Adrian Achuthan

CCL17 in Inflammation and Pain

Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook

Journal article  |  2020  |  The Journal of Immunology

It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..

IL-23 in arthritic and inflammatory pain development in mice

Kevin M-C Lee, Zihao Zhang, Adrian Achuthan, Andrew J Fleetwood, Julia E Smith, John A Hamilton, Andrew D Cook

Journal article  |  2020  |  Arthritis Research and Therapy

BACKGROUND: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthriti..

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  Osteoarthritis and Cartilage

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

GM-CSF: A Promising Target in Inflammation and Autoimmunity

Kevin MC Lee, Adrian A Achuthan, John A Hamilton

Journal article  |  2020  |  IMMUNOTARGETS AND THERAPY

The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro t..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  Journal of Clinical Investigation

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A Hamilton, Rita A Busuttil, Alex Boussioutas

Journal article  |  2019  |  Nature Communications

GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook

Journal article  |  2019  |  The Journal of Immunology

CSF-1 in Inflammatory and Arthritic Pain Development

Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton

Journal article  |  2018  |  The Journal of Immunology

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan

Journal article  |  2018  |  Journal of Biological Chemistry

CCL17 blockade as a therapy for osteoarthritis pain and disease

Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Foerster, John A Hamilton, Andrew D Cook

Journal article  |  2018  |  Arthritis Research and Therapy