After completing my PhD at the University of Melbourne (2007), I did my post-doctoral training at the Institute of Molecular and Cell Biology Institute, Singapore with an Australian Endeavour Research Fellowship. I pursued a short stint at the Burnet Institute in 2009, before returning to the University of Melbourne in 2010.
I led a small research team to conduct a commercial contract research towards identifying a GM-CSF gene signature under the auspices of as MorphoSys AG, conducting Phase I anti-GM-CSF clinical trial in rheumatoid arthritis. Following the successful completion of the trial, GlaxoSmithKline acquired the rights to conduct Phase IIb clinical trials. Subsequently, I was instrumental in securing a four-year commercial research contract with GlaxoSmithKline to investigate the molecular mechanisms responsible for GM-CSF-mediated inflammation in rheumatoid arthritis. A number of publications in leading journals and a significant patent emerged from this. In 2018, I was appointed as the Honours Coordinator at the Department of Medicine, Royal Melbourne Hospital overseeing the largest cohort of Honour students in the Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne.
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Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macro..
Displaying the 6 most recent projects by Adrian Achuthan.
Internal Research Grant
Displaying the 31 most recent scholarly works by Adrian Achuthan.
Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice
KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook
Journal article | 2020 | Osteoarthritis and Cartilage
OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages
David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood
Journal article | 2019 | Journal of Clinical Investigation
TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17
Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Anne D Christensen, Adrian Achuthan, Andrew J Fleetwood, Derek C Lacey, Julia E Smith, Irmgard Foerster, John A Hamilton
Journal article | 2018 | JCI Insight
Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity
Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton
Journal article | 2018 | Cell Death & Disease
Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles
Andrew J Fleetwood, Man KS Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds, John A Hamilton
Journal article | 2017 | Frontiers in Cellular and Infection Microbiology
G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease
Ming-Chin Lee, James A McCubbin, Anne D Christensen, Daniel P Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M Brierley, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Robin L Anderson, John A Hamilton, Andrew D Cook
Journal article | 2017 | The Journal of Immunology
Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation
Adrian Achuthan, Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Melody WN Chang, Cynthia Louis, Andrew J Fleetwood, Derek C Lacey, Anne D Christensen, Ashlee T Frye, Pui Yeng Lam, Hitoshi Kusano, Koji Nomura, Nancy Steiner, Irmgard Foerster, Stephen L Nutt, Moshe Olshansky, Stephen J Turner, John A Hamilton
Journal article | 2016 | Journal of Clinical Investigation
Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System IMPLICATIONS FOR PERIODONTITIS
Andrew J Fleetwood, Neil M O'Brien-Simpson, Paul D Veith, Roselind S Lam, Adrian Achuthan, Andrew D Cook, William Singleton, Ida K Lund, Eric C Reynolds, John A Hamilton
Journal article | 2015 | Journal of Biological Chemistry
Endogenous leukaemia inhibitory factor signalling reduces axonal damage in mice with EAE
MM Gresle, E Alexandrou, B Wang, G Egan, M Ayres, V Jokubaitis, A Jonas, AM Friedhuber, W Doherty, A Achuthan, G Shaw, J Vacher, M Sendtner, TJ Kilpatrick, H Butzkueven
Conference Proceedings | 2012 | MULTIPLE SCLEROSIS JOURNAL
Honours, Awards and Fellowships
Senior Research Fellow
Medicine - Royal Melbourne Hospital
Australasian Society for Immunology
International Cytokine & Interferon Society
American Society for Biochemistry and Molecular Biology
International Society for Fibrinolysis and Proteolysis
Australian Society for Biochemistry and Molecular Biology
Bachelor of Biomedical Science (Hons)
University of Melbourne
University of Melbourne
Master of Applied Finance