Marc Antoine Sani

TOAC spin-labeled peptides tailored for DNP-NMR studies in lipid membrane environments.

Shiying Zhu, Ehsan Kachooei, Jeffrey R Harmer, Louise J Brown, Frances Separovic, Marc-Antoine Sani

Journal article  |  2021  |  Biophys J

The benefit of combining in-cell solid-state dynamic nuclear polarization (DNP) NMR and cryogenic temperatures is providing suffic..

Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

Sunnia Rajput, Marc-Antoine Sani, David W Keizer, Frances Separovic

Journal article  |  2021  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques p..

Polarization Transfer to External Nuclear Spins Using Ensembles of Nitrogen-Vacancy Centers

AJ Healey, LT Hall, GAL White, T Teraji, M-A Sani, F Separovic, J-P Tetienne, LCL Hollenberg

Journal article  |  2021  |  PHYSICAL REVIEW APPLIED

The nitrogen-vacancy (N-V) center in diamond has emerged as a candidate to noninvasively hyperpolarize nuclear spins in molecular ..

Foldamers afford improved theranostics targeting cholecystokinin-2 receptor positive cancers

Alicia Corlett, Marc-Antoine Sani, Jessica Van Zuylekom, Craig Hutton, Mohammad Haskali

Conference Proceedings  |  2021  |  NUCLEAR MEDICINE AND BIOLOGY

C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1

Shiying Zhu, Wenyi Li, Neil O'Brien-Simpson, Frances Separovic, Marc-Antoine Sani

Conference Proceedings  |  2021  |  AMINO ACIDS

Cationic antimicrobial peptides have been investigated for their potential use in combating infections by targeting the cell membr..

A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin-2 Receptor-Positive Cancer

Alicia Corlett, Marc-Antoine Sani, Jessica Van Zuylekom, Ching-Seng Ang, Elisabeth von Guggenberg, Carleen Cullinane, Benjamin Blyth, Rodney J Hicks, Peter D Roselt, Philip E Thompson, Craig A Hutton, Mohammad B Haskali

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

Proteins adopt unique folded secondary and tertiary structures that are responsible for their remarkable biological properties. Th..

Structural Disruptions of the Outer Membranes of Gram-Negative Bacteria by Rationally Designed Amphiphilic Antimicrobial Peptides

Haoning Gong, Xuzhi Hu, Mingrui Liao, Ke Fa, Daniela Ciumac, Luke A Clifton, Marc-Antoine Sani, Stephen M King, Armando Maestro, Frances Separovic, Thomas A Waigh, Hai Xu, Andrew J McBain, Jian Ren Lu

Journal article  |  2021  |  ACS APPLIED MATERIALS & INTERFACES

Gram-negative bacteria are covered by both an inner cytoplasmic membrane (IM) and an outer membrane (OM). Antimicrobial peptides (..

Expression and purification of the native C-amidated antimicrobial peptide maculatin 1.1

Shiying Zhu, Daniel K Weber, Frances Separovic, Marc-Antoine Sani

Journal article  |  2021  |  JOURNAL OF PEPTIDE SCIENCE

Maculatin 1.1 (Mac1) is an antimicrobial peptide (AMP) from an Australian tree frog and exhibits low micromolar activity against G..

C-Terminus Amidation Influences Biological Activity and Membrane Interaction of Maculatin 1.1

Shiying Zhu, Frances Separovic, Marc-Antoine Sani

Journal article  |  2021  |  Biophysical Journal

Cationic antimicrobial peptides (cAMPs) have been considered for potential use in combating infections by their targeting of the c..

Prospects for nuclear spin hyperpolarization of molecular samples using nitrogen-vacancy centers in diamond

J-P Tetienne, LT Hall, AJ Healey, GAL White, M-A Sani, F Separovic, LCL Hollenberg

Journal article  |  2021  |  PHYSICAL REVIEW B

After initial proof-of-principle demonstrations, optically pumped nitrogen-vacancy (NV) centers in diamond have been proposed as a..