Stephen Turner

Running to Stand Still: Naive CD8( ) T Cells Actively Maintain a Program of Quiescence

Taylah J Bennett, Vibha AV Udupa, Stephen J Turner

Journal article  |  2020  |  International Journal of Molecular Sciences

CD8+ T cells play a pivotal role in clearing intracellular pathogens and combatting tumours. Upon infection, naïve CD8+ T cells di..

A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs

Matthew C Canver, Pratibha Tripathi, Michael J Bullen, Moshe Olshansky, Yogesh Kumar, Lee H Wong, Stephen J Turner, Samuel Lessard, Luca Pinello, Stuart H Orkin, Partha Pratim Das

Journal article  |  2020  |  Journal of Biological Chemistry

Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the noncoding genome and control..

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey, et al.

Journal article  |  2020  |  Science Immunology

The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..

The Impact of MHC Class I Dose on Development and Maintenance of the Polyclonal Naive CD8( ) T Cell Repertoire

Xavier YX Sng, Jasmine Li, Pirooz Zareie, Lisa M Assmus, Jason KC Lee, Claerwen M Jones, Stephen J Turner, Stephen R Daley, Kylie M Quinn, Nicole L La Gruta

Journal article  |  2020  |  The Journal of Immunology

Naive CD8+ T cell survival in the periphery is critically dependent on tonic TCR signaling through peptide + MHC class I (MHCI) re..

Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  Science Immunology

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

Adil Doganay Duru, Renhua Sun, Eva B Allerbring, Jesseka Chadderton, Nadir Kadri, Xiao Han, Kaliroi Peqini, Hannes Uchtenhagen, Chaithanya Madhurantakam, Sara Pellegrino, Tatyana Sandalova, Per-Ake Nygren, Stephen J Turner, Adnane Achour

Journal article  |  2020  |  PLoS Pathogens

Viral escape from CD8+ cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge..

Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8( )T cells

Annabell Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Dedreia Tull, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, Axel Kallies, Malcolm McConville, Stephen J Turner, Thomas Gebhardt, Sammy Bedoui

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Timothy SC Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J Pediongco, Bronwyn S Meehan, Lyudmila Kostenko, Stephen J Turner, Alexandra J Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey

Journal article  |  2019  |  Cell Reports

Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including m..

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article  |  2019  |  Immunity

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

Early T-BET Expression Ensures an Appropriate CD8( ) Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection

Julia E Prier, Jasmine Li, Linden J Gearing, Moshe Olshansky, Xavier YX Sng, Paul J Hertzog, Stephen J Turner

Journal article  |  2019  |  The Journal of Immunology

Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of e..