Misty Jenkins

Towards Immunotherapy for Pediatric Brain Tumors

Stacie Shiqi Wang, Pratiti Bandopadhayay, Misty Rayna Jenkins

Journal article  |  2019  |  Trends in Immunology

Pediatric brain tumors are the leading cause of childhood cancer-related death. Immunotherapy is a powerful new approach for treat..

Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska

Journal article  |  2019  |  Clinical & Translational Immunology

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey

Journal article  |  2018  |  Scientific Reports

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

AJ Davenport, RS Cross, KA Watson, Y Liao, W Shi, HM Prince, PA Beavis, JA Trapani, MH Kershaw, DS Ritchie, PK Darcy, PJ Neeson, MR Jenkins

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  Diabetes

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2( ) Tumors

Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R Jenkins, Kelly M Ramsbottom, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, Peter W Atadja, Michael A Henderson, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2017  |  Cancer Research

PD-1 blockade enhances elotuzumab efficacy in mouse tumor models

Natalie A Bezman, Amy Jhatakia, Alper Y Kearney, Ty Brender, Mark Maurer, Karla Henning, Misty R Jenkins, Amy J Rogers, Paul J Neeson, Alan J Korman, Michael D Robbins, Robert F Graziano

Journal article  |  2017  |  Blood Advances

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Vivien R Sutton, Amelia J Brennan, Sarah Ellis, Jill Danne, Kevin Thia, Misty R Jenkins, Ilia Voskoboinik, Gunnar Pejler, Ricky W Johnstone, Daniel M Andrews, Joseph A Trapani

Journal article  |  2016  |  FEBS Journal

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

Alexander J Davenport, Misty R Jenkins, Ryan S Cross, Carmen S Yong, H Miles Prince, David S Ritchie, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  Cancer Immunology Research

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Misty R Jenkins, Jesse A Rudd-Schmidt, Jamie A Lopez, Kelly M Ramsbottom, Stuart I Mannering, Daniel M Andrews, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2015  |  The Journal of Experimental Medicine

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker consequences?

Joseph A Trapani, Ilia Voskoboinik, Misty R Jenkins

Journal article  |  2015  |  OncoImmunology

CAR-T cells are serial killers

Alexander J Davenport, Misty R Jenkins, David S Ritchie, H Miles Prince, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  OncoImmunology

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

Misty R Jenkins, Jane C Stinchcombe, Byron B Au-Yeung, Yukako Asano, Alex T Ritter, Arthur Weiss, Gillian M Griffiths

Journal article  |  2014  |  eLife

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

Jamie A Lopez, Misty R Jenkins, Jesse A Rudd-Schmidt, Amelia J Brennan, Jillian C Danne, Stuart I Mannering, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2013  |  Journal of Immunology

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Jamie A Lopez, Olivia Susanto, Misty R Jenkins, Natalya Lukoyanova, Vivien R Sutton, Ruby HP Law, Angus Johnston, Catherina H Bird, Phillip I Bird, James C Whisstock, Joseph A Trapani, Helen R Saibil, Ilia Voskoboinik

Journal article  |  2013  |  Blood

Centrosome docking at the immunological synapse is controlled by Lck signaling

Andy Tsun, Ihjaaz Qureshi, Jane C Stinchcombe, Misty R Jenkins, Maike de la Roche, Joanna Kleczkowska, Rose Zamoyska, Gillian M Griffiths

Journal article  |  2011  |  Journal of Cell Biology

The synapse and cytolytic machinery of cytotoxic T cells

Misty R Jenkins, Gillian M Griffiths

Journal article  |  2010  |  Current Opinion in Immunology

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

Misty R Jenkins, Andy Tsun, Jane C Stinchcombe, Gillian M Griffiths

Journal article  |  2009  |  Immunity

Visualizing CTL activity for different CD8( ) effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing

MR Jenkins, NL La Gruta, PC Doherty, JA Trapani, SJ Turner, NJ Waterhouse

Journal article  |  2009  |  Cell Death & Differentiation

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8( ) T cells

Misty R Jenkins, Justine Mintern, Nicole L La Gruta, Katherine Kedzierska, Peter C Doherty, Stephen J Turner

Journal article  |  2008  |  Journal of Immunology

Granzyme K Expressing Cytotoxic T Lymphocytes Protects Against Influenza Virus in Granzyme AB(-/-) Mice

Misty R Jenkins, Joseph A Trapani, Peter C Doherty, Stephen J Turner

Journal article  |  2008  |  Viral Immunology

Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL

Misty R Jenkins, Katherine Kedzierska, Peter C Doherty, Stephen J Turner

Journal article  |  2007  |  Journal of Immunology

Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8( ) T cell memory

Katherine Kedzierska, John Stambas, Misty R Jenkins, Rachael Keating, Stephen J Turner, Peter C Doherty

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel

Ruwei Xu, Evan A Thomas, Misty Jenkins, Elena V Gazina, Cindy Chiu, Sarah E Heron, John C Mulley, Ingrid E Scheffer, Samuel F Berkovic, Steven Petrou

Journal article  |  2007  |  Molecular and Cellular Neurosciences

Addition of a prominent epitope affects influenza a virus-specific CD8( ) T cell immunodominance hierarchies when antigen is limiting

Misty Rayna Jenkins, Richard Webby, Peter C Doherty, Stephen J Turner

Journal article  |  2006  |  Journal of Immunology

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

NJ Waterhouse, VR Sutton, KA Sedelies, A Ciccone, M Jenkins, SJ Turner, PI Bird, JA Trapani

Journal article  |  2006  |  Journal of Cell Biology

GABRD encoding a protein for extra- or peri-synaptic GABA(A) receptors is a susceptibility locus for generalized epilepsies

LM Dibbens, HJ Feng, LA Harkin, BL Hodgson, D Scott, M Jenkins, S Petrou, GR Sutherland, IE Scheffer, SF Berkovic, RL Macdonald, JC Mulley

Journal article  |  2004  |  Human Molecular Genetics