Leonard Harrison

Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study

Megan AS Penno, Helena Oakey, Priya Augustine, Mario Taranto, Simon C Barry, Peter G Colman, Maria E Craig, Elizabeth A Davis, Lynne C Giles, Mark Harris, Aveni Haynes, Kelly McGorm, Grant Morahan, Claire Morbey, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth, et al.

Journal article  |  2020  |  Pediatric Diabetes

AIM: We aimed to monitor pancreatic exocrine function longitudinally in relation to the development of islet autoimmunity and type..

Clinical trial data validate the C-peptide estimate model in type 1 diabetes

John M Wentworth, Naiara G Bediaga, Stephen E Gitelman, Carmela Evans-Molina, Peter A Gottlieb, Peter G Colman, Michael J Haller, Leonard C Harrison

Journal article  |  2020  |  Diabetologia

Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter I Lipkin, Kelly McGorm, Grant Morahan, Claire Morbey, Ignatius CN Pang, et al.

Journal article  |  2020  |  Pediatric Diabetes

Background: Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compar..

Gut microbiota composition during infancy and subsequent behavioural outcomes

Amy Loughman, Anne-Louise Ponsonby, Martin O'Hely, Christos Symeonides, Fiona Collier, Mimi LK Tang, John Carlin, Sarath Ranganathan, Katrina Allen, Angela Pezic, Richard Saffery, Felice Jacka, Leonard C Harrison, Peter D Sly, Peter Vuillermin

Journal article  |  2020  |  EBioMedicine

BACKGROUND: Despite intense interest in the relationship between gut microbiota and brain development, longitudinal data from huma..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

Siglec-10 expression is up-regulated in activated human CD4( ) T cells

E Bandala-Sanchez, NG Bediaga, G Naselli, AM Neale, LC Harrison

Journal article  |  2020  |  Human Immunology

Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on hu..

Does rotavirus turn on type 1 diabetes?

Leonard C Harrison, Kirsten P Perrett, Kim Jachno, Terry M Nolan, Margo C Honeyman

Journal article  |  2019  |  PLOS Pathogens

Naive regulatory T cells in infancy: Associations with perinatal factors and development of food allergy

Fiona Collier, Anne-Louise Ponsonby, Martin O'Hely, Mimi LK Tang, Richard Saffery, John Molloy, Lawrence E Gray, Sarath Ranganathan, David Burgner, Katrina J Allen, Susanne Brix, Peter J Vuillermin

Journal article  |  2019  |  Allergy

BACKGROUND: In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequen..

Coding Error in Study of Rotavirus Vaccination and Type 1 Diabetes in Children

Kirsten P Perrett, Kim Jachno, Terry M Nolan, Leonard C Harrison

Journal article  |  2019  |  JAMA Pediatrics

Specific Sialoforms Required for the Immune Suppressive Activity of Human Soluble CD52

Abdulrahman M Shathili, Esther Bandala-Sanchez, Alan John, Ethan D Goddard-Borger, Morten Thaysen-Andersen, Arun V Everest-Dass, Timothy E Adams, Leonard C Harrison, Nicolle H Packer

Journal article  |  2019  |  Frontiers in Immunology

Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: A prospective cohort study

Jessica E Harbison, Alexandra J Roth-Schulze, Lynne C Giles, Cuong D Tran, Katrina M Ngui, Megan A Penno, Rebecca L Thomson, John M Wentworth, Peter G Colman, Maria E Craig, Grant Morahan, Anthony T Papenfuss, Simon C Barry, Leonard C Harrison, Jennifer J Couper

Journal article  |  2019  |  Pediatric Diabetes

Controversies in medicine: redefining the diagnosis of type 1 diabetes

Jennifer J Couper, Leonard C Harrison

Journal article  |  2019  |  Medical Journal of Australia

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Mingjing Hu, David Eviston, Peter Hsu, Eliana Marino, Ann Chidgey, Brigitte Santner-Nanan, Kahlia Wong, James L Richards, Yu Anne Yap, Fiona Collier, Ann Quinton, Steven Joung, Michael Peek, Ron Benzie, Laurence Macia, David Wilson, Ann-Louise Ponsonby, Mimi LK Tang, Martin O'Hely, Norelle L Daly, et al.

Journal article  |  2019  |  Nature Communications

Correction for Bandala-Sanchez et al., CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Glycoprotein acetyls (GlycA) at 12 months are associated with high-sensitivity C-reactive protein and early life inflammatory immune measures

Fiona Collier, Susan Ellul, Markus Juonala, Anne-Louise Ponsonby, Peter Vuillermin, Richard Saffery, David Burgner, John Carlin, Sarath Ranganathan, Peter Sly, Mimi Tang, Katie Allen, Leonard C Harrison, Terry Dwyer

Journal article  |  2019  |  Pediatric Research

Association of Rotavirus Vaccination With the Incidence of Type 1 Diabetes in Children

Kirsten P Perrett, Kim Jachno, Terry M Nolan, Leonard C Harrison

Journal article  |  2019  |  JAMA Pediatrics

Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter Ian Lipkin, Grant Morahan, Claire Morbey, Ignatius CN Pang, Anthony T Papenfuss, et al.

Journal article  |  2019  |  Open Forum Infectious Diseases

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

John M Wentworth, Naiara G Bediaga, Lynne C Giles, Mario Ehlers, Stephen E Gitelman, Susan Geyer, Carmella Evans-Molina, Leonard C Harrison

Journal article  |  2019  |  Diabetologia

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

Michelle So, Colleen M Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M Wentworth, Leonard C Harrison, Balasubramanian Krishnamurthy, Helen E Thomas, Christine Rodda, Fergus J Cameron, Jacinta McMahon, Thomas WH Kay, Stuart I Mannering

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood

John M Wentworth, Naiara G Bediaga, Megan AS Penno, Esther Bandala-Sanchez, Komal N Kanojia, Konstantinos A Kouremenos, Jennifer J Couper, Leonard C Harrison

Journal article  |  2018  |  Metabolomics

Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation

Helen Cao, Mark Biondo, Hadi Lioe, Samantha Busfield, Veronika Rayzman, Bernhard Nieswandt, Konrad Bork, Leonard C Harrison, Priscilla Auyeung, Henriette Farkas, Dorottya Csuka, Matthias Pelzing, Steve Dower, Michael J Wilson, Andrew Nash, Marc W Nolte, Con Panousis

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

Larger household size is associated with an increased proportion of regulatory T cells in cord blood

F Collier, A Ponsonby, M O'Hely, ML Tang, KJ Allen, LC Harrison, JB Carlin, R Saffery, PD Sly, S Ranganathan, PJ Vuillermin

Conference Proceedings  |  2018  |  ALLERGY

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

Esther Bandala-Sanchez, Naiara G Bediaga, Ethan D Goddard-Borger, Katrina Ngui, Gaetano Naselli, Natalie L Stone, Alana M Neale, Lesley A Pearce, Ahmad Wardak, Peter Czabotar, Thomas Haselhorst, Andrea Maggioni, Lauren A Hartley-Tassell, Timothy E Adams, Leonard C Harrison

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development

Timothy M Johanson, Hannah D Coughlan, Aaron TL Lun, Naiara G Bediaga, Gaetano Naselli, Alexandra L Garnham, Leonard C Harrison, Gordon K Smyth, Rhys S Allan

Journal article  |  2018  |  PLOS Genetics

Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study

Mark Simon Stein, Gregory John Ward, Helmut Butzkueven, Trevor John Kilpatrick, Leonard Charles Harrison

Journal article  |  2018  |  Molecular Medicine

Cord Blood CD8( ) T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner

Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison

Journal article  |  2018  |  Frontiers in Immunology

Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis

Jocelyn Sietsma Penington, Megan AS Penno, Katrina M Ngui, Nadim J Ajami, Alexandra J Roth-Schulze, Stephen A Wilcox, Esther Bandala-Sanchez, John M Wentworth, Simon C Barry, Cheryl Y Brown, Jennifer J Couper, Joseph F Petrosino, Anthony T Papenfuss, Leonard C Harrison

Journal article  |  2018  |  Scientific Reports

CD52 inhibits Toll-like receptor activation of NF-kappa B and triggers apoptosis to suppress inflammation

Maryam Rashidi, Esther Bandala-Sanchez, Kate E Lawlor, Yuxia Zhang, Alana M Neale, Swarna L Vijayaraj, Robert O'Donoghue, John M Wentworth, Timothy E Adams, James E Vince, Leonard C Harrison

Journal article  |  2018  |  Cell Death & Differentiation

Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells

Petra Augstein, Thomas Loudovaris, Esther Bandala-Sanchez, Peter Heinke, Gaetano Naselli, Lily Lee, Wayne J Hawthorne, L Jorge Gonez, Alana M Neale, Francois Vaillant, Helen E Thomas, Thomas W Kay, Ilia Banakh, Leonard C Harrison

Journal article  |  2018  |  Pancreas

Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release

JM Wentworth, J-G Zhang, E Bandala-Sanchez, G Naselli, R Liu, M Ritchie, GK Smyth, PE O'Brien, LC Harrison

Journal article  |  2017  |  International Journal of Obesity

Transient Impairment of Islet Architectural Development in Pancreas-Specific Bmpr1a-Deleted Prenatal Mice Involves Reduced Expression of E-Cadherin

Fang-Xu Jiang, Leonard C Harrison

Journal article  |  2017  |  Stem Cells and Development

Type 1 diabetes: a disease of developmental origins

Jessica E Phillips, Jennifer J Couper, Megan AS Penno, Leonard C Harrison

Journal article  |  2017  |  Pediatric Diabetes

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Eliana Marino, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap, Jacinta Knight, Craig McKenzie, Jan Kranich, Ana Carolina Oliveira, Fernando J Rossello, Balasubramanian Krishnamurthy, Christian M Nefzger, Laurence Macia, Alison Thorburn, Alan G Baxter, Grant Morahan, Lee H Wong, Jose M Polo, Robert J Moore, Trevor J Lockett, et al.

Journal article  |  2017  |  Nature Immunology

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity

Ezio Bonifacio, Chantal Mathieu, Gerald T Nepom, Anette-G Ziegler, Henry Anhalt, Michael J Haller, Leonard C Harrison, Matthias Hebrok, Jake A Kushner, Jill M Norris, Mark Peakman, Alvin C Powers, John A Todd, Mark A Atkinson

Journal article  |  2017  |  Diabetologia

Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease

Anette-G Ziegler, Ezio Bonifacio, Alvin C Powers, John A Todd, Leonard C Harrison, Mark A Atkinson

Journal article  |  2016  |  Diabetes

Autoreactive T cells in chronic spontaneous urticaria target the IgE Fc receptor I alpha subunit

Priscilla Auyeung, Diana Mittag, Philip D Hodgkin, Leonard C Harrison

Journal article  |  2016  |  Journal of Allergy and Clinical Immunology

MicroRNAs in CD4( ) T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes (vol 68, pg 52, 2016)

Yuxia Zhang, Zhi-Ping Feng, Gaetano Naselli, Fiona Bell, James Wettenhall, Priscilla Auyeung, Justine A Ellis, Anne-Louise Ponsonby, Terence P Speed, Mark MW Chong, Leonard C Harrison

Journal article  |  2016  |  Journal of Autoimmunity

MicroRNAs in CD4( ) T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes

Yuxia Zhang, Zhi-Ping Feng, Gaetano Naselli, Fiona Bell, James Wettenhall, Priscilla Auyeung, Justine A Ellis, Anne-Louise Ponsonby, Terence P Speed, Mark MW Chong, Leonard C Harrison

Journal article  |  2016  |  Journal of Autoimmunity

G(M3) ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

JM Wentworth, G Naselli, K Ngui, GK Smyth, R Liu, PE O'Brien, C Bruce, J Weir, M Cinel, PJ Meikle, LC Harrison

Journal article  |  2016  |  International Journal of Obesity

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression

Alberto Pugliese, David Boulware, Liping Yu, Sunanda Babu, Andrea K Steck, Dorothy Becker, Henry Rodriguez, Linda DiMeglio, Carmella Evans-Molina, Leonard C Harrison, Desmond Schatz, Jerry P Palmer, Carla Greenbaum, George S Eisenbarth, Jay M Sosenko

Journal article  |  2016  |  Diabetes

Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy

Yuxia Zhang, Fiona Collier, Gaetano Naselli, Richard Saffery, Mimi LK Tang, Katrina J Allen, Anne-Louise Ponsonby, Leonard C Harrison, Peter Vuillermin

Journal article  |  2016  |  Science Translational Medicine

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

Andrew J Murphy, Michael J Kraakman, Helene L Kammoun, Dragana Dragoljevic, Man KS Lee, Kate E Lawlor, John M Wentworth, Ajithkumar Vasanthakumar, Motti Gerlic, Lachlan W Whitehead, Ladina DiRago, Louise Cengia, Rachael M Lane, Donald Metcalf, James E Vince, Leonard C Harrison, Axel Kallies, Benjamin T Kile, Ben A Croker, Mark A Febbraio, et al.

Journal article  |  2016  |  Cell Metabolism

Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells

Petra Augstein, Gaetano Naselli, Thomas Loudovaris, Wayne J Hawthorne, Peter Campbell, Esther Bandala-Sanchez, Kelly Rogers, Peter Heinke, Helen E Thomas, Thomas W Kay, Leonard C Harrison

Journal article  |  2015  |  Diabetes Research and Clinical Practice

Foreword

Patrizia Caraveo, Neil Gehrels, Gianpiero Tagliaferri

Journal article  |  2015  |  Journal of High Energy Astrophysics

Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis

Fang-Xu Jiang, Yuji Mishina, Akma Baten, Grant Morahan, Leonard C Harrison

Journal article  |  2015  |  Biology Open

Immune Modulation by Vitamin D and Its Relevance to Food Allergy

Noor HA Suaini, Yuxia Zhang, Peter J Vuillermin, Katrina J Allen, Leonard C Harrison

Journal article  |  2015  |  NUTRIENTS

A randomised controlled trial of high dose vitamin D in recent-onset type 2 diabetes

Shirley Elkassaby, Leonard C Harrison, Namita Mazzitelli, John M Wentworth, Peter G Colman, Timothy Spelman, Spiros Fourlanos

Journal article  |  2014  |  Diabetes Research and Clinical Practice

Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model.

Jamie L Brady, Leonard C Harrison, David J Goodman, Peter J Cowan, Wayne J Hawthorne, Philip J O'Connell, Robyn M Sutherland, Andrew M Lew

Journal article  |  2014  |  Clinical & Translational Immunology

Monoclonal antibodies (mAbs) have been a spectacular clinical and commercial success in the treatment of cancer and autoimmune dis..

Maturity-onset diabetes of the young type 5 in a family with diabetes and mild kidney disease diagnosed by whole exome sequencing

JM Wentworth, V Lukic, M Bahlo, M Finlay, C Nguyen, G Morahan, LC Harrison

Journal article  |  2014  |  Internal Medicine Journal

Rotavirus Infection Induces Transient Pancreatic Involution and Hyperglycemia in Weanling Mice

Margo C Honeyman, David Laine, Yifan Zhan, Sarah Londrigan, Carl Kirkwood, Leonard C Harrison

Journal article  |  2014  |  PLoS ONE

The polycomb repressive complex 2 governs life and death of peripheral T cells

Yuxia Zhang, Sarah Kinkel, Jovana Maksimovic, Esther Bandala-Sanchez, Maria C Tanzer, Gaetano Naselli, Jian-Guo Zhang, Yifan Zhan, Andrew M Lew, John Silke, Alicia Oshlack, Marnie E Blewitt, Leonard C Harrison

Journal article  |  2014  |  Blood

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8 T cells in type 1 diabetes

BO Roep, N Solvason, PA Gottlieb, JR Abreu, LC Harrison, GS Eisenbarth, L Yu, M Leviten, WA Hagopian, JB Buse, M Von Herrath, J Quan, RS King, WH Robinson, PJ Utz, H Garren, L Steinman

Journal article  |  2014  |  Diabetes Technology & Therapeutics

Prevention of Autoimmune Disease: The Type 1 Diabetes Paradigm

LC Harrison, JM Wentworth

Book Chapter  |  2013

Trials in type 1 diabetes: Antigen-specific therapies

Ken T Coppieters, Leonard C Harrison, Matthias G von Herrath

Journal article  |  2013  |  Clinical Immunology

Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells

Yuxia Zhang, Jovana Maksimovic, Gaetano Naselli, Junyan Qian, Michael Chopin, Marnie E Blewitt, Alicia Oshlack, Leonard C Harrison

Journal article  |  2013  |  Blood

Antigen-Based Vaccination and Prevention of Type 1 Diabetes

Leonard C Harrison, John M Wentworth, Yuxia Zhang, Esther Bandala-Sanchez, Ralph M Boehmer, Alana M Neale, Natalie L Stone, Gaetano Naselli, Julian J Bosco, Priscilla Auyeung, Maryam Rashidi, Petra Augstein, Grant Morahan

Journal article  |  2013  |  Current Diabetes Reports

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes

Megan AS Penno, Jennifer J Couper, Maria E Craig, Peter G Colman, William D Rawlinson, Andrew M Cotterill, Timothy W Jones, Leonard C Harrison

Journal article  |  2013  |  BMC PEDIATRICS

T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10

Esther Bandala-Sanchez, Yuxia Zhang, Simone Reinwald, James A Dromey, Bo-Han Lee, Junyan Qian, Ralph M Boehmer, Leonard C Harrison

Journal article  |  2013  |  Nature Immunology

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8( ) T Cells in Type 1 Diabetes

Bart O Roep, Nanette Solvason, Peter A Gottlieb, Joana RF Abreu, Leonard C Harrison, George S Eisenbarth, Liping Yu, Michael Leviten, William A Hagopian, John B Buse, Matthias von Herrath, Joanne Quan, Robert S King, William H Robinson, Paul J Utz, Hideki Garren, Lawrence Steinman

Journal article  |  2013  |  Science Translational Medicine

Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms

Nguyen Cao, Michael D Varney, Leonard C Harrison, Grant Morahan

Journal article  |  2013  |  Diabetes

An Antibody-Based Leukocyte-Capture Microarray for the Diagnosis of Systemic Lupus Erythematosus

Ming-Wei Lin, Joshua WK Ho, Leonard C Harrison, Cristobal G dos Remedios, Stephen Adelstein

Journal article  |  2013  |  PLoS One

Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model

Jamie L Brady, Robyn M Sutherland, Manuela Hancock, Susie Kitsoulis, Mireille H Lahoud, Peta M Phillips, Wayne J Hawthorne, Anthony JF d'Apice, Peter J Cowan, Leonard C Harrison, Philip J O'Connell, Andrew M Lew

Journal article  |  2013  |  Xenotransplantation

Rotavirus and type 1 diabetes

MC Honeyman, LC Harrison

Book Chapter  |  2013

The Parahox gene Pdx1 is required to maintain positional identity in the adult foregut

Andrew M Holland, Sonia Garcia, Gaetano Naselli, Raymond J Macdonald, Leonard C Harrison

Journal article  |  2013  |  The International Journal of Developmental Biology

Adult Pancreas Side Population Cells Expand after beta Cell Injury and Are a Source of Insulin-Secreting Cells

Ilia Banakh, Leonel J Gonez, Robyn M Sutherland, Gaetano Naselli, Leonard C Harrison

Journal article  |  2012  |  PLoS One

Revisiting regulatory T cells in type 1 diabetes

Yuxia Zhang, Esther Bandala-Sanchez, Leonard C Harrison

Journal article  |  2012  |  Current Opinion in Endocrinology, Diabetes and Obesity

Insulin-specific vaccination for type 1 diabetes A step closer?

Leonard C Harrison

Journal article  |  2012  |  Human Vaccines & Immunotherapeutics

Activated Protein C Inhibits Pancreatic Islet Inflammation, Stimulates T Regulatory Cells, and Prevents Diabetes in Non-obese Diabetic (NOD) Mice

Meilang Xue, Suat Dervish, Leonard C Harrison, Gregory Fulcher, Christopher J Jackson

Journal article  |  2012  |  Journal of Biological Chemistry

INSGFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

SJ Micallef, X Li, JV Schiesser, CE Hirst, QC Yu, SM Lim, MC Nostro, DA Elliott, F Sarangi, LC Harrison, G Keller, AG Elefanty, EG Stanley

Journal article  |  2012  |  Diabetologia

Fulminant type 1 diabetes in Australia in the absence of humoral and cellular immune responses to pancreatic islet autoantigens

I Lee, LC Harrison, PG Colman

Journal article  |  2012  |  Diabetes Research and Clinical Practice

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis

MS Stein, Y Liu, OM Gray, JE Baker, SC Kolbe, MR Ditchfield, GF Egan, PJ Mitchell, LC Harrison, H Butzkueven, TJ Kilpatrick

Journal article  |  2011  |  Neurology

acDCs enhance human antigen-specific T-cell responses

Emanuela Martinuzzi, Georgia Afonso, Marie-Claude Gagnerault, Gaetano Naselli, Diana Mittag, Behazine Combadiere, Christian Boitard, Nathalie Chaput, Laurence Zitvogel, Leonard C Harrison, Roberto Mallone

Journal article  |  2011  |  Blood

Forward Light Scatter Is a Simple Measure of T-Cell Activation and Proliferation but Is Not Universally Suited for Doublet Discrimination

Ralph M Boehmer, Esther Bandala-Sanchez, Leonard C Harrison

Journal article  |  2011  |  Cytometry Part A

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

Diana Mittag, Anna I Proietto, Thomas Loudovaris, Stuart I Mannering, David Vremec, Ken Shortman, Li Wu, Leonard C Harrison

Journal article  |  2011  |  The Journal of Immunology

Persistently autoantibody-negative type 1 diabetes: Rich pickings or much ado about nothing?

Leonard C Harrison

Journal article  |  2011  |  Pediatric Diabetes

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

Spiros Fourlanos, Christine Perry, Shane A Gellert, Emanuela Martinuzzi, Roberto Mallone, Jeanne Butler, Peter G Colman, Leonard C Harrison

Journal article  |  2011  |  Diabetes

Generation and expansion of regulatory human CD4( ) T-cell clones specific for pancreatic islet autoantigens

James A Dromey, Bo Han Lee, Hua Yu, Helen E Young, Daniel J Thearle, Kent P Jensen, Stuart I Mannering, Leonard C Harrison

Journal article  |  2011  |  Journal of Autoimmunity

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis

MS Stein, Y Liu, OM Gray, J Baker, S Kolbe, MR Ditchfield, GF Egan, PJ Mitchell, L Harrison, H Butzkueven, TJ Kilpatrick

Journal article  |  2011  |  Neurology

Interleukin-1 beta Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells Implications for the Timing of Tolerizing Immunotherapy

Sebastien Bertin-Maghit, Dimeng Pang, Brendan O'Sullivan, Shannon Best, Emily Duggan, Sanjoy Paul, Helen Thomas, Thomas WH Kay, Leonard C Harrison, Raymond Steptoe, Ranjeny Thomas

Journal article  |  2011  |  Diabetes

A Randomized Controlled Trial of High-Dose Vitamin D2 Followed by Intranasal Insulin in Alzheimer's Disease

Mark S Stein, Samuel C Scherer, Kylie S Ladd, Leonard C Harrison

Journal article  |  2011  |  Journal of Alzheimer's Disease

Pro-Inflammatory CD11c( )CD206( ) Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

John M Wentworth, Gaetano Naselli, Wendy A Brovvn, Lisa Doyle, Belinda Phipson, Gordon K Smyth, Martin Wabitsch, Paul E O'Brien, Leonard C Harrison

Journal article  |  2010  |  Diabetes

The effector T cell response to ryegrass pollen is counterregulated by simultaneous induction of regulatory T cells.

Diana Mittag, Anja Scholzen, Nirupama Varese, Lorraine Baxter, Geza Paukovics, Leonard C Harrison, Jennifer M Rolland, Robyn E O'Hehir

Journal article  |  2010  |  The Journal of Immunology

Allergy is associated with pathological Th2 responses to otherwise harmless environmental Ags. In contrast, nonallergic individual..

Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens.

Margo C Honeyman, Natalie L Stone, Ben A Falk, Gerald Nepom, Leonard C Harrison

Journal article  |  2010  |  The Journal of Immunology

In type 1 diabetes, insulin-producing beta cells in the islets of the pancreas are destroyed by autoreactive T cells. Rotavirus (R..

Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).

Joan E Hilner, Letitia H Perdue, Elizabeth G Sides, June J Pierce, Ana M Wägner, Alan Aldrich, Amanda Loth, Lotte Albret, Lynne E Wagenknecht, Concepcion Nierras, Beena Akolkar, undefined T1DGC

Journal article  |  2010  |  Clinical Trials: Journal of the Society for Clinical Trials

BACKGROUND AND PURPOSE: The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a)..

Reappraising the stereotypes of diabetes in the modern diabetogenic environment.

John M Wentworth, Spiros Fourlanos, Leonard C Harrison

Journal article  |  2009  |  Nature Reviews Endocrinology

The prevailing concentration of blood glucose is a result of the integrated regulation of insulin secretion and insulin action. Ne..

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Jeffrey C Barrett, David G Clayton, Patrick Concannon, Beena Akolkar, Jason D Cooper, Henry A Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Vincent Plagnol, Flemming Pociot, Helen Schuilenburg, Deborah J Smyth, Helen Stevens, John A Todd, Neil M Walker, Stephen S Rich, undefined Type 1 Diabetes Genetics Consortium

Journal article  |  2009  |  Nature Genetics

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk facto..

Congenital rubella, diabetes and HLA.

MC Honeyman, LC Harrison

Journal article  |  2009  |  Diabetologia

Weight Gain in Early Life Predicts Risk of Islet Autoimmuity in Children With a First-Degree Relative With Type 1 Diabetes

Jennifer J Couper, Sarah Beresford, Craig Hirte, Peter A Baghurst, Angie Pollard, Brian D Tait, Leonard C Harrison, Peter G Colman

Journal article  |  2009  |  Diabetes Care

Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10.

L Jorge Góñez, Gaetano Naselli, Ilia Banakh, Hideo Niwa, Leonard C Harrison

Journal article  |  2008  |  Molecular Medicine

Steroid hormones induce changes in gene expression by binding to intracellular receptors that then translocate to the nucleus. Ste..

Type 1 diabetes: lessons for other autoimmune diseases?

Leonard C Harrison, Margo C Honeyman, Grant Morahan, John M Wentworth, Shirley Elkassaby, Peter G Colman, Spiros Fourlanos

Journal article  |  2008  |  Journal of Autoimmunity

Type 1 diabetes (T1D) satisfies many of the criteria for an autoimmune disease. The impact of the environment to promote the devel..

Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1.

Petra Augstein, Peter Heinke, Eckhard Salzsieder, Rita Grimm, Jürgen Giebel, Christel Salzsieder, Leonard C Harrison

Journal article  |  2008  |  Diabetes and Vascular Disease Research

Mitochondria of pancreatic beta-cells are potential targets of intrinsic and extrinsic apoptotic pathways in the autoimmune pathog..

The accelerator hypothesis and increasing incidence of type 1 diabetes

Spiros Fourlanos, Leonard C Harrison, Peter G Colman

Journal article  |  2008  |  Current Opinion in Endocrinology, Diabetes and Obesity

The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes

Spiros Fourlanos, Michael D Varney, Brian D Tait, Grant Morahan, Margo C Honeyman, Peter G Colman, Leonard C Harrison

Journal article  |  2008  |  Diabetes Care

Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control (FASEB Journal (2006) 20, (565-567) DOI:10.1096/fj.05-4879fje))

KR Knight, Y Uda, MF Findlay, DL Brown, KJ Cronin, E Jamieson, T Tai, E Keramidaris, AJ Penington, J Rophael, LC Harrison, WA Morrison

Journal article  |  2008  |  The FASEB Journal

Vaccination against self to prevent autoimmune disease: the type 1 diabetes model.

Leonard C Harrison

Journal article  |  2008  |  Immunology & Cell Biology

Immune tolerance to self-antigens is physiological. Given a repertoire of self-reactive, potentially pathogenic lymphocytes, thera..

Preface

CJ Greenbaum, LC Harrison

Book  |  2008

What are the prospects for preventing autoimmune diabetes?

CJ Greenbaum, LC Harrison

Book Chapter  |  2008

Reappraising the stereotypes of diabetes

LC Harrison, JM Wentworth, S Elkassaby, S Fourlanos, CJ Greenbaum

Book Chapter  |  2008

Diabetes: Translating research into practice

CJ Greenbaum, LC Harrison

Book  |  2008

Seasonal changes in preprandial glucose, A1C, and blood pressure in diabetic patients: response to Liang.

Margo C Honeyman, Shirley Elkassaby, Leonard C Harrison

Journal article  |  2007  |  Diabetes Care

Endocrine cells develop within pancreatic bud-like structures derived from mouse ES cells differentiated in response to BMP4 and retinoic acid

Suzanne J Micallef, Xueling Li, Mary E Janes, Steven A Jackson, Robyn M Sutherland, Andrew M Lew, Leonard C Harrison, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2007  |  Stem Cell Res.

Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra-intestinal sites.

Sanda Stankovic, Yifan Zhan, Leonard C Harrison

Journal article  |  2007  |  European Journal of Immunology

Cells with the phenotype of intraepithelial lymphocytes (IEL) are present systemically and have been implicated in immune regulati..

Does insulin resistance need resistin?

John M Wentworth, Leonard C Harrison

Journal article  |  2007  |  The Journal of Clinical Endocrinology & Metabolism

Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing.

Jennifer M Barker, Kim McFann, Leonard C Harrison, Spiros Fourlanos, Jeffrey Krischer, David Cuthbertson, H Peter Chase, George S Eisenbarth, undefined DPT-1 Study Group

Journal article  |  2007  |  The Journal of Pediatrics

OBJECTIVE: To determine the relationship of intravenous (IVGTT) and oral (OGTT) glucose tolerance tests abnormalities to diabetes ..

Prevention of Autoimmune Disease: Type 1 Diabetes as a Paradigm

LC Harrison

Book Chapter  |  2006

A clinical screening tool identifies autoimmune diabetes in adults: Response to Davis et al. [7]

S Fourlanos, LC Harrison, PG Colman

Journal article  |  2006  |  Diabetes Care

Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.

Parth Narendran, Alana M Neale, Bo Han Lee, Katrina Ngui, Raymond J Steptoe, Grant Morahan, Ole Madsen, James A Dromey, Kent P Jensen, Leonard C Harrison

Journal article  |  2006  |  Proceedings of the National Academy of Sciences

Genes for peripheral tissue-restricted self-antigens are expressed in thymic and hematopoietic cells. In thymic medullary epitheli..

TCR gamma delta intraepithelial lymphocytes are required for self-tolerance.

Natasha R Locke, Sanda Stankovic, David P Funda, Leonard C Harrison

Journal article  |  2006  |  The Journal of Immunology

Neonatal thymectomy (NTX) impairs T cell regulation and leads to organ-specific autoimmune disease in susceptible mouse strains. I..

Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.

Andrew M Holland, L Jorge Góñez, Gaetano Naselli, Raymond J Macdonald, Leonard C Harrison

Journal article  |  2005  |  Diabetes

The homeodomain transcription factor Pdx1 is essential for pancreas development. To investigate the role of Pdx1 in the adult panc..

Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells.

Fang-Xu Jiang, Leonard C Harrison

Journal article  |  2005  |  Experimental Cell Research

We previously reported that bone morphogenetic proteins (BMPs), members of the transforming growth factor superfamily, together wi..

Pulmonary CD4 cytokine responses in mice reveal differences in the relative immunogenicity of cold-adapted influenza A vaccine donor strains.

Mark D Wareing, Leonard C Harrison, Gregory A Tannock

Journal article  |  2005  |  Vaccine

We previously described differences in the 50% protective dose and isotype-specific antibody secreting cell (ASC) responses to US ..

The prospect of vaccination to prevent type 1 diabetes.

Leonard C Harrison

Journal article  |  2005  |  Human Vaccines

Type 1 diabetes (T1D) is an autoimmune disease in which genes and environment contribute to cell-mediated immune destruction of in..

An efficient method for cloning human autoantigen-specific T cells.

Stuart I Mannering, James A Dromey, Jessica S Morris, Daniel J Thearle, Kent P Jensen, Leonard C Harrison

Journal article  |  2005  |  Journal of Immunological Methods

T-cell clones are valuable tools for investigating T-cell specificity in infectious, autoimmune and malignant diseases. T cells sp..

Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity.

Spiros Fourlanos

Journal article  |  2005  |  Pediatric Diabetes

Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.

Fang-Xu Jiang, Leonard C Harrison

Journal article  |  2005  |  Differentiation

The epidermal growth factor (EGF) family is implicated in the development and function of multiple cells and organs, including the..

Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1 myeloid progenitor cells that differentiate in vivo into resting dendritic cells.

Raymond J Steptoe, Janine M Ritchie, Lynelle K Jones, Leonard C Harrison

Journal article  |  2005  |  Diabetes

The nature of the T-cell response to antigen is governed by the activation state of the antigen-presenting dendritic cell (DC). Im..

CD4 T cell proliferation in response to GAD and proinsulin in healthy, pre-diabetic, and diabetic donors.

Stuart I Mannering, Jessica S Morris, Natalie L Stone, Kent P Jensen, Peter M VAN Endert, Leonard C Harrison

Conference Proceedings  |  2004  |  Annals of the New York Academy of Sciences

The ability to measure proliferation of autoantigen-specific T cells is critical for the evaluation of cellular immune function. U..

Insulin resistance is a risk factor for progression to Type 1 diabetes (vol 47, pg 1661, 2004)

S Fourlanos, P Narendran, GB Byrnes, PG Colman, LC Harrison

Journal article  |  2004  |  Diabetologia

Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas.

Petra Augstein, Jeanette Bahr, Gerhild Wachlin, Peter Heinke, Sabine Berg, Eckhard Salzsieder, Leonard C Harrison

Journal article  |  2004  |  Journal of Autoimmunity

In type 1 diabetes, autoimmune inflammation of pancreatic islets of Langerhans ('insulitis') results in destruction of insulin-pro..

Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues.

Anne M Johnston, Gaetano Naselli, Hideo Niwa, Thomas Brodnicki, Leonard C Harrison, L Jorge Góñez

Journal article  |  2004  |  Genes to Cells

Mutations in the triple PDZ domain-containing protein harmonin have been identified as the cause of Usher deafness syndrome type 1..

TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death

YF Zhan, DP Funda, AL Every, P Fundova, JF Purton, DR Liddicoat, TJ Cole, DI Godfrey, JL Brady, SI Mannering, LC Harrison, AM Lew

Journal article  |  2004  |  INTERNATIONAL IMMUNOLOGY

Fas ligand down-regulates cytokine-induced Fas receptor expression on insulinoma (NIT-1), but not islet cells, from autoimmune nonobese diabetic mice.

P Augstein, P Heinke, E Salzsieder, S Berg, R Rettig, C Salzsieder, LC Harrison

Journal article  |  2004  |  Endocrinology

In the pathogenesis of autoimmune type 1 diabetes, the apoptosis receptor Fas appears de novo on the surface of insulin-producing ..

Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation.

Raymond J Steptoe, Sanda Stankovic, Sash Lopaticki, Lynelle K Jones, Leonard C Harrison, Grant Morahan

Journal article  |  2004  |  Journal of Autoimmunity

The non-obese diabetic (NOD) mouse is a unique and invaluable model of autoimmune disease, in particular type 1 diabetes. Bone mar..

Progenitor cells in the adult pancreas.

Andrew M Holland, L Jorge Góñez, Leonard C Harrison

Journal article  |  2004  |  Diabetes/Metabolism Research and Reviews

The beta-cell mass in the adult pancreas possesses the ability to undergo limited regeneration following injury. Identifying the p..

Mucosal tolerance to prevent type 1 diabetes: can the outcome be improved in humans?

Arno Hanninen, Leonard C Harrison

Journal article  |  2004  |  The Review of Diabetic Studies

The results of trials in which autoantigens have been fed to individuals affected by autoimmune diseases - multiple sclerosis, rhe..

Erratum: Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes (Diabetes (2003) 52 (1059-1065))

CJ Greenbaum, LC Harrison

Journal article  |  2003  |  Diabetes

Difference in generating mouse pancreatic epithelial cell colonies in vitro.

Fang-Xu Jiang, Leonard C Harrison

Journal article  |  2003  |  Pancreas

Proinsulin-a pathogenic autoantigen in type 1 diabetes.

Parth Narendran, Stuart I Mannering, Leonard C Harrison

Journal article  |  2003  |  Autoimmunity Reviews

Type 1 diabetes (T1D) is an autoimmune disease characterised by immunity to pancreatic beta-cell autoantigens, associated with bet..

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes.

Raymond J Steptoe, Janine M Ritchie, Leonard C Harrison

Journal article  |  2003  |  Journal of Clinical Investigation

Bone marrow or hematopoietic stem cell transplantation is a potential treatment for autoimmune disease. The clinical application o..

Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes.

Carla J Greenbaum, Leonard C Harrison, undefined Immunology of Diabetes Society

Journal article  |  2003  |  Diabetes

Antigen-induced regulatory T cells in autoimmunity.

Matthias G von Herrath, Leonard C Harrison

Journal article  |  2003  |  Nature Reviews Immunology

The ultimate goal of any treatment for autoimmune diseases is antigen- and/or site-specific suppression of pathology. Autoaggressi..

(Pro)insulin-specific regulatory T cells.

Leonard C Harrison, Natasha R Solly, Nathan R Martinez

Book  |  2003  |  Novartis Foundation symposium

Regulatory anti-diabetogenic T cells (T(reg)) can be induced by the mucosal administration of insulin or proinsulin peptides, in t..

Late-onset autoimmune diabetes in relatives of people with type 1 diabetes

S Fourlanos, PG Colman, LC Harrison

Conference Proceedings  |  2003  |  Annals of the New York Academy of Sciences

Distinct distribution of laminin and its integrin receptors in the pancreas.

Fang-Xu Jiang, Gaetano Naselli, Leonard C Harrison

Journal article  |  2002  |  Journal of Histochemistry & Cytochemistry

Tissue function is regulated by the extracellular microenvironment including cell basement membranes, in which laminins are a majo..

Extracellular signals and pancreatic beta-cell development: a brief review.

Fang-Xu Jiang, Leonard C Harrison

Journal article  |  2002  |  Molecular Medicine

Cell lineage development is a finely tuned process of proliferation and differentiation, survival and apoptosis, that is regulated..

High avidity antibodies to fetal pig pancreas endocrine cells transfer rejection but are not normally generated to fetal pig pancreas xenografts

A Fox, J Mountford, A Braakhuis, LC Harrison

Journal article  |  2002  |  Xenotransplantation

Development of autoantibodies to islet antigens during childhood: Implications for preclinical type 1 diabetes screening

PG Colman, PD McNair, S Gellert, K Kewming, RS Schmidli, CE Steele, LC Harrison

Journal article  |  2002  |  Pediatric Diabetes

Evidence from twins for acquired cellular immune hyperactivity in type 1 diabetes.

Nikolai Petrovsky, Kirsten O Kyvik, Vagn Bonnevie-Nielsen, Henning Beck-Nielsen, Anders Green, Leonard C Harrison

Journal article  |  2002  |  Immunology

Type 1 diabetes has been associated with an increased frequency of activated T cells and T-cell hyperactivity to non-specific and ..

Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing

RM Sutherland, BS McKenzie, Y Zhan, AJ Corbett, A Fox-Marsh, HM Georgiou, LC Harrison, AM Lew

Journal article  |  2002  |  International immunology

Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice.

Raymond J Steptoe, Janine M Ritchie, Leonard C Harrison

Journal article  |  2002  |  The Journal of Immunology

Aberrant dendritic cell (DC) development and function may contribute to autoimmune disease susceptibility. To address this hypothe..

Emerging evidence that molecules expressed by mammalian tissue grafts are recognized by the innate immune system

A Fox-Marsh, LC Harrison

Journal article  |  2002  |  Journal of Leukocyte Biology

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells.

Fang-Xu Jiang, Edouard G Stanley, L Jorge Gonez, Leonard C Harrison

Journal article  |  2002  |  Journal of Cell Science

Extracellular signals that guide pancreas cell development are not well characterized. In an in vitro culture system of dissociate..

Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

A Hanninen, NR Martinez, GM Davey, WR Heath, LC Harrison

Journal article  |  2002  |  Journal of Clinical Investigation

Understanding autoimmune diabetes: insights from mouse models.

Luciano Adorini, Silvia Gregori, Leonard C Harrison

Journal article  |  2002  |  Trends in Molecular Medicine

Type 1 or insulin-dependent diabetes is an autoimmune disease that causes the selective destruction of insulin-secreting beta cell..

The non-immune RIP-Kb mouse is a useful host for islet transplantation, as the diabetes is spontaneous, mild and predictable.

Robyn M Sutherland, Joanne N Mountford, Janette Allison, Leonard C Harrison, Andrew M Lew

Journal article  |  2002  |  International Journal of Diabetes Research

Chemically-induced diabetic mice and spontaneously diabetic NOD mice have been valuable as recipients for experimental islet trans..

Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes.

W Chen, I Bergerot, JF Elliott, LC Harrison, N Abiru, GS Eisenbarth, TL Delovitch

Journal article  |  2001  |  The Journal of Immunology

The expression of pro(insulin) in the thymus may lead to the negative selection of pro(insulin) autoreactive T cells and periphera..

Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop.

DL Kaufman, R Tisch, N Sarvetnick, L Chatenoud, LC Harrison, K Haskins, A Quinn, E Sercarz, B Singh, M von Herrath, D Wegmann, L Wen, D Zekzer

Conference Proceedings  |  2001  |  Diabetes

A workshop on autoreactive T-cell responses in NOD mice was held to optimize autoreactive T-cell detection methodologies. Using di..

Risk assessment, prediction and prevention of type 1 diabetes

LC Harrison

Journal article  |  2001  |  Pediatric Diabetes

Cytotoxic T cells to an epitope in the islet autoantigen IA-2 are not disease-specific.

K Takahashi, MC Honeyman, LC Harrison

Journal article  |  2001  |  Clinical Immunology

Cytotoxic CD8 T lymphocytes (CTL) are effectors of pancreatic islet beta-cell destruction in type 1 diabetes but, with the excepti..

Mucosal antigen primes diabetogenic cytotoxic T-Lymphocytes regardless of dose or delivery route

A Hanninen, A Braakhuis, WR Heath, LC Harrison

Journal article  |  2001  |  Diabetes

Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycan.

FX Jiang, E Georges-Labouesse, LC Harrison

Journal article  |  2001  |  Molecular Medicine

BACKGROUND: The ability to manipulate the development of pancreatic insulin-producing beta cells has implications for the treatmen..

Innate and adaptive immune responses to nonvascular xenografts: Evidence that macrophages are direct effecters of xenograft rejection

A Fox, J Mountford, A Braakhuis, LC Harrison

Journal article  |  2001  |  The Journal of Immunology

Fuzzy neural network-based prediction of the motif for MHC class II binding peptides

H Noguchi, T Hanai, H Honda, LC Harrison, T Kobayashi

Journal article  |  2001  |  Journal of Bioscience and Bioengineering

The mucosal interface between 'self' and 'non-self' determines the impact of environment on autoimmune diabetes.

NR Solly, MC Honeyman, LC Harrison

Journal article  |  2001  |  Current directions in autoimmunity

Antigen-specific therapy for autoimmune disease.

LC Harrison, DA Hafler

Journal article  |  2000  |  Current Opinion in Immunology

The application of self-antigens as therapeutic tools is validated in inbred animal models of autoimmune disease. Mechanisms of an..

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.

AM Johnston, G Naselli, LJ Gonez, RM Martin, LC Harrison, HJ DeAizpurua

Journal article  |  2000  |  Oncogene

We have cloned a member of the STE20/SPS1 protein kinase family from a transformed rat pancreatic beta cell line. SPAK (STE20/SPS1..

Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes

MC Honeyman, BS Coulson, NL Stone, SA Gellert, PN Goldwater, CE Steele, JJ Couper, BD Tait, PG Colman, LC Harrison

Journal article  |  2000  |  Diabetes

A novel subtype of type 1 diabetes mellitus.

MC Honeyman, BS Coulson, LC Harrison

Journal article  |  2000  |  New England Journal of Medicine

Toxic shock syndrome associated with newly diagnosed type I diabetes.

JJ Couper, N Kallincos, A Pollard, M Honeyman, P Prager, LC Harrison, M Rischmueller

Journal article  |  2000  |  Journal of Paediatrics and Child Health

Studies of two post-mortem pancreata of children at the onset of type I diabetes have suggested activation and expansion of islet ..

The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library.

S Gregori, E Bono, F Gallazzi, J Hammer, LC Harrison, L Adorini

Journal article  |  2000  |  International Immunology

The MHC class II molecule I-Ag7 is essential for the development of insulin-dependent diabetes mellitus (IDDM) in the non-obese di..

Innate immunity and graft rejection

A Fox, LC Harrison

Journal article  |  2000  |  Immunological Reviews

Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody.

PG Colman, C Steele, JJ Couper, SJ Beresford, T Powell, K Kewming, A Pollard, S Gellert, B Tait, M Honeyman, LC Harrison

Journal article  |  2000  |  Diabetologia

AIMS/HYPOTHESIS: To determine the sequence of development of islet autoantibodies and their relation to HLA genes in infants at ri..

Gamma delta T cells as mediators of mucosal tolerance: the autoimmune diabetes model.

A Hänninen, LC Harrison

Journal article  |  2000  |  Immunological Reviews

Mucosal delivery of soluble antigen induces systemic tolerance and has been applied to the prevention of autoimmune diseases. We h..

Manipulation of mucosa-mediated immunoregulation

LC Harrison, NR Martinez, NR Solly, A Hanninen

Journal article  |  2000  |  Immunologist

Innate immunity and xenograft rejection

A Fox, J Mountford, A Braakhuis, LC Harrison

Journal article  |  2000  |  Immunologist

The beta cell in autoimmune diabetes: many mechanisms and pathways of loss.

TW Kay, HE Thomas, LC Harrison, J Allison

Journal article  |  2000  |  Trends in Endocrinology & Metabolism

Death of pancreatic beta cells is the final step in the pathogenesis of type 1 diabetes before it becomes clinically apparent. App..

Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity.

JJ Couper, C Steele, S Beresford, T Powell, K McCaul, A Pollard, S Gellert, B Tait, LC Harrison, PG Colman

Journal article  |  1999  |  Diabetes

The hypothesis that early exposure to cow's milk or lack of breast-feeding predisposes to type 1 diabetes remains controversial. W..

Cow's milk and type 1 diabetes: the real debate is about mucosal immune function.

LC Harrison, MC Honeyman

Journal article  |  1999  |  Diabetes

The hypothesis that early exposure of the infant to cow's milk (or lack of breast-feeding) predisposes the child to type 1 diabete..

Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.

FX Jiang, DS Cram, HJ DeAizpurua, LC Harrison

Journal article  |  1999  |  Diabetes

Extracellular factors that regulate the growth and differentiation of cell lineages in the pancreatic primordia are poorly underst..

Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice

A Fox, M Koulmanda, TE Mandel, N van Rooijen, LC Harrison

Journal article  |  1998  |  Transplantation

Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes

P Augstein, AG Elefanty, J Allison, LC Harrison

Journal article  |  1998  |  Diabetologia

Retroviral superantigens and type 1 diabetes mellitus.

VJ Murphy, LC Harrison, WA Rudert, P Luppi, M Trucco, A Fierabracci, PA Biro, GF Bottazzo

Journal article  |  1998  |  Cell

Neural network-based prediction of candidate T-cell epitopes.

MC Honeyman, V Brusic, NL Stone, LC Harrison

Journal article  |  1998  |  Nature Biotechnology

Activation of T cells requires recognition by T-cell receptors of specific peptides bound to major histocompatibility complex (MHC..

Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes.

K Takahashi, MC Honeyman, LC Harrison

Journal article  |  1998  |  Journal of Immunology

Dendritic cells (DC) present Ag to naive T cells and are therefore pivotal in shaping immune responses. DC may either immunize or ..

IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes.

JJ Couper, LC Harrison, JJ Aldis, PG Colman, MC Honeyman, A Ferrante

Journal article  |  1998  |  Human Immunology

Pancreatic islet beta cell destruction leading to insulin-dependent diabetes mellitus (IDDM) is believed to be mediated by a T-hel..

beta-cell apoptosis in an accelerated model of autoimmune diabetes

P Augstein, LA Stephens, J Allison, AG Elefanty, M Ekberg, TWH Kay, LC Harrison

Journal article  |  1998  |  Molecular Medicine

The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing

PG Colman, P McNair, H Margetts, RS Schmidli, GA Werther, FP Alford, GM Ward, BD Tait, MC Honeyman, LC Harrison

Journal article  |  1998  |  Medical Journal of Australia

Relationship between peptide selectivities of human transporters associated with antigen processing and HLA class I molecules.

S Daniel, V Brusic, S Caillat-Zucman, N Petrovsky, L Harrison, D Riganelli, F Sinigaglia, F Gallazzi, J Hammer, PM van Endert

Journal article  |  1998  |  Journal of Immunology

Efficiency of presentation of a peptide epitope by a MHC class I molecule depends on two parameters: its binding to the MHC molecu..

Prolonged response of multicentric reticulohistiocytosis to low dose methotrexate.

JL Rentsch, EM Martin, LC Harrison, IP Wicks

Journal article  |  1998  |  Journal of Rheumatology

We describe a case of multicentric reticulohistiocytosis complicated by central retinal vein thrombosis and trigeminal neuropathy...

T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents.

MC Honeyman, NL Stone, LC Harrison

Journal article  |  1998  |  Molecular Medicine

The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type 1 diabetes. T-cell epitope peptides i..

Diurnal rhythms of pro-inflammatory cytokines: regulation by plasma cortisol and therapeutic implications.

N Petrovsky, P McNair, LC Harrison

Journal article  |  1998  |  Cytokine

Clinical features of certain immuno-inflammatory disorders such as rheumatoid arthritis and asthma exhibit diurnal fluctuation, wh..

Dual-parameter model for prediction of type I diabetes mellitus.

GS Eisenbarth, R Gianani, L Yu, M Pietropaolo, CF Verge, HP Chase, MJ Redondo, P Colman, L Harrison, R Jackson

Journal article  |  1998  |  Proceedings of the Association of American Physicians

The recent cloning and recombinant expression of novel islet autoantigens [glutamic acid decarboxylase (GAD) 65 and islet-cell aut..

The chronobiology of human cytokine production.

N Petrovsky, LC Harrison

Journal article  |  1998  |  International Reviews of Immunology

Cytokine production in human whole blood exhibits diurnal rhythmicity. Peak production of the pro-inflammatory cytokines IFN-gamma..

MHCPEP, a database of MHC-binding peptides: update 1997.

V Brusic, G Rudy, LC Harrison

Journal article  |  1998  |  Nucleic Acids Research

MHCPEP (http://wehih.wehi.edu.au/mhcpep/) is a curated database comprising over 13 000 peptide sequences known to bind MHC molecul..

Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network.

V Brusic, G Rudy, G Honeyman, J Hammer, L Harrison

Journal article  |  1998  |  Bioinformatics

MOTIVATION: Prediction methods for identifying binding peptides could minimize the number of peptides required to be synthesized a..

Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM.

RS Schmidli, PG Colman, L Cui, WP Yu, K Kewming, C Jankulovski, LC Harrison, CJ Pallen, HJ DeAizpurua

Journal article  |  1998  |  Autoimmunity

Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein ty..

Immunology of IDDM.

H Noorchashm, W Kwok, A Rabinovitch, LC Harrison

Conference Proceedings  |  1997  |  Diabetologia

Strategies for identifying and predicting islet autoantigen T-cell epitopes in insulin-dependent diabetes mellitus.

MC Honeyman, V Brusic, LC Harrison

Journal article  |  1997  |  Annals of Medicine

T cells recognize peptide epitopes bound to major histocompatibility complex molecules. Human T-cell epitopes have diagnostic and ..

A multimeric form of soluble recombinant sheep LFA-3 (CD58) inhibits human T-cell proliferation.

K Yamashita, CR Parish, HS Warren, LC Harrison

Journal article  |  1997  |  Immunology

The rosetting of T cells by sheep erythrocytes is mediated through the interaction of the CD2 molecule on T cells with T11TS, a mo..

Dendritic cells generated from human blood in granulocyte macrophage-colony stimulating factor and interleukin-7.

K Takahashi, MC Honeyman, LC Harrison

Journal article  |  1997  |  Human Immunology

Dendritic cells (DC), with potentially important clinical applications, have been generated from human peripheral blood monocytes ..

Diurnal rhythmicity of human cytokine production: a dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance?

N Petrovsky, LC Harrison

Journal article  |  1997  |  Journal of Immunology

Diurnal rhythmicity is a characteristic of neuroendocrine pathways but is less understood in relation to immune function. We asked..

Identification of pancreatic beta cell-related genes by representational difference analysis.

H Niwa, LC Harrison, HJ DeAizpurua, DS Cram

Journal article  |  1997  |  Endocrinology

A knowledge of beta cell-specific gene expression provides a basis for identifying proteins potentially involved in beta cell func..

Direct evidence for the expression of multiple endogenous retroviruses in the synovial compartment in rheumatoid arthritis

K Nakagawa, V Brusic, G McColl, LC Harrison

Journal article  |  1997  |  Arthritis & Rheumatism

High T cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes.

MC Honeyman, N Stone, H de Aizpurua, MJ Rowley, LC Harrison

Journal article  |  1997  |  Journal of Autoimmunity

Pancreatic islet beta-cell destruction leading to insulin-dependent diabetes mellitus (IDDM) is an autoimmune T cell-mediated proc..

Absence of peripheral blood T cell responses to 'shared epitope' containing peptides in recent onset rheumatoid arthritis

GJ McColl, J Hammer, LC Harrison

Journal article  |  1997  |  Annals of the Rheumatic Diseases

A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice.

LC Harrison, MC Honeyman, S Trembleau, S Gregori, F Gallazzi, P Augstein, V Brusic, J Hammer, L Adorini

Journal article  |  1997  |  Journal of Experimental Medicine

The class II major histocompatibility complex molecule I-A(g7) is strongly linked to the development of spontaneous insulin-depend..

HLA class II-associated polymorphism of interferon-gamma production. Implications for HLA-disease association.

N Petrovsky, LC Harrison

Journal article  |  1997  |  Human Immunology

One of several possible mechanisms for the HLA-disease association is HLA-related polymorphism of cytokine expression. However, wi..

Molecular mimicry-from hypothesis towards evidence.

V Brusic, G Rudy, LC Harrison

Journal article  |  1997  |  Immunology Today

Application of genetic search in derivation of matrix models of peptide binding to MHC molecules.

V Brusic, C Schönbach, M Takiguchi, V Ciesielski, LC Harrison

Journal article  |  1997  |  Proceedings / ... International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology

T cells of the vertebrate immune system recognise peptides bound by major histocompatibility complex (MHC) molecules on the surfac..

Erratum: Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice (Diabetes (1997) 46 (34-39))

MB French, J Allison, DS Cram, HE Thomas, M Dempsey-Collier, A Silva, HM Georgiou, TW Kay, LC Harrison, AM Lew

Journal article  |  1997  |  Diabetes

Evidence for the viral aetiology of IDDM.

N Petrovsky, LC Harrison, KO Kyvik, H Beck-Nielsen, A Green, V Bonnevie-Nielsen

Journal article  |  1997  |  Autoimmunity

MHCPEP, a database of MHC-binding peptides: update 1996.

V Brusic, G Rudy, AP Kyne, LC Harrison

Journal article  |  1997  |  Nucleic Acids Research

MHCPEP is a curated database comprising over 9000 peptide sequences known to bind MHC molecules. Entries are compiled from publish..

Identification of pancreatic β cell-related genes by representational difference analysis

H Niwa, LC Harrison, HJ DeAizpurua, DS Cram

Conference Proceedings  |  1997  |  Experimental and Clinical Endocrinology and Diabetes

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice.

MB French, J Allison, DS Cram, HE Thomas, M Dempsey-Collier, A Silva, HM Georgiou, TW Kay, LC Harrison, AM Lew

Journal article  |  1997  |  Diabetes

IDDM in humans and in nonobese diabetic (NOD) mice is a T-cell-dependent autoimmune disease in which the beta-cells of the pancrea..

T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease.

N Manolios, S Collier, J Taylor, J Pollard, LC Harrison, V Bender

Journal article  |  1997  |  Nature Medicine

This study describes a novel method of inhibiting T-cell function by the use of peptides rationally designed from the T-cell antig..

Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes.

LC Harrison, M Dempsey-Collier, DR Kramer, K Takahashi

Journal article  |  1996  |  Journal of Experimental Medicine

Cellular immune hyporesponsiveness can be induced by the presentation of soluble protein antigens to mucosal surfaces. Most studie..

Cow's milk and IDDM.

LC Harrison

Journal article  |  1996  |  The Lancet

Cytokine regulation of glutamate decarboxylase biosynthesis in isolated rat islets of Langerhans

RS Schmidli, BE Faulkner-Jones, LC Harrison, RFL James, HJ DeAizpurua

Journal article  |  1996  |  Biochemical Journal

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease in which cytokines are thought to play an important role in β-..

The potential roles of endogenous retroviruses in autoimmunity.

K Nakagawa, LC Harrison

Journal article  |  1996  |  Immunological Reviews

Endogenous retroviruses (ERVs) are estimated to comprise up to 1% of human DNA. While the genome of many ERVs is interrupted by te..

Cytokine regulation of glutamate decarboxylase biosynthesis in isolated rat islets of Langerhans.

RS Schmidli, BE Faulkner-Jones, LC Harrison, RF James, HJ DeAizpurua

Journal article  |  1996  |  The Biochemical journal

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease in which cytokines are thought to play an important role in be..

Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus

G Morahan, DX Huang, BD Tait, PG Colman, LC Harrison

Journal article  |  1996  |  Science

MHCPEP--a database of MHC-binding peptides: update 1995.

V Brusic, G Rudy, AP Kyne, LC Harrison

Journal article  |  1996  |  Nucleic Acids Research

MHCPEP is a curated database comprising over 6000 peptide sequences known to bind MHC molecules. Entries are compiled from publish..

Both TH1 and TH2 cytokine mRNAs are expressed in the NOD mouse pancreas in vivo.

BE Faulkner-Jones, M Dempsey-Collier, TE Mandel, LC Harrison

Journal article  |  1996  |  Autoimmunity

In NOD mice, autoimmune recognition and destruction of pancreatic islet beta-cells appear to be independently regulated: all mice ..

Th1 and Th2: swinging to a hormonal rhythm.

N Petrovsky, LC Harrison

Journal article  |  1995  |  Immunology Today

Antigen-specific therapy for autoimmune disease: prospects for the prevention of insulin-dependent diabetes.

LC Harrison

Journal article  |  1995  |  Molecular Medicine

Cytokine-based human whole blood assay for the detection of antigen-reactive T cells.

N Petrovsky, LC Harrison

Journal article  |  1995  |  Journal of Immunological Methods

The measurement of cytokines produced by activated T cells refines assessment of cellular immune function and facilitates whole bl..

TRANSCRIPTION AND TRANSLATION OF 2 GLUTAMATE-DECARBOXYLASE GENES IN THE ILEUM OF RAT, MOUSE AND GUINEA-PIG

S WILLIAMSON, BE FAULKNERJONES, DS CRAM, JB FURNESS, LC HARRISON

Journal article  |  1995  |  Journal of the Autonomic Nervous System

ANTIBODIES TO SYNOVIAL ANTIGENS IN RECENT-ONSET RHEUMATOID-ARTHRITIS

GJ MCCOLL, DS CRAM, LC HARRISON

Journal article  |  1995  |  Arthritis & Rheumatism

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

G Rudy, N Stone, LC Harrison, PG Colman, P McNair, V Brusic, MB French, MC Honeyman, B Tait, AM Lew

Journal article  |  1995  |  Molecular Medicine

BACKGROUND: Insulin (1) and glutamic acid decarboxylase (GAD) (2) are both autoantigens in insulin-dependent diabetes mellitus (ID..

HLA-DRB1-ASTERISK-0401 IS ASSOCIATED WITH SUSCEPTIBILITY TO INSULIN-DEPENDENT DIABETES-MELLITUS INDEPENDENTLY OF THE DQB1 LOCUS

BD TAIT, BP DRUMMOND, MD VARNEY, LC HARRISON

Journal article  |  1995  |  European Journal of Immunogenetics

Reproducibility of the first-phase insulin response to intravenous glucose is not improved by retrograde cannulation and arterialization or the use of a lower glucose dose.

PD McNair, PG Colman, FP Alford, LC Harrison

Journal article  |  1995  |  Diabetes Care

OBJECTIVE: To determine whether the reproducibility of the first-phase insulin response (FPIR) measured during an intravenous gluc..

Sequence similarity between beta-cell autoantigens.

G Rudy, V Brusic, LC Harrison, AM Lew

Journal article  |  1995  |  Immunology Today

ANALYSIS OF FAMILIES AT RISK FOR INSULIN-DEPENDENT DIABETES-MELLITUS REVEALS THAT HLA ANTIGENS INFLUENCE PROGRESSION TO CLINICAL-DISEASE

MC HONEYMAN, LC HARRISON, B DRUMMOND, PG COLMAN, BD TAIT

Journal article  |  1995  |  Molecular Medicine

Glutamic acid decarboxylase-67 (GAD67): expression relative to GAD65 in human islets and mapping of autoantibody epitopes.

DS Cram, B Faulkner-Jones, J Kun, LC Harrison

Journal article  |  1995  |  Endocrinology

Glutamic acid decarboxylase (GAD), a target of both autoantibodies and autoreactive T-cells in insulin-dependent diabetes (IDD), e..

HLA ANTIGENS AND AGE AT DIAGNOSIS OF INSULIN-DEPENDENT DIABETES-MELLITUS

BD TAIT, LC HARRISON, BP DRUMMOND, V STEWART, MD VARNEY, MC HONEYMAN

Journal article  |  1995  |  Human Immunology

HLA-matched control subjects are essential in studies of susceptibility to IDDM.

N Petrovsky, LC Harrison

Journal article  |  1995  |  Diabetologia

NEW PERSPECTIVES ON RHEUMATOID-ARTHRITIS

I WICKS, G MCCOLL, L HARRISON

Journal article  |  1994  |  Immunology Today

Do glutamic acid decarboxylase antibodies improve the prediction of IDDM in first-degree relatives at risk for IDDM?

RS Schmidli, PG Colman, LC Harrison

Conference Proceedings  |  1994  |  Journal of Autoimmunity

To determine whether the predictive value of islet cell antibodies (ICA) and insulin autoantibodies (IAA) is increased by measurem..

Characterization of ganglioside associated with the thyrotrophin receptor.

W Kielczynski, RK Bartholomeusz, LC Harrison

Journal article  |  1994  |  Glycobiology

The receptor protein for thyrotrophin (thyroid-stimulating hormone; TSH) is associated with a glycosphingolipid moiety. The protei..

Natural history of humoral immunity to glutamic acid decarboxylase in non-obese diabetic (NOD) mice.

HJ De Aizpurua, MB French, N Chosich, LC Harrison

Journal article  |  1994  |  Journal of Autoimmunity

Autoantibodies to glutamic acid decarboxylase (GAD) are present in humans before and after the onset of clinical insulin-dependent..

Islet cell antibodies. Light at the end of the tube?

LC Harrison

Journal article  |  1994  |  Diabetes Care

MHCPEP: a database of MHC-binding peptides.

V Brusic, G Rudy, LC Harrison

Journal article  |  1994  |  Nucleic Acids Research

MHCPEP is a curated database comprising over 4000 peptide sequences known to bind MHC molecules. Entries are compiled from publish..

High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop.

RS Schmidli, PG Colman, E Bonifacio, GF Bottazzo, LC Harrison

Journal article  |  1994  |  Diabetes

Glutamic acid decarboxylase antibodies (GADAbs) are being increasingly used in clinical and research programs for the prediction a..

Circadian rhythmicity of interferon-gamma production in antigen-stimulated whole blood.

N Petrovsky, P McNair, LC Harrison

Journal article  |  1994  |  Chronobiologia

Recently, assessment of T cell function has been refined by the ability to measure cytokines produced by activated T cells. We dev..

INVERSE RELATION BETWEEN HUMORAL AND CELLULAR-IMMUNITY TO GLUTAMIC-ACID DECARBOXYLASE IN SUBJECTS AT RISK OF INSULIN-DEPENDENT DIABETES

LC HARRISON, MC HONEYMAN, HJ DEAIZPURUA, RS SCHMIDLI, PG COLMAN, BD TAIT, DS CRAM

Journal article  |  1994  |  Journal of Endocrinological Investigation

Effects of dexfenfluramine on glucose turnover in non-insulin-dependent diabetes mellitus.

J Proietto, AW Thorburn, S Fabris, LC Harrison

Journal article  |  1994  |  Diabetes Research and Clinical Practice

Dexfenfluramine, a serotonin agonist with effects on the central nervous system (CNS), lowers blood glucose in patients with non-i..

Antibodies to glutamic acid decarboxylase in at-risk and clinical insulin-dependent diabetic subjects: relationship to age, sex and islet cell antibody status, and temporal profile.

RS Schmidli, HJ DeAizpurua, LC Harrison, PG Colman

Journal article  |  1994  |  Journal of Autoimmunity

Antibodies to glutamic decarboxylase (GADAb) are present in insulin-dependent diabetes (IDD) but their association with age and se..

Endogenous TNF production differs between high and low diabetes incidence non-obese diabetic (NOD) mice.

N Chosich, E Rockett, LC Harrison

Journal article  |  1994  |  Autoimmunity

Tumour necrosis factor (TNF) has been implicated in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). To investigate..

New perspectives on rheumatoid arthritis

I Wicks, G McColl, L Harrison

Journal article  |  1994  |  Immunology Today

Antibody specificities of Thai and Australian scleroderma sera with topoisomerase I recombinant fusion proteins.

DS Cram, N Fisicaro, LJ McNeilage, RL Coppel, LC Harrison

Journal article  |  1993  |  Journal of Immunology

Autoantibodies that react with the nuclear enzyme topoisomerase I (Topo I) are used as a diagnostic marker of diffuse scleroderma...

Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat.

BE Faulkner-Jones, DS Cram, J Kun, LC Harrison

Journal article  |  1993  |  Endocrinology

Glutamic acid decarboxylase (GAD) catalyzes synthesis of the inhibitory neurotransmitter gamma-amino butyric acid. Two homologous ..

Cytokine production in response to Epstein-Barr virus infection of peripheral blood mononuclear cells in vitro.

S Whittingham, G Naselli, LC Harrison, AW Boyd, J Cebon, I Jack

Journal article  |  1993  |  Immunology and Cell Biology

To obtain a better understanding of the immune response to Epstein-Barr virus (EBV), we measured the cytokines tumour necrosis fac..

Suppression of diabetes mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (anti-I-Ag7) islet-derived CD4 T-cell line.

N Chosich, LC Harrison

Journal article  |  1993  |  Diabetologia

The non-obese diabetic (NOD) mouse is a spontaneous model of human insulin-dependent diabetes mellitus. Both CD4+ and CD8+ T cells..

Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins.

PJ Leedman, B Faulkner-Jones, DS Cram, PJ Harrison, J West, E O'Brien, R Simpson, RL Coppel, LC Harrison

Journal article  |  1993  |  Proceedings of the National Academy of Sciences

Human actin binding protein (ABP) links specific membrane glycoproteins to cytoskeletal actin microfilaments. In human platelets a..

INVERSE RELATION BETWEEN HUMORAL AND CELLULAR-IMMUNITY TO GLUTAMIC-ACID DECARBOXYLASE IN SUBJECTS AT RISK OF INSULIN-DEPENDENT DIABETES

LC HARRISON, MC HONEYMAN, HJ DEAIZPURUA, RS SCHMIDLI, PG COLMAN, BD TAIT, DS CRAM

Journal article  |  1993  |  The Lancet

Molecular cloning of full-length glutamic acid decarboxylase 67 from human pancreas and islets.

K Yamashita, DS Cram, LC Harrison

Journal article  |  1993  |  Biochemical and Biophysical Research Communications

Glutamic acid decarboxylase (GAD) is a pancreatic islet autoantigen in insulin-dependent diabetes (IDD). Two forms of GAD, GAD65 a..

Transcription factor jun-B is target of autoreactive T-cells in IDDM.

MC Honeyman, DS Cram, LC Harrison

Journal article  |  1993  |  Diabetes

Target antigens defined by autoantibodies in IDDM include insulin, a putative glycolipid that reacts with islet cell antibodies, a..

Nonimmune thyroid destruction results from transgenic overexpression of an allogeneic major histocompatibility complex class I protein.

AG Frauman, P Chu, LC Harrison

Journal article  |  1993  |  Molecular and Cellular Biology

The overexpression of major histocompatibility complex (MHC) class I molecules in endocrine epithelial cells is an early feature o..

Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes.

MC Honeyman, DS Cram, LC Harrison

Journal article  |  1993  |  The Journal of Experimental Medicine

Glutamic acid decarboxylase (GAD) has been shown to be a target of autoantibodies in insulin-dependent diabetes (IDD). Two forms o..

The immunologic insult in type 1 diabetes.

MC Honeyman, LC Harrison

Journal article  |  1993  |  Springer Seminars in Immunopathology

A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes.

HJ DeAizpurua, MC Honeyman, LC Harrison

Journal article  |  1992  |  Journal of Autoimmunity

The development of insulin-dependent diabetes mellitus (IDDM) is associated with circulating antibodies to a pancreatic islet prot..

Reproducibility of estimating first phase insulin responses to intravenous glucose

M Koschmann, FP Alford, GM Ward, J Walters, PG Colman, LC Harrison

Journal article  |  1992  |  Diabetes, Nutrition and Metabolism - Clinical and Experimental

GLUTAMIC-ACID DECARBOXYLASE AUTOANTIBODIES IN PRECLINICAL INSULIN-DEPENDENT DIABETES

HJ DEAIZPURUA, YM WILSON, LC HARRISON

Journal article  |  1992  |  Proceedings of the National Academy of Sciences

Insulin-dependent diabetes mellitus (IDDM) is associated with serum antibodies that precipitate a 64-kDa pancreatic islet cell pro..

IDENTIFICATION OF A DOPAMINE-BINDING PROTEIN ON THE MEMBRANE OF THE HUMAN PLATELET

B DEAN, AJ MCADAM, S SUNDRAM, G PAVEY, LC HARRISON, DL COPOLOV

Journal article  |  1992  |  Biochemical Journal

An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM.

HJ DeAizpurua, LC Harrison, DS Cram

Journal article  |  1992  |  Diabetes

To detect serum antibodies to GAD in subjects with IDDM, three recombinant mBGAD 67 peptides encompassing the full-length protein ..

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited.

LC Harrison

Journal article  |  1992  |  Immunology Today

A major goal of research into IDDM has been the identification of the 'causative antigen'. As described in this article by Len Har..

Comparison of two commonly used standard IVGTTs.

PG Colman, V Stewart, J Kean, M Koschmann, F Alford, G Ward, D Deam, LC Harrison

Journal article  |  1992  |  Diabetes Care

OBJECTIVE: To compare the magnitude and reproducibility of the FPIR measured during two different IVGTT protocols in nondiabetic s..

Lack of specificity of islet cell surface antibodies (ICSA) in IDDM.

C Peterson, IL Campbell, LC Harrison

Journal article  |  1992  |  Diabetes Research and Clinical Practice

Human islets were isolated by collagenase digestion and tissue culture from pancreata obtained from organ donor subjects and dispe..

Glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

HJ DeAizpurua, LC Harrison

Journal article  |  1992  |  Diabetes / Metabolism Reviews

Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes.

LC Harrison, SX Chu, HJ DeAizpurua, M Graham, MC Honeyman, PG Colman

Journal article  |  1992  |  Journal of Clinical Investigation

The destruction of pancreatic islet beta cells in insulin-dependent diabetes mellitus (IDDM) is thought to be T cell mediated. To ..

Antitopoisomerase I monoclonal autoantibodies from scleroderma patients and tight skin mouse interact with similar epitopes.

T Muryoi, KN Kasturi, MJ Kafina, DS Cram, LC Harrison, T Sasaki, CA Bona

Journal article  |  1992  |  The Journal of Experimental Medicine

We have generated for the first time monoclonal antibodies (mAbs) specific for topoisomerase I (topo I) from scleroderma patients,..

Enhanced insulin-receptor tyrosine kinase activity associated with chromosomal translocation (1;19) in a pre-B-cell leukemia line.

JD Newman, LC Harrison, GS Eckardt, I Jack

Journal article  |  1992  |  International Journal of Cancer

The gene for the insulin receptor has been assigned to chromosome 19 near the breakpoint of the translocation t(1;19) which occurs..

Comparison of two commonly used standard IVGTTs

PG Colman, V Stewart, J Kean, M Koschmann, F Alford, G Ward, D Deam, LC Harrison

Journal article  |  1992  |  Diabetes Care

Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-gamma antibody.

TW Kay, IL Campbell, L Oxbrow, LC Harrison

Journal article  |  1991  |  Diabetologia

Overexpression of class I major histocompatibility complex (MHC) proteins on pancreatic islet cells is a characteristic of autoimm..

Transgenic approaches to understanding the role of MHC genes in insulin dependent diabetes mellitus. I. Immune and non-immune mechanisms of beta cell destruction.