Leonard Harrison

Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome

Alexandra J Roth-Schulze, Megan AS Penno, Katrina M Ngui, Helena Oakey, Esther Bandala-Sanchez, Alannah D Smith, Theo R Allnutt, Rebecca L Thomson, Peter J Vuillermin, Maria E Craig, William D Rawlinson, Elizabeth A Davis, Mark Harris, Georgia Soldatos, Peter G Colman, John M Wentworth, Aveni Haynes, Simon C Barry, Richard O Sinnott, Grant Morahan, et al.

Journal article  |  2021  |  MICROBIOME

BACKGROUND: The gut microbiome changes in response to a range of environmental conditions, life events and disease states. Pregnan..

The dark side of insulin: A primary autoantigen and instrument of self-destruction in type 1 diabetes.

Leonard C Harrison

Journal article  |  2021  |  Mol Metab

BACKGROUND: Since its discovery 100 years ago, insulin, as the 'cure' for type 1 diabetes, has rescued the lives of countless indi..

Expanding the taxonomic range in the fecal metagenome

Theo R Allnutt, Alexandra J Roth-Schulze, Leonard C Harrison

Journal article  |  2021  |  BMC BIOINFORMATICS

BACKGROUND: Except for bacteria, the taxonomic diversity of the human fecal metagenome has not been widely studied, despite the po..

Multi-level remodelling of chromatin underlying activation of human T cells

Naiara G Bediaga, Hannah D Coughlan, Timothy M Johanson, Alexandra L Garnham, Gaetano Naselli, Jan Schroeder, Liam G Fearnley, Esther Bandala-Sanchez, Rhys S Allan, Gordon K Smyth, Leonard C Harrison

Journal article  |  2021  |  SCIENTIFIC REPORTS

Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage develop..

Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study

Megan AS Penno, Helena Oakey, Priya Augustine, Mario Taranto, Simon C Barry, Peter G Colman, Maria E Craig, Elizabeth A Davis, Lynne C Giles, Mark Harris, Aveni Haynes, Kelly McGorm, Grant Morahan, Claire Morbey, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth, et al.

Journal article  |  2020  |  PEDIATRIC DIABETES

BACKGROUNDS: We aimed to monitor pancreatic exocrine function longitudinally in relation to the development of islet autoimmunity ..

Clinical trial data validate the C-peptide estimate model in type 1 diabetes

John M Wentworth, Naiara G Bediaga, Stephen E Gitelman, Carmela Evans-Molina, Peter A Gottlieb, Peter G Colman, Michael J Haller, Leonard C Harrison

Journal article  |  2020  |  DIABETOLOGIA

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Peter J Vuillermin, Martin O'Hely, Fiona Collier, Katrina J Allen, Mimi LK Tang, Leonard C Harrison, John B Carlin, Richard Saffery, Sarath Ranganathan, Peter D Sly, Lawrence Gray, John Molloy, Angela Pezic, Michael Conlon, David Topping, Karen Nelson, Charles R Mackay, Laurence Macia, Jennifer Koplin, Samantha L Dawson, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have..

A pilot study of the feasibility of empagliflozin in recent-onset type 1 diabetes.

John M Wentworth, Spiros Fourlanos, Peter G Colman, Leonard C Harrison

Journal article  |  2020  |  Metabol Open

Introduction: Sodium-glucose linked transporter (SGLT) inhibitors could improve glycaemia and simplify insulin regimens in recent-..

Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter I Lipkin, Kelly McGorm, Grant Morahan, Claire Morbey, Ignatius CN Pang, et al.

Journal article  |  2020  |  PEDIATRIC DIABETES

Background: Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compar..

Gut microbiota composition during infancy and subsequent behavioural outcomes

Amy Loughman, Anne-Louise Ponsonby, Martin O'Hely, Christos Symeonides, Fiona Collier, Mimi LK Tang, John Carlin, Sarath Ranganathan, Katrina Allen, Angela Pezic, Richard Saffery, Felice Jacka, Leonard C Harrison, Peter D Sly, Peter Vuillermin

Journal article  |  2020  |  EBIOMEDICINE

BACKGROUND: Despite intense interest in the relationship between gut microbiota and brain development, longitudinal data from huma..