Adrian Achuthan

The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis

Sarah F Stuart, Ayenachew Bezawork-Geleta, Zammam Areeb, Juliana Gomez, Vanessa Tsui, Ahmad Zulkifli, Lucia Paradiso, Jordan Jones, Hong PT Nguyen, Tracy L Putoczki, Paul V Licciardi, George Kannourakis, Andrew P Morokoff, Adrian A Achuthan, Rodney B Luwor

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioblastoma cells adapt to changes in glucose availability through metabolic plasticity allowing for cell survival and continued ..

Dexamethasone ameliorates arthritis through epigenetic and transcriptional regulation of CCL17 production

A Achuthan

Journal article  |  2022  |  FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, which leads to poor quality of life due to the debilitatin..

Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization

Kevin Ming-Chin Lee, Adrian A Achuthan, David P De Souza, Tanya J Lupancu, Katrina J Binger, Man KS Lee, Yangsong Xu, Malcolm J McConville, Nicole A de Weerd, Dragana Dragoljevic, Paul J Hertzog, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2022  |  CELL REPORTS

Metabolic adaptations can directly influence the scope and scale of macrophage activation and polarization. Here we explore the im..

Introduction to the Special Issue: The regulation of the immune system by colony stimulating factors (CSFs) in the steady state and pathology

John A Hamilton, Adrian A Achuthan

Journal article  |  2021  |  SEMINARS IN IMMUNOLOGY

Targeting GM-CSF in inflammatory and autoimmune disorders

Adrian A Achuthan, Kevin MC Lee, John A Hamilton

Journal article  |  2021  |  SEMINARS IN IMMUNOLOGY

Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a growth factor for its ability to promote ..

CCL17 in Inflammation and Pain

Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..

IL-23 in arthritic and inflammatory pain development in mice

Kevin M-C Lee, Zihao Zhang, Adrian Achuthan, Andrew J Fleetwood, Julia E Smith, John A Hamilton, Andrew D Cook

Journal article  |  2020  |  ARTHRITIS RESEARCH & THERAPY

BACKGROUND: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthriti..

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  OSTEOARTHRITIS AND CARTILAGE

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

GM-CSF: A Promising Target in Inflammation and Autoimmunity

Kevin MC Lee, Adrian A Achuthan, John A Hamilton

Journal article  |  2020  |  IMMUNOTARGETS AND THERAPY

The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro t..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  JOURNAL OF CLINICAL INVESTIGATION

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle inter..