Leonard Harrison

Multi-level remodelling of chromatin underlying activation of human T cells.

Naiara G Bediaga, Hannah D Coughlan, Timothy M Johanson, Alexandra L Garnham, Gaetano Naselli, Jan Schröder, Liam G Fearnley, Esther Bandala-Sanchez, Rhys S Allan, Gordon K Smyth, Leonard C Harrison

Journal article  |  2021  |  Scientific Reports

Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage develop..

Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study

Megan AS Penno, Helena Oakey, Priya Augustine, Mario Taranto, Simon C Barry, Peter G Colman, Maria E Craig, Elizabeth A Davis, Lynne C Giles, Mark Harris, Aveni Haynes, Kelly McGorm, Grant Morahan, Claire Morbey, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth, et al.

Journal article  |  2020  |  Pediatric Diabetes

AIM: We aimed to monitor pancreatic exocrine function longitudinally in relation to the development of islet autoimmunity and type..

Clinical trial data validate the C-peptide estimate model in type 1 diabetes

John M Wentworth, Naiara G Bediaga, Stephen E Gitelman, Carmela Evans-Molina, Peter A Gottlieb, Peter G Colman, Michael J Haller, Leonard C Harrison

Journal article  |  2020  |  Diabetologia

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Peter J Vuillermin, Martin O'Hely, Fiona Collier, Katrina J Allen, Mimi LK Tang, Leonard C Harrison, John B Carlin, Richard Saffery, Sarath Ranganathan, Peter D Sly, Lawrence Gray, John Molloy, Angela Pezic, Michael Conlon, David Topping, Karen Nelson, Charles R Mackay, Laurence Macia, Jennifer Koplin, Samantha L Dawson, et al.

Journal article  |  2020  |  Nature Communications

In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have..

Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter I Lipkin, Kelly McGorm, Grant Morahan, Claire Morbey, Ignatius CN Pang, et al.

Journal article  |  2020  |  Pediatric Diabetes

Background: Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compar..

Gut microbiota composition during infancy and subsequent behavioural outcomes

Amy Loughman, Anne-Louise Ponsonby, Martin O'Hely, Christos Symeonides, Fiona Collier, Mimi LK Tang, John Carlin, Sarath Ranganathan, Katrina Allen, Angela Pezic, Richard Saffery, Felice Jacka, Leonard C Harrison, Peter D Sly, Peter Vuillermin

Journal article  |  2020  |  EBioMedicine

BACKGROUND: Despite intense interest in the relationship between gut microbiota and brain development, longitudinal data from huma..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

Siglec-10 expression is up-regulated in activated human CD4( ) T cells

E Bandala-Sanchez, NG Bediaga, G Naselli, AM Neale, LC Harrison

Journal article  |  2020  |  Human Immunology

Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on hu..

Does rotavirus turn on type 1 diabetes?

Leonard C Harrison, Kirsten P Perrett, Kim Jachno, Terry M Nolan, Margo C Honeyman

Journal article  |  2019  |  PLoS Pathogens

Naive regulatory T cells in infancy: Associations with perinatal factors and development of food allergy

Fiona Collier, Anne-Louise Ponsonby, Martin O'Hely, Mimi LK Tang, Richard Saffery, John Molloy, Lawrence E Gray, Sarath Ranganathan, David Burgner, Katrina J Allen, Susanne Brix, Peter J Vuillermin

Journal article  |  2019  |  Allergy

BACKGROUND: In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequen..