Geoffrey Donnan

Feasibility trial of metformin XR in people with pre-diabetes and stroke (MIPPS)-randomised open blinded endpoint controlled trial

M Tabesh, M Hachem, LH Lau, K Borschmann, L Churilov, SAL Price, P Sumithran, G Donnan, J Zajac, V Thijs, EI Ekinci

Journal article  |  2021  |  Journal of Clinical Neuroscience

Does Intravenous Thrombolysis Within 4.5 to 9 Hours Increase Clot Migration Leading to Endovascular Inaccessibility?

Jeremy C Lim, Leonid Churilov, Andrew Bivard, Henry Ma, Richard J Dowling, Bruce CV Campbell, Mark W Parsons, Stephen M Davis, Geoffrey A Donnan, Peter J Mitchell, Bernard Yan

Journal article  |  2021  |  Stroke

BACKGROUND AND PURPOSE: Distal clot migration is a recognized event following intravenous thrombolysis (IVT) in the setting of acu..

Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggests aspirin did not improve outcomes in older adults with chronic kidney disease.

Rory Wolfe, James B Wetmore, Robyn L Woods, John J McNeil, Hugh Gallagher, Paul Roderick, Rowan Walker, Mark R Nelson, Christopher M Reid, Raj C Shah, Michael E Ernst, Jessica E Lockery, Andrew M Tonkin, Walter P Abhayaratna, Peter Gibbs, Erica M Wood, Suzanne E Mahady, Jeff D Williamson, Geoffrey A Donnan, Geoffrey C Cloud, et al.

Journal article  |  2021  |  Kidney International

The role of aspirin for primary prevention in older adults with chronic kidney disease (CKD) is unclear. Therefore, post hoc analy..

Five-Year Prognosis After TIA or Minor Ischemic Stroke in Asian and Non-Asian Populations.

Takao Hoshino, Shinichiro Uchiyama, Lawrence KS Wong, Kazuo Kitagawa, Hugo Charles, Julien Labreuche, Philippa C Lavallée, Gregory W Albers, Louis R Caplan, Geoffrey A Donnan, José M Ferro, Michael G Hennerici, Carlos Molina, Peter M Rothwell, P Gabriel Steg, Pierre-Jean Touboul, Éric Vicaut, Pierre Amarenco, undefined TIA registry.org Investigators

Journal article  |  2021  |  Neurology

OBJECTIVE: To determine long-term vascular outcomes of Asian patients who experienced TIA or minor ischemic stroke and to compare ..

Patterns of Infarction on MRI in Patients With Acute Ischemic Stroke and Cardio-Embolism: A Systematic Review and Meta-Analysis

Angelos Sharobeam, Leonid Churilov, Mark Parsons, Geoffrey A Donnan, Stephen M Davis, Bernard Yan

Journal article  |  2020  |  Frontiers in Neurology

Background: Cardioembolic strokes are common however atrial fibrillation, the most common cause, is often asymptomatic and difficu..

Tranexamic acid in patients with intracerebral haemorrhage (STOP-AUST): a multicentre, randomised, placebo-controlled, phase 2 trial

Atte Meretoja, Nawaf Yassi, Teddy Y Wu, Leonid Churilov, Gerli Sibolt, Jiann-Shing Jeng, Timothy Kleinig, Neil J Spratt, Vincent Thijs, Tissa Wijeratne, Der-Yang Cho, Darshan Shah, Geoffrey C Cloud, Phan Thanh, Christopher Bladin, Andrew Moey, Richard I Aviv, Christen D Barras, Gagan Sharma, Chung Y Hsu, et al.

Journal article  |  2020  |  The Lancet Neurology

BACKGROUND: Despite intracerebral haemorrhage causing 5% of deaths worldwide, few evidence-based therapeutic strategies other than..

Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals

Enayet Karim Chowdhury, Michael E Ernst, Mark Nelson, Karen Margolis, Lawrie J Beilin, Collin Johnston, Robyn Woods, Anne Murray, Rory Wolfe, Elsdon Storey, Raj C Shah, Jessica Lockery, Andrew Tonkin, Anne Newman, Walter Abhayaratna, Nigel Stocks, Sharyn Fitzgerald, Suzanne Orchard, Ruth Trevaks, Geoffrey Donnan, et al.

Journal article  |  2020  |  Journal of Hypertension

OBJECTIVES: The AHA/ACC-2017 hypertension guideline recommends an age-independent target blood pressure (BP) of less than 130/80 m..

The impact of the DWI-FLAIR-mismatch in the ECASS-4 trial - A post hoc analysis.

Johannes Ar Pfaff, Martin Bendszus, Geoffrey Donnan, Carlos Molina, Didier Leys, Peter D Schellinger, Stefan Schwab, Danilo Toni, Nils Wahlgren, Werner Hacke, Peter Arthur Ringleb

Journal article  |  2020  |  European Stroke Journal

Introduction: To investigate the impact of a mismatch between diffusion-weighted imaging (DWI) and fluid attenuated inversion reco..

Cost-Effectiveness of Tenecteplase Before Thrombectomy for Ischemic Stroke

Lan Gao, Marj Moodie, Peter J Mitchell, Leonid Churilov, Timothy J Kleinig, Nawaf Yassi, Bernard Yan, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis, Bruce CV Campbell

Journal article  |  2020  |  Stroke

BACKGROUND AND PURPOSE: Tenecteplase improved functional outcomes and reduced the requirement for endovascular thrombectomy in isc..

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Goetz Thomalla, Florent Boutitie, Henry Ma, Masatoshi Koga, Peter Ringleb, Lee H Schwamm, Ona Wu, Martin Bendszus, Christopher F Bladin, Bruce CV Campbell, Bastian Cheng, Leonid Churilov, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Mayumi Fukuda-Doi, Manabu Inoue, Timothy J Kleinig, Lawrence L Latour, Robin Lemmens, et al.

Journal article  |  2020  |  The Lancet

BACKGROUND: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to..