Andrew Bjorksten

Functional analysis of RYR1 variants in patients with confirmed susceptibility to malignant hyperthermia.

Ruth White, Anja H Schiemann, Sophie M Burling, Andrew Bjorksten, Terasa Bulger, Robyn Gillies, Philip M Hopkins, Erik-Jan Kamsteeg, Roslyn G Machon, Sean Massey, Dorota Miller, Margaret Perry, Marc MJ Snoeck, Jeremy Stephens, Neil Street, Luuk R van den Bersselaar, Kathryn M Stowell

Journal article  |  2022  |  Br J Anaesth

BACKGROUND: A major bottleneck to the introduction of noninvasive presymptomatic diagnostic tests for the pharmacogenetic disorder..

Levobupivacaine plasma concentrations following repeat caudal anesthetics

Geoff Frawley, Luis Ignacio Cortinez, Brian J Anderson, Andrew Bjorksten, Sebastian King

Journal article  |  2022  |  PEDIATRIC ANESTHESIA

AIM: A single caudal anesthetic at the start of lower abdominal surgery is unlikely to provide prolonged analgesia. A second cauda..

Pre-operative exercise and pyrexia as modifying factors in malignant hyperthermia (MH).

Sheila Riazi, Luuk R van den Bersselaar, Gunilla Islander, Luc Heytens, Marc MJ Snoeck, Andrew Bjorksten, Robyn Gillies, George Dranitsaris, Anna Hellblom, Susan Treves, Gudrun Kunst, Nicol C Voermans, Heinz Jungbluth

Journal article  |  2022  |  Neuromuscul Disord

Malignant hyperthermia (MH) is a life-threatening reaction triggered by volatile anesthetics and succinylcholine. MH is caused by ..

CLINICAL RESEARCH

S Riazi, L van den Bersselaar, G Islander, L Heytens, M Snoeck, A Bjorksten, R Gillies, G Dranitsaris, A Hellblom, S Treves, N Voermans, H Jungbluth

Journal article  |  2021  |  Neuromuscular Disorders

A genetic mystery in malignant hyperthermia 'solved'?

AH Schiemann, AR Bjorksten, RL Gillies, BM Hockey, C Ball, N Pollock, T Bulger, KM Stowell

Journal article  |  2018  |  Br J Anaesth

Junctional membrane Ca2 dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation

Tanya R Cully, Rocky H Choi, Andrew R Bjorksten, D George Stephenson, Robyn M Murphy, Bradley S Launikonis

Journal article  |  2018  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

We used the nanometer-wide tubules of the transverse tubular (t)-system of human skeletal muscle fibers as sensitive sensors for t..

Self-Organized Nanostructure Modified Microelectrode for Sensitive Electrochemical Glutamate Detection in Stem Cells-Derived Brain Organoids

Babak Nasr, Rachael Chatterton, Jason Hsien Ming Yong, Pegah Jamshidi, Giovanna Marisa D'Abaco, Andrew Robin Bjorksten, Omid Kavehei, Gursharan Chana, Mirella Dottori, Efstratios Skafidas

Journal article  |  2018  |  BIOSENSORS-BASEL

Neurons release neurotransmitters such as glutamate to communicate with each other and to coordinate brain functioning. As increas..

Functional Characterization of C-terminal Ryanodine Receptor 1 Variants Associated with Central Core Disease or Malignant Hyperthermia.

Remai Parker, Anja H Schiemann, Elaine Langton, Terasa Bulger, Neil Pollock, Andrew Bjorksten, Robyn Gillies, David Hutchinson, Richard Roxburgh, Kathryn M Stowell

Journal article  |  2017  |  J Neuromuscul Dis

BACKGROUND: Central core disease and malignant hyperthermia are human disorders of skeletal muscle resulting from aberrant Ca2+ ha..

Sequencing of genes involved in the movement of calcium across human skeletal muscle sarcoplasmic reticulum: continuing the search for genes associated with malignant hyperthermia

AR Bjorksten, RL Gilles, BM Hockey, D Du Sart

Journal article  |  2016  |  ANAESTHESIA AND INTENSIVE CARE

The genetic basis of malignant hyperthermia (MH) is not fully characterised and likely involves more than just the currently class..

Peritumoural glutamate correlates with post-operative seizures in supratentorial gliomas

Andrew Neal, Tanya Yuen, Andrew R Bjorksten, Patrick Kwan, Terence J O'Brien, Andrew Morokoff

Journal article  |  2016  |  JOURNAL OF NEURO-ONCOLOGY

To examine the impact of glutamate on post-operative seizures and survival in a cohort of patients with grade II to IV supratentor..