Rachel Davey

A20 controls RANK-dependent osteoclast formation and bone physiology.

Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amélie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D Zajac, Rachel A Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu JM Bertrand, et al.

Journal article  |  2022  |  EMBO Rep

The anti-inflammatory protein A20 serves as a critical brake on NF-κB signaling and NF-κB-dependent inflammation. In humans, polym..

The Importance of Sex in Preclinical Studies of Bone

Rachel A Davey

Journal article  |  2022  |  JOURNAL OF BONE AND MINERAL RESEARCH

Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia

Lucia Moreira, Abhijit Takawale, David A Menassa, Constantinos Psarros, Neelam Mehta, Neil Evans, Marc-Antoine Gillis, Angela Lee, Patrice Naud, Mary Norris, Michele V Clarke, Patricia K Russell, Barbara Casadei, Shoumo Bhattacharya, Jeffrey D Zajac, Rachel A Davey, Martin Sirois, Rana Sayeed, George Krasopoulos, Charles Redwood, et al.

Journal article  |  2022  |  Journal of Molecular and Cellular Cardiology

The AR in bone marrow progenitor cells protects against short-term high-caloric diet-induced weight gain in male mice

Varun S Venkatesh, Patricia K Russell, Barbara Fam White, Michele Clarke, Suzanne Golub, Salvatore Mangiofico, Christian Haralambous, Julie Lokan, Sof Andrikopoulos, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2022  |  JOURNAL OF MOLECULAR ENDOCRINOLOGY

We previously identified a novel pathway of testosterone action via the androgen receptor (AR) in bone marrow mesenchymal precurso..

The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Varun S Venkatesh, Mathis Grossmann, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2022  |  OBESITY REVIEWS

Obesity is associated with hypothalamic-pituitary-testicular axis dysregulation in males. Here, we summarize recent evidence deriv..

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver (vol 11, 22975, 2021)

Najla AlOgayil, Klara Bauermeister, Jose Hector Galvez, Varun S Venkatesh, Qinwei Kim-wee Zhuang, Matthew L Chang, Rachel A Davey, Jeffrey D Zajac, Kinuyo Ida, Akihide Kamiya, Teruko Taketo, Guillaume Bourque, Anna K Naumova

Journal article  |  2021  |  SCIENTIFIC REPORTS

The original version of this Article contained an error in Figure 5 where the labels indicating the names of the tested loci were ..

Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models

Aarti Patel, Ryoichi Kimura, Wen Fu, Rania Soudy, David MacTavish, David Westaway, Jing Yang, Rachel A Davey, Jeffrey D Zajac, Jack H Jhamandas

Journal article  |  2021  |  MOLECULAR NEUROBIOLOGY

Based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a class B G protein-coupled receptor (GPCR), is a po..

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver

Najla AlOgayil, Klara Bauermeister, Jose Hector Galvez, Varun S Venkatesh, Qinwei Kim-wee Zhuang, Matthew L Chang, Rachel A Davey, Jeffrey D Zajac, Kinuyo Ida, Akihide Kamiya, Teruko Taketo, Guillaume Bourque, Anna K Naumova

Journal article  |  2021  |  SCIENTIFIC REPORTS

Sexual dimorphism in gene regulation, including DNA methylation, is the main driver of sexual dimorphism in phenotypes. However, t..

Neuronal androgen receptor is required for activity dependent enhancement of peripheral nerve regeneration

Patricia J Ward, Rachel A Davey, Jeffrey D Zajac, Arthur W English

Journal article  |  2021  |  DEVELOPMENTAL NEUROBIOLOGY

Neuronal activity after nerve injury can enhance axon regeneration and the restoration of function. The mechanism for this enhance..

Changes in white adipose tissue gene expression in a randomized control trial of dieting obese men with lowered serum testosterone alone or in combination with testosterone treatment

Mathis Grossmann, Mark Ng Tang Fui, Tian Nie, Rudolf Hoermann, Michele V Clarke, Ada S Cheung, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2021  |  ENDOCRINE

PURPOSE: The aim of this study was to determine early weight loss-associated changes in subcutaneous abdominal white adipose tissu..