Michael Kershaw

A histone deacetylase inhibitor, panobinostat, enhances chimeric receptor antigen T cell anti-tumor effect against pancreatic cancer.

Aesha I Ali, Minyu Wang, Bianca von Scheidt, Pilar M Dominguez, Aaron J Harrison, Daniela GM Tantalo, Jian Kang, Amanda J Oliver, Jack D Chan, Xin Du, Yuchen Bai, Belinda Lee, Ricky W Johnstone, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2021  |  Clin Cancer Res

PURPOSE: Here we describe a combination chimeric antigen receptor (CAR) T cell therapy that eradicated the majority of tumors in t..

Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies.

Daniela Gm Tantalo, Amanda J Oliver, Bianca von Scheidt, Aaron J Harrison, Scott N Mueller, Michael H Kershaw, Clare Y Slaney

Journal article  |  2021  |  J Immunother Cancer

Rapid advances in immunotherapy have identified adoptive cell transfer as one of the most promising approaches for the treatment o..

Generating CAR T cells from tumor-infiltrating lymphocytes.

Jane K Mills, Melissa A Henderson, Lauren Giuffrida, Pasquale Petrone, Jennifer A Westwood, Phillip K Darcy, Paul J Neeson, Michael H Kershaw, David E Gyorki

Journal article  |  2021  |  Ther Adv Vaccines Immunother

Background: Tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T-cell therapies have demonstrated promising..

Enhancing co-stimulation of CAR T cells to improve treatment outcomes in solid cancers

Aaron J Harrison, Xin Du, Bianca von Scheidt, Michael H Kershaw, Clare Y Slaney

Journal article  |  2021  |  Immunotherapy Advances

Summary Co-stimulation is a fundamental component of T cell biology and plays a key role in determining the quality..

EARLY-PHENOTYPE LEWIS Y CAR-T CELLS PERSIST BETTER IN VIVO AND INDUCE SOLID TUMOR REGRESSION IN COMBINATION WITH ANTI-PD1

Deborah Meyran, Joe Zhu, Jeanne Butler, Sean Macdonald, Daniela Tantalo, Niko Thio, Kevin Sek, Paul Ekert, Michael Kershaw, Joe Trapani, Phillip Darcy, Paul Neeson

Conference Proceedings  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BackgroundChimeric antigen receptor (CAR-T) cells are a promising new therapy for patients with cancer. However, in contrast to th..

Challenges and Opportunities for Effective Cancer Immunotherapies

Clare Y Slaney, Michael H Kershaw

Journal article  |  2020  |  CANCERS

Using immunotherapy to treat cancers can be traced back to the 1890s, where a New York physician William Coley used heat-killed ba..

NOVEL COMBINATION IMMUNOTHERAPY FOR BOOSTING AND PRIMING IMMUNE RESPONSES IN PANCREATIC CANCER: STRONG ANTI-TUMOUR EFFECTS WITH INTERLEUKIN-15 AND CD40 AGONIST TREATMENT

Jonas Van Audenaerde, Elly Marcq, Bianca von Scheidt, Ashleigh Davey, Amanda Oliver, Jorrit De Waele, Delphine Quatannens, Jinthe Van Loenhout, Patrick Pauwels, Geert Roeyen, Filip Lardon, Clare Slaney, Marc Peeters, Michael Kershaw, Phillip Darcy, Evelien Smits

Conference Proceedings  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BackgroundWith the poorest 5-year survival of all cancers, improving treatment for pancreatic cancer is one of the biggest challen..

Tissue-specific tumour microenvironments are an emerging determinant of immunotherapy responses

Amanda J Oliver, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  JOURNAL OF THORACIC DISEASE

Chimeric antigen receptor T cell therapies for thoracic cancers-challenges and opportunities

Jack D Chan, Aaron J Harrison, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  JOURNAL OF THORACIC DISEASE

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  FEBS JOURNAL

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..