I am a research and teaching academic with 50% of teaching and course coordination and 50% of research workload. My research is focused on enteric neuropathy associated with Inflammatory Bowel Disease (IBD), colorectal cancer (2nd most common cancer in the world) and side-effects of anti-cancer chemotherapy (experienced by 90% of cancer patients).
My research significantly contributes to understanding of mechanisms underlying these problems and proposes novel therapies. Being a medical graduate, I focus on pre-clinical studies that have translational value and direct impact on patient’s life and outcomes of the treatment. My research is original and internationally valued as evidenced by 82 presentations (oral and poster) at including 26 invited speaker/oral presentations the National and International meetings. I have organized and chaired 3 international and 1 national symposiums. My research program has been funded by 4 NHMRC grants (CIA in 2), NHMRC Peter Doherty Fellowship, equipment grants, 4 near-miss NHMRC grants and several competitive grants from other external funding bodies. I have established a functional research laboratory at the Western Center for Health, Research and Education (WCHRE) at Sunshine Hospital (currently 1.5 staff and 17 students) and pre-clinical animal models of IBD, colorectal cancer, chemotherapy, inflammation-induced cancer and methamphetamine-induced depression. Studies in pre-clinical animal models of disease have significantly progressed into the development of novel therapies. Moreover, this attracted a number of international visiting scientists (postgraduate students and senior researchers) from Austria, Canada, Germany, Netherlands, Spain, and China working on collaborative research projects in my lab. Active collaborations with Prof Kelley (USA), Prof Abalo (Spain), Prof Schaefer (Germany), Prof Bornstein (Melbourne University), Prof Apostolopoulos (Victoria University), A/Prof Eri (Tasmania University) and many other internal, national and international collaborations. I have supervised 55 research students including 12 PhD, 4 MSc and provide mentoring to early career researchers.
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Kulmira Nurgali's selected work
Targeting the CCR3-eotaxin axis mitigates enteric neuropathy and gastrointestinal dysfunct..
Apurinic/apyrimidinic endonuclease 1/redox factor-1 as a novel therapeutic target for infl..
Displaying the 6 most recent projects by Kulmira Nurgali.
Internal Research Grant
Displaying the 61 most recent scholarly works by Kulmira Nurgali.
Chemotherapy-induced enteric neuropathy and gastrointestinal dysfunction: Mechanisms and novel treatments
Rachel M McQuade, Vanesa Stojanovska, Rhiannon Filippone, Lauren Shakian, Nyanbol Kuol, Majid Hassanzadeganroudsari, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali
Conference Proceedings | 2020 | NEUROGASTROENTEROLOGY AND MOTILITY
The multiple faces of tryptophan in bone biology
Ahmed Al Saedi, Shilpa Sharma, Matthew A Summers, Kulmira Nurgali, Gustavo Duque
Journal article | 2020 | Experimental Gerontology
Osteoporosis is highly prevalent in older persons. While many advances have been made in the field of osteoporosis, current treatm..
The complex interaction between the tumor micro-environment and immune checkpoints in breast cancer
V Barriga, N Kuol, K Nurgali, V Apostolopoulos
Journal article | 2019 | Cancers
The progression of breast cancer and its association with clinical outcome and treatment remain largely unexplored. Accumulating d..
Targeting eotaxin-1 and CCR3 receptor alleviates enteric neuropathy and colonic dysfunction in TNBS-induced colitis in guinea pigs.
RT Filippone, AM Robinson, V Jovanovska, R Stavely, V Apostolopoulos, JC Bornstein, K Nurgali
Journal article | 2018 | Neurogastroenterology & Motility
BACKGROUND: The accumulation of eosinophils is mediated by the chemokine receptor-3 (CCR3)-eotaxin axis. Increased expression of e..
Oxaliplatin-induced changes in microbiota, TLR4 cells and enhanced HMGB1 expression in the murine colon
Vanesa Stojanovska, Rachel M McQuade, Sarah Fraser, Monica Prakash, Shakuntla Gondalia, Rhian Stavely, Enzo Palombo, Vasso Apostolopoulos, Samy Sakkal, Kulmira Nurgali
Journal article | 2018 | PLOS ONE
The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter
Rhian Stavely, Sarah Fraser, Shilpa Sharma, Ahmed A Rahman, Vanesa Stojanovska, Samy Sakkal, Vasso Apostolopoulos, Paul Bertrand, Kulmira Nurgali
Journal article | 2018 | Inflammatory Bowel Diseases
Crosstalk between cancer and the neuro-immune system.
Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali
Journal article | 2018 | Journal of Neuroimmunology
In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing ..
Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15
Rachel M McQuade, Vanesa Stojanovska, Rhian Stavely, Cara Timpani, Aaron C Petersen, Raquel Abalo, Joel C Bornstein, Emma Rybalka, Kulmira Nurgali
Journal article | 2018 | British Journal of Pharmacology
The mechanisms tumor cells utilize to evade the host's immune system.
Nyanbol Kuol, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos
Journal article | 2017 | Maturitas
The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote t..
Resveratrol alleviates oxidative damage in enteric neurons and associated gastrointestinal dysfunction caused by chemotherapeutic agent oxaliplatin.
Elizabeth L Donald, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali
Journal article | 2017 | Maturitas
Oxaliplatin is a first-line chemotherapeutic agent used for the treatment of colorectal cancer. Its use is associated with severe ..
Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons
Rachel M McQuade, Vanesa Stojanovska, Elizabeth L Donald, Ahmed A Rahman, Dean G Campelj, Raquel Abalo, Emma Rybalka, Joel C Bornstein, Kulmira Nurgali
Journal article | 2017 | Frontiers in Physiology
Methamphetamine: Effects on the brain, gut and immune system.
Monica D Prakash, Kathy Tangalakis, Juliana Antonipillai, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos
Journal article | 2017 | Pharmacological Research
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates mood, alertness, energy levels and concentrat..
Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis
Ainsley M Robinson, Ahmed A Rahman, Simona E Carbone, Sarron Randall-Demllo, Rhiannon Filippone, Joel C Bornstein, Rajaraman Eri, Kulmira Nurgali
Journal article | 2017 | American Journal of Physiology-Gastrointestinal and Liver Physiology
Structural changes in the epithelium of the small intestine and immune cell infiltration of enteric ganglia following acute mucosal damage and local inflammation
Louise Pontell, Patricia Castelucci, Maria Bagyanszki, Tanja Jovic, Michelle Thacker, Kulmira Nurgali, Romke Bron, John B Furness
Journal article | 2009 | Virchows Archiv: an international journal of pathology
Effects of compounds that influence I-K (KCNN4) channels on afterhyperpolarizing potentials, and determination of I-K channel sequence, in guinea pig enteric neurons
Trung V Nguyen, Hayato Matsuyama, Jonathan Baell, Billie Hunne, Christopher J Fowler, Julia E Smith, Kulmira Nurgali, John B Furness
Journal article | 2007 | Journal of Neurophysiology
Intermediate-conductance calcium-activated potassium channels in enteric neurones of the mouse: pharmacological, molecular and immunochemical evidence for their role in mediating the slow afterhyperpolarization
CB Neylon, K Nurgali, B Hunne, HL Robbins, S Moore, MX Chen, JB Furness
Journal article | 2004 | Journal of Neurochemistry
Honours, Awards and Fellowships
NHMRCF - NHMRC Fellowship
International Society of Autonomic Neuroscience (ISAN)
GESA (Gastroenterological Society of Australia)
Australian Neuroscience Society (ANS)
Doctor of Philosophy
University of Melbourne
Master of Science
Kazakh Academy of Science