Agar, Anna Galanopoulos, Alex W Hewitt, Stuart MacGregor, Stuart L Graham, Richard Mills, Angela Shulz, John Landers, Robert J Casson, Jamie E Craig

Journal article  |  2021  |  Ophthalmology

PURPOSE: To investigate the association between cardiovascular disease and baseline structural defects and disease progression in ..

An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.

Ayub Qassim, Emmanuelle Souzeau, Owen M Siggs, Mark M Hassall, Xikun Han, Helen L Griffiths, N Andrew Frost, Neeru A Vallabh, James F Kirwan, Geeta Menon, Angela J Cree, Anna Galanopoulos, Ashish Agar, Paul R Healey, Stuart L Graham, John Landers, Robert J Casson, Puya Gharahkhani, Colin E Willoughby, Alex W Hewitt, et al.

Journal article  |  2020  |  Ophthalmology

PURPOSE: To examine the combined effects of common genetic variants associated with intraocular pressure (IOP) on primary open-ang..

Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort A Mendelian Randomization Study

Xikun Han, Jue-Sheng Ong, Jiyuan An, Jamie E Craig, Puya Gharahkhani, Alex W Hewitt, Stuart MacGregor

Journal article  |  2020  |  JAMA Ophthalmology

Importance: Rhegmatogenous retinal detachment is a potentially sight-threatening condition. The role of myopia or intraocular pres..

Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma

Owen M Siggs, Emmanuelle Souzeau, Deepa A Taranath, Andrew Dubowsky, Angela Chappell, Tiger Zhou, Shari Javadiyan, Jillian Nicholl, Lisa S Kearns, Sandra E Staffieri, Andrew Narita, James EH Smith, John Pater, Alex W Hewitt, Jonathan B Ruddle, James E Elder, David A Mackey, Kathryn P Burdon, Jamie E Craig

Journal article  |  2020  |  Ophthalmology

PURPOSE: Developmental abnormalities of the ocular anterior segment in some cases can lead to ocular hypertension and glaucoma. CP..

The genetic and clinical landscape of nanophthalmos and posterior microphthalmos in an Australian cohort

Owen M Siggs, Mona S Awadalla, Emmanuelle Souzeau, Sandra E Staffieri, Lisa S Kearns, Kate Laurie, Abraham Kuot, Ayub Qassim, Thomas L Edwards, Michael A Coote, Erica Mancel, Mark J Walland, Joanne Dondey, Anna Galanopoulous, Robert J Casson, Richard A Mills, Daniel G MacArthur, Jonathan B Ruddle, Kathryn P Burdon, Jamie E Craig

Journal article  |  2020  |  Clinical Genetics

Nanophthalmos and posterior microphthalmos are ocular abnormalities in which both eyes are abnormally small, and typically associa..

Effect of phacoemulsification cataract surgery on intraocular pressure in early glaucoma: A prospective multi-site study.

Ayub Qassim, Mark J Walland, John Landers, Mona Awadalla, Thi Nguyen, Jason Loh, Angela M Schulz, Bronwyn Ridge, Anna Galanopoulos, Ashish Agar, Alex W Hewitt, Stuart L Graham, Paul R Healey, Robert J Casson, Jamie E Craig

Journal article  |  2020  |  Clinical & Experimental Ophthalmology

IMPORTANCE: Cataract and primary open-angle glaucoma (POAG) commonly co-exist, and cataract surgery is thought to reduce intraocul..

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

Qiao Fan, Alfred Pozarickij, Nicholas YQ Tan, Xiaobo Guo, Virginie JM Verhoeven, Veronique Vitart, Jeremy A Guggenheim, Masahiro Miyake, J Willem L Tideman, Anthony P Khawaja, Liang Zhang, Stuart MacGregor, Rene Hoehn, Peng Chen, Ginevra Biino, Juho Wedenoja, Seyed Ehsan Saffari, Milly S Tedja, Jing Xie, Carla Lanca, et al.

Journal article  |  2020  |  Communications Biology

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and b..

Association of Genetic Variation With Keratoconus

Bennet J McComish, Srujana Sahebjada, Yelena Bykhovskaya, Colin E Willoughby, Andrea J Richardson, Abi Tenen, Jac C Charlesworth, Stuart MacGregor, Paul Mitchell, Sionne EM Lucas, Richard A Mills, David A Mackey, Xiaohui Li, Jie Jin Wang, Richard A Jensen, Jerome I Rotter, Kent D Taylor, Alex W Hewitt, Yaron S Rabinowitz, Paul N Baird, et al.

Journal article  |  2020  |  JAMA Ophthalmology

Importance: Keratoconus is a condition in which the cornea progressively thins and protrudes in a conical shape, severely affectin..

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration.

Tobias Strunz, Susette Lauwen, Christina Kiel, undefined International AMD Genomics Consortium (IAMDGC), Anneke den Hollander, Bernhard HF Weber

Journal article  |  2020  |  Scientific Reports

Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent geneti..

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

Jamie E Craig, Xikun Han, Ayub Qassim, Mark Hassall, Jessica N Cooke Bailey, Tyler G Kinzy, Anthony P Khawaja, Jiyuan An, Henry Marshall, Puya Gharahkhani, Robert P Igo, Stuart L Graham, Paul R Healey, Jue-Sheng Ong, Tiger Zhou, Owen Siggs, Matthew H Law, Emmanuelle Souzeau, Bronwyn Ridge, Pirro G Hysi, et al.

Journal article  |  2020  |  Nature Genetics