Andrew Bjorksten

A genetic mystery in malignant hyperthermia 'solved'?

AH Schiemann, AR Bjorksten, RL Gillies, BM Hockey, C Ball, N Pollock, T Bulger, KM Stowell

Journal article  |  2018  |  British Journal of Anaesthesia

Self-Organized Nanostructure Modified Microelectrode for Sensitive Electrochemical Glutamate Detection in Stem Cells-Derived Brain Organoids

Babak Nasr, Rachael Chatterton, Jason Hsien Ming Yong, Pegah Jamshidi, Giovanna Marisa D'Abaco, Andrew Robin Bjorksten, Omid Kavehei, Gursharan Chana, Mirella Dottori, Efstratios Skafidas

Journal article  |  2018  |  Biosensors

Functional Characterization of C-terminal Ryanodine Receptor 1 Variants Associated with Central Core Disease or Malignant Hyperthermia.

Remai Parker, Anja H Schiemann, Elaine Langton, Terasa Bulger, Neil Pollock, Andrew Bjorksten, Robyn Gillies, David Hutchinson, Richard Roxburgh, Kathryn M Stowell

Journal article  |  2017  |  Journal of Neuromuscular Diseases

BACKGROUND: Central core disease and malignant hyperthermia are human disorders of skeletal muscle resulting from aberrant Ca2+ ha..

Sequencing of genes involved in the movement of calcium across human skeletal muscle sarcoplasmic reticulum: continuing the search for genes associated with malignant hyperthermia

AR Bjorksten, RL Gilles, BM Hockey, D Du Sart

Journal article  |  2016  |  Anaesthesia and Intensive Care

Comparative Plasma and Cerebrospinal Fluid Pharmacokinetics of Paracetamol After Intravenous and Oral Administration

Roger A Langford, Malcolm Hogg, Andrew R Bjorksten, Daryl L Williams, Kate Leslie, Kris Jamsen, Carl Kirkpatrick

Journal article  |  2016  |  Anesthesia & Analgesia

Pharmacokinetics of levobupivacaine following infant spinal anesthesia

Geoff Frawley, Ben Hallett, Tony Velkov, Andrew Bjorksten

Journal article  |  2016  |  Pediatric Anesthesia

The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

Jared Ching, Stephanie Amiridis, Stanley S Stylli, Andrew R Bjorksten, Nicole Kountouri, Thomas Zheng, Lucy Paradiso, Rodney B Luwor, Andrew P Morokoff, Terence J O'Brien, Andrew H Kaye

Journal article  |  2015  |  ONCOTARGET

Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families

RL Gillies, AR Bjorksten, D Du Sart, BM Hockey

Journal article  |  2015  |  Anaesthesia and Intensive Care

Glutamate quantification in patients with supratentorial gliomas using chemical shift imaging

SV Liubinas, KJ Drummond, PM Desmond, A Bjorksten, AP Morokoff, AH Kaye, TJ O'Brien, BA Moffat

Journal article  |  2014  |  NMR in Biomedicine

Glutamate is associated with a higher risk of seizures in patients with gliomas

Tanya I Yuen, Andrew P Morokoff, Andrew Bjorksten, Giovanna D'Abaco, Lucy Paradiso, Sue Finch, Daniel Wong, Christopher A Reid, Kim L Powell, Kate J Drummond, Mark A Rosenthal, Andrew H Kaye, Terence J O'Brien

Journal article  |  2012  |  Neurology

Cardiac output and propofol concentrations in prone surgical patients

K Leslie, CY-X Wu, AR Bjorksten, DL Williams, G Ludbrook, E Williamson

Journal article  |  2011  |  Anaesthesia and Intensive Care

A comparison of parametric and non-parametric approaches to target-controlled infusion of propofol

DP Crankshaw, MJ Brown, AR Bjorksten

Journal article  |  2010  |  Anaesthesia and Intensive Care

Automated responsiveness monitor to titrate propofol sedation.

Anthony G Doufas, Nobutada Morioka, Adel N Mahgoub, Andrew R Bjorksten, Steven L Shafer, Daniel I Sessler

Journal article  |  2009  |  Anesthesia & Analgesia

BACKGROUND: In previous studies, we showed that failure to respond to automated responsiveness monitor (ARM) precedes potentially ..

King-Denborough syndrome caused by a novel mutation in the ryanodine receptor gene

CE D'Arcy, A Bjorksten, EM Yiu, A Bankier, R Gillies, CA McLean, LK Shield, MM Ryan

Journal article  |  2008  |  Neurology

Cardiovascular testing in Fabry disease: exercise capacity reduction, chronotropic incompetence and improved anaerobic threshold after enzyme replacement

T Lobo, J Morgan, A Bjorksten, K Nicholls, L Grigg, E Centra, G Becker

Journal article  |  2008  |  Internal Medicine Journal

Identification of genetic mutations in Australian malignant hyperthermia families using sequencing of RYR1 hotspots.

RL Gillies, AR Bjorksten, M Davis, D Du Sart

Journal article  |  2008  |  Anaesthesia and Intensive Care

Advances in analysis of the RYR1 gene (which encodes the skeletal muscle ryanodine receptor) show that genetic examination is a us..

Autonomic effects of epidural and intravenous fentanyl.

MD Larson, PD Berry, J May, A Bjorksten, DI Sessler

Journal article  |  2007  |  British Journal of Anaesthesia

BACKGROUND: We tested the hypothesis that there is greater suppression of autonomic reflexes during general anaesthesia when fenta..

Nitrous oxide and anesthetic requirement for loss of response to command during propofol anesthesia

D Karalapillai, K Leslie, A Umranikar, AR Bjorksten

Journal article  |  2006  |  Anesthesia and Analgesia

Pharmacokinetics of intravenous N-acetylcysteine in men at rest and during exercise.

Malcolm Brown, Andrew Bjorksten, Ivan Medved, Michael McKenna

Journal article  |  2004  |  European Journal of Clinical Pharmacology

OBJECTIVE: We aimed to determine the pharmacokinetics (PK) of N-acetylcysteine (NAC) at rest and during exercise when given by con..

Induction speed is not a determinant of propofol pharmacodynamics.

Anthony G Doufas, Maryam Bakhshandeh, Andrew R Bjorksten, Steven L Shafer, Daniel I Sessler

Journal article  |  2004  |  Anesthesiology

BACKGROUND: Evidence suggests that the rate at which intravenous anesthetics are infused may influence their plasma-effect site eq..

N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals

I Medved, MJ Brown, AR Bjorksten, KT Murphy, AC Petersen, S Sostaric, X Gong, MJ McKenna

Journal article  |  2004  |  Journal of Applied Physiology

Latency of pupillary reflex dilation during general anesthesia.

Merlin D Larson, Peter D Berry, Jacqueline May, Andrew Bjorksten, Daniel I Sessler

Journal article  |  2004  |  Journal of Applied Physiology

Areas of insensibility produced by neuraxial anesthesia or peripheral nerve blocks can be detected during general anesthesia by fa..

Comparison of disposable and reusable laryngeal mask airways in spontaneously ventilating adult patients.

MM Cao, T Webb, AR Bjorksten

Journal article  |  2004  |  Anaesthesia and Intensive Care

Recent studies have indicated that despite stringent sterilization processes, the reusable silicone laryngeal mask airway (LMA) ha..

Pethidine and skin warming to prevent shivering during endovascular cooling

K Leslie, D Williams, K Irwin, AR Bjorksten, DI Sessler

Journal article  |  2004  |  Anaesthesia and Intensive Care

Dantrolene reduces the threshold and gain for shivering.

Chun-Ming Lin, Sharma Neeru, Anthony G Doufas, Edwin Liem, Yunus Muneer Shah, Anupama Wadhwa, Rainer Lenhardt, Andrew Bjorksten, Akiko Taguchi, Barhara Kabon, Daniel I Sessler, Andrea Kurz

Journal article  |  2004  |  Anesthesia & Analgesia

UNLABELLED: Dantrolene is used for treatment of life-threatening hyperthermia, yet its thermoregulatory effects are unknown. We te..

Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise.

Ivan Medved, Malcolm J Brown, Andrew R Bjorksten, Michael J McKenna

Journal article  |  2004  |  Journal of Applied Physiology

The production of reactive oxygen species in skeletal muscle is linked with muscle fatigue. This study investigated whether the an..

Automated responsiveness test and bispectral index monitoring during propofol and propofol/N2O sedation.

AG Doufas, M Bakhshandeh, GS Haugh, AR Bjorksten, R Greif, DI Sessler

Journal article  |  2003  |  Acta Anaesthesiologica Scandinavica

BACKGROUND: Sedation practice, especially when non-anaesthesia personnel are involved, requires efficient anaesthetic depth monito..

A new system to target the effect-site during propofol sedation.

AG Doufas, M Bakhshandeh, AR Bjorksten, R Greif, DI Sessler

Journal article  |  2003  |  Acta Anaesthesiologica Scandinavica

BACKGROUND: We evaluated a new, integrated, covariate-adjusted, target-controlled infusion system during sedation with propofol co..

Dexmedetomidine and meperidine additively reduce the shivering threshold in humans.

Anthony G Doufas, Chun-Ming Lin, Mohammad-Irfan Suleman, Edwin B Liem, Rainer Lenhardt, Nobutada Morioka, Ozan Akça, Yunus M Shah, Andrew R Bjorksten, Daniel I Sessler

Journal article  |  2003  |  Stroke

BACKGROUND AND PURPOSE: Hypothermia might prove to be therapeutically beneficial in stroke victims; however, even mild hypothermia..

N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans.

I Medved, MJ Brown, AR Bjorksten, JA Leppik, S Sostaric, MJ McKenna

Journal article  |  2003  |  Journal of Applied Physiology

Infusion of the antioxidant N-acetylcysteine (NAC) reduces fatigability in electrically evoked human muscle contraction, but due t..

Alfentanil infusion as a component of intravenous anaesthesia for coronary artery bypass surgery with "fast-track" recovery

DW Blake, CF Royse, AG Royse, AR Bjorksten, PF Soeding, J Pang

Journal article  |  2003  |  Anaesthesia and Intensive Care

Mild core hypothermia and anesthetic requirement for loss of responsiveness during propofol anesthesia for craniotomy

K Leslie, AR Bjorksten, A Ugoni, P Mitchell

Journal article  |  2002  |  Anesthesia & Analgesia

Buspirone and meperidine synergistically reduce the shivering threshold.

M Mokhtarani, AN Mahgoub, N Morioka, AG Doufas, M Dae, TE Shaughnessy, AR Bjorksten, DI Sessler

Journal article  |  2001  |  Anesthesia & Analgesia

UNLABELLED: Mild hypothermia (i.e., 34 degrees C) may prove therapeutic for patients with stroke, but it usually provokes shiverin..

Neither nalbuphine nor atropine possess special antishivering activity.

R Greif, S Laciny, AM Rajek, MD Larson, AR Bjorksten, AG Doufas, M Bakhshandeh, M Mokhtarani, DI Sessler

Journal article  |  2001  |  Anesthesia & Analgesia

The special antishivering action of meperidine may be mediated by its kappa or anticholinergic actions. We therefore tested the hy..

Automated responsiveness test (ART) predicts loss of consciousness and adverse physiologic responses during propofol conscious sedation.

AG Doufas, M Bakhshandeh, AR Bjorksten, R Greif, DI Sessler

Journal article  |  2001  |  Anesthesiology

BACKGROUND: The authors evaluated a device designed to provide conscious sedation with propofol (propofol-air), or propofol combin..

Opioids inhibit febrile responses in humans, whereas epidural analgesia does not: an explanation for hyperthermia during epidural analgesia.

C Negishi, R Lenhardt, M Ozaki, K Ettinger, H Bastanmehr, AR Bjorksten, DI Sessler

Journal article  |  2001  |  Anesthesiology

BACKGROUND: Epidural analgesia is frequently associated with hyperthermia during labor and in the postoperative period. The conven..

Alfentanil reduces the febrile response to interleukin-2 in humans.

C Negishi, JS Kim, R Lenhardt, DI Sessler, M Ozaki, K Vuong, H Bastanmehr, AR Bjorksten

Journal article  |  2000  |  Critical Care Medicine

OBJECTIVE: Manifestation of intraoperative fever is impaired by volatile anesthetics and muscle relaxants. Opioids are common anes..

Exercise hemodynamic performance of the pulmonary autograft following the Ross procedure

GF Porter, PD Skillington, AR Bjorksten, JG Morgan, AG Yapanis, LE Grigg

Conference Proceedings  |  1999  |  Journal of Heart Valve Disease

The effects of physical treatment on induced fever in humans.

R Lenhardt, C Negishi, DI Sessler, K Vuong, H Bastanmehr, JS Kim, AR Bjorksten

Journal article  |  1999  |  The American Journal of Medicine

PURPOSE: Initial treatments for fever include the amelioration of underlying causes and administration of antipyretic medications...

Tramadol reduces the sweating, vasoconstriction, and shivering thresholds.

JL De Witte, JS Kim, DI Sessler, H Bastanmehr, AR Bjorksten

Journal article  |  1998  |  Anesthesia & Analgesia

UNLABELLED: The analgesic tramadol inhibits the neuronal reuptake of norepinephrine and 5-hydroxytryptamine, facilitates 5-hydroxy..

Meperidine and alfentanil do not reduce the gain or maximum intensity of shivering.

T Ikeda, DI Sessler, F Tayefeh, C Negishi, M Turakhia, D Marder, AR Bjorksten, MD Larson

Journal article  |  1998  |  Anesthesiology

BACKGROUND: Thermoregulatory shivering can be characterized by its threshold (triggering core temperature), gain (incremental inte..

Alfentanil blocks reflex pupillary dilation in response to noxious stimulation but does not diminish the light reflex.

MD Larson, A Kurz, DI Sessler, M Dechert, AR Bjorksten, F Tayefeh

Journal article  |  1997  |  Anesthesiology

BACKGROUND: Estimation of the mu-agonist opioid effect in anesthetized and paralyzed patients is often imprecise and can be obscur..

The efficacy of intra-articular morphine for postoperative knee arthroscopy analgesia

MD Richardson, AR Bjorksten, JAL Hart, K McCullough

Journal article  |  1997  |  Arthroscopy: The Journal of Arthroscopic & Related Surgery

This article describes two prospective, randomized, double-blind clinical trials designed to investigate this. Trial 1 compared a ..

The effects of cardiopulmonary bypass on total and unbound plasma concentrations of propofol and midazolam.

PJ Dawson, AR Bjorksten, DW Blake, JC Goldblatt

Journal article  |  1997  |  Journal of Cardiothoracic and Vascular Anesthesia

OBJECTIVE: To examine the effects of cardiopulmonary bypass (CPB) on total and unbound plasma concentrations of propofol and midaz..

The arterial blood propofol concentration preventing movement in 50% of healthy women after skin incision.

DT Andrews, K Leslie, DI Sessler, AR Bjorksten

Journal article  |  1997  |  Anesthesia & Analgesia

To target appropriate drug concentrations and to facilitate comparisons between drugs, the potency of propofol must be firmly esta..

Determination of eltanolone in human plasma by high-performance liquid chromatography.

DJ Jones, AR Bjorksten, DP Crankshaw

Journal article  |  1997  |  Journal of Chromatography B: Biomedical Sciences and Applications

A high-performance liquid chromatographic method for the determination of eltanolone in plasma has been developed. Plasma samples ..

Meperidine decreases the shivering threshold twice as much as the vasoconstriction threshold.

A Kurz, T Ikeda, DI Sessler, MD Larson, AR Bjorksten, M Dechert, R Christensen

Journal article  |  1997  |  Anesthesiology

BACKGROUND: Meperidine administration is a more effective treatment for shivering than equianalgesic doses of other opioids. Howev..

The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine.

T Ikeda, A Kurz, DI Sessler, J Go, M Kurz, K Belani, M Larson, AR Bjorksten, M Dechert, R Christensen

Conference Proceedings  |  1997  |  Annals of the New York Academy of Sciences

In summary, both mu-receptor and combined mu/kappa-receptor opioids impair thermoregulatory control. Alfentanil, a pure mu-recepto..

Effects of temperature and propofol on hepatic blood flow - Response

K Leslie, DI Sessler, AR Bjorksten, A Moayeri

Journal article  |  1996  |  Anesthesia & Analgesia

Alfentanil slightly increases the sweating threshold and markedly reduces the vasoconstriction and shivering thresholds.

A Kurz, JC Go, DI Sessler, K Kaer, MD Larson, AR Bjorksten

Journal article  |  1995  |  Anesthesiology

BACKGROUND: Hypothermia is common in surgical patients and victims of major trauma; it also results from environmental exposure an..

Midazolam minimally impairs thermoregulatory control.

A Kurz, DI Sessler, R Annadata, M Dechert, R Christensen, AR Bjorksten

Journal article  |  1995  |  Anesthesia & Analgesia

Perioperative hypothermia usually results largely from pharmacologic inhibition of normal thermoregulatory control. Midazolam is a..

Propofol linearly reduces the vasoconstriction and shivering thresholds.

T Matsukawa, A Kurz, DI Sessler, AR Bjorksten, B Merrifield, C Cheng

Journal article  |  1995  |  Anesthesiology

BACKGROUND: Skin temperature is best kept constant when determining response thresholds because both skin and core temperatures co..

MILD HYPOTHERMIA ALTERS PROPOFOL PHARMACOKINETICS AND INCREASES THE DURATION OF ACTION OF ATRACURIUM

K LESLIE, DI SESSLER, AR BJORKSTEN, A MOAYERI

Journal article  |  1995  |  Anesthesia & Analgesia

The maximum depth of an atracurium neuromuscular block antagonized by edrophonium to effect adequate recovery.

GH Beemer, PH Goonetilleke, AR Bjorksten

Journal article  |  1995  |  Anesthesiology

BACKGROUND: The inability of edrophonium to rapidly reverse a deep nondepolarizing neuromuscular block may be due to inadequate do..

Detection of ketorolac enantiomers in human plasma using enantioselective liquid chromatography.

DJ Jones, AR Bjorksten

Journal article  |  1994  |  Journal of Chromatography B: Biomedical Sciences and Applications

A high-performance liquid chromatographic method for the determination of the enantiomers of ketorolac in human plasma has been de..

PROPOFOL CAUSES A DOSE-DEPENDENT DECREASE IN THE THERMOREGULATORY THRESHOLD FOR VASOCONSTRICTION BUT HAS LITTLE EFFECT ON SWEATING

K LESLIE, DI SESSLER, AR BJORKSTEN, M OZAKI, T MATSUKAWA, M SCHROEDER, S LIN

Journal article  |  1994  |  Anesthesiology

Effect of body build on the clearance of atracurium: implication for drug dosing.

GH Beemer, AR Bjorksten, DP Crankshaw

Journal article  |  1993  |  Anesthesia & Analgesia

To determine factors that influenced the clearance (Cl) of atracurium, 80 adult patients of varying body build were given an atrac..

Pharmacodynamics of atracurium in clinical practice: effect of plasma potassium, patient demographics, and concurrent medication.

GH Beemer, AR Bjorksten

Journal article  |  1993  |  Anesthesia & Analgesia

To determine which factors influenced the pharmacodynamics of atracurium in clinical practice, the steady-state plasma concentrati..

Pharmacokinetic/pharmacodynamic modelling of atracurium.

DM Fisher

Journal article  |  1993  |  British Journal of Anaesthesia

Determinants of antagonism of non-depolarizing neuromuscular block.

JR Campbell

Journal article  |  1991  |  British Journal of Anaesthesia

Pharmacokinetics of atracurium.

CJ Parker, JM Hunter

Journal article  |  1991  |  British Journal of Anaesthesia

Determinants of the reversal time of competitive neuromuscular block by anticholinesterases.

GH Beemer, AR Bjorksten, PJ Dawson, RJ Dawson, PJ Heenan, BA Robertson

Journal article  |  1991  |  British Journal of Anaesthesia

We have assessed, in 200 patients, the determinants of the reversal time of competitive neuromuscular block by anticholinesterase ..

Single-shot Intercostal Nerve Block as an Adjunct to Post-operative Pain Control for Upper Abdominal Surgery in the Obese Patient

PH Pearce, AR Bjorksten

Journal article  |  1991  |  Obesity Surgery

SIMPLE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE ANALYSIS OF THE NONDEPOLARIZING NEUROMUSCULAR BLOCKING-DRUGS IN CLINICAL ANESTHESIA

AR BJORKSTEN, GH BEEMER, DP CRANKSHAW

Journal article  |  1990  |  Journal of Chromatography B: Biomedical Sciences and Applications

PHARMACODYNAMICS OF ATRACURIUM DURING PROPOFOL, THIOPENTONE AND OPIOID ANESTHESIA

GH BEEMER, AR BJORKSTEN, DP CRANKSHAW

Journal article  |  1990  |  British Journal of Anaesthesia

Accurate monitoring of neuromuscular blockade using a peripheral nerve stimulator--a review.

GH Beemer, JH Reeves, AR Bjorksten

Journal article  |  1990  |  Anaesthesia and Intensive Care

For normal anaesthetic practice, monitoring of neuromuscular blockade is best performed by stimulation of the ulnar nerve at the w..

PHARMACOKINETICS OF ATRACURIUM DURING CONTINUOUS INFUSION

GH BEEMER, AR BJORKSTEN, DP CRANKSHAW

Journal article  |  1990  |  British Journal of Anaesthesia

Early postoperative seizures in neurosurgical patients administered atracurium and isoflurane.

GH Beemer, PJ Dawson, AR Bjorksten, NE Edwards

Journal article  |  1989  |  Anaesthesia and Intensive Care

Monoamine oxidase inhibitors revisited.

DG Wells, AR Bjorksten

Journal article  |  1989  |  Canadian Journal of Anaesthesia

Adverse reactions to atracurium and alcuronium. A prospective surveillance study.

GH Beemer, WL Dennis, PR Platt, AR Bjorksten, AB Carr

Journal article  |  1988  |  British Journal of Anaesthesia

A multicentre prospective surveillance study was undertaken to compare the incidence and severity of adverse reactions attributed ..

The effects of cardiopulmonary bypass on plasma concentrations and protein binding of methohexital and thiopental.

AR Bjorksten, DP Crankshaw, DJ Morgan, PR Prideaux

Journal article  |  1988  |  Journal of Cardiothoracic Anesthesia

The effects of cardiopulmonary bypass (CPB) on plasma concentrations and protein binding of methohexital and thiopental were studi..

PLASMA DRUG EFFLUX - A NEW APPROACH TO OPTIMIZATION OF DRUG INFUSION FOR CONSTANT BLOOD-CONCENTRATION OF THIOPENTAL AND METHOHEXITAL

DP CRANKSHAW, MD BOYD, AR BJORKSTEN

Journal article  |  1987  |  Anesthesiology