Michael Kershaw

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  The FEBS Journal

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells.

Jack D Chan, Bianca von Scheidt, Bijun Zeng, Amanda J Oliver, Ashleigh S Davey, Aesha I Ali, Ranjeny Thomas, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw, Riccardo Dolcetti, Clare Y Slaney

Journal article  |  2020  |  Clinical & Translational Immunology

Objectives: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achie..

Enterotoxins can support CAR T cells against solid tumors

Bianca von Scheidt, Minyu Wang, Amanda J Oliver, Jack D Chan, Metta K Jana, Aesha I Ali, Fiona Clow, John D Fraser, Kylie M Quinn, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Enhancing CAR T cell therapy by enabling their interaction with antigen-presenting cells

CY Slaney, P Wang, JD Chan, PK Darcy, MH Kershaw

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

DEVELOPMENT OF NEXT GENERATION CAR'S TARGETING THE LEWIS Y ANTIGEN FOR THE TREATMENT OF CANCER

D Meyran, J Zhu, J Buttler, D Tantalo, M Neeson, P Ekert, M Kershaw, J Trapani, P Darcy, P Neeson

Conference Proceedings  |  2019  |  Cytotherapy

Genetic Redirection of T Cells for the Treatment of Pancreatic Cancer

Aesha I Ali, Amanda J Oliver, Tinaz Samiei, Jack D Chan, Michael H Kershaw, Clare Y Slaney

Journal article  |  2019  |  Frontiers in Oncology

Tissue-specific tumor microenvironments influence responses to immunotherapies

Amanda J Oliver, Ashleigh S Davey, Simon P Keam, Sherly Mardiana, Jack D Chan, Bianca von Scheidt, Paul A Beavis, Imran G House, Jonas RM Van Audernaerde, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2019  |  Clinical & Translational Immunology

Objectives: Investigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenviro..

Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Joseph Cherng Huei Kong, Glen Robert Guerra, Rosemary Magdalena Millen, Sara Roth, Huiling Xu, Paul Joseph Neeson, Phillip Kevin Darcy, Michael Henry Kershaw, Shienny Sampurno, Jordane Malaterre, David Shi Hao Liu, Duc Pham Toan, Vignesh Narasimhan, Minyu Wang, Yu-Kuan Huang, Kumar Visvanathan, Jacob McCormick, Andrew Craig Lynch, Satish Warrier, Michael Michael, et al.

Journal article  |  2018  |  JCO Precision Oncology

Natural killer cells and their therapeutic role in pancreatic cancer: A systematic review

Jonas RM Van Audenaerde, Geert Roeyen, Phillip K Darcy, Michael H Kershaw, M Peeters, Evelien LJ Smits

Journal article  |  2018  |  Pharmacology & Therapeutics

Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4( )Foxp3(-) Cell-Mediated Modulation of CD103( ) Dendritic Cells

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Alexander J Davenport, Emma V Petley, Imran G House, Junyun Lai, Kevin Sek, Nicole Milenkovski, Liza B John, Sherly Mardiana, Clare Y Slaney, Joseph A Trapani, Sherene Loi, Michael H Kershaw, Nicole M Haynes, Phillip K Darcy

Journal article  |  2018  |  Cancer Immunology Research

CARs versus BiTEs: A Comparison between T Cell-Redirection Strategies for Cancer Treatment

Clare Y Slaney, Pin Wang, Phillip K Darcy, Michael H Kershaw

Journal article  |  2018  |  Cancer Discovery

Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma

H Halse, AJ Colebatch, P Petrone, MA Henderson, JK Mills, H Snow, JA Westwood, S Sandhu, JM Raleigh, A Behren, J Cebon, PK Darcy, MH Kershaw, GA McArthur, DE Gyorki, PJ Neeson

Journal article  |  2018  |  Scientific Reports

A multifunctional role for adjuvant anti-4-1BB therapy in augmenting antitumor responses by CAR T cells

Sherly Mardiana, Liza B John, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

Conference Proceedings  |  2018  |  Clinical Research (Excluding Clinical Trials)

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown, Andrew Grigg, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

AJ Davenport, RS Cross, KA Watson, Y Liao, W Shi, HM Prince, PA Beavis, JA Trapani, MH Kershaw, DS Ritchie, PK Darcy, PJ Neeson, MR Jenkins

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Tissue-Dependent Tumor Microenvironments and Their impact on immunotherapy Responses

Amanda J Oliver, Peter KH Lau, Ashleigh S Unsworth, Sherene Loi, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Jennifer A Westwood, Sarah Ellis, Jill Danne, Chad Johnson, Viola Oorschot, Georg Ramm, David C Tscharke, Alexander J Davenport, James C Whisstock, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2017  |  Oncotarget

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Sathana Dushyanthen, Zhi Ling Teo, Franco Caramia, Peter Savas, Christopher P Mintoff, Balaji Virassamy, Melissa A Henderson, Stephen J Luen, Mariam Mansour, Michael H Kershaw, Joseph A Trapani, Paul J Neeson, Roberto Salgado, Grant A McArthur, Justin M Balko, Paul A Beavis, Phillip K Darcy, Sherene Loi

Journal article  |  2017  |  Nature Communications

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney, Bianca von Scheidt, Alexander J Davenport, Paul A Beavis, Jennifer A Westwood, Sherly Mardiana, David C Tscharke, Sarah Ellis, H Miles Prince, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth, Michele W Teng, Aesha Ali, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo, Paul Neeson, Phillip K Darcy, Michael H Kershaw

Journal article  |  2017  |  Clinical Cancer Research

CAR T-cell therapy of solid tumors

Carmen SM Yong, Valerie Dardalhon, Christel Devaud, Naomi Taylor, Phillip K Darcy, Michael H Kershaw

Journal article  |  2017  |  Immunology & Cell Biology

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Sherly Mardiana, Liza B John, Melissa A Henderson, Clare Y Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J Davenport, Joseph A Trapani, Paul J Neeson, Sherene Loi, Nicole M Haynes, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

Journal article  |  2017  |  Cancer Research

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Jane K Mills, Kevin Sek, Ryan S Cross, Alexander J Davenport, Liza B John, Sherly Mardiana, Clare Y Slaney, Ricky W Johnstone, Joseph A Trapani, John Stagg, Sherene Loi, Lev Kats, David Gyorki, Michael H Kershaw, Phillip K Darcy

Journal article  |  2017  |  Journal of Clinical Investigation

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

Carmen SM Yong, Liza B John, Christel Devaud, Miles H Prince, Ricky W Johnstone, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw

Journal article  |  2016  |  ONCOTARGET

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, David Gyorki, Paul J Neeson, Phillip K Darcy

Journal article  |  2016  |  Seminars in Immunology

Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice

Carmen SM Yong, Jennifer A Westwood, Jan Schroeder, Anthony T Papenfuss, Bianca von Scheidt, Maria Moeller, Christel Devaud, Phillip K Darcy, Michael H Kershaw

Journal article  |  2015  |  PLOS ONE

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic

Connie PM Duong, Carmen SM Yong, Michael H Kershaw, Clare Y Slaney, Phillip K Darcy

Journal article  |  2015  |  Molecular Immunology

Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene

Carmen SM Yong, Janelle Sharkey, Belinda Duscio, Ben Venville, Wei-Zen Wei, Richard F Jones, Clare Y Slaney, Gisela Mir Arnau, Anthony T Papenfuss, Jan Schroeder, Phillip K Darcy, Michael H Kershaw

Journal article  |  2015  |  PLOS ONE

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses

Paul A Beavis, Nicole Milenkovski, Melissa A Henderson, Liza B John, Bertrand Allard, Sherene Loi, Michael H Kershaw, John Stagg, Phillip K Darcy

Journal article  |  2015  |  CANCER IMMUNOLOGY RESEARCH

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

Alexander J Davenport, Misty R Jenkins, Ryan S Cross, Carmen S Yong, H Miles Prince, David S Ritchie, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  CANCER IMMUNOLOGY RESEARCH

CD73: A potential biomarker for anti-PD-1 therapy

Paul A Beavis, Clare Y Slaney, Nicole Milenkovski, Melissa A Henderson, Sherene Loi, John Stagg, Michael H Kershaw, Phillip K Darcy

Journal article  |  2015  |  OncoImmunology

Cross-talk between tumors can affect responses to therapy

Christel Devaud, Liza B John, Jennifer A Westwood, Carmen SM Yong, Paul A Beavis, Reto A Schwendener, Phillip K Darcy, Michael H Kershaw

Journal article  |  2015  |  OncoImmunology

CAR-T cells are serial killers

Alexander J Davenport, Misty R Jenkins, David S Ritchie, H Miles Prince, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  OncoImmunology

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, Paul J Neeson, Phillip K Darcy

Journal article  |  2015  |  Immunotherapy

Trafficking of T Cells into Tumors

Clare Y Slaney, Michael H Kershaw, Phillip K Darcy

Journal article  |  2014  |  Cancer Research

Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors

Christel Devaud, Jennifer A Westwood, Michele WL Teng, Liza B John, Carmen SM Yong, Connie PM Duong, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  OncoImmunology

Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice

Christel Devaud, Carmen SM Yong, Liza B John, Jennifer A Westwood, Connie PM Duong, Colin M House, Delphine Denoyer, Jason Li, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  PLoS ONE

Foxp3 expression in T regulatory cells and other cell lineages

Christel Devaud, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  CANCER IMMUNOLOGY IMMUNOTHERAPY

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers

Jennifer A Westwood, Geoffrey M Matthews, Jake Shortt, David Faulkner, Hollie J Pegram, Connie PM Duong, Marta Chesi, P Leif Bergsagel, Leslie L Sharp, Richard D Huhn, Phillip K Darcy, Ricky W Johnstone, Michael H Kershaw

Journal article  |  2014  |  Leukemia Research

The potential impact of mouse model selection in preclinical evaluation of cancer immunotherapy

Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  OncoImmunology

Routes of Delivery for CpG and Anti-CD137 for the Treatment of Orthotopic Kidney Tumors in Mice

Jennifer A Westwood, Titaina CU Potdevin Hunnam, Hollie J Pegram, Rodney J Hicks, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  PLoS ONE

Clinical application of genetically modified T cells in cancer therapy.

Michael H Kershaw, Jennifer A Westwood, Clare Y Slaney, Phillip K Darcy

Journal article  |  2014  |  Clinical & Translational Immunology

Immunotherapies are emerging as highly promising approaches for the treatment of cancer. In these approaches, a variety of materia..

Manipulating immune cells for adoptive immunotherapy of cancer

Phillip K Darcy, Paul Neeson, Carmen SM Yong, Michael H Kershaw

Journal article  |  2014  |  Current Opinion in Immunology

Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy

Christel Devaud, Jennifer A Westwood, Liza B John, Jacqueline K Flynn, Sophie Paquet-Fifield, Connie PM Duong, Carmen SM Yong, Hollie J Pegram, Steven A Stacker, Marc G Achen, Trina J Stewart, Linda A Snyder, Michele WL Teng, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  Molecular Therapy

Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia

David S Ritchie, Paul J Neeson, Amit Khot, Stefan Peinert, Tsin Tai, Kellie Tainton, Karen Chen, Mandy Shin, Dominic M Wall, Dirk Hoenemann, Peter Gambell, David A Westerman, Javier Haurat, Jennifer A Westwood, Andrew M Scott, Lucy Kravets, Michael Dickinson, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, et al.

Journal article  |  2013  |  Molecular Therapy

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

Liza B John, Christel Devaud, Connie PM Duong, Carmen S Yong, Paul A Beavis, Nicole M Haynes, Melvyn T Chow, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2013  |  Clinical Cancer Research

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

Liza B John, Michael H Kershaw, Phillip K Darcy

Journal article  |  2013  |  OncoImmunology

Enhancing immunotherapy using chemotherapy and radiation to modify the tumor microenvironment

Michael H Kershaw, Christel Devaud, Liza B John, Jennifer A Westwood, Phillip K Darcy

Journal article  |  2013  |  OncoImmunology

Gene-engineered T cells for cancer therapy

Michael H Kershaw, Jennifer A Westwood, Phillip K Darcy

Journal article  |  2013  |  Nature Reviews Cancer

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy

Christel Devaud, Liza B John, Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  OncoImmunology

Making Macrophages Eat Cancer

Michael H Kershaw, Mark J Smyth

Journal article  |  2013  |  Science

Chimeric antigen receptor-redirected T cells display multifunctional capacity and enhanced tumor-specific cytokine secretion upon secondary ligation of chimeric receptor

Melissa A Henderson, Carmen SM Yong, Connie PM Duong, Alexander J Davenport, Liza B John, Christel Devaud, Paul Neeson, Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  Immunotherapy

Engineering T Cell Function Using Chimeric Antigen Receptors Identified Using a DNA Library Approach

Connie PM Duong, Jennifer A Westwood, Carmen SM Yong, Amanda Murphy, Christel Devaud, Liza B John, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  PLOS ONE

A Mutant Tat Protein Provides Strong Protection from HIV-1 Infection in Human CD4( ) T Cells

Ann Apolloni, Min-Husan Lin, Haran Sivakumaran, Dongsheng Li, Michael HR Kershaw, David Harrich

Journal article  |  2013  |  Human Gene Therapy

Cancer Immunoediting: From Surveillance to Escape

MWL Teng, MH Kershaw, MJ Smyth

Book Chapter  |  2013

Environmental enrichment does not impact on tumor growth in mice.

Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  F1000Research

The effect of environmental enrichment (EE) on a variety of physiologic and disease processes has been studied in laboratory mice...

Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting.

David F Stroncek, Cornelis JM Melief, Luciano Castiello, Alessandra Cesano, Martin A Cheever, Sara Civini, Begonya Comin-Anduix, Thomas F Gajewski, Philip D Greenberg, Pawel Kalinski, Howard L Kaufman, Michael H Kershaw, Samir N Khleif, Francesco Marincola, William Merritt, David H Munn, Daniel J Powell, Nicholas P Restifo, Steven A Rosenberg, Raj K Puri, et al.

Conference Proceedings  |  2013  |  Journal for ImmunoTherapy of Cancer

The 27 annual meeting of the Society for Immunotherapy of Cancer (SITC) was held on October 26–28, 2012 in North Bethesda, Marylan..

Using electroporation to determine function of a chimeric antigen receptor in T cell and macrophage cell lines

CSM Yong, CPM Duong, C Devaud, LB John, PK Darcy, MH Kershaw

Journal article  |  2013  |  The Open Gene Therapy Journal

Virotherapy, gene transfer and immunostimulatory monoclonal antibodies

Jose I Quetglas, Liza B John, Michael H Kershaw, Luis Alvarez-Vallina, Ignacio Melero, Phillip K Darcy, Cristian Smerdou

Journal article  |  2012  |  ONCOIMMUNOLOGY

Oncolytic Virus and Anti-4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer

Liza B John, Linda J Howland, Jacqueline K Flynn, Alison C West, Christel Devaud, Connie P Duong, Trina J Stewart, Jenny A Westwood, Z Sheng Guo, David L Bartlett, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2012  |  Cancer Research

The Adjuvant Effects of Antibodies

Mark J Smyth, Michael H Kershaw

Journal article  |  2011  |  Science

Autoimmunity associated with immunotherapy of cancer

Sally M Amos, Connie PM Duong, Jennifer A Westwood, David S Ritchie, Richard P Junghans, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Blood

Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice

Sally M Amos, Hollie J Pegram, Jennifer A Westwood, Liza B John, Christel Devaud, Chris J Clarke, Nicholas P Restifo, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Cancer Immunology, Immunotherapy

Activating and inhibitory receptors of natural killer cells

Hollie J Pegram, Daniel M Andrews, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Immunology and Cell Biology

Enhancing the specificity of T-cell cultures for adoptive immunotherapy of cancer

Connie PM Duong, Jennifer A Westwood, Linda J Berry, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Immunotherapy

Natural Innate and Adaptive Immunity to Cancer

Matthew D Vesely, Michael H Kershaw, Robert D Schreiber, Mark J Smyth

Journal article  |  2011  |  Annual Review of Immunology

Alloreactive natural killer cells in hematopoietic stem cell transplantation

Hollie J Pegram, David S Ritchie, Mark J Smyth, Andres Wiernik, H Miles Prince, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Leukemia Research

Tumor Ablation by Gene-Modified T Cells in the Absence of Autoimmunity

Leanne XJ Wang, Jennifer A Westwood, Maria Moeller, Connie PM Duong, Wei-Zen Wei, Jordane Malaterre, Joseph A Trapani, Paul Neeson, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2010  |  Cancer Research

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8( ) T cells with effector and central memory-like phenotype

P Neeson, A Shin, KM Tainton, P Guru, HM Prince, SJ Harrison, S Peinert, MJ Smyth, JA Trapani, MH Kershaw, PK Darcy, DS Ritchie

Journal article  |  2010  |  Gene Therapy

Characterizing the anti-tumor function of adoptively transferred NK cells in vivo

Hollie J Pegram, Nicole M Haynes, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2010  |  Cancer Immunology, Immunotherapy

CD11c( ) Dendritic Cells and B Cells Contribute to the Tumoricidal Activity of Anti-DR5 Antibody Therapy in Established Tumors

Nicole M Haynes, Edwin D Hawkins, Ming Li, Nicole M McLaughlin, Guenther J Haemmerling, Reto Schwendener, Astar Winoto, Allen Wensky, Hideo Yagita, Kazuyoshi Takeda, Michael H Kershaw, Phillip K Darcy, Mark J Smyth

Journal article  |  2010  |  Journal of Immunology

Anti-tumor activity of genetically redirected T cells against orthotopic kidney cancer in mice

JA Westwood, P Mayura-Guru, WK Murray, HJ Pegram, SM Amos, CL van Puyenbroek, R Cameron, MJ Smyth, Y Xu, PK Darcy, MH Kershaw

Journal article  |  2010  |  The Open Gene Therapy Journal

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen

S Peinert, HM Prince, PM Guru, MH Kershaw, MJ Smyth, JA Trapani, P Gambell, S Harrison, AM Scott, FE Smyth, PK Darcy, K Tainton, P Neeson, DS Ritchie, D Hoenemann

Journal article  |  2010  |  Gene Therapy

Genetic redirection of T cells for cancer therapy

Jennifer A Westwood, Michael H Kershaw

Journal article  |  2010  |  Journal of Leukocyte Biology

Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice

Jennifer A Westwood, Phillip K Darcy, Preethi Mayura Guru, Janelle Sharkey, Hollie J Pegram, Sally M Amos, Mark J Smyth, Michael H Kershaw

Journal article  |  2010  |  Journal of Translational Medicine

Enhancing adoptive immunotherapy of cancer

Jennifer A Westwood, Linda J Berry, Leanne XJ Wang, Connie PM Duong, Hollie J Pegram, Phillip K Darcy, Michael H Kershaw

Journal article  |  2010  |  Expert Opinion on Biological Therapy

Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice

Jennifer A Westwood, Nicole M Haynes, Janelle Sharkey, Nicole McLaughlin, Hollie J Pegram, Reto A Schwendener, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2009  |  Clinical Cancer Research

Bcl-2 over-expression and genetic manipulation of T cells provides tumor specificity and enhanced resistance to apoptosis in vitro

HJ Pegram, PK Darcy, MH Kershaw

Journal article  |  2009  |  The Open Gene Therapy Journal

Chimeric T cells for adoptive immunotherapy of cancer: using what have we learned to plan for the future

Stefan Peinert, Michael H Kershaw, H Miles Prince

Journal article  |  2009  |  Immunotherapy

Genetic modification of natural killer cells for adoptive cellular immunotherapy

Hollie J Pegram, Michael H Kershaw, Phillip K Darcy

Journal article  |  2009  |  Immunotherapy

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4( ) and CD8( ) T cells for use in the adoptive immunotherapy of cancer

K Birkholz, A Hombach, C Krug, S Reuter, M Kershaw, E Kaempgen, G Schuler, H Abken, N Schaft, J Doerrie

Journal article  |  2009  |  Gene Therapy

The Lewis-Y Carbohydrate Antigen is Expressed by Many Human Tumors and Can Serve as a Target for Genetically Redirected T cells Despite the Presence of Soluble Antigen in Serum

Jennifer A Westwood, William K Murray, Melanie Trivett, Nicole M Haynes, Benjamin Solomon, Linda Mileshkin, David Ball, Michael Michael, Angela Burman, Preethi Mayura-Guru, Joseph A Trapani, Stefan Peinert, Dirk Honemann, H Miles Prince, Andrew M Scott, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2009  |  Journal of Immunotherapy

Genetic Regulation of the Response to Her-2 DNA Vaccination in Human Her-2 Transgenic Mice

Olga Radkevich-Brown, Jennifer Jacob, Nfichael Kershaw, Wei-Zen Wei

Journal article  |  2009  |  Cancer Research

Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer

Benjamin B Williams, Meg Wall, Rebecca Yu Miao, Brenda Williams, Ivan Bertoncello, Michael H Kershaw, Theo Mantamadiotis, Michelle Haber, Murray D Norris, Anand Gautam, Phillip K Darcy, Robert G Ramsay

Journal article  |  2008  |  Cancer Immunology, Immunotherapy

Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo

Hollie J Pegram, Jacob T Jackson, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2008  |  Journal of Immunology

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

JA Westwood, WK Murray, M Trivett, A Shin, P Neeson, DP MacGregor, NM Haynes, JA Trapani, P Mayura-Guru, S Fox, S Peinert, D Honemann, HM Prince, D Ritchie, AM Scott, FE Smyth, MJ Smyth, PK Darcy, MH Kershaw

Journal article  |  2008  |  Gene Therapy

Interleukin 21 enhances antibody-mediated tumor rejection

Mark J Smyth, Michele WL Teng, Janelle Sharkey, Jennifer A Westwood, Nicole M Haynes, Hideo Yagita, Kazuyoshi Takeda, Pallavur V Sivakumar, Michael H Kershaw

Journal article  |  2008  |  Cancer Research

Opening the gateway to tumors

Michael H Kershaw

Journal article  |  2008  |  Nature Medicine

Sustained antigen-specific antitumor recall response mediated by gene-modified CD4( ) T helper-1 and CD8( ) T cells

Maria Moeller, Michael H Kershaw, Rachel Cameron, Jennifer A Westwood, Joseph A Trapani, Mark J Smyth, Phillip K Darcy

Journal article  |  2007  |  Cancer Research

Differential development of murine dendritic cells by GM-CSF versus flt3 ligand has implications for inflammation and trafficking

Yuekang Xu, Yifan Zhan, Andrew M Lew, Shalin H Naik, Michael H Kershaw

Journal article  |  2007  |  Journal of Immunology

Tumor-specific dendritic cells generated by genetic redirection of Toll-like receptor signaling against the tumor-associated antigen, erbB2

Y Xu, PK Darcy, MH Kershaw

Journal article  |  2007  |  Cancer Gene Therapy

Combined natural killer T-cell-based immunotherapy eradicates established tumors in mice

Michele WL Teng, Jennifer A Westwood, Phillip K Darcy, Janelle Sharkey, Moriya Tsuji, Richard W Franck, Steven A Porcelli, Gurdyal S Besra, Kaztiyoshi Takeda, Hideo Yagita, Michael H Kershaw, Mark J Smyth

Journal article  |  2007  |  Cancer Research

Antitumor activity of dual-specific T cells and influenza virus

A Murphy, JA Westwood, LE Brown, MWL Teng, M Moeller, Y Xu, MJ Smyth, P Hwu, PK Darcy, MH Kershaw

Journal article  |  2007  |  Cancer Gene Therapy

Adoptive transfer of chimeric Fc(epsilon)RI gene-modified human T cells for cancer immunotherapy

Michele WL Teng, Michael H Kershaw, Jacob T Jackson, Mark J Smyth, Phillip K Darcy

Journal article  |  2006  |  Human Gene Therapy

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

Michael H Kershaw, Jennifer A Westwood, Linda L Parker, Gang Wang, Zelig Eshhar, Sharon A Mavroukakis, Donald E White, John R Wunderlich, Silvana Canevari, Linda Rogers-Freezer, Clara C Chen, James C Yang, Steven A Rosenberg, Patrick Hwu

Journal article  |  2006  |  Clinical Cancer Research

Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

JA Westwood, MJ Smyth, MWL Teng, M Moeller, JA Trapani, AM Scott, FE Smyth, GA Cartwright, BE Power, D Honemann, HM Prince, PK Darcy, MH Kershaw

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

Supernatural T cells: Genetic modification of T cells for cancer therapy

MH Kershaw, MWL Teng, MJ Smyth, PK Darcy

Journal article  |  2005  |  Nature Reviews Immunology

T cells gene-engineered with DAP12 mediate effector function in an NKG2D-dependent and major histocompatibility complex-independent manner

MWL Teng, MH Kershaw, Y Hayakawa, L Cerutti, SM Jane, PK Darcy, MJ Smyth

Journal article  |  2005  |  Journal of Biological Chemistry

Adoptive transfer of gene-engineered CD4( ) helper T cells induces potent primary and secondary tumor rejection

M Moeller, NM Haynes, MH Kershaw, JT Jackson, MWL Teng, SE Street, L Cerutti, SM Jane, JA Trapani, MJ Smyth, PK Darcy

Journal article  |  2005  |  Blood

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation

MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, SJ Thomas, A Pasam, R Iazzolino, LE Dow, NJ Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert, SM Russell

Journal article  |  2005  |  Immunity

Gene modification strategies to induce tumor immunity

A Murphy, JA Westwood, MWL Teng, M Moeller, PK Darcy, MH Kershaw

Journal article  |  2005  |  Immunity

Cytokines in cancer immunity and immunotherapy

MJ Smyth, E Cretney, MH Kershaw, Y Hayakawa

Journal article  |  2004  |  Immunological Reviews

Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer

MH Kershaw, JT Jackson, NM Haynes, MWL Teng, M Moeller, Y Hayakawa, SE Street, R Cameron, JE Tanner, JA Trapani, MJ Smyth, PK Darcy

Journal article  |  2004  |  Journal of Immunology

Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes

MWL Teng, MH Kershaw, M Moeller, MJ Smyth, PK Darcy

Journal article  |  2004  |  Human Gene Therapy

A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

M Moeller, NM Haynes, JA Trapani, MWL Teng, JT Jackson, JE Tanner, L Cerutti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2004  |  Cancer Gene Therapy

Cutting edge: Novel priming of tumor-speciftic immunity by NKG2D-triggered NK cell-mediated tumor rejection and Th1-independent CD4( ) T cell pathway

JA Westwood, JM Kelly, JE Tanner, MH Kershaw, MJ Smyth, Y Hayakawa

Journal article  |  2004  |  The Journal of Immunology

Discovery of an innate cancer resistance gene?

Mark J Smyth, Michael H Kershaw

Journal article  |  2003  |  Molecular Interventions

Dual-specific T cells combine proliferation and antitumor activity

MH Kershaw, JA Westwood, P Hwu

Journal article  |  2002  |  Nature Biotechnology

Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation

NM Haynes, JA Trapani, MWL Teng, JT Jackson, L Cerruti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2002  |  Journal of Immunology

Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2

MH Kershaw, G Wang, JA Westwood, RK Pachynski, HL Tiffany, FM Marincola, E Wang, HA Young, PM Murphy, P Hwu

Journal article  |  2002  |  Human Gene Therapy

MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells

JM Sloan, MH Kershaw, CE Touloukian, R Lapointe, PF Robbins, NP Restifo, P Hwu

Journal article  |  2002  |  Cancer Gene Therapy

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

NM Haynes, JA Trapani, MWL Teng, JT Jackson, L Cerruti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2002  |  Gene Therapy

Increased functional expression of transgene in primary human lymphocytes using retroviral vectors modified with IRES and splicing motifs

RE Royal, MH Kershaw, ME Reeves, G Wang, T Daly, J Treisman, J Lam, P Hwu

Journal article  |  2002  |  Gene Therapy

Immunization against endogenous retroviral tumor-associated antigens

MH Kershaw, C Hsu, W Mondesire, LL Parker, G Wang, WW Overwijk, R Lapointe, JC Yang, RF Wang, NP Restifo, P Hwu

Journal article  |  2001  |  Cancer Research

Generation of gene-modified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature

MH Kershaw, JA Westwood, ZP Zhu, L Witte, SK Libutti, P Hwu

Journal article  |  2000  |  Human Gene Therapy

Recognition of human colon cancer by T cells transduced with a chimeric receptor gene

T Daly, RE Royal, MH Kershaw, J Treisman, G Wang, WP Li, D Herlyn, Z Eshhar, P Hwu

Journal article  |  2000  |  Cancer Gene Therapy

Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes

NM Haynes, MJ Smyth, MH Kershaw, JA Trapani, PK Darcy

Journal article  |  1999  |  Cancer Immunology, Immunotherapy

Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing

RW Johnstone, MH Kershaw, JA Trapani

Journal article  |  1998  |  Biochemistry

Xenospecific CD8( ) cytotoxic T lymphocyte generation - Accessory function for CD4( ) T cells and natural killer 1.1( ) cells

MJ Smyth, MH Kershaw, PK Darcy

Journal article  |  1998  |  Transplantation

Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma

PK Darcy, MH Kershaw, JA Trapani, MJ Smyth

Journal article  |  1998  |  European Journal of Immunology

Adoptive transfer: The role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo

MJ Smyth, MH Kershaw, PK Darcy, JA Trapani

Journal article  |  1998  |  Xenotransplantation

Hormonal regulation of spermatogenesis in the hypophysectomized rat: FSH maintenance of cellular viability during pubertal spermatogenesis.

LD Russell, M Kershaw, KE Borg, A El Shennawy, SS Rulli, RJ Gates, RS Calandra

Journal article  |  1998  |  Journal of Andrology

The potential for follicle-stimulating hormone (FSH) to promote germ-cell survival and the cellular sites of FSH action were studi..

Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth

MH Kershaw, PK Darcy, JA Trapani, D MacGregor, MJ Smyth

Journal article  |  1998  |  Oncology Research

Xenogeneic mouse anti-human NK cytotoxicity is mediated via perforin

MJ Smyth, KYT Thia, MH Kershaw

Journal article  |  1997  |  Xenotransplantation

Xenospecific cytotoxic T lymphocytes - Potent lysis in vitro and in vivo

MJ Smyth, MH Kershaw, JA Trapani

Journal article  |  1997  |  Transplantation

The use of chimeric human FC epsilon receptor I to redirect cytotoxic T lymphocytes to tumors

MH Kershaw, PK Darcy, JA Trapani, MJ Smyth

Journal article  |  1996  |  Journal of Leukocyte Biology

Xenospecific cytotoxic T lymphocytes use perforin- and Fas-mediated lytic pathways

MJ Smyth, VR Sutton, MH Kershaw, JA Trapani

Journal article  |  1996  |  Transplantation

Redirected cytotoxic effector function - Requirements for expression of chimeric single chain high affinity immunoglobulin E receptors

MH Kershaw, PK Darcy, MD Hulett, PM Hogarth, JA Trapani, MJ Smyth

Journal article  |  1996  |  Journal of Biological Chemistry

A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1

MJ Smyth, MD OConnor, JA Trapani, MH Kershaw, RI Brinkworth

Journal article  |  1996  |  Journal of Immunology

Cytotoxic lymphocyte-mediated immunotherapy

MJ Smyth, MH Kershaw

Journal article  |  1995  |  Australian and New Zealand Journal of Medicine

Cytotoxic CD8+ T cells and NK cells play a role in the elimination of some viruses, graft rejection, antitumour responses, immunor..

Cytotoxic lymphocytes: redirecting the cell-mediated immune response for the therapy of cancer.

MH Kershaw, JA Trapani, MJ Smyth

Journal article  |  1995  |  Therapeutic Immunology

Cytotoxic CD8+ T cells and NK cells are involved in the elimination of some viruses, graft rejection, antitumour responses, immuno..

USE OF THE 5'-FLANKING REGION OF THE MOUSE PERFORIN GENE TO EXPRESS HUMAN FC-GAMMA RECEPTOR-I IN CYTOTOXIC T-LYMPHOCYTES

MJ SMYTH, MH KERSHAW, MD HULETT, IFC MCKENZIE, JA TRAPANI

Journal article  |  1994  |  Journal of Leukocyte Biology

HYPOTHESIS - CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES ACTIVATE TARGET-CELL ENDONUCLEASES TO TRIGGER APOPTOSIS

MJ SMYTH, KA BROWNE, KYT THIA, VA APOSTOLIDIS, MH KERSHAW, JA TRAPANI

Journal article  |  1994  |  Clinical and Experimental Pharmacology and Physiology

Upon interaction with target cells, cytotoxic T lymphocytes and natural killer cells vectorially secrete highly specialized cytopl..