Graham Mackay

Fc Binding by Fc gamma RIIa Is Essential for Cellular Activation by the Anti-Fc gamma RIIa mAbs 8.26 and 8.2

Bruce D Wines, Halina M Trist, Sandra Esparon, Rachael E Impey, Graham A Mackay, Robert K Andrews, Tatiana P Soares da Costa, Geoffrey A Pietersz, Ross Baker, P Mark Hogarth

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic acti..

MRGPRX2 activation in mast cells by neuromuscular blocking agents and other agonists: Modulation by sugammadex

Nithya A Fernandopulle, Stephanie S Zhang, Paul F Soeding, Graham A Mackay

Journal article  |  2021  |  CLINICAL AND EXPERIMENTAL ALLERGY

BACKGROUND: Neuromuscular-blocking agents (NMBAs) can cause both IgE-dependent and IgE-independent anaphylactic reactions, with ac..

Reply to correspondence of Elst et al

Nithya Fernandopulle, Stephanie Zhang, Paul Soeding, Graham Mackay

Journal article  |  2021  |  CLINICAL AND EXPERIMENTAL ALLERGY

We thank Elst and colleagues for their commentary on our recently published article in this journal, which facilitates greater dis..

Antibody or Anybody? Considering the Role of MRGPRX2 in Acute Drug-Induced Anaphylaxis and as a Therapeutic Target.

Graham A Mackay, Nithya A Fernandopulle, Jie Ding, Jeremy McComish, Paul F Soeding

Journal article  |  2021  |  Front Immunol

Acute anaphylaxis to small molecule drugs is largely considered to be antibody-mediated with immunogloblin E (IgE) and mast cell a..

Differential activation of human mast cells by the antibiotics polymyxin B and colistin

Graham Mackay, Stephanie Zhang, Nithya Fernandopulle, James Ziogas, Paul Soeding

Conference Proceedings  |  2020  |  BRITISH JOURNAL OF PHARMACOLOGY

Identification of an Immortalized Human Airway Epithelial Cell Line with Dyskinetic Cilia

Li Eon Kuek, Paul Griffin, Paul Martinello, Alison N Graham, Paul Kalitsis, Philip J Robinson, Graham A Mackay

Journal article  |  2018  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Primary ciliary dyskinesia is an inherited, currently incurable condition. In the respiratory system, primary ciliary dyskinesia c..

The Rare Anaphylaxis-Associated Fc gamma RIIa3 Exhibits Distinct Characteristics From the Canonical Fc gamma RIIa1

Jessica C Anania, Halina M Trist, Catherine S Palmer, Peck Szee Tan, Betty P Kouskousis, Alicia M Chenoweth, Stephen J Kent, Graham A Mackay, Alberta Hoi, Rachel Koelmeyer, Charlotte Slade, Vanessa L Bryant, Philip D Hodgkin, Pei Mun Aui, Menno C van Zelm, Bruce D Wines, P Mark Hogarth

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses an..

Expression and function of a novel membrane-spanning protein, MS4A8B, in the human airways

LE Kuek, A Stewart, M Hulett, D Davies, G Mackay

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

FGD2 is a novel negative regulator of IgE-dependent mast cell activation

GA Mackay, LE Kuek, P Heng, A Gavin

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The MS4A family: counting past 1, 2 and 3

Li Eon Kuek, Melanie Leffler, Graham A Mackay, Mark D Hulett

Journal article  |  2016  |  IMMUNOLOGY AND CELL BIOLOGY

The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD2..