Understanding how a fertilized oocyte develops into a viable embryo, and then goes onto become a healthy individual has been my lifetime interest. I completed my BSc (Hons) and my PhD, under the supervision of Henry Leese, at the University of York in the UK.
Following a Fellowship at Harvard Medical School, in the laboratory of John Biggers, I moved to Monash Medical Centre to work with Alan Trounson. My work focused on the metabolism and physiology of the preimplantation mammalian embryo, which led to the development of culture systems capable of supporting the embryos of several mammalian species including the human, mouse, cow and sheep. This work also laid the foundations for the generation of the world’s first human embryonic stem cells. In 1997 I moved back to the USA to become the Scientific Director of the Colorado Centre for Reproductive Medicine, where I was able to undertake translational research and further develop our understanding of early human development. In 2007 I returned to Australia to take up the position of Chair of Zoology and have been the Head of Department since 2009.
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Prospective randomized multicentre comparison on sibling oocytes comparing G-Series media ..
Determining The Impacts Of Epigenetic Modifying Drugs On Germline Programming And Offsprin..
Displaying the 27 most recent projects by David Gardner.
Stem Cells Australia (ARC Funding) Using Ipsc-Derived Neuronal Cultures For Drug Discovery In Neurogenetic Epileptic Disorders (2019 Petrou Project - ARC Cash)
Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw ..
Internal Research Grant
Displaying the 361 most recent scholarly works by David Gardner.
Clinical application of embryo aneuploidy testing by next-generation sequencing.
Carmen Rubio, Lorena Rodrigo, Carmen Garcia-Pascual, Vanessa Peinado, Inmaculada Campos-Galindo, Sandra Garcia-Herrero, Carlos Simón
Journal article | 2019 | Biology of Reproduction
We review here the evolution in the field of embryo aneuploidy testing over the last 20 years, from the analysis of a subset of ch..
25 historic papers: an ASRM 75th birthday gift from Fertility and Sterility
Craig Niederberger, Antonio Pellicer, Carlos Simon, Martin Kathrins, Marc Goldstein, Mark Sigman, Peter N Schlegel, Santiago Munne, David K Gardner, Ana Cobo, Christos Coutifaris, Jacques Donnez, Hugh S Taylor, Linda C Giudice, Bart CJM Fauser, Steven R Lindheim, Zev Rosenwaks, Robert F Casper, Dominique de Ziegler, William E Gibbons, et al.
Journal article | 2019 | Fertility and Sterility
Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells
Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim
Journal article | 2019 | Stem Cells International
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Ashok Agarwal, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Rupin Shah, Sheryl T Homa, Ranjith Ramasamy, Edmund Ko, Kelton Tremellen, Sandro Esteves, Ahmad Majzoub, Juan G Alvarez, David K Gardner, Channa N Jayasena, Jonathan W Ramsay, Chak-Lam Cho, Ramadan Saleh, Denny Sakkas, James M Hotaling, Scott D Lundy, et al.
Journal article | 2019 | The World Journal of Men's Health
Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen character..
Metabolomic and Transcriptional Analyses Reveal Atmospheric Oxygen During Human Induced Pluripotent Stem Cell Generation Impairs Metabolic Reprogramming
James Spyrou, David K Gardner, Alexandra J Harvey
Journal article | 2019 | STEM CELLS
The transition to pluripotency invokes profound metabolic restructuring; however, reprogramming is accompanied by the retention of..
Forty years of IVF
Craig Niederberger, Antonio Pellicer, Jacques Cohen, David K Gardner, Gianpiero D Palermo, Claire L O'Neill, Stephen Chow, Zev Rosenwaks, Ana Cobo, Jason E Swain, William B Schoolcraft, Rene Frydman, Lauren A Bishop, Davora Aharon, Catherine Gordon, Erika New, Alan Decherney, Seang Lin Tan, Richard J Paulson, James M Goldfarb, et al.
Journal article | 2018 | Fertility and Sterility
Embryonic gene transcription in the spiny mouse (Acomys cahirinus): a new model of embryonic genome activation.
Jared Mamrot, David Gardner, Peter Temple-Smith, Hayley Dickinson
Journal article | 2018
Our understanding of genetic mechanisms driving early embryonic development is primarily based on experiments conducted on mice, h..
Addition of interleukin-6 to mouse embryo culture increases blastocyst cell number and influences the inner cell mass to trophectoderm ratio
Rebecca L Kelley, David K Gardner
Journal article | 2017 | Clinical and Experimental Reproductive Medicine
OBJECTIVE: In vitro culture of preimplantation embryos is improved by grouping embryos together in a drop of media. Individually c..
Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture
Boon Siang Nicholas Tan, Joly Kwek, Chong Kum Edwin Wong, Nicholas J Saner, Charlotte Yap, Fernando Felquer, Michael B Morris, David K Gardner, Peter D Rathjen, Joy Rathjen
Journal article | 2016 | PLOS ONE
De novo transcriptome assembly for the spiny mouse (Acomys cahirinus)
Jared Mamrot, Roxane Legaie, Stacey Ellery, Trevor Wilson, David Gardner, David Walker, Peter Temple-Smith, Anthony Papenfuss, Hayley Dickinson
Journal article | 2016
Abstract Background: Spiny mice of the genus Acomys are small desert-dwelling rodents that display physiological characteristics n..
Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters
Boon Siang Nicholas Tan, Peter D Rathjen, Alexandra J Harvey, David K Gardner, Joy Rathjen
Journal article | 2016 | Mechanisms of Development
Redox and Anti-Oxidant State Within Cattle Oocytes Following In Vitro Maturation With Bone Morphogenetic Protein 15 and Follicle Stimulating Hormone
Melanie L Sutton-McDowall, Malcolm Purdey, Hannah M Brown, Andrew D Abell, David G Mottershead, Pablo D Cetica, Gabriel C Dalvit, Ewa M Goldys, Robert B Gilchrist, David K Gardner, Jeremy G Thompson
Journal article | 2015 | Molecular Reproduction and Development
Cryopreservation in ART and concerns with contamination during cryobanking.
Mark G Larman, Shu Hashimoto, Yoshiharu Morimoto, David K Gardner
Journal article | 2014 | Reproductive Medicine and Biology
The cryopreservation of gametes and embryos is vital to numerous fields of reproductive biology, including assisted human reproduc..
Embryo transfer cannot delineate between the maternal pregnancy environment and germ line effects in the transgenerational transmission of disease in rats
Melanie Tran, Linda A Gallo, Alanna N Hanvey, Andrew J Jefferies, Kerryn T Westcott, Luise A Cullen-McEwen, David K Gardner, Karen M Moritz, Mary E Wlodek
Journal article | 2014 | American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Metabolic Differences in Bovine Cumulus-Oocyte Complexes Matured In Vitro in the Presence or Absence of Follicle-Stimulating Hormone and Bone Morphogenetic Protein 15
Melanie L Sutton-McDowall, David G Mottershead, David K Gardner, Robert B Gilchrist, Jeremy G Thompson
Journal article | 2012 | Biology of Reproduction
Salute to a giant ... Robert Geoffrey Edwards
Kamal Ahuja, Fiona Bennett, Jacques Cohen, Ruth Edwards, Huw Pritchard, Ann Silver, Julio Sirlin, John Slee, Dannie Abse, MJ Ashwood-Smith, Barry Bavister, J Michael Bedford, Henning M Beier, Richard Bronson, Bruce Cattanach, Joseph C Daniel, Edwin A Dawes, Malcolm Ferguson-Smith, Richard Gardner, Dave Griffin, et al.
Journal article | 2011 | REPRODUCTIVE BIOMEDICINE ONLINE
The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting.
undefined Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology
Conference Proceedings | 2011 | Human Reproduction
BACKGROUND: Many variations in oocyte and embryo grading make inter-laboratory comparisons extremely difficult. This paper reports..
Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting
Basak Balaban, Daniel Brison, Gloria Calderon, James Catt, Joe Conaghan, Lisa Cowan, Thomas Ebner, David Gardner, Thorir Hardarson, Kersti Lundin, M Cristina Magli, David Mortimer, Sharon Mortimer, Santiago Munne, Dominique Royere, Lynette Scott, Johan Smitz, Alan Thornhill, Jonathan van Blerkom, Etienne Van den Abbeel
Journal article | 2011 | Reproductive BioMedicine Online
A randomized controlled study of human Day 3 embryo cryopreservation by slow freezing or vitrification: vitrification is associated with higher survival, metabolism and blastocyst formation
B Balaban, B Urman, B Ata, A Isiklar, MG Larman, R Harnilton, DK Gardner
Journal article | 2008 | Human Reproduction
Metabolism, protein content, and in vitro embryonic development of goat cumulus-oocyte complexes matured with physiological concentrations of glucose and L-lactate
JR Herrick, M Lane, DK Gardner, E Behboodi, E Memili, S Blash, Y Echelard, RL Krisher
Journal article | 2006 | Molecular Reproduction and Development
Metabolic regulation of in-vitro-produced bovine embryos. II. Effects of phenazine ethosulfate, sodium azide and 2,4-dinitrophenol during post-compaction development on glucose metabolism and lipid accumulation
Jose Fernando De La Torre-Sanchez, David K Gardner, Kimberly Preis, John Gibbons, George E Seidel
Journal article | 2006 | Reproduction, Fertility and Development
Infertility therapy-associated multiple pregnancies (births): an ongoing epidemic.
Eli Y Adashi, Pedro N Barri, Richard Berkowitz, Peter Braude, Elizabeth Bryan, Judith Carr, Jean Cohen, John Collins, Paul Devroey, René Frydman, David Gardner, Marc Germond, Jan Gerris, Luca Gianaroli, Lars Hamberger, Colin Howles, Howard Jones, Bruno Lunenfeld, Andrew Pope, Meredith Reynolds, et al.
Journal article | 2003 | Reproductive BioMedicine Online
ENHANCED RATES OF CLEAVAGE AND DEVELOPMENT FOR SHEEP ZYGOTES CULTURED TO THE BLASTOCYST STAGE IN-VITRO IN THE ABSENCE OF SERUM AND SOMATIC-CELLS - AMINO-ACIDS, VITAMINS, AND CULTURING EMBRYOS IN GROUPS STIMULATE DEVELOPMENT
DK GARDNER, M LANE, A SPITZER, PA BATT
Journal article | 1994 | Biology of Reproduction
Honours, Awards and Fellowships
Earl Plunkett Lecturer
Robert Edwards Scientific Achievement Award
SART Prize Paper
Junior Scientist Award
K. M. Stott Prize for Excellence in Scientific Research
K. M. Stott Prize for Excellence in Scientific Research
Science and Engineering Research Council Scholarship
FAA - Fellow of the Australian Academy of Science
American Society for Reproductive Medicine
European Society for Human Reproduction and Embryology
International Embryo Transfer Society
Society for the Study of Reproduction (USA)
Australian Society for Reproductive Biology
Traveling Fellowship (Uk)
Agricultural and Food Research Council
Society for the Study of Fertility (UK)
Doctor of Biology
University of York
Bachelor of Science (Honours)
University of York