Graham Mackay

The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation

Lin Hsin, Nithya A Fernandopulle, Jie Ding, Chris Lumb, Nicholas Veldhuis, John A Karas, Susan E Northfield, Graham A Mackay

Journal article  |  2022  |  PHARMACOLOGY RESEARCH & PERSPECTIVES

The tachykinin neuropeptide substance P (SP) is the canonical agonist peptide for the neurokinin 1 receptor (NK1 R). More recently..

The first reptilian allergen and major allergen for fish-allergic patients: Crocodile beta-parvalbumin

Thimo Ruethers, Roni Nugraha, Aya C Taki, Andrea O'Malley, Shaymaviswanathan Karnaneedi, Stephanie Zhang, A Brenda Kapingidza, Sam Mehr, Sandip D Kamath, Maksymilian Chruszcz, Graham Mackay, Dianne E Campbell, Andreas L Lopata

Journal article  |  2022  |  PEDIATRIC ALLERGY AND IMMUNOLOGY

BACKGROUND: Clinical cross-reactivity between bony fish, cartilaginous fish, frog, and chicken muscle has previously been demonstr..

Goat milk skin products may cause the development of goat milk allergy

Joseph Francis De Luca, Graham Angus Mackay, Josh William Chatelier, Samantha Sing-Yi Chan, Stephanie Sihan Zhang, Jack Godsell, Kymble Spriggs, Charlotte Slade, Jo Anne Douglass

Journal article  |  2022  |  CLINICAL AND EXPERIMENTAL ALLERGY

Antibody or Anybody? Considering the Role of MRGPRX2 in Acute Drug-Induced Anaphylaxis and as a Therapeutic Target

Graham A Mackay, Nithya A Fernandopulle, Jie Ding, Jeremy McComish, Paul F Soeding

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Acute anaphylaxis to small molecule drugs is largely considered to be antibody-mediated with immunogloblin E (IgE) and mast cell a..

Fc Binding by Fc gamma RIIa Is Essential for Cellular Activation by the Anti-Fc gamma RIIa mAbs 8.26 and 8.2

Bruce D Wines, Halina M Trist, Sandra Esparon, Rachael E Impey, Graham A Mackay, Robert K Andrews, Tatiana P Soares da Costa, Geoffrey A Pietersz, Ross Baker, P Mark Hogarth

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic acti..

MRGPRX2 activation in mast cells by neuromuscular blocking agents and other agonists: Modulation by sugammadex

Nithya A Fernandopulle, Stephanie S Zhang, Paul F Soeding, Graham A Mackay

Journal article  |  2021  |  CLINICAL AND EXPERIMENTAL ALLERGY

BACKGROUND: Neuromuscular-blocking agents (NMBAs) can cause both IgE-dependent and IgE-independent anaphylactic reactions, with ac..

Reply to correspondence of Elst et al

Nithya Fernandopulle, Stephanie Zhang, Paul Soeding, Graham Mackay

Journal article  |  2021  |  CLINICAL AND EXPERIMENTAL ALLERGY

Differential activation of human mast cells by the antibiotics polymyxin B and colistin

Graham Mackay, Stephanie Zhang, Nithya Fernandopulle, James Ziogas, Paul Soeding

Conference Proceedings  |  2020  |  BRITISH JOURNAL OF PHARMACOLOGY

Identification of an Immortalized Human Airway Epithelial Cell Line with Dyskinetic Cilia

Li Eon Kuek, Paul Griffin, Paul Martinello, Alison N Graham, Paul Kalitsis, Philip J Robinson, Graham A Mackay

Journal article  |  2018  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Primary ciliary dyskinesia is an inherited, currently incurable condition. In the respiratory system, primary ciliary dyskinesia c..

The Rare Anaphylaxis-Associated Fc gamma RIIa3 Exhibits Distinct Characteristics From the Canonical Fc gamma RIIa1

Jessica C Anania, Halina M Trist, Catherine S Palmer, Peck Szee Tan, Betty P Kouskousis, Alicia M Chenoweth, Stephen J Kent, Graham A Mackay, Alberta Hoi, Rachel Koelmeyer, Charlotte Slade, Vanessa L Bryant, Philip D Hodgkin, Pei Mun Aui, Menno C van Zelm, Bruce D Wines, P Mark Hogarth

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses an..