Geoffrey Donnan

Effects of intensive blood pressure lowering on cerebral ischaemia in thrombolysed patients: insights from the ENCHANTED trial.

Chen Chen, Menglu Ouyang, Sheila Ong, Luyun Zhang, Guobin Zhang, Candice Delcourt, Grant Mair, Leibo Liu, Laurent Billot, Qiang Li, Xiaoying Chen, Mark Parsons, Joseph P Broderick, Andrew M Demchuk, Philip M Bath, Geoffrey A Donnan, Christopher Levi, John Chalmers, Richard I Lindley, Sheila O Martins, et al.

Journal article  |  2023  |  EClinicalMedicine

BACKGROUND: Intensive blood pressure lowering may adversely affect evolving cerebral ischaemia. We aimed to determine whether inte..

Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion: An EXTEND-IA TNK Trials Analysis

Vignan Yogendrakumar, Leonid Churilov, Prodipta Guha, James Beharry, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Helen Brown, Helen M Dewey, Tissa Wijeratne, Bernard Yan, Gagan Sharma, Patricia M Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis, Bruce CV Campbell

Journal article  |  2023  |  STROKE

BACKGROUND: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that influence altepl..

Tenecteplase Improves Reperfusion across Time in Large Vessel Stroke.

Vignan Yogendrakumar, James Beharry, Leonid Churilov, Khairunnisa Alidin, Melissa Ugalde, Lauren Pesavento, Louise Weir, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Darshan G Shah, Helen M Dewey, Tissa Wijeratne, Bernard Yan, Patricia M Desmond, Gagan Sharma, Mark W Parsons, Geoffrey A Donnan, et al.

Journal article  |  2023  |  Ann Neurol

OBJECTIVE: Tenecteplase improves reperfusion compared to alteplase in patients with large vessel occlusions. To determine whether ..

Tenecteplase versus alteplase for stroke thrombolysis evaluation (TASTE): A multicentre, prospective, randomized, open-label, blinded-endpoint, controlled phase III non-inferiority trial protocol

Andrew Bivard, Carlos Garcia-Esperon, Leonid Churilov, Neil Spratt, Michelle Russell, Bruce C Campbell, Philip Choi, Timothy Kleinig, Henry Ma, Hugh Markus, Carlos Molina, Chung Hsu, Chon-Haw Tsai, Atte Meretoja, Daniel Strbian, Kenneth Butcher, Teddy Wu, Stephen Davis, Geoffrey Donnan, Christopher Levi, et al.

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF STROKE

RATIONALE: Alteplase is the only approved thrombolytic agent for acute stroke. An alternative plasminogen activator, tenecteplase,..

Abstract WMP47: Low Sensitivity Of Widely Used Emergency Dispatch Algorithm For Thrombectomy Patients - Implications For Mobile Stroke Units

Ahmed Haliem, Candice M Menezes, leonid churilov, Karen L Smith, Belinda Delardes, Skye Coote, Damien Easton, Francesca Langenberg, James Beharry, Vignan Yogendrakumar, Louise C Weir, Peter J Mitchell, Geoffrey A Donnan, Stephen Davis, Bruce Campbell, Henry Zhao

Journal article  |  2023  |  Stroke

Introduction: Widely used emergency dispatch algorithms such as the Advanced Medical Priority Dispatch System (AMPDS) ..

Abstract 92: Tenecteplase Treatment And Thrombus Characteristics Associated With Early Reperfusion - An EXTEND-IA TNK Trials Analysis

Vignan Yogendrakumar, Leonid Churilov, Prodipta Guha, James Beharry, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Helen Brown, Helen M Dewey, Tissa H Wijeratne, Bernard Yan, Gagan Sharma, Patricia Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen Davis, Bruce Campbell

Journal article  |  2023  |  Stroke

Background: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that infl..

CYP2C19 Genotyping to Guide Antiplatelet Therapy for the Secondary Prevention of Lacunar Strokes.

Luciano A Sposato, Geoffrey Alan Donnan

Journal article  |  2023  |  Neurology

Mediation of Successful Reperfusion Effect through Infarct Growth and Cerebral Edema: A Pooled, Patient-Level Analysis of EXTEND-IA Trials and SELECT Prospective Cohort

Amrou Sarraj, Deep K Pujara, Leonid Churilov, Clark W Sitton, Felix Ng, Ameer E Hassan, Michael G Abraham, Spiros L Blackburn, Gagan Sharma, Nawaf Yassi, Timothy Kleinig, Darshan Shah, Teddy Y Wu, Wondwossen G Tekle, Ronald F Budzik, William J Hicks, Nirav Vora, Randall C Edgell, Diogo Haussen, Santiago Ortega-Gutierrez, et al.

Journal article  |  2023  |  ANNALS OF NEUROLOGY

OBJECTIVE: Reperfusion therapy is highly beneficial for ischemic stroke. Reduction in both infarct growth and edema are plausible ..

Thrombectomy Outcomes With General vs Nongeneral Anesthesia A Pooled Patient-Level Analysis From the EXTEND-IA Trials and SELECT Study

Amrou Sarraj, Gregory W Albers, Peter J Mitchell, Ameer E Hassan, Michael G Abraham, Spiros Blackburn, Gagan Sharma, Nawaf Yassi, Timothy J Kleinig, Darshan G Shah, Teddy Y Wu, Muhammad Shazam Hussain, Wondwoseen G Tekle, Santiago Ortega Gutierrez, Amin Nima Aghaebrahim, Diogo C Haussen, Gabor Toth, Deep Pujara, Ronald F Budzik, William Hicks, et al.

Journal article  |  2023  |  NEUROLOGY

BACKGROUND AND OBJECTIVES: The effect of anesthesia choice on endovascular thrombectomy (EVT) outcomes is unclear. Collateral stat..

A phase III, multi-arm multi-stage covariate-adjusted response-adaptive randomized trial to determine optimal early mobility training after stroke (AVERT DOSE)

Julie Bernhardt, Leonid Churilov, Helen Dewey, Geoffrey Donnan, Fiona Ellery, Coralie English, Lan Gao, Kathryn Hayward, Frances Horgan, Bent Indredavik, Hannah Johns, Peter Langhorne, Richard Lindley, Sheila Martins, Md Ali Katijjahbe, Sandy Middleton, Marj Moodie, Jeyaraj Pandian, Brooke Parsons, Thompson Robinson, et al.

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF STROKE

RATIONALE: The evidence base for acute post-stroke rehabilitation is inadequate and global guideline recommendations vary. AIM: To..