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Lara Lipton's selected work
Identification Of Novel Genes Predisposing To Familial Colorectal Cancer By Full Exome Seq..
How can digital health be used to improve outcomes in pancreatic ductal adenocarcinoma (PD..
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast c..
Translating The Human Cancer Genome Project Into Better Outcomes For Patients With Cancer
Displaying the 3 most recent projects by Lara Lipton.
Displaying the 55 most recent scholarly works by Lara Lipton.
Development and validation of a targeted gene sequencing panel for application to disparate cancers.
Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, Simon A Mueller, et al.
Journal article | 2019 | Scientific Reports
Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..
How can digital health be used to improve outcomes in pancreatic ductal adenocarcinoma (PDAC)? Examining the potential of the PURPLE translational pancreatic cancer platform
Belinda Lee, Julia Shapiro, Benjamin Thomson, Sumitra Ananda, Lara Lipton, Sue-Anne McLachlan, Rachel Wong, Prasad Cooray, Matthew Burge, Kate Clarke, Sharon Pattison, Mehrdad Nikfarjam, Niall Tebbutt, Marion Harris, Daniel Croagh, David Goldstein, Adnan Nagrial, Rob Zielinski, Amitesh Roy, Cheng Ean Chee, et al.
Conference Proceedings | 2019 | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.
Journal article | 2019 | npj Breast Cancer
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..
The Upper Gastrointestinal Cancer Registry (UGICR): a clinical quality registry to monitor and improve care in upper gastrointestinal cancers
Ashika D Maharaj, Jennifer F Holland, Ri O Scarborough, Sue M Evans, Liane J Ioannou, Wendy Brown, Daniel G Croagh, Charles HC Pilgrim, James G Kench, Lara R Lipton, Trevor Leong, John J McNeil, Mehrdad Nikfarjam, Ahmad Aly, Paul R Burton, Paul A Cashin, Julie Chu, Cuong P Duong, Peter Evans, David Goldstein, et al.
Journal article | 2019 | BMJ Open
PURPOSE: The Upper Gastrointestinal Cancer Registry (UGICR) was developed to monitor and improve the quality of care provided to p..
Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival
Shehara Mendis, Sophie Beck, Belinda Lee, Margaret Lee, Rachel Wong, Suzanne Kosmider, Jeremy Shapiro, Desmond Yip, Simone Steel, Louise Nott, Ross Jennens, Lara Lipton, Matthew Burge, Kathryn Field, Sumitra Ananda, Hui-Li Wong, Peter Gibbs
Journal article | 2019 | Asia-Pacific Journal of Clinical Oncology
Monitoring quality of care for patients with pancreatic cancer: a modified Delphi consensus
Ashika D Maharaj, Liane Ioannou, Daniel Croagh, John Zalcberg, Rachel E Neale, David Goldstein, Neil Merrett, James G Kench, Kate White, Charles HC Pilgrim, Lorraine Chantrill, Peter Cosman, Andrew Kneebone, Lara Lipton, Mehrdad Nikfarjam, Jennifer Philip, Charbel Sandroussi, Peter Tagkalidis, Richard Chye, Koroush S Haghighi, et al.
Journal article | 2019 | HPB
Precision oncology using a clinician-directed, tailored approach to molecular profiling
Michael Lam, Ben Tran, Sophie Beck, Jeanne Tie, Dishan Herath, James Whittle, Edmond M Kwan, Stephen B Fox, Andrew Fellowes, Sumitra Ananda, Lara Lipton, Peter Gibbs, Mark A Rosenthal, Jayesh Desai
Journal article | 2018 | Asia-Pacific Journal of Clinical Oncology
AGITG nabnec: A randomised phase II study of nab-paclitaxel in combination with carboplatin as first line treatment of gastrointestinal neuroendocrine carcinomas.
Lorraine A Chantrill, Lara Rachel Lipton, Michael Hofman, Val Gebski, Anthony Gill, Ben Markman, Sonia Yip, Christos Stelios Karapetis, Nick Pavlakis, Shu Fen Wong, David Turner Ransom, Katrin Marie Sjoquist, Adnan Nagrial, Michael Michael, Uzma Rayani, Martinus Oostendorp, John Simes, Mustafa Khasraw
Conference Proceedings | 2018 | Journal of Clinical Oncology
Phase II Study of First-Line Trebananib Plus Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Ghassan K Abou-Alfa, Jean-Frederic Blanc, Steven Miles, Tom Ganten, Joerg Trojan, Jonathan Cebon, Andre K Liem, Lara Lipton, Charu Gupta, Benjamin Wu, Michael Bass, Ellen Hollywood, Jennifer Ma, Margaret Bradley, Jason Litten, Leonard B Saltz
Journal article | 2017 | The Oncologist
Use and impact of bevacizumab in patients undergoing liver resection for metastatic colorectal cancer in routine clinical practice.
Edmond Michael Kwan, Belinda Lee, Hui-Li Wong, Margaret Lee, Rachel Wong, Jeremy David Shapiro, Matthew E Burge, Lara Rachel Lipton, Suzanne Kosmider, Peter Gibbs
Conference Proceedings | 2016 | Journal of Clinical Oncology
"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic
John P Parisot, Heather Thorne, Andrew Fellowes, Ken Doig, Mark Lucas, John J McNeil, Brett Doble, Alexander Dobrovic, Thomas John, Paul A James, Lara Lipton, David Ashley, Theresa Hayes, Paul McMurrick, Gary Richardson, Paula Lorgelly, Stephen B Fox, David M Thomas
Journal article | 2015 | Journal of Personalized Medicine
Phase II trial of selective internal radiation therapy and systemic chemotherapy for liver-predominant metastases from pancreatic adenocarcinoma
Peter Gibbs, Cuong Do, Lara Lipton, David N Cade, Michael J Tapner, David Price, Geoff D Bower, Richard Dowling, Meir Lichtenstein, Guy A van Hazel
Journal article | 2015 | BMC Cancer
Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer
Robert N Jorissen, Michael Christie, Dmitri Mouradov, Anuratha Sakthianandeswaren, Shan Li, Christopher Love, Zheng-Zhou Xu, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Antony W Burgess, Dana Busam, Qi Zhao, Robert L Strausberg, Lara Lipton, Jayesh Desai, et al.
Journal article | 2015 | British Journal of Cancer
A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial
CS Fuchs, S Azevedo, T Okusaka, J-L Van Laethem, LR Lipton, H Riess, C Szczylik, MJ Moore, M Peeters, G Bodoky, M Ikeda, B Melichar, R Nemecek, S Ohkawa, A Swieboda-Sadlej, SA Tjulandin, E Van Cutsem, R Loberg, V Haddad, JL Gansert, et al.
Journal article | 2015 | Annals of Oncology
Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation
Nishi Kothari, Richard Kim, Robert N Jorissen, Jayesh Desai, Jeanne Tie, Hui-Li Wong, Ian Farragher, Ian Jones, Fiona L Day, Shan Li, Anuratha Sakthinandeswaren, Michelle Palmieri, Lara Lipton, Michael Schell, Jamie K Teer, David Shibata, Timothy Yeatman, Oliver M Sieber, Peter Gibbs, Ben Tran
Journal article | 2015 | Acta Oncologica
Identification of six new susceptibility loci for invasive epithelial ovarian cancer
Karoline B Kuchenbaecker, Susan J Ramus, Jonathan Tyrer, Andrew Lee, Howard C Shen, Jonathan Beesley, Kate Lawrenson, Lesley McGuffog, Sue Healey, Janet M Lee, Tassja J Spindler, Yvonne G Lin, Tanja Pejovic, Yukie Bean, Qiyuan Li, Simon Coetzee, Dennis Hazelett, Alexander Miron, Melissa Southey, Mary Beth Terry, et al.
Journal article | 2015 | Nature Genetics
Germline Variants and Advanced Colorectal Adenomas: Adenoma Prevention with Celecoxib Trial Genome-wide Association Study
Jiping Wang, Luis G Carvajal-Carmona, Jen-Hwa Chu, Ann G Zauber, Michikai Kubo, Koichi Matsuda, Malcolm Dunlop, Richard S Houlston, Oliver Sieber, Lara Lipton, Peter Gibbs, Nicholas G Martin, Grant W Montgomery, Joanne Young, Paul N Baird, Mark J Ratain, Yusuke Nakamura, Scott T Weiss, Ian Tomlinson, Monica M Bertagnolli
Journal article | 2013 | Clinical Cancer Research
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations
Dmitri Mouradov, Enric Domingo, Peter Gibbs, Robert N Jorissen, Shan Li, Pik Ying Soo, Lara Lipton, Jayesh Desai, Havard E Danielsen, Dahmane Oukrif, Marco Novelli, Christopher Yau, Christopher C Holmes, Ian T Jones, Stephen McLaughlin, Peter Molloy, Nicholas J Hawkins, Robyn Ward, Rachel Midgely, David Kerr, et al.
Journal article | 2013 | American Journal of Gastroenterology
Developing a national database for metastatic colorectal cancer management: perspectives and challenges
K Field, H-L Wong, J Shapiro, S Kosmider, J Tie, S Bae, D Yip, J McKendrick, L Nott, J Desai, M Harold, L Lipton, G Stefanou, L Lim, P Parente, P Gibbs
Journal article | 2013 | Internal Medicine Journal
Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis
M Christie, RN Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui, L Lipton, J Desai, IT Jones, S McLaughlin, RL Ward, NJ Hawkins, AR Ruszkiewicz, J Moore, AW Burgess, D Busam, Q Zhao, RL Strausberg, AJ Simpson, et al.
Journal article | 2013 | Oncogene
PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer
Fiona L Day, Robert N Jorissen, Lara Lipton, Dmitri Mouradov, Anuratha Sakthianandeswaren, Michael Christie, Shan Li, Cary Tsui, Jeannie Tie, Jayesh Desai, Zheng-Zhou Xu, Peter Molloy, Vicki Whitehall, Barbara A Leggett, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, et al.
Journal article | 2013 | Clinical Cancer Research
Risk of Metachronous Colon Cancer Following Surgery for Rectal Cancer in Mismatch Repair Gene Mutation Carriers
Aung Ko Win, Susan Parry, Bryan Parry, Matthew F Kalady, Finlay A Macrae, Dennis J Ahnen, Graeme P Young, Lara Lipton, Ingrid Winship, Alex Boussioutas, Joanne P Young, Daniel D Buchanan, Julie Arnold, Loic Le Marchand, Polly A Newcomb, Robert W Haile, Noralane M Lindor, Steven Gallinger, John L Hopper, Mark A Jenkins
Journal article | 2013 | Annals of Surgical Oncology
The effect of different dosing regimens of motesanib on the gallbladder: a randomized phase 1b study in patients with advanced solid tumors
Lee S Rosen, Lara Lipton, Timothy J Price, Neil D Belman, Ralph V Boccia, Herbert I Hurwitz, Joe J Stephenson, Lori J Wirth, Sheryl Mccoy, Yong-jiang Hei, Cheng-Pang Hsu, Niall C Tebbutt
Journal article | 2013 | BMC Cancer
Loss of SDHA Expression Identifies SDHA Mutations in Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumors
Trisha Dwight, Diana E Benn, Adele Clarkson, Ricardo Vilain, Lara Lipton, Bruce G Robinson, Roderick J Clifton-Bligh, Anthony J Gill
Journal article | 2013 | American Journal of Surgical Pathology
SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer
Nicholas I Fleming, Robert N Jorissen, Dmitri Mouradov, Michael Christie, Anuratha Sakthianandeswaren, Michelle Palmieri, Fiona Day, Shan Li, Cary Tsui, Lara Lipton, Jayesh Desai, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Hong-Jian Zhu, John M Mariadason, Antony W Burgess, et al.
Journal article | 2013 | Cancer Research
How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer
Kaaren J Watts, Bettina Meiser, Gillian Mitchell, Judy Kirk, Christobel Saunders, Michelle Peate, Jessica Duffy, Patrick J Kelly, Margaret Gleeson, Kristine Barlow-Stewart, Belinda Rahman, Michael Friedlander, Kathy Tucker
Journal article | 2012 | BMC Cancer
PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis
Anuratha Sakthianandeswaren, Michael Christie, Carla D'Andreti, Cary Tsui, Robert N Jorissen, Shan Li, Nicholas I Fleming, Peter Gibbs, Lara Lipton, Jordane Malaterre, Robert G Ramsay, Toby J Phesse, Matthias Ernst, Rosemary E Jeffery, Richard Poulsom, Simon J Leedham, Stefania Segditsas, Ian PM Tomlinson, Oliver K Bernhard, Richard J Simpson, et al.
Journal article | 2011 | Cancer Research
Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation
Jeanne Tie, Peter Gibbs, Lara Lipton, Michael Christie, Robert N Jorissen, Antony W Burgess, Matthew Croxford, Ian Jones, Rachel Langland, Suzanne Kosmider, Daniel McKay, Gideon Bollag, Keith Nolop, Oliver M Sieber, Jayesh Desai
Journal article | 2011 | International Journal of Cancer
KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer
Jeanne Tie, Lara Lipton, Jayesh Desai, Peter Gibbs, Robert N Jorissen, Michael Christie, Katharine J Drummond, Benjamin NJ Thomson, Valery Usatoff, Peter M Evans, Adrian W Pick, Simon Knight, Peter WG Carne, Roger Berry, Adrian Polglase, Paul McMurrick, Qi Zhao, Dana Busam, Robert L Strausberg, Enric Domingo, et al.
Journal article | 2011 | Clinical Cancer Research
Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer
Robert N Jorissen, Peter Gibbs, Michael Christie, Saurabh Prakash, Lara Lipton, Jayesh Desai, David Kerr, Lauri A Aaltonen, Diego Arango, Mogens Kruhoffer, Torben F Orntoft, Claus Lindbjerg Andersen, Mike Gruidl, Vidya P Kamath, Steven Eschrich, Timothy J Yeatman, Oliver M Sieber
Journal article | 2009 | Clinical Cancer Research
DNA Copy-Number Alterations Underlie Gene Expression Differences between Microsatellite Stable and Unstable Colorectal Cancers
Robert N Jorissen, Lara Lipton, Peter Gibbs, Matthew Chapman, Jayesh Desai, Ian T Jones, Timothy J Yeatman, Philip East, Ian PM Tomlinson, Hein W Verspaget, Lauri A Aaltonen, Mogens Kruhoffer, Torben F Orntoft, Claus Lindbjerg Andersen, Oliver M Sieber
Journal article | 2008 | Clinical Cancer Research
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian PM Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Kimberley Howarth, Alan M Pittman, Sarah Spain, Steven Lubbe, Axel Walther, Kate Sullivan, Emma Jaeger, Sarah Fielding, Andrew Rowan, Jayaram Vijayakrishnan, Enric Domingo, Ian Chandler, Zoe Kemp, Mobshra Qureshi, Susan M Farrington, Albert Tenesa, et al.
Journal article | 2008 | Nature Genetics
A family with juvenile polyposis linked to the BMPR1A locus: Cryptic mutation or closely linked gene?
Elizabeth Chow, Lara Lipton, Luis G Carvajal-Carmona, Gordon Arthur, Prithi Bhathal, Gurjeet Kaur, Emma Jaeger, Kelly Woodford-Richens, Kimberley Howarth, Ian Tomlinson, Finlay Macrae
Journal article | 2007 | Journal of Gastroenterology and Hepatology
Hyperplastic polyposis syndrome: Phenotypic presentations and the role of MBD4 and MYH
Elizabeth Chow, Lara Lipton, Elly Lynch, Rebecca D'Souza, Clelia Aragona, Lindy Hodgkin, Gregor Brown, Ingrid Winship, Melissa Barker, Daniel Buchanan, Shannon Cowie, Steve Nasioulas, Desiree du Sart, Joanne Young, Barbara Leggett, Jeremy Jass, Finlay Macrae
Journal article | 2006 | Gastroenterology
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
V Johnson, LR Lipton, C Cummings, AT Eftekhar Sadat, L Izatt, SV Hodgson, IC Talbot, HJW Thomas, AJR Silver, IPM Tomlinson
Journal article | 2005 | Journal of Medical Genetics
OBJECTIVE: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families ..
A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history.
Brindusa Truta, Brian A Allen, Peggy G Conrad, Vivian Weinberg, Glenn A Miller, Rob Pomponio, Lara R Lipton, Germano Guerra, Ian PM Tomlinson, Marvin H Sleisenger, Young S Kim, Jonathan P Terdiman
Journal article | 2005 | Familial Cancer
OBJECTIVES: Adenomatous polyposis of the colon is often secondary to an inherited mutation in adenomatous polyposis coli (APC) gen..
Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients
M Crabtree, OM Sieber, L Lipton, SV Hodgson, H Lamlum, HJW Thomas, K Neale, RKS Phillips, K Heinimann, IPM Tomlinson
Journal article | 2003 | Oncogene
Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.
Päivi Laiho, Tuija Hienonen, Auli Karhu, Lara Lipton, Yan Aalto, Huw JW Thomas, Karin Birkenkamp-Demtroder, Shirley Hodgson, Reijo Salovaara, Jukka-Pekka Mecklin, Heikki Järvinen, Sakari Knuutila, Sarah Halford, Torben F Ørntoft, Ian Tomlinson, Virpi Launonen, Richard Houlston, Lauri A Aaltonen
Journal article | 2003 | Oncogene
We have allelotyped a series of 104 Finnish colorectal cancers (CRCs) using 372 polymorphic markers spaced, on average, at 10 cM i..
Medicine - Royal Melbourne Hospital
Surgery - Royal Melbourne Hospital