Adrian Achuthan

CCL17 in Inflammation and Pain

Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..

IL-23 in arthritic and inflammatory pain development in mice

Kevin M-C Lee, Zihao Zhang, Adrian Achuthan, Andrew J Fleetwood, Julia E Smith, John A Hamilton, Andrew D Cook

Journal article  |  2020  |  ARTHRITIS RESEARCH & THERAPY

BACKGROUND: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthriti..

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  OSTEOARTHRITIS AND CARTILAGE

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

GM-CSF: A Promising Target in Inflammation and Autoimmunity

Kevin MC Lee, Adrian A Achuthan, John A Hamilton

Journal article  |  2020  |  IMMUNOTARGETS AND THERAPY

The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro t..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  JOURNAL OF CLINICAL INVESTIGATION

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle inter..

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A Hamilton, Rita A Busuttil, Alex Boussioutas

Journal article  |  2019  |  NATURE COMMUNICATIONS

Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to character..

GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

Studies have demonstrated the importance of a GM-CSF→IFN regulatory factor 4 (IRF4)→CCL17 pathway, first identified in monocytes/m..

CSF-1 in Inflammatory and Arthritic Pain Development

Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton

Journal article  |  2018  |  JOURNAL OF IMMUNOLOGY

Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, ..

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, w..

CCL17 blockade as a therapy for osteoarthritis pain and disease

Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Foerster, John A Hamilton, Andrew D Cook

Journal article  |  2018  |  ARTHRITIS RESEARCH & THERAPY

BACKGROUND: Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of infla..