Prof Stephen Turner

I completed my PhD in 1997 at Monash University, Melbourne, Victoria in viral immunology. I then worked as a postdoctoral fellow at the University of Melbourne with Dr Janet Ruby studying host-virus interactions (ectromelia virus).

In 1999, I moved to the laboratory of Professor Peter Doherty, Department of Immunology at St Jude Children's Research Hospital, Memphis, TN, USA. I returned with Professor Doherty in 2002 to help set up his laboratory in the Department of Microbiology and Immunology, The University of Melbourne. I have since established my own research group examining both molecular and cellular aspects of killer T cell immunity to virus infection.

Find out more about Stephen Turner's experience

Stephen Turner's highlights

FEATURED Journal article

Helping Themselves: Optimal Virus-Specific CD4 T Cell Responses Require Help via CD4 T Cell Licensing of Dendritic Cells

Stephen Turner's selected work

Investigation Of Compounds With Antiviral Activities Against Influenza A Infection.

Research Contracts

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD..

Journal article

A Single Molecule Real-Time Dna Sequencing Facility

Research Grant

T cell immunity as a tool for studying epigenetic regulation of cellular differentiation.

Journal article

Limiting The Impact Of Influenza

Research Grant

Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus..

Journal article

Projects

Displaying the 31 most recent projects by Stephen Turner.

Investigation Of Compounds With Antiviral Activities Against Influenza A Infection.

2016 - 2017

Completed

A Single Molecule Real-Time Dna Sequencing Facility

A PacBio SMRT sequencing facility will be established and used to accelerate ten specific research programs across a breadth of biological d..

2015 - 2015

Completed

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

2015 - 2019

Completed

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

2015 - 2019

Completed

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

2015 - 2019

Completed

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

2015 - 2019

Completed

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

2015 - 2019

Completed

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

2015 - 2019

Completed

A Single Molecule Real-Time Dna Sequencing Facility - Matching Contribution

A PacBio SMRT sequencing facility will be established and used to accelerate ten specific research programs across a breadth of biological d..

2015 - 2015

Completed

Study Of The Enzymes That Underpin The Genetic Blueprint For Maintaining T Cell Immunity.

Recovery from infection, or vaccination, results in the establishment of protective immunity that persists for the life of an individual. Un..

2014 - 2016

Completed

Dissection Of Influenza-Specific Human T Cell Immunity

2013 - 2014

Completed

Understanding T Cell Immunity Induced By Infection

2011 - 2015

Completed

Molecular Control Of Virus-Specific T Cell Responses

Upon virus infection, a subset of white blood cells, called killer T cells, are recruited to fight the infection. This proposal aims to exam..

2011 - 2013

Completed

Functional Characterization Of Ssb2: A Novel Single-Stranded Dna Binding Protein

Defects in the DNA damage response pathway underpin many human genetic disorders and diseases. A detailed understanding of this pathway has ..

2010 - 2012

Completed

Identification Of Determinants Associated With Pathogenicity Of Swine-Origin 2009 A (H1n1) Influenza Virus

nan

2010 - 2010

Completed

Understanding And Controlling Influenza

While current influenza vaccines blunt winter epidemics, they must be updated frequently to keep up with virus mutation and they do not prot..

2010 - 2014

Completed

Understanding And Controlling Influenza

While current influenza vaccines blunt winter epidemics, they must be updated frequently to keep up with virus mutation and they do not prot..

2010 - 2014

Completed

Identification Of Determinants Associated With Pathogenicity Of Swine-Origin 2009 A (H1n1) Influenza Virus

nan

2009 - 2010

Completed

Understanding The Extent Of Cross-Reactive T Cell Immunity Between H1n1 09 And Seasonal Influenza Strains.

nan

2009 - 2010

Completed

Understanding The Recognition Requirements For Virus-Specific T Cells

Viral infection results in the activation and proliferation of T cells that eradicate infected cells. Recognition of infected cells is medit..

2008 - 2010

Completed

Epigenetic And Transcriptional Regulation Of Cd8 T Cell Effector Function

2007 - 2012

Completed

Identifying Molecular Factors That Control Killer T Cell Function

2007 - 2007

Completed

Genetic Regulation Of Cytotoxic T Cell Function

A major role for cytotoxic, or killer, T cells is the recognition and removal of virus infected or tumor cells from a host. Upon recognition..

2007 - 2009

Completed

Structural Basis Of Influenza A Virus-Specific Cd8+ T Cell Receptor Diversity

Viral infection results in the activation and proliferation of virus-specific T cells that mediate clearance of virally infected cells. Reco..

Molecular Aspects Of Virus-Specific Cd8+ T Cell Immunity

Completed

Structural And Functional Studies Of Virus-Specific Cd8 T Cell Responses

nan

Assessment Of Alpha-Galactosylceramide As A Novel Adjuvant For Pandemic Influenza A Virus Vaccines

The occurrence of human infections with pathogenic avian H5N1 Influenza A viruses was the first documentation of these viruses demonstrating..

Establishing The Capacity For H5n1 Challenge Of Ferrets Within Australia & Optimising Pandemic Vaccines In This Model

Australia is currently in the process of manufacturing vaccines for use in people against strains of avian influenza viruses circulating in ..

Multi-Photon Imaging For Infection, Immunity, And Self Recognition

This proposal will address a gap in our imaging capabilities, allowing us to visualise the movement of immune cells and infectious agents su..

Naive T-Cell Repertoires And Their Contribution To The Immune Response.

Understanding The T Cell Repertoire In Health And Disease

Immune recognition of viruses usually involves a large number of different 'killer T cells' that kill cells infected by virus. However, duri..

31

Projects

Project Types

Research Grant

Research Contracts

Internal Research Grant

Scholarly Works

Displaying the 161 most recent scholarly works by Stephen Turner.

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Timothy SC Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J Pediongco, Bronwyn S Meehan, Lyudmila Kostenko, Stephen J Turner, Alexandra J Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey

Journal article | 2019 | Cell Reports

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article | 2019 | Immunity

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

Early T-BET Expression Ensures an Appropriate CD8 Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection.

Julia E Prier, Jasmine Li, Linden J Gearing, Moshe Olshansky, Xavier YX Sng, Paul J Hertzog, Stephen J Turner

Journal article | 2019 | The Journal of Immunology

Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of e..

Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

Journal article | 2019 | Immunology & Cell Biology

Development of a KDM6b shRNA conditional knock down mouse model

Julia Prier, Marnie Blewitt, Ross Dickins, Stephen Turner

Journal article | 2019

Abstract Antigen-specific CD8 + T cell differentiation in response to infection is associated with specific changes in the chromat..

CD4( ) T help promotes influenza virus-specific CD8( ) T cell memory by limiting metabolic dysfunction

Jolie G Cullen, Hayley A McQuilten, Kylie M Quinn, Moshe Olshansky, Brendan E Russ, Alison Morey, Sanna Wei, Julia E Prier, Nicole L La Gruta, Peter C Doherty, Stephen J Turner

Journal article | 2019 | Proceedings of the National Academy of Sciences

Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo

Joel Z Ma, Wy Ching Ng, Luke Zappia, Linden J Gearing, Moshe Olshansky, Kym Pham, Karey Cheong, Arthur Hsu, Stephen J Turner, Odilia Wijburg, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article | 2019 | Journal of Virology

Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8( ) T Cells during Activation in an Alternative Cytokine Environment

Kim L Harland, Annette Fox, Simone Nussing, Luca Hensen, Katherine Kedzierska, Stephen J Turner, Anne Kelso

Journal article | 2018 | The Journal of Immunology

Age-Related Decline in Primary CD8( ) T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8( ) T Cells

Kylie M Quinn, Annette Fox, Kim L Harland, Brendan E Russ, Jasmine Li, Thi HO Nguyen, Liyen Loh, Moshe Olshanksy, Haroon Naeem, Kirill Tsyganov, Florian Wiede, Rosela Webster, Chantelle Blyth, Xavier YX Sng, Tony Tiganis, David Powell, Peter C Doherty, Stephen J Turner, Katherine Kedzierska, Nicole L La Gruta

Journal article | 2018 | Cell Reports

Clonally diverse CD38( )HLA-DR( )CD8( ) T cells persist during fatal H7N9 disease

Zhongfang Wang, Lingyan Zhu, Thi HO Nguyen, Yanmin Wan, Sneha Sant, Sergio M Quinones-Parra, Jeremy Chase Crawford, Auda A Eltahla, Simone Rizzetto, Rowena A Bull, Chenli Qiu, Marios Koutsakos, E Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, et al.

Journal article | 2018 | Nature Communications

T Cell LEGO: Identifying the Master Builders and What They Do.

Jasmine Li, Stephen J Turner

Journal article | 2018 | Immunity

Understanding how cell fate decisions are made during cellular differentiation and the mechanisms that drive them is a holy grail ..

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton

Journal article | 2018 | Cell Death & Disease

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8( ) T Cell-Lineage-Specific Function

Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle LT Nguyen, Linden J Gearing, Thi HO Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nussing, Georges Khoury, Damian FJ Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article | 2017 | Cell Reports

Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine

Regan J Anderson, Jasmine Li, Lukasz Kedzierski, Benjamin J Compton, Colin M Hayman, Taryn L Osmond, Ching-wen Tang, Kathryn J Farrand, Hui-Fern Koay, Catarina Filipa Dos Santos Sa E Almeida, Lauren R Holz, Geoffrey M Williams, Margaret A Brimble, Zhongfang Wang, Marios Koutsakos, Katherine Kedzierska, Dale I Godfrey, Ian F Hermans, Stephen J Turner, Gavin F Painter

Journal article | 2017 | ACS Chemical Biology

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8 T cell response magnitude

Kylie M Quinn, Wan-Ting Kan, Katherine A Watson, Brian J Liddicoat, Natasha G Swan, Hayley McQuilten, Alice E Denton, Jasmine Li, Weisan Chen, Lorena E Brown, David C Jackson, Patrick C Reading, Peter C Doherty, Katherine Kedzierska, Lukasz Kedzierski, Stephen J Turner, Nicole L La Gruta

Journal article | 2017 | PLOS ONE

Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells

Wen Juan Tu, Kristine Hardy, Christopher R Sutton, Robert McCuaig, Jasmine Li, Jenny Dunn, Abel Tan, Vedran Brezar, Melanie Morris, Gareth Denyer, Sau Kuen Lee, Stephen J Turner, Nabila Seddiki, Corey Smith, Rajiv Khanna, Sudha Rao

Journal article | 2017 | Scientific Reports

Can T cells be too exhausted to fight back?

Stephen J Turner, Brendan E Russ

Journal article | 2016 | Science

Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection

Matthew R Olson, Brendon Y Chua, Kim L Good-Jacobson, Peter C Doherty, David C Jackson, Stephen J Turner

Journal article | 2016 | Immunology and Cell Biology

Nuclear PKC-theta facilitates rapid transcriptional responses in human memory CD4( ) T cells through p65 and H2B phosphorylation

Jasmine Li, Kristine Hardy, Chan Phetsouphanh, Wen Juan Tu, Elissa L Sutcliffe, Robert McCuaig, Christopher R Sutton, Anjum Zafar, C Mee LingMunier, John J Zaunders, Yin Xu, Angelo Theodoratos, Abel Tan, Pek SiewLim, Tobias Knaute, Antonia Masch, Johannes Zerweck, Vedran Brezar, Peter J Milburn, Jenny Dunn, et al.

Journal article | 2016 | Journal of Cell Science

Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus-specific CD8( ) T cells

Michelle LT Nguyen, Lauren Hatton, Jasmine Li, Moshe Olshansky, Anne Kelso, Brendan E Russ, Stephen J Turner

Journal article | 2016 | European Journal of Immunology

T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming

Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui

Journal article | 2016 | Cell Reports

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

Brendon Y Chua, Chinn Yi Wong, Edin J Mifsud, Kathryn M Edenborough, Toshiki Sekiya, Amabel CL Tan, Francesca Mercuri, Steve Rockman, Weisan Chen, Stephen J Turner, Peter C Doherty, Anne Kelso, Lorena E Brown, David C Jackson

Journal article | 2015 | mBio

Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses

Nicola L Bird, Matthew R Olson, Aeron C Hurt, Christine M Oshansky, Ding Yuan Oh, Patrick C Reading, Brendon Y Chua, Yilun Sun, Li Tang, Andreas Handel, David C Jackson, Stephen J Turner, Paul G Thomas, Katherine Kedzierska

Journal article | 2015 | PLOS ONE

Epitope-specific CD4( ), but not CD8( ), T-cell responses induced by recombinant influenza A viruses protect against Mycobacterium tuberculosis infection

Manuela Florido, Roman Pillay, Caitlin M Gillis, Yingju Xia, Stephen J Turner, James A Triccas, John Stambas, Warwick J Britton

Journal article | 2015 | European Journal of Immunology

Fixed Expression of Single Influenza Virus-Specific TCR Chains Demonstrates the Capacity for TCR alpha- and beta-Chain Diversity in the Face of Peptide-MHC Class I Specificity

E Bridie Clemens, Peter C Doherty, Nicole L La Gruta, Stephen J Turner

Journal article | 2015 | The Journal of Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

Jamie Rossjohn, Stephanie Gras, John J Miles, Stephen J Turner, Dale I Godfrey, James McCluskey

Journal article | 2015 | Annual Review of Immunology

Granzyme B Promotes Cytotoxic Lymphocyte Transmigration via Basement Membrane Remodeling

Monica D Prakash, Marcia A Munoz, Rohit Jain, Philip L Tong, Aulikki Koskinen, Matthias Regner, Oded Kleifeld, Bosco Ho, Matthew Olson, Stephen J Turner, Paulus Mrass, Wolfgang Weninger, Phillip I Bird

Journal article | 2014 | Immunity

Helping Themselves: Optimal Virus-Specific CD4 T Cell Responses Require Help via CD4 T Cell Licensing of Dendritic Cells

Matthew R Olson, Shirley GK Seah, Jolie Cullen, Marie Greyer, Kathryn Edenborough, Peter C Doherty, Sammy Bedoui, Andrew M Lew, Stephen J Turner

Journal article | 2014 | The Journal of Immunology

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8( ) T Cell Differentiation

Brendan E Russ, Moshe Olshanksy, Heather S Smallwood, Jasmine Li, Alice E Denton, Julia E Prier, Angus T Stock, Hayley A Croom, Jolie G Cullen, Michelle LT Nguyen, Stephanie Rowe, Matthew R Olson, David B Finkelstein, Anne Kelso, Paul G Thomas, Terry P Speed, Sudha Rao, Stephen J Turner

Journal article | 2014 | Immunity

T cell mediated immunity to influenza: mechanisms of viral control

Nicole L La Gruta, Stephen J Turner

Journal article | 2014 | Trends in Immunology (formerly Immunology Today)

CD154( ) CD4( ) T-cell dependence for effective memory influenza virus-specific CD8( ) T-cell responses

Matthew R Olson, Shirley GK Seah, Kathryn Edenborough, Peter C Doherty, Andrew M Lew, Stephen J Turner

Journal article | 2014 | Immunology and Cell Biology

The Influenza Virus-Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells

Tania Cukalac, Jesseka Chadderton, Weiguang Zeng, Jolie G Cullen, Wan Ting Kan, Peter C Doherty, David C Jackson, Stephen J Turner, Nicole L La Gruta

Journal article | 2014 | Journal of Immunology

The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses

Brendon Y Chua, Matthew R Olson, Sammy Bedoui, Toshiki Sekiya, Chinn Y Wong, Stephen J Turner, David C Jackson

Journal article | 2014 | Immunology and Cell Biology

Epigenetic plasticity of Cd8a locus during CD8( ) T-cell development and effector differentiation and reprogramming

Kim L Harland, E Bridie Day, Simon H Apte, Brendan E Russ, Peter C Doherty, Stephen J Turner, Anne Kelso

Journal article | 2014 | Nature Communications

Reproducible selection of high avidity CD8( ) T-cell clones following secondary acute virus infection

Tania Cukalac, Jesseka Chadderton, Andreas Handel, Peter C Doherty, Stephen J Turner, Paul G Thomas, Nicole L La Gruta

Journal article | 2014 | Proceedings of the National Academy of Sciences of the United States of America

Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules?

SBG Eckle, SJ Turner, J Rossjohn, J McCluskey

Journal article | 2013 | Current opinion in immunology

Predisposed alpha beta T cell antigen receptor recognition of MHC and MHC-I like molecules?

Sidonia BG Eckle, Stephen J Turner, Jamie Rossjohn, James McCluskey

Journal article | 2013 | Current Opinion in Immunology

Acute emergence and reversion of influenza A virus quasispecies within CD8( ) Tcell antigenic peptides

Sophie A Valkenburg, Sergio Quinones-Parra, Stephanie Gras, Naomi Komadina, Jodie McVernon, Zhongfang Wang, Hanim Halim, Pina Iannello, Catherine Cole, Karen Laurie, Anne Kelso, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

Journal article | 2013 | Nature Communications

Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Coinfection

Manuela Florido, Michael A Grima, Caitlin M Gillis, Yingju Xia, Stephen J Turner, James A Triccas, John Stambas, Warwick J Britton

Journal article | 2013 | Journal of Immunology

Preemptive priming readily overcomes structure-based mechanisms of virus escape

Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Lauren A Hatton, Nicola A Bird, Kelly-Anne Twist, Hanim Halim, David C Jackson, Anthony W Purcell, Stephen J Turner, Peter C Doherty, Jamie Rossjohn, Katherine Kedzierska

Journal article | 2013 | Proceedings of the National Academy of Sciences of the United States of America

Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

Megumi Takiguchi, Lukas E Dow, Julia E Prier, Catherine L Carmichael, Benjamin T Kile, Stephen J Turner, Scott W Lowe, David CS Huang, Ross A Dickins

Journal article | 2013 | PLoS One

T cell immunity as a tool for studying epigenetic regulation of cellular differentiation.

Brendan E Russ, Julia E Prier, Sudha Rao, Stephen J Turner

Journal article | 2013 | Frontiers in Genetics

Cellular differentiation is regulated by the strict spatial and temporal control of gene expression. This is achieved, in part, by..

Influenza-induced, helper-independent CD8( ) T cell responses use CD40 costimulation at the late phase of the primary response

Shirley GK Seah, Jamie L Brady, Emma M Carrington, Wy Ching Ng, Robyn M Sutherland, Manuela S Hancock, Nicole L La Gruta, Lorena E Brown, Stephen J Turner, Andrew M Lew, Yifan Zhan

Journal article | 2013 | Journal of Leukocyte Biology

Cell-mediated immunity

Stephen J Turner, Peter C Doherty, Anne Kelso

Book Chapter | 2013

A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned

Stephanie Gras, Scott R Burrows, Stephen J Turner, Andrew K Sewell, James McCluskey, Jamie Rossjohn

Journal article | 2012 | Immunological Reviews

Impact of Sex Steroid Ablation on Viral, Tumour and Vaccine Responses in Aged Mice

Tracy SP Heng, Jessica J Reiseger, Anne L Fletcher, Graham R Leggatt, Olivia J White, Katerina Vlahos, Ian H Frazer, Stephen J Turner, Richard L Boyd

Journal article | 2012 | PLoS One

Unlike CD4( ) T-cell help, CD28 costimulation is necessary for effective primary CD8( ) T-cell influenza-specific immunity

Shirley GK Seah, Emma M Carrington, Wy C Ng, Gabrielle T Belz, Jamie L Brady, Robyn M Sutherland, Manuela S Hancock, Nicole L La Gruta, Lorena E Brown, Stephen J Turner, Yifan Zhan, Andrew M Lew

Journal article | 2012 | European Journal of Immunology

Early Priming Minimizes the Age-Related Immune Compromise of CD8( ) T Cell Diversity and Function

Sophie A Valkenburg, Vanessa Venturi, Thurston HY Dang, Nicola L Bird, Peter C Doherty, Stephen J Turner, Miles P Davenport, Katherine Kedzierska

Journal article | 2012 | PLoS Pathogens

Electrostatic-mediated enhancement of protein antigen immunogenicity using charged TLR2-targeting lipopeptides

Brendon Y Chua, David Pejoski, Stephen J Turner, Weiguang Zeng, David C Jackson

Journal article | 2012 | Procedia in Vaccinology

Defining the molecular blueprint that drives CD8( ) T cell differentiation in response to infection

Brendan E Russ, Alice E Denton, Lauren Hatton, Hayley Croom, Matthew R Olson, Stephen J Turner

Journal article | 2012 | Frontiers in Immunology

Affinity Thresholds for Naive CD8( ) CTL Activation by Peptides and Engineered Influenza A Viruses

Alice E Denton, Robb Wesselingh, Stephanie Gras, Carole Guillonneau, Matthew R Olson, Justine D Mintern, Weiguang Zeng, David C Jackson, Jamie Rossjohn, Philip D Hodgkin, Peter C Doherty, Stephen J Turner

Journal article | 2011 | Journal of Immunology

alpha beta T Cell Receptors Come Out Swinging

Stephen J Turner, Jamie Rossjohn

Journal article | 2011 | Immunity

Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8( ) T cells

Alice E Denton, Brendan E Russ, Peter C Doherty, Sudha Rao, Stephen J Turner

Journal article | 2011 | Proceedings of the National Academy of Sciences of the United States of America

Soluble Proteins Induce Strong CD8( ) T Cell and Antibody Responses through Electrostatic Association with Simple Cationic or Anionic Lipopeptides That Target TLR2

Brendon Y Chua, David Pejoski, Stephen J Turner, Weiguang Zeng, David C Jackson

Journal article | 2011 | Journal of Immunology

A semi-invariant V(alpha)10( ) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

Adam P Uldrich, Onisha Patel, Garth Cameron, Daniel G Pellicci, E Bridie Day, Lucy C Sullivan, Konstantinos Kyparissoudis, Lars Kjer-Nielsen, Julian P Vivian, Benjamin Cao, Andrew G Brooks, Spencer J Williams, Petr Illarionov, Gurdyal S Besra, Stephen J Turner, Steven A Porcelli, James McCluskey, Mark J Smyth, Jamie Rossjohn, Dale I Godfrey

Journal article | 2011 | Nature Immunology

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8( ) T-cell responses

E Bridie Day, Carole Guillonneau, Stephanie Gras, Nicole L La Gruta, Dario AA Vignali, Peter C Doherty, Anthony W Purcell, Jamie Rossjohn, Stephen J Turner

Journal article | 2011 | Proceedings of the National Academy of Sciences of the United States of America

Effect of MHC Class I Diversification on Influenza Epitope-Specific CD8( ) T Cell Precursor Frequency and Subsequent Effector Function

E Bridie Day, Kim L Charlton, Nicole L La Gruta, Peter C Doherty, Stephen J Turner

Journal article | 2011 | Journal of Immunology

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

Shirley GK Seah, Robyn M Sutherland, Nicole L La Gruta, Lorena E Brown, Emma M Carrington, Gabrielle T Belz, Jamie L Brady, Stephen J Turner, Yifan Zhan, Andrew M Lew

Journal article | 2011 | European Journal of Immunology

Memory precursor phenotype of CD8( ) T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection

Hayley A Croom, Alice E Denton, Sophie A Valkenburg, Natasha G Swan, Matthew R Olson, Stephen J Turner, Peter C Doherty, Katherine Kedzierska

Journal article | 2011 | European Journal of Immunology

Precision Medicine: Dawn of Supercomputing in ‘omics Research

M Reumann, KE Holt, M Inouye, T Stinear, B Goudey, G Abraham, Q WANG, F Shi, A Kowalczyk, A Pearce, A Isaac, BJ Pope, H Butzkueven, J Wagner, S Moore, M Downton, PC Church, SJ Turner, J Field, M Southey, et al.

Conference Proceedings | 2011

T-cell immunity against the A(H1N1) 2009 pandemic virus

S VALKENBURG, K Laurie, A Kelso, SJT Turner, PCD Doherty, KK Kedzierska

Journal article | 2011 | Microbiology Australia

Shaping the T-cell repertoire in the periphery

Stacey Allen, Stephen J Turner, Dorothee Bourges, Paul A Gleeson, Ian R van Driel

Journal article | 2011 | Immunology and Cell Biology

The Immune Response to Influenza A Viruses

Justine D Mintern, Carole Guillonneau, Stephen J Turner, Peter C Doherty

Journal article | 2011 | Birkhauser Advances in Infectious Diseases

Influenza Epitope-Specific CD8( ) T Cell Avidity, but Not Cytokine Polyfunctionality, Can Be Determined by TCR beta Clonotype

Jessica M Moffat, Andreas Handel, Peter C Doherty, Stephen J Turner, Paul G Thomas, Nicole L La Gruta

Journal article | 2010 | Journal of Immunology

Q&A: H1N1 pandemic influenza - what's new?

Stephen J Turner, Peter C Doherty, Anne Kelso

Journal article | 2010 | BMC Biology

Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8( ) T cells

Sophie A Valkenburg, E Bridie Day, Natasha G Swan, Hayley A Croom, Francis R Carbone, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

Journal article | 2010 | European Journal of Immunology

Multiplexed combinatorial tetramer staining in a mouse model of virus infection

Tania Cukalac, Sophie A Valkenburg, Nicole L La Gruta, Stephen J Turner, Peter C Doherty, Katherine Kedzierska

Journal article | 2010 | Journal of Immunological Methods

Protective Efficacy of Cross-Reactive CD8( ) T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L La Gruta, Paul G Thomas, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

Journal article | 2010 | PLoS Pathogens

Forewarned Is Forearmed

Nicole La Gruta, Stephen J Turner

Journal article | 2010 | Immunity

Cross- reactive CD8( ) T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses

Stephanie Gras, Lukasz Kedzierski, Sophie A Valkenburg, Karen Laurie, Yu Chih Liu, Justin T Denholm, Michael J Richards, Guus F Rimmelzwaan, Anne Kelso, Peter C Doherty, Stephen J Turner, Jamie Rossjohn, Katherine Kedzierska

Journal article | 2010 | Proceedings of the National Academy of Sciences of the United States of America

The Role of Epigenetics in the Acquisition and Maintenance of Effector Function in Virus-Specific CD8 T Cells

Matthew R Olson, Brendan E Russ, Peter C Doherty, Stephen J Turner

Journal article | 2010 | IUBMB Life

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

Nicole L La Gruta, William T Rothwell, Tania Cukalac, Natasha G Swan, Sophie A Valkenburg, Katherine Kedzierska, Paul G Thomas, Peter C Doherty, Stephen J Turner

Journal article | 2010 | Journal of Clinical Investigation

Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

Alex Theodossis, Carole Guillonneau, Andrew Welland, Lauren K Ely, Craig S Clements, Nicholas A Williamson, Andrew I Webb, Jacqueline A Wilce, Roger J Mulder, Michelle A Dunstone, Peter C Doherty, James McCluskey, Anthony W Purcell, Stephen J Turner, Jamie Rossjohn

Journal article | 2010 | Proceedings of the National Academy of Sciences of the United States of America

Influenza A virus-specific CD8( ) T-cell responses: from induction to function

MR Olson, BE Russ, PC Doherty, SJ Turner, J Stambas

Journal article | 2010 | Future Virology

Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression (vol 183, pg 7063, 2009)

Torsten Juelich, Elissa L Sutcliffe, Alice Denton, Yiqing He, Peter C Doherty, Christopher R Parish, Stephen J Turner, David J Tremethick, Sudha Rao

Journal article | 2010 | The Journal of Immunology

Q&A: H1N1 pandemic influenza - what's new?

S TURNER, P DOHERTY, A KELSO

Journal article | 2010 | BMC Biology

Interplay between Chromatin Remodeling and Epigenetic Changes during Lineage-Specific Commitment to Granzyme B Expression

Torsten Juelich, Elissa Sutcliffe, Alice Denton, Yiqing He, Peter C Doherty, Christopher Parish, Steven J Turner, David Tremethick, Sudha Rao

Journal article | 2009 | Journal of Immunology

Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env(311-320) virus

Tania Cukalac, Jessica M Moffat, Vanessa Venturi, Miles P Davenport, Peter C Doherty, Stephen J Turner, John Stambas

Journal article | 2009 | Vaccine

Role of CD8( ) T-cell immunity in influenza infection: potential use in future vaccine development.

Nicole La Gruta, Anne Kelso, Lorena E Brown, Wiesan Chen, David C Jackson, Stephen J Turner

Journal article | 2009 | Expert Review of Respiratory Medicine

Continued circulation of the highly pathogenic avian H5N1 influenza A virus has many people worried that an influenza pandemic is ..

Evaluation of Recombinant Influenza Virus-Simian Immunodeficiency Virus Vaccines in Macaques

Amy Sexton, Robert De Rose, Jeanette C Reece, Sheilajen Alcantara, Liyen Loh, Jessica M Moffat, Karen Laurie, Aeron Hurt, Peter C Doherty, Stephen J Turner, Stephen J Kent, John Stambas

Journal article | 2009 | Journal of Virology

Functional implications of T cell receptor diversity

Stephen J Turner, Nicole L La Gruta, Katherine Kedzierska, Paul G Thomas, Peter C Doherty

Journal article | 2009 | Current Opinion in Immunology

Thinking About Broadly Cross-Reactive Vaccines

PC Doherty, SJ Turner

Journal article | 2009 | Clinical Pharmacology and Therapeutics

Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection

Jessica M Moffat, Thomas Gebhardt, Peter C Doherty, Stephen J Turner, Justine D Mintern

Journal article | 2009 | European Journal of Immunology

Transience of MHC Class I-restricted antigen presentation after influenza A virus infection

Justine D Mintern, Sammy Bedoui, Gayle M Davey, Jessica M Moffat, Peter C Doherty, Stephen J Turner

Journal article | 2009 | Proceedings of the National Academy of Sciences of the United States of America

Visualizing CTL activity for different CD8( ) effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing

MR Jenkins, NL La Gruta, PC Doherty, JA Trapani, SJ Turner, NJ Waterhouse

Journal article | 2009 | Cell Death & Differentiation

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity

Carole Guillonneau, Justine D Mintern, Francois-Xavier Hubert, Aeron C Hurt, Gurdyal S Besra, Steven Porcelli, Ian G Barr, Peter C Doherty, Dale I Godfrey, Stephen J Turner

Journal article | 2009 | Proceedings of the National Academy of Sciences of the United States of America

Chimeric virus-like particles for the delivery of an inserted conserved influenza A-specific CTL epitope

Wan-Shoo Cheong, Jessica Reiseger, Stephen John Turner, Richard Boyd, Hans-Jurgen Netter

Journal article | 2009 | Antiviral Research

Division-linked differentiation can account for CD8( ) T-cell phenotype in vivo

Timothy E Schlub, Vanessa Venturi, Katherine Kedzierska, Cameron Wellard, Peter C Doherty, Stephen J Turner, Ruy M Ribeiro, Philip D Hodgkin, Miles P Davenport

Journal article | 2009 | European Journal of Immunology

Q&A: What do we know about influenza and what can we do about it?

P DOHERTY, S TURNER

Journal article | 2009 | Journal of Biology

Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus?

S TURNER, L BROWN, P DOHERTY, A Kelso

Journal article | 2009 | Journal of Biology

Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus?

Stephen J Turner, Lorena E Brown, Peter C Doherty, Anne Kelso

Journal article | 2009 | Journal of Biology

Q&A: What do we know about influenza and what can we do about it?

Peter C Doherty, Stephen J Turner

Journal article | 2009 | Journal of Biology

Complete modification of TCR specificity and repertoire selection does not perturb a CD8( ) T cell immunodominance hierarchy

Katherine Kedzierska, Carole Guillonneau, Stephanie Gras, Lauren A Hatton, Richard Webby, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner

Journal article | 2008 | Proceedings of the National Academy of Sciences of the United States of America

Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination

Annett Miller, Rob J Center, John Stambas, Georgia Deliyannis, Peter C Doherty, Jane L Howard, Stephen J Turner, Damian FJ Purcell

Journal article | 2008 | Vaccine

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8( ) T cells

Misty R Jenkins, Justine Mintern, Nicole L La Gruta, Katherine Kedzierska, Peter C Doherty, Stephen J Turner

Journal article | 2008 | Journal of Immunology

Granzyme K Expressing Cytotoxic T Lymphocytes Protects Against Influenza Virus in Granzyme AB(-/-) Mice

Misty R Jenkins, Joseph A Trapani, Peter C Doherty, Stephen J Turner

Journal article | 2008 | Viral Immunology

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8( ) TCR repertoires and facilitates optimal CTL responses

Katherine Kedzierska, Paul G Thomas, Vanessa Venturi, Miles P Davenport, Peter C Doherty, Stephen J Turner, Nicole L La Gruta

Journal article | 2008 | Journal of Immunology

Anti-SIV Cytolytic Molecules in Pigtail Macaques

Erik Rollman, Stephen J Turner, Katherine Kedzierska, Stephen J Kent

Journal article | 2008 | AIDS Research and Human Retroviruses

Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice

Rosa C Gualano, Michelle J Hansen, Ross Vlahos, Jessica E Jones, Ruth A Park-Jones, Georgia Deliyannis, Stephen J Turner, Karen A Duca, Gary P Anderson

Journal article | 2008 | Respiratory Research

Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice.

Rosa C Gualano, Michelle J Hansen, Ross Vlahos, Jessica E Jones, Ruth A Park-Jones, Georgia Deliyannis, Stephen J Turner, Karen A Duca, Gary P Anderson

Journal article | 2008 | Respiratory research

BACKGROUND: Cigarette smoke has both pro-inflammatory and immunosuppressive effects. Both active and passive cigarette smoke expos..

Homogenization of TCR repertoires within secondary CD62L(high) and CD62L(low) virus-specific CD8( ) T cell populations

Katherine Kedzierska, Vanessa Venturi, Sophie A Valkenburg, Miles P Davenport, Stephen J Turner, Peter C Doherty

Journal article | 2008 | Journal of Immunology

Epitope-specific TCR beta repertoire diversity imparts no functional advantage on the CD8( ) T cell response to cognate viral peptides

Nicole L La Gruta, Paul G Thomas, Andrew I Webb, Michelle A Dunstone, Tania Cukalac, Peter C Doherty, Anthony W Purcell, Jamie Rossjohn, Stephen J Turner

Journal article | 2008 | Proceedings of the National Academy of Sciences of the United States of America

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

Katherine Kedzierska, Nicole L La Gruta, John Stambas, Stephen J Turner, Peter C Doherty

Journal article | 2008 | Molecular Microbiology

Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield

Peter Halasz, Gavan Holloway, Stephen J Turner, Barbara S Coulson

Journal article | 2008 | Journal of Virology

Lipopeptide Vaccines Illustrate the Potential Role of Subtype-Crossreactive T Cell Responses in the Control of Seasonal and Pandemic Influenza

L BROWN, G Deliyannis, K KEDZIERSKA, YF LAU, WC NG, W ZENG, B GILBERTSON, B LIM, JCA COBBIN, D JACKSON, S TURNER, A KELSO

Conference Proceedings | 2008 | Options for the Control of Influenza VI

Method for assessing the similarity between subsets of the T cell receptor repertoire

Vanessa Venturi, Katherine Kedzierska, Mark M Tanaka, Stephen J Turner, Peter C Doherty, Miles P Davenport

Journal article | 2008 | Journal of Immunological Methods

The immune response to influenza A viruses

J MINTERN, C GUILLONNEAU, S TURNER, P DOHERTY

Book Chapter | 2008