Anderly Chueh

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

Anderly C Chueh, Gahana Advani, Momeneh Foroutan, Jai Smith, Nadia Ng, Harshal Nandurkar, Daisy S Lio, Hong-Jian Zhu, Yuh-Ping Chong, Heather Verkade, Donald J Fujita, Jeffrey Bjorge, Faiza Basheer, Jet Phey Lim, Ian Luk, Amardeep Dhillon, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver Sieber, Frederic Hollande, et al.

Journal article  |  2021  |  ONCOGENE

Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC..

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chueh, Judy Doherty, Francois Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, et al.

Journal article  |  2021  |  CELL DEATH & DISEASE

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limita..

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

Lars Togel, Rebecca Nightingale, Rui Wu, Anderly C Chueh, Sheren Al-Obaidi, Ian Luk, Mercedes Davalos-Salas, Fiona Chionh, Carmel Murone, Daniel D Buchanan, Zac Chatterton, Oliver M Sieber, Diego Arango, Niall C Tebbutt, David Williams, Amardeep S Dhillon, John M Mariadason

Journal article  |  2018  |  SCIENTIFIC REPORTS

The ERK signalling pathway regulates key cell fate decisions in the intestinal epithelium and is frequently dysregulated in colore..

Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer

Anderly C Chueh, Mun-Sem Liew, Prudence A Russell, Marzena Walkiewicz, Aparna Jayachandran, Maud HW Starmans, Paul C Boutros, Gavin Wright, Stephen A Barnett, John M Mariadason, Thomas John

Journal article  |  2017  |  ONCOTARGET

Cancer-Testis antigens (CTA) are immunogenic molecules with normal tissue expression restricted to testes but with aberrant expres..

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity toHDACInhibitors across Tumor Types

Anderly C Chueh, Janson WT Tse, Michael Dickinson, Paul Ioannidis, Laura Jenkins, Lars Togel, BeeShin Tan, Ian Luk, Mercedes Davalos-Salas, Rebecca Nightingale, Matthew R Thompson, Bryan RG Williams, Guillaume Lessene, Erinna F Lee, Walter D Fairlie, Amardeep S Dhillon, John M Mariadason

Journal article  |  2017  |  CLINICAL CANCER RESEARCH

Purpose: Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules approved for the treatment of cutaneous T-..

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia LY Ng, Anderly C Chueh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E Turk, Thomas E Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng

Journal article  |  2017  |  CELL COMMUNICATION AND SIGNALING

BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases ..

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

Lars Togel, Rebecca Nightingale, Anderly C Chueh, Aparna Jayachandran, Hoanh Tran, Toby Phesse, Rui Wu, Oliver M Sieber, Diego Arango, Amardeep S Dhillon, Mark A Dawson, Beatriz Diez-Dacal, Timothy C Gahman, Panagis Filippakopoulos, Andrew K Shiau, John M Mariadason

Journal article  |  2016  |  MOLECULAR CANCER THERAPEUTICS

Inhibitors of the bromodomain and extraterminal domain (BET) protein family attenuate the proliferation of several tumor cell line..

A beacon of hope in stroke therapy Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Ashfaqul Hoque, M Iqbal Hossain, S Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic CH Ng, Anderly C Chueh, Carli Roulston, Heung-Chin Cheng

Journal article  |  2016  |  PHARMACOLOGY & THERAPEUTICS

Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors, is a major cause of neuronal ..

Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

Aparna Jayachandran, Pu-Han Lo, Anderly C Chueh, Prashanth Prithviraj, Ramyar Molania, Mercedes Davalos-Salas, Matthew Anaka, Marzena Walkiewicz, Jonathan Cebon, Andreas Behren

Journal article  |  2016  |  BMC CANCER

BACKGROUND: The metabolism of cancer cells is often reprogrammed by dysregulation of metabolic enzymes. Transketolase-like 1 (TKTL..

Markov process-based retrieval for encrypted JPEG images

Hang Cheng, Xinpeng Zhang, Jiang Yu, Fengyong Li

Journal article  |  2016  |  EURASIP JOURNAL ON INFORMATION SECURITY