Adam Wheatley

Phenotypic and functional characterization of pharmacologically expanded Vγ9Vδ2 T cells in pigtail macaques

IM Barber-Axthelm, KM Wragg, R Esterbauer, TH Amarasena, VRB Barber-Axthelm, AK Wheatley, AM Gibbon, SJ Kent, JA Juno

Journal article  |  2023  |  iScience

While gaining interest as treatment for cancer and infectious disease, the clinical efficacy of Vγ9Vδ2 T cell-based immunotherapeu..

Prime-boost, double-dose influenza vaccine immunity in COPD: a pilot observational study.

Gary P Anderson, Louis B Irving, Andrew Jarnicki, Katherine Kedzierska, Marios Koutsakos, Stephen Kent, Aeron C Hurt, Adam K Wheatley, Thi HO Nguyen, Natale Snape, John W Upham

Journal article  |  2023  |  ERJ Open Res

BACKGROUND: COPD patients are more susceptible to viral respiratory infections and their sequelae, and have intrinsically weaker i..

SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses

Marios Koutsakos, Arnold Reynaldi, Wen Shi Lee, Julie Nguyen, Thakshila Amarasena, George Taiaroa, Paul Kinsella, Kwee Chin Liew, Thomas Tran, Helen E Kent, Hyon-Xhi Tan, Louise C Rowntree, Thi HO Nguyen, Paul G Thomas, Katherine Kedzierska, Jan Petersen, Jamie Rossjohn, Deborah A Williamson, David Khoury, Miles P Davenport, et al.

Journal article  |  2023  |  Immunity

Engineered Ferritin Nanoparticle Vaccines Enable Rapid Screening of Antibody Functionalization to Boost Immune Responses.

Mai N Vu, Emily H Pilkington, Wen Shi Lee, Hyon-Xhi Tan, Thomas P Davis, Nghia P Truong, Stephen J Kent, Adam K Wheatley

Journal article  |  2023  |  Adv Healthc Mater

Employing monoclonal antibodies to target vaccine antigens to different immune cells within lymph nodes where adaptive immunity is..

Survey of activation-induced genome architecture reveals a novel enhancer of Myc

Wing Fuk Chan, Hannah D Coughlan, Michelle Ruhle, Nadia Iannarella, Carolina Alvarado, Joanna R Groom, Christine R Keenan, Andrew J Kueh, Adam K Wheatley, Gordon K Smyth, Rhys S Allan, Timothy M Johanson

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

The transcription factor Myc is critically important in driving cell proliferation, a function that is frequently dysregulated in ..

Prospective comprehensive profiling of immune responses to COVID-19 vaccination in patients on zanubrutinib therapy.

Thi HO Nguyen, Chhay Lim, Masa Lasica, Ashley Whitechurch, Surekha Tennakoon, Natalie R Saunders, Lilith F Allen, Louise C Rowntree, Brendon Y Chua, Lukasz Kedzierski, Hyon-Xhi Tan, Adam K Wheatley, Stephen J Kent, Theo Karapanagiotidis, Suellen Nicholson, Deborah A Williamson, Monica A Slavin, Constantine S Tam, Katherine Kedzierska, Benjamin W Teh

Journal article  |  2023  |  EJHaem

Zanubrutinib-treated and treatment-naïve patients with chronic lymphocytic leukaemia (CLL) or Waldenstrom's macroglobulinaemia wer..

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 (vol 13, 889372, 2022)

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale I Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy WW Chung, et al.

Journal article  |  2023  |  FRONTIERS IN IMMUNOLOGY

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The memory B cell response to influenza vaccination is impaired in older persons.

Alice R Burton, Stephane M Guillaume, William S Foster, Adam K Wheatley, Danika L Hill, Edward J Carr, Michelle A Linterman

Journal article  |  2022  |  Cell Rep

Influenza infection imparts an age-related increase in mortality and morbidity. The most effective countermeasure is vaccination; ..

Nice and slow make the germinal centers go: measured and escalating antigen delivery enhance durability and quality of humoral immune responses against HIV-1

Hyon-Xhi Tan, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

A recently published article has confirmed that a novel immunization method of sustained and escalating antigen delivery augments ..

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian FJ Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, et al.

Journal article  |  2022  |  ISCIENCE

The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monocl..