Adrian Achuthan

CCL17 in Inflammation and Pain

Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook

Journal article  |  2020  |  The Journal of Immunology

It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..

IL-23 in arthritic and inflammatory pain development in mice

Kevin M-C Lee, Zihao Zhang, Adrian Achuthan, Andrew J Fleetwood, Julia E Smith, John A Hamilton, Andrew D Cook

Journal article  |  2020  |  Arthritis Research & Therapy

BACKGROUND: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthriti..

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  Osteoarthritis and Cartilage

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  Journal of Clinical Investigation

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A Hamilton, Rita A Busuttil, Alex Boussioutas

Journal article  |  2019  |  Nature Communications

GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook

Journal article  |  2019  |  The Journal of Immunology

CSF-1 in Inflammatory and Arthritic Pain Development

Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton

Journal article  |  2018  |  The Journal of Immunology

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan

Journal article  |  2018  |  Journal of Biological Chemistry

CCL17 blockade as a therapy for osteoarthritis pain and disease

Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Foerster, John A Hamilton, Andrew D Cook

Journal article  |  2018  |  ARTHRITIS RESEARCH & THERAPY

TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17

Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Anne D Christensen, Adrian Achuthan, Andrew J Fleetwood, Derek C Lacey, Julia E Smith, Irmgard Foerster, John A Hamilton

Journal article  |  2018  |  JCI Insight

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton

Journal article  |  2018  |  CELL DEATH & DISEASE

Cytokine-Induced Acute Inflammatory Monoarticular Arthritis

Adrian Achuthan, Ming-Chin Lee, Reem Saleh, Andrew J Fleetwood, John A Hamilton, Andrew D Cook

Book Chapter  |  2018  |  Methods in Molecular Biology

Newly identified molecular mechanism of glucocorticoid action in arthritis

Adrian Achuthan, Amy Hsu, Tanya Lupancu, Ming-Ching Lee, Reem Saleh, Andrew Fleetwood, Andrew Cook, John Hamilton

Conference Proceedings  |  2017  |  CYTOKINE

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

Andrew J Fleetwood, Man KS Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds, John A Hamilton

Journal article  |  2017  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease

Ming-Chin Lee, James A McCubbin, Anne D Christensen, Daniel P Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M Brierley, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Robin L Anderson, John A Hamilton, Andrew D Cook

Journal article  |  2017  |  The Journal of Immunology

Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation

Adrian Achuthan, Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Melody WN Chang, Cynthia Louis, Andrew J Fleetwood, Derek C Lacey, Anne D Christensen, Ashlee T Frye, Pui Yeng Lam, Hitoshi Kusano, Koji Nomura, Nancy Steiner, Irmgard Foerster, Stephen L Nutt, Moshe Olshansky, Stephen J Turner, John A Hamilton

Journal article  |  2016  |  JOURNAL OF CLINICAL INVESTIGATION

A new GM-CSF-dependent pathway in arthritis

A Achuthan, M-C Lee, R Saleh, A Frye, A Fleetwood, A Cook, J Hamilton

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage urokinase plasminogen activator system

A Fleetwood, N O'Brien-Simpson, P Veith, R Lam, A Achuthan, A Cook, W Singleton, I Lund, E Reynolds, J Hamilton

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

IRF6 Regulates the Expression of IL-36 gamma by Human Oral Epithelial Cells in Response to Porphyromonas gingivalis

Jennifer Huynh, Glen M Scholz, Jiamin Aw, Mei Qi Kwa, Adrian Achuthan, John A Hamilton, Eric C Reynolds

Journal article  |  2016  |  JOURNAL OF IMMUNOLOGY

Colony Stimulating Factors

A Fleetwood, A Achuthan, JA Hamilton

Book Chapter  |  2016

As the largest integrated source of immunological knowledge currently available, Encyclopedia of Immunobiology is a go-to referenc..

Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System IMPLICATIONS FOR PERIODONTITIS

Andrew J Fleetwood, Neil M O'Brien-Simpson, Paul D Veith, Roselind S Lam, Adrian Achuthan, Andrew D Cook, William Singleton, Ida K Lund, Eric C Reynolds, John A Hamilton

Journal article  |  2015  |  JOURNAL OF BIOLOGICAL CHEMISTRY

GM-CSF-induced CCL17 expression in monocytes/macrophages is IRF4 dependent: a pathway of potential significance in inflammation

A Achuthan, P-Y Lam, MW Chang, AJ Fleetwood, DC Lacey, AD Cook, JA Hamilton

Conference Proceedings  |  2014  |  FEBS JOURNAL

Urokinase Plasminogen Activator Is a Central Regulator of Macrophage Three-Dimensional Invasion, Matrix Degradation, and Adhesion

Andrew J Fleetwood, Adrian Achuthan, Heidi Schultz, Anneline Nansen, Kasper Almholt, Pernille Usher, John A Hamilton

Journal article  |  2014  |  Journal of Immunology

Colony stimulating factors and myeloid cell biology in health and disease

John A Hamilton, Adrian Achuthan

Journal article  |  2013  |  Trends in Immunology (formerly Immunology Today)

Defining GM-CSF- and Macrophage-CSF Dependent Macrophage Responses by In Vitro Models

Derek C Lacey, Adrian Achuthan, Andrew J Fleetwood, Hang Dinh, John Roiniotis, Glen M Scholz, Melody W Chang, Sandra K Beckman, Andrew D Cook, John A Hamilton

Journal article  |  2012  |  Journal of Immunology

Endogenous leukaemia inhibitory factor signalling reduces axonal damage in mice with EAE

MM Gresle, E Alexandrou, B Wang, G Egan, M Ayres, V Jokubaitis, A Jonas, AM Friedhuber, W Doherty, A Achuthan, G Shaw, J Vacher, M Sendtner, TJ Kilpatrick, H Butzkueven

Conference Proceedings  |  2012  |  MULTIPLE SCLEROSIS JOURNAL

MICROARRAY PROFILING OF MOUSE AND HUMAN MACROPHAGES

DC Lacey, H Dinh, A Achuthan, AD Cook, G Scholz, JA Hamilton

Conference Proceedings  |  2011  |  INFLAMMATION RESEARCH

MICROARRAY PROFILING OF CSF-DEPENDENT MURINE AND HUMAN MACROPHAGES

D Lacey, H Dinh, A Achuthan, G Scholz, A Cook, J Hamilton

Conference Proceedings  |  2011  |  INTERNAL MEDICINE JOURNAL

Role of SNARE proteins in the pathogenesis of HIV

Adrian Achuthan, Jing Ling Zhou, Suzanne Crowe, Anthony Jaworowski

Conference Proceedings  |  2010  |  FASEB JOURNAL

Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages

Adrian Achuthan, Paul Masendycz, Jamie A Lopez, Thao Nguyen, David E James, Matthew J Sweet, John A Hamilton, Glen M Scholz

Journal article  |  2008  |  Molecular and Cellular Biology

CpG DNA enhances macrophage cell spreading by promoting the Src-family kinase-mediated phosphorylation of paxillin

Adrian Achuthan, Caryn Elsegood, Paul Masendycz, John A Hamilton, Glen M Scholz

Journal article  |  2006  |  Cellular Signaling

A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor

GA Manes, P Masendycz, T Nguyen, A Achuthan, H Dinh, JA Hamilton, GM Scholz

Journal article  |  2006  |  FEBS Journal

Regulation of Syntaxin 7 expression and function in macrophages by CSF-1

Adrian Achuthan, Jamie Lopez, Matthew Sweet, David James, John Hamilton, Glen Scholz

Conference Proceedings  |  2005  |  INFLAMMATION RESEARCH