Chandana Herath

Liver-Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug-Resistant Gene 2-Knockout Mice

Indu G Rajapaksha, Lakmie S Gunarathne, Khashayar Asadi, Sharon C Cunningham, Alexandra Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath

Journal article  |  2019  |  Hepatology Communications

Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products

Dinali H Fernando, Josephine M Forbes, Peter W Angus, Chandana B Herath

Journal article  |  2019  |  International Journal of Molecular Sciences

Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population and is now a major cause of liver disease-rela..

Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats

Lakmie S Gunarathne, Peter W Angus, Chandana B Herath

Journal article  |  2019  |  Frontiers in Physiology

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Stephen Casey, Robert Schierwagen, Kai Yan Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus

Journal article  |  2019  |  Journal of Clinical Medicine

Current therapies and novel approaches for biliary diseases.

Indu G Rajapaksha, Peter W Angus, Chandana B Herath

Journal article  |  2019  |  World Journal of Gastrointestinal Pathophysiology

Chronic liver diseases that inevitably lead to hepatic fibrosis, cirrhosis and/or hepatocellular carcinoma have become a major cau..

The Effects of Diabetes and High-Fat Diet on Polymodal Nociceptor and Cold Thermoreceptor Nerve Terminal Endings in the Corneal Epithelium

Abdulhakeem S Alamri, James A Brock, Chandana B Herath, Indu G Rajapaksha, Peter W Angus, Jason J Ivanusic

Journal article  |  2019  |  Investigative Opthalmology & Visual Science

Effects of angiotensin-(1-7) and angiotensin II on vascular tone in human cirrhotic splanchnic vessels

Stephen Casey, Chandana Herath, Indu Rajapaksha, Robert Jones, Peter Angus

Journal article  |  2018  |  Peptides

The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice

Indu G Rajapaksha, Kai Y Mak, Ping Huang, Louise M Burrell, Peter W Angus, Chandana B Herath

Journal article  |  2018  |  SCIENTIFIC REPORTS

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Aowen Zhuang, Felicia Yt Yap, Clinton Bruce, Chris Leung, Manuel R Plan, Mitchell A Sullivan, Chandana Herath, Domenica McCarthy, Karly C Sourris, Phillip Kantharidis, Melinda T Coughlan, Mark A Febbraio, Mark P Hodson, Matthew J Watt, Peter Angus, Benjamin L Schulz, Josephine M Forbes

Journal article  |  2017  |  Scientific Reports

The Adeno-associated Virus - A Safe and Promising Vehicle for Liver-specific Gene Therapy of Inherited and Non-inherited Disorders

Kai Y Mak, Indu G Rajapaksha, Peter W Angus, Chandana B Herath

Journal article  |  2017  |  Current Gene Therapy

Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

Christopher Leung, Chandana B Herath, Zhiyuan Jia, Sof Andrikopoulos, Bronwyn E Brown, Michael J Davies, Leni R Rivera, John B Furness, Josephine M Forbes, Peter W Angus

Journal article  |  2016  |  WORLD JOURNAL OF GASTROENTEROLOGY

Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis

Sabine Klein, Chandana B Herath, Robert Schierwagen, Josephine Grace, Tom Haltenhof, Frank E Uschner, Christian P Strassburg, Tilman Sauerbruch, Thomas Walther, Peter W Angus, Jonel Trebicka

Journal article  |  2015  |  PLOS ONE

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

Kai Y Mak, Ruth Chin, Sharon C Cunningham, Miriam R Habib, Joseph Torresi, Alexandra F Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath

Journal article  |  2015  |  Molecular Therapy

Increased aortic intimal proliferation due to MasR deletion in vitro

Hiba Alsaadon, Peter Kruzliak, Arthur Smardencas, Alan Hayes, Michael Bader, Peter Angus, Chandana Herath, Anthony Zulli

Journal article  |  2015  |  International Journal of Experimental Pathology

Role of the Alternate RAS in Liver Disease and the GI Tract

CB Herath, KY Mak, PW Angus

Book Chapter  |  2015

Damage to enteric neurons occurs in mice that develop fatty liver disease but not diabetes in response to a high-fat diet

LR Rivera, C Leung, RV Pustovit, BL Hunne, S Andrikopoulos, C Herath, A Testro, PW Angus, JB Furness

Journal article  |  2014  |  Neurogastroenterology & Motility

Dietary glycotoxins exacerbate progression of experimental fatty liver disease

Christopher Leung, Chandana B Herath, Zhiyuan Jia, Michelle Goodwin, Kai Yan Mak, Matthew J Watt, Josephine M Forbes, Peter W Angus

Journal article  |  2014  |  JOURNAL OF HEPATOLOGY

Profiles of perfluoroalkyl substances in the liver and serum of patients with liver cancer and cirrhosis in Australia

Leo WY Yeung, Keerthi S Guruge, Sachi Taniyasu, Nobuyoshi Yamashita, Peter W Angus, Chandana B Herath

Journal article  |  2013  |  Ecotoxicology and Environmental Safety

Activation of the Mas Receptor by Angiotensin-(1-7) in the Renin-Angiotensin System Mediates Mesenteric Vasodilatation in Cirrhosis

Josephine A Grace, Sabine Klein, Chandana B Herath, Michaela Granzow, Robert Schierwagen, Noemi Masing, Thomas Walther, Tilman Sauerbruch, Louise M Burrell, Peter W Angus, Jonel Trebicka

Journal article  |  2013  |  GASTROENTEROLOGY

Therapeutic potential of targeting the renin angiotensin system in portal hypertension.

Chandana B Herath, Josephine A Grace, Peter W Angus

Journal article  |  2013  |  World Journal of Gastrointestinal Pathophysiology

Portal hypertension is responsible for the bulk of the morbidity and mortality in patients with cirrhosis. Drug therapy to reduce ..

Advanced glycation end products augment experimental hepatic fibrosis

Michelle Goodwin, Chandana Herath, Zhiyuan Jia, Chris Leung, Melinda T Coughlan, Josephine Forbes, Peter Angus

Journal article  |  2013  |  Journal of Gastroenterology and Hepatology

Angiotensin-(1-7) reduces the perfusion pressure response to angiotensin II and methoxamine via an endothelial nitric oxide-mediated pathway in cirrhotic rat liver

Chandana B Herath, Kai Mak, Louise M Burrell, Peter W Angus

Journal article  |  2013  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intramural generated Angiotensin 1-7 mediates splanchnic vasodilation via mas-receptor stimulation and thereby vascular dysfunction in cirrhosis

Sabine Klein, Josephine A Grace, Michaela Granzow, Robert Schierwagen, Chandana B Herath, Louise M Burrell, Peter W Angus, Tilman Sauerbruch, Jonel Trebicka

Conference Proceedings  |  2012  |  HEPATOLOGY

Advanced glycosylation endproducts in nonalcoholic steatohepatitis: a second hit that drives hepatic stellate cell activation?

Christopher Leung, Chandana Herath, Zhiyuan Jia, Michelle Goodwin, Kai Yan Mak, Josephine M Forbes, Peter Angus

Journal article  |  2012  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Update on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options

Josephine A Grace, Chandana B Herath, Kai Yan Mak, Louise M Burrell, Peter W Angus

Journal article  |  2012  |  Clinical Science

Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract

M Garg, PW Angus, LM Burrell, C Herath, PR Gibson, JS Lubel

Journal article  |  2012  |  Alimentary Pharmacology and Therapeutics

INCREASED FORMATION OF SPLANCHNIC VASCULAR ANGIOTENSIN-(1-7) FROM ANGIOTENSIN I AND ANGIOTENSIN II IS MEDIATED BY ANGIOTENSIN CONVERTING ENZYME-2 IN EXPERIMENTAL CIRRHOSIS AND PORTAL HYPERTENSION

Josephine A Grace, Chandana B Herath, Zhiyuan Jia, Louise M Burrell, Peter W Angus

Conference Proceedings  |  2011  |  HEPATOLOGY

Increased formation of splanchnic vascular angiotensin-(1-7) from angiotensin I and angiotensin II is mediated by angiotensin converting enzyme-2 in experimental cirrhosis and portal hypertension

JA Grace, Z Jia, CB Herath, LM Burrell, PW Angus

Journal article  |  2011  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Is our diet ageing us? How advanced glycation endproducts (ages) worsen fatty liver disease

C Leung, CB Herath, J Zhiyuan, M Goodwin, KY Mak, A Morley, VT Nguyen, JM Forbes, PW Angus

Journal article  |  2011  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Transforming growth factor beta family expression at the bovine feto-maternal interface

Kumiko Sugawara, Keiichiro Kizaki, Chandana B Herath, Yoshihisa Hasegawa, Kazuyoshi Hashizume

Journal article  |  2010  |  Reproductive Biology and Endocrinology

ANGIOTENSIN-(1-7) IS A MESENTERIC VASODILATOR IN EXPERIMENTAL CIRRHOSIS

Josephine A Grace, Zhiyuan Jia, Chandana B Herath, Louise M Burrell, Peter W Angus

Conference Proceedings  |  2010  |  HEPATOLOGY

Angiotensin-(1-7) is a mesenteric vasodilator in experimental cirrhosis

JA Grace, Z Jia, CB Herath, LM Burrell, PW Angus

Journal article  |  2010  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

ADVANCED GLYCATION ENDPRODUCTS AUGMENT HEPATIC FIBROSIS IN AN EXPERIMENTAL MODEL OF CHRONIC LIVER DISEASE

Michelle Goodwin, Chandana B Herath, Zhiyuan Jia, Josephine M Forbes, Peter W Angus

Conference Proceedings  |  2010  |  HEPATOLOGY

Angiotensin-(1-7) reduces portal pressure via guanylate cyclase-dependent nitric oxide but angiotensin ii receptor independent pathway in cirrhotic rat liver

CB Herath, K Mak, Z Jia, LM Burrell, PW Angus

Journal article  |  2010  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Changes in the renin angiotensin system during the development of colorectal cancer liver metastases

Jaclyn H Neo, Eleanor I Ager, Peter W Angus, Jin Zhu, Chandana B Herath, Christopher Christophi

Journal article  |  2010  |  BMC Cancer

Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat

John S Lubel, Chandana B Herath, Jorge Tchongue, Josephine Grace, Zhiyuan Jia, Karen Spencer, David Casley, Peter Crowley, William Sievert, Louise M Burrell, Peter W Angus

Journal article  |  2009  |  Clinical Science

ANGIOTENSIN-(1-7) ATTENUATES ANGIOTENSIN II-INDUCED INCREASES IN HEPATIC RESISTANCE VIA NON-MAS RECEPTOR MEDIATED PATHWAY IN CIRRHOTIC RAT LIVER

Chandana B Herath, Zhiyuan Jia, Louise M Burrell, Peter W Angus

Conference Proceedings  |  2009  |  HEPATOLOGY

Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats

William Kemp, Andrew Kompa, Arintaya Phrommintikul, Chandana Herath, Zhiyuan Jia, Peter Angus, Catriona McLean, Stuart Roberts, Henry Krum

Journal article  |  2009  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

The role of rage (receptor for advanced glycation endproducts) in hepatic fibrogenesis

MA Goodwin, CB Herath, Z Jia, M Coughlan, JM Forbes, PW Angus

Journal article  |  2009  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2

Chandana B Herath, John S Lubel, Zhiyuan Jia, Elena Velkoska, David Casley, Lindsay Brown, Chris Tikellis, Louise M Burrell, Peter W Angus

Journal article  |  2009  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Angiotensin converting enzyme 2 (ACE2) activity in fetal calf serum: implications for cell culture research

JS Lubel, CB Herath, E Velkoska, DJ Casley, LM Burrell, PW Angus

Journal article  |  2008  |  Cytotechnology

The effects of advanced glycation end products on hepatic fibrogenesis

MA Clonan, CB Herath, J Zhiyuan, JM Forbes, PW Angus

Journal article  |  2008  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Liver disease and the renin-angiotensin system: Recent discoveries and clinical implications

John S Lubel, Chandana B Herath, Louise M Burrell, Peter W Angus

Journal article  |  2008  |  Journal of Gastroenterology and Hepatology

Liver disease and the renin-angiotensin system: Recent discoveries and clinical implications

John S Lubel, Chandana B Herath, Louise M Burrell, Peter W Angus

Journal article  |  2008  |  Journal of Gastroenterology and Hepatology (Australia)

Ang 1-7 fails to potentiate acetylcholine vasodilatation in the preconstricted in situ perfused cirrhotic rat liver

JS Lubel, C Herath, Z Jia, LM Burrell, Pw Angus

Conference Proceedings  |  2008  |  GUT

New insights into the angiotensin 1-7/MAS receptor interaction from a murine model of hepatic fibrosis and hepatic stellate cell culture

JS Lubel, CB Herath, Z Jia, J Tchongue, W Sievert, LM Burrell, RW Angus

Conference Proceedings  |  2008  |  Journal of Hepatology

Angiotensin 1-7 reduces bile duct proliferation and hepatic fibrosis in the bile duct ligated rat

John S Lubel, Chandano B Herath, Zhiyuan Jia, Louise M Burrell, Peter W Angus

Conference Proceedings  |  2007  |  HEPATOLOGY

Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis

Chandana B Herath, Fiona J Warner, John S Lubel, Rachael G Dean, Zhiyuan Jia, Rebecca A Lew, A Ian Smith, Louise M Burrell, Peter W Angus

Journal article  |  2007  |  Hepatology

Chronic liver injury is associated with the upregulation of the ACE2-angiotensin-(1-7)-Mas axis in the rat

CB Herath, JS Lubel, FJ Warner, Z Jia, RG Dean, RA Lew, IA Smith, LM Burrell, PW Angus

Conference Proceedings  |  2007  |  Journal of Hepatology

Develop-mental aberrations of liver gene expression in bovine fetuses derived from somatic cell nuclear transplantation

Chandana B Herath, Hiroko Ishiwata, Satoshi Shiojima, Tadashi Kadowaki, Susumu Katsuma, Koichi Ushizawa, Kei Imai, Toru Takahashi, Akira Hirasawa, Seiya Takahashi, Yoshiaki Izaike, Gozoh Tsujimoto, Kazuyoshi Hashizume

Journal article  |  2006  |  Cloning and Stem Cells

cDNA microarray analysis of bovine embryo gene expression profiles during the pre-implantation period.

Koichi Ushizawa, Chandana B Herath, Kanako Kaneyama, Satoshi Shiojima, Akira Hirasawa, Toru Takahashi, Kei Imai, Kazuhiko Ochiai, Tomoyuki Tokunaga, Yukio Tsunoda, Gozoh Tsujimoto, Kazuyoshi Hashizume

Journal article  |  2004  |  Reproductive Biology and Endocrinology

BACKGROUND: After fertilization, embryo development involves differentiation, as well as development of the fetal body and extra-e..

Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats

CB Herath, WZ Jin, G Watanabe, K Arai, AK Suzuki, K Taya

Journal article  |  2004  |  Endocrine

Pregnancy-associated changes in genome-wide gene expression profiles in the liver of cow throughout pregnancy

CB Herath, S Shiojima, H Ishiwata, S Katsuma, T Kadowaki, K Ushizawa, K Imai, T Takahashi, A Hirasawa, G Tsujimoto, K Hashizume

Journal article  |  2004  |  Biochemical and Biophysical Research Communications

Proliferative potential of endometrial stromal cells, and endometrial and placental expression of cyclin in the bovine.

Nobuhiko Yamauchi, Toshiaki Takezawa, Keiichiro Kizaki, Chandana B Herath, Kazuyoshi Hashizume

Journal article  |  2003  |  Journal of Reproduction and Development

The objective of the present investigation was to study proliferative activity of fibroblast-like endometrial stromal cells in bov..

Expression of integrin subunits depend on bovine endometrial stromal cells cultured in vitro

N Yamauchi, K Kizaki, O Yamada, T Takahashi, CB Herath, K Hashizume

Journal article  |  2003  |  Connective Tissue

Localization and secretion of inhibins in the equine fetal ovaries.

Yumiko Tanaka, Hiroyuki Taniyama, Nobuo Tsunoda, Chandana B Herath, Rie Nakai, Hiromi Shinbo, Natsuko Nagamine, Yasuo Nambo, Shun-Ichi Nagata, Gen Watanabe, Nigel P Groome, Kazuyoshi Taya

Journal article  |  2003  |  Biology of Reproduction

To clarify the source of inhibins in equine female fetuses, concentrations of immunoreactive (ir-) inhibin, inhibin pro-alphaC, an..

Inhibin B regulating follicle-stimulating hormone secretion during testicular recrudescence in the male golden hamster.

Wanzhu Jin, Chandana B Herath, Midori Yoshida, Koji Y Arai, Erina Saita, Shi Zhanquan, Longquan Ren, Gen Watanabe, Nigel P Groome, Kazuyoshi Taya

Journal article  |  2002  |  Journal of Andrology

In the present study, to clarify whether inhibin affects follicle-stimulating hormone (FSH) secretion in the recrudescence of the ..

The testis as a major source of circulating inhibins in the male equine fetus during the second half of gestation.

Yumiko Tanaka, Hiroyuki Taniyama, Nobuo Tsunoda, Hiromi Shinbo, Natsuko Nagamine, Yasuo Nambo, Shun-ichi Nagata, Gen Watanabe, Chandana B Herath, Nigel P Groome, Kazuyoshi Taya

Journal article  |  2002  |  Journal of Andrology

Immunolocalization of the inhibin (a) and inhibin/activin (beta3A and betaB) subunit proteins in equine fetal testes was investiga..

Serous cysts are a benign component of the cyclic ovary in the guinea pig with an incidence dependent upon inhibin bioactivity.

FangXiong Shi, Brian K Petroff, Chandana B Herath, Manao Ozawa, Gen Watanabe, Kazuyoshi Taya

Journal article  |  2002  |  Journal of Veterinary Medical Science

Ovaries were collected from normal cycling female guinea pigs on each day of the estrous cycle (n = 5 per day) for histological an..

Regulation of follicle-stimulating hormone secretion by estradiol and dimeric inhibins in the infantile female rat.

CB Herath, M Yamashita, G Watanabe, W Jin, S Tangtrongsup, A Kojima, NP Groome, AK Suzuki, K Taya

Journal article  |  2001  |  Biology of Reproduction

Plasma and ovarian levels of the dimeric forms of inhibin and plasma estradiol-17beta were investigated and compared with changes ..

Superovulation, fertilization and in vitro embryo development in mice after administration of an inhibin-neutralizing antiserum.

H Wang, CB Herath, G Xia, G Watanabe, K Taya

Journal article  |  2001  |  Reproduction

The present study was conducted to investigate the effect of immunoneutralization against endogenous inhibin on oocyte and embryo ..

Inhibins in the male Göttingen miniature pig: Leydig cells are the predominant source of inhibin B.

W Jin, KY Arai, CB Herath, M Kondo, H Ishi, Y Tanioka, G Watanabe, NP Groome, K Taya

Journal article  |  2001  |  Journal of Andrology

The expression of inhibin subunits in the testes of the Göttingen miniature pig was examined by in situ hybridization and immunohi..

Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor

CB Herath, G Watanabe, WZ Jin, J Noguchi, K Akiyama, K Kuramoto, NP Groome, K Taya

Journal article  |  2001  |  Journal of Andrology

This study was undertaken to investigate the endocrine changes that occur in male Tig:Wistar rats with Leydig cell tumors, with sp..

Exposure of neonatal female rats to p-tert-octylphenol disrupts afternoon surges of luteinizing hormone, follicle-stimulating hormone and prolactin secretion, and interferes with sexual receptive behavior in adulthood

CB Herath, G Watanabe, S Katsuda, M Yoshida, AK Suzuki, K Taya

Journal article  |  2001  |  Biology of Reproduction

The present study investigated the effects of exposure of neonatal female rats to p-tert-octylphenol (OP) on estrogen-induced afte..

Testicular secretion of inhibin in the male golden hamster (Mesocricetus auratus)

WZ Jin, S Wada, KY Arai, H Kishi, CB Herath, G Watanabe, AK Suzuki, NP Groome, K Taya

Journal article  |  2001  |  Journal of Andrology

To identify the cellular source of inhibin in the male golden hamster, we have used complementary approaches, immunohistochemistry..

Secretion of inhibin A and inhibin B throughout pregnancy and the early postpartum period in chimpanzees.

M Kondo, M Kondo, T Udono, WZ Jin, WZ Jin, M Funakoshi, K Shimizu, M Itoh, CB Herath, G Watanabe, G Watanabe, NP Groome, K Taya, K Taya

Journal article  |  2001  |  Journal of Endocrinology

Plasma concentrations of inhibin A and inhibin B during pregnancy and early lactation in chimpanzees were determined by enzyme-lin..

Vagotomy suppresses cephalic phase insulin release in sheep.

CB Herath, GW Reynolds, DD MacKenzie, SR Davis, PM Harris

Journal article  |  1999  |  Experimental Physiology

The effect of selective vagotomy of the abomasum, pylorus, duodenum and liver on insulin release during the cephalic phase of dige..