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Dr

Adrian Achuthan

Senior Research Fellow
Medicine - Royal Melbourne Hospital
Monocytes
Macrophages
Dendritic Cells
Cytokines
Chemokines
Transcription and Epigenetic Factors
science & technology
life sciences & biomedicine
inflammation
Adrian Achuthan's Profile Picture
Dr

Adrian Achuthan

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Exploring the functional roles of leukocytes in the progression of inflammatory disease
Adrian Achuthan's Profile Picture
Dr

Adrian Achuthan

 

After completing my PhD at the University of Melbourne (2007), I did my post-doctoral training at the Institute of Molecular and Cell Biology Institute, Singapore with an Australian Endeavour Research Fellowship. I pursued a short stint at the Burnet Institute in 2009, before returning to the University of Melbourne in 2010.

I led a small research team to conduct a commercial contract research towards identifying a GM-CSF gene signature under the auspices of as MorphoSys AG, conducting Phase I anti-GM-CSF clinical trial in rheumatoid arthritis. Following the successful completion of the trial, GlaxoSmithKline acquired the rights to conduct Phase IIb clinical trials. Subsequently, I was instrumental in securing a four-year commercial research contract with GlaxoSmithKline to investigate the molecular mechanisms responsible for GM-CSF-mediated inflammation in rheumatoid arthritis. A number of publications in leading journals and a significant patent emerged from this. In 2018, I was appointed as the Honours Coordinator at the Department of Medicine, Royal Melbourne Hospital overseeing the largest cohort of Honour students in the Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne.

Projects

Displaying the 6 most recent projects by Adrian Achuthan.

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Ccl17 And Ccl22 Research Program

2020 - 2022
Active
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Lex34425 Cytokines And Pain

2019 - 2021
Active
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Rebalancing The Levels Of Ccl17 And Ccl22 To Improve Rheumatoid Arthritis

2019 - 2021
Active
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Elucidating The Roles Of Ccr4 Ligands In Rheumatoid Arthritis

2018 - 2018
Completed
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Ccl17 Is A General Pain Regulator - Lex 31020

2018 - 2019
Completed
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Cytokines In Inflammation

2014 - 2017
Completed

6

Projects

Project Types

4

Research Contracts

1

Internal Research Grant

1

Research Grant

Scholarly Works

Displaying the 31 most recent scholarly works by Adrian Achuthan.

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Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  Osteoarthritis and Cartilage

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

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Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  Journal of Clinical Investigation

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Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A Hamilton, Rita A Busuttil, Alex Boussioutas

Journal article  |  2019  |  Nature Communications

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GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook

Journal article  |  2019  |  The Journal of Immunology

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CSF-1 in Inflammatory and Arthritic Pain Development

Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton

Journal article  |  2018  |  The Journal of Immunology

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Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan

Journal article  |  2018  |  Journal of Biological Chemistry

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CCL17 blockade as a therapy for osteoarthritis pain and disease

Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Foerster, John A Hamilton, Andrew D Cook

Journal article  |  2018  |  Arthritis Research & Therapy

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TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17

Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Anne D Christensen, Adrian Achuthan, Andrew J Fleetwood, Derek C Lacey, Julia E Smith, Irmgard Foerster, John A Hamilton

Journal article  |  2018  |  JCI Insight

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Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton

Journal article  |  2018  |  Cell Death & Disease

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Cytokine-Induced Acute Inflammatory Monoarticular Arthritis

Adrian Achuthan, Ming-Chin Lee, Reem Saleh, Andrew J Fleetwood, John A Hamilton, Andrew D Cook

Book Chapter  |  2018  |  Methods in Molecular Biology

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Newly identified molecular mechanism of glucocorticoid action in arthritis

Adrian Achuthan, Amy Hsu, Tanya Lupancu, Ming-Ching Lee, Reem Saleh, Andrew Fleetwood, Andrew Cook, John Hamilton

Conference Proceedings  |  2017  |  CYTOKINE

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Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

Andrew J Fleetwood, Man KS Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds, John A Hamilton

Journal article  |  2017  |  Frontiers in Cellular and Infection Microbiology

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G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease

Ming-Chin Lee, James A McCubbin, Anne D Christensen, Daniel P Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M Brierley, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Robin L Anderson, John A Hamilton, Andrew D Cook

Journal article  |  2017  |  The Journal of Immunology

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Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation

Adrian Achuthan, Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Melody WN Chang, Cynthia Louis, Andrew J Fleetwood, Derek C Lacey, Anne D Christensen, Ashlee T Frye, Pui Yeng Lam, Hitoshi Kusano, Koji Nomura, Nancy Steiner, Irmgard Foerster, Stephen L Nutt, Moshe Olshansky, Stephen J Turner, John A Hamilton

Journal article  |  2016  |  Journal of Clinical Investigation

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A new GM-CSF-dependent pathway in arthritis

A Achuthan, M-C Lee, R Saleh, A Frye, A Fleetwood, A Cook, J Hamilton

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage urokinase plasminogen activator system

A Fleetwood, N O'Brien-Simpson, P Veith, R Lam, A Achuthan, A Cook, W Singleton, I Lund, E Reynolds, J Hamilton

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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IRF6 Regulates the Expression of IL-36 gamma by Human Oral Epithelial Cells in Response to Porphyromonas gingivalis

Jennifer Huynh, Glen M Scholz, Jiamin Aw, Mei Qi Kwa, Adrian Achuthan, John A Hamilton, Eric C Reynolds

Journal article  |  2016  |  The Journal of Immunology

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Colony Stimulating Factors

A Fleetwood, A Achuthan, JA Hamilton

Book Chapter  |  2016

As the largest integrated source of immunological knowledge currently available, Encyclopedia of Immunobiology is a go-to referenc..

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Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System IMPLICATIONS FOR PERIODONTITIS

Andrew J Fleetwood, Neil M O'Brien-Simpson, Paul D Veith, Roselind S Lam, Adrian Achuthan, Andrew D Cook, William Singleton, Ida K Lund, Eric C Reynolds, John A Hamilton

Journal article  |  2015  |  Journal of Biological Chemistry

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GM-CSF-induced CCL17 expression in monocytes/macrophages is IRF4 dependent: a pathway of potential significance in inflammation

A Achuthan, P-Y Lam, MW Chang, AJ Fleetwood, DC Lacey, AD Cook, JA Hamilton

Conference Proceedings  |  2014  |  FEBS JOURNAL

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Urokinase Plasminogen Activator Is a Central Regulator of Macrophage Three-Dimensional Invasion, Matrix Degradation, and Adhesion

Andrew J Fleetwood, Adrian Achuthan, Heidi Schultz, Anneline Nansen, Kasper Almholt, Pernille Usher, John A Hamilton

Journal article  |  2014  |  Journal of Immunology

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Colony stimulating factors and myeloid cell biology in health and disease

John A Hamilton, Adrian Achuthan

Journal article  |  2013  |  Trends in Immunology (formerly Immunology Today)

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Defining GM-CSF- and Macrophage-CSF Dependent Macrophage Responses by In Vitro Models

Derek C Lacey, Adrian Achuthan, Andrew J Fleetwood, Hang Dinh, John Roiniotis, Glen M Scholz, Melody W Chang, Sandra K Beckman, Andrew D Cook, John A Hamilton

Journal article  |  2012  |  Journal of Immunology

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Endogenous leukaemia inhibitory factor signalling reduces axonal damage in mice with EAE

MM Gresle, E Alexandrou, B Wang, G Egan, M Ayres, V Jokubaitis, A Jonas, AM Friedhuber, W Doherty, A Achuthan, G Shaw, J Vacher, M Sendtner, TJ Kilpatrick, H Butzkueven

Conference Proceedings  |  2012  |  MULTIPLE SCLEROSIS JOURNAL

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MICROARRAY PROFILING OF MOUSE AND HUMAN MACROPHAGES

DC Lacey, H Dinh, A Achuthan, AD Cook, G Scholz, JA Hamilton

Conference Proceedings  |  2011  |  INFLAMMATION RESEARCH

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MICROARRAY PROFILING OF CSF-DEPENDENT MURINE AND HUMAN MACROPHAGES

D Lacey, H Dinh, A Achuthan, G Scholz, A Cook, J Hamilton

Conference Proceedings  |  2011  |  INTERNAL MEDICINE JOURNAL

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Role of SNARE proteins in the pathogenesis of HIV

Adrian Achuthan, Jing Ling Zhou, Suzanne Crowe, Anthony Jaworowski

Conference Proceedings  |  2010  |  FASEB JOURNAL

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Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages

Adrian Achuthan, Paul Masendycz, Jamie A Lopez, Thao Nguyen, David E James, Matthew J Sweet, John A Hamilton, Glen M Scholz

Journal article  |  2008  |  Molecular and Cellular Biology

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CpG DNA enhances macrophage cell spreading by promoting the Src-family kinase-mediated phosphorylation of paxillin

Adrian Achuthan, Caryn Elsegood, Paul Masendycz, John A Hamilton, Glen M Scholz

Journal article  |  2006  |  Cellular Signaling

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A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor

GA Manes, P Masendycz, T Nguyen, A Achuthan, H Dinh, JA Hamilton, GM Scholz

Journal article  |  2006  |  FEBS Journal

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Regulation of Syntaxin 7 expression and function in macrophages by CSF-1

Adrian Achuthan, Jamie Lopez, Matthew Sweet, David James, John Hamilton, Glen Scholz

Conference Proceedings  |  2005  |  INFLAMMATION RESEARCH

31

Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Clinical Sciences
Immunology
Biochemistry and Cell Biology
Clinical (organs, Diseases and Abnormal Conditions)
Dentistry
Expanding Knowledge
Public Health (excl. Specific Population Health)
Oncology and Carcinogenesis

Honours, Awards and Fellowships

2003

Postgraduate

Melbourne Research Scholarship
1999

Undergraduate

Melbourne Access Scholarship

2

Awards

Credentials

Positions

Senior Research Fellow

Medicine - Royal Melbourne Hospital

Member

Australasian Society for Immunology

Member

International Cytokine & Interferon Society

Member

American Society for Biochemistry and Molecular Biology

Member

International Society for Fibrinolysis and Proteolysis

Member

Australian Society for Biochemistry and Molecular Biology

Education

Bachelor of Biomedical Science (Hons)

University of Melbourne

PhD

University of Melbourne

Master of Applied Finance

Kaplan Professional

Links