Rachel Davey

Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models

Aarti Patel, Ryoichi Kimura, Wen Fu, Rania Soudy, David MacTavish, David Westaway, Jing Yang, Rachel A Davey, Jeffrey D Zajac, Jack H Jhamandas

Journal article  |  2021  |  MOLECULAR NEUROBIOLOGY

Based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a class B G protein-coupled receptor (GPCR), is a po..

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver

Najla AlOgayil, Klara Bauermeister, Jose Hector Galvez, Varun S Venkatesh, Qinwei Kim-wee Zhuang, Matthew L Chang, Rachel A Davey, Jeffrey D Zajac, Kinuyo Ida, Akihide Kamiya, Teruko Taketo, Guillaume Bourque, Anna K Naumova

Journal article  |  2021  |  SCIENTIFIC REPORTS

Sexual dimorphism in gene regulation, including DNA methylation, is the main driver of sexual dimorphism in phenotypes. However, t..

Vitamin D receptor expression in mature osteoclasts reduces bone loss due to low dietary calcium intake in male mice

Yolandi Starczak, Daniel C Reinke, Kate R Barratt, Patricia K Russell, Michelle Clarke, Rachel A Davey, Gerald J Atkins, Paul H Anderson

Journal article  |  2021  |  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mature osteoclasts express the vitamin D receptor (VDR) and are able to respond to active vitamin D (1α, 25-dihydroxyvitamin D3; 1..

Neuronal androgen receptor is required for activity dependent enhancement of peripheral nerve regeneration

Patricia J Ward, Rachel A Davey, Jeffrey D Zajac, Arthur W English

Journal article  |  2021  |  DEVELOPMENTAL NEUROBIOLOGY

Neuronal activity after nerve injury can enhance axon regeneration and the restoration of function. The mechanism for this enhance..

Changes in white adipose tissue gene expression in a randomized control trial of dieting obese men with lowered serum testosterone alone or in combination with testosterone treatment

Mathis Grossmann, Mark Ng Tang Fui, Tian Nie, Rudolf Hoermann, Michele V Clarke, Ada S Cheung, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2021  |  ENDOCRINE

PURPOSE: The aim of this study was to determine early weight loss-associated changes in subcutaneous abdominal white adipose tissu..

The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice

Rachel A Davey, Michele Clarke, Suzanne B Golub, Patricia K Russell, Jeffrey D Zajac

Journal article  |  2021  |  JOURNAL OF ENDOCRINOLOGY

The physiological role of calcitonin, and its receptor, the CTR (or Calcr), has long been debated. We previously provided the firs..

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

Lucia M Moreira, Abhijit Takawale, Mohit Hulsurkar, David A Menassa, Agne Antanaviciute, Satadru K Lahiri, Neelam Mehta, Neil Evans, Constantinos Psarros, Paul Robinson, Alexander J Sparrow, Marc-Antoine Gillis, Neil Ashley, Patrice Naud, Javier Barallobre-Barreiro, Konstantinos Theofilatos, Angela Lee, Mary Norris, Michele V Clarke, Patricia K Russell, et al.

Journal article  |  2020  |  NATURE

Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly ..

Relationship between Serum PTH and Metabolic Biomarkers

Syu Mi Sam, Sabashini Ramchand, Rachel Davey, Samantha Richardson, Jeffrey Zajac, Janine Danks

Conference Proceedings  |  2020  |  JOURNAL OF BONE AND MINERAL RESEARCH

Androgens stimulate erythropoiesis through the DNA-binding activity of the androgen receptor in non-hematopoietic cells

Julie F McManus, Nhu-Y N Nguyen, Rachel A Davey, Helen E MacLean, Giovanna Pomilio, Matthew P McCormack, Wan Sze Chiu, Andrew H Wei, Jeffrey D Zajac, David J Curtis

Journal article  |  2020  |  EUROPEAN JOURNAL OF HAEMATOLOGY

BACKGROUND: Androgens function through DNA and non-DNA binding-dependent signalling of the androgen receptor (AR). How androgens p..

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2020  |  NATURE

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..