Our research team investigates the biology of white blood cells called cytotoxic lymphocytes. These cells are the serial killers of the immune system, and it’s their job to seek and destroy cancerous and virus infected cells.
We are studying the cell biology behind how killer lymphocytes acquire the ability to kill and detach from cancer cells.
Recent advances in cancer immunotherapy have aimed to recruit the immune system to fight cancer; this has shown great clinical promise.
Our work is trying to understand the cell biology of an effective immune response to extend these therapies to cover a broader range of malignancies, and allow for sustained immune responses.
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Misty Jenkins' highlights
Misty Jenkins' selected work
Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissu..
Displaying the 5 most recent projects by Misty Jenkins.
Displaying the 27 most recent scholarly works by Misty Jenkins.
Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation
Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska
Journal article | 2019 | Clinical & Translational Immunology
Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma
Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey
Journal article | 2018 | Scientific Reports
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity
AJ Davenport, RS Cross, KA Watson, Y Liao, W Shi, HM Prince, PA Beavis, JA Trapani, MH Kershaw, DS Ritchie, PK Darcy, PJ Neeson, MR Jenkins
Journal article | 2018 | Proceedings of the National Academy of Sciences
Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas
Journal article | 2017 | Diabetes
HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2( ) Tumors
Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R Jenkins, Kelly M Ramsbottom, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, Peter W Atadja, Michael A Henderson, Ricky W Johnstone, Nicole M Haynes
Journal article | 2017 | Cancer Research
Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity
Vivien R Sutton, Amelia J Brennan, Sarah Ellis, Jill Danne, Kevin Thia, Misty R Jenkins, Ilia Voskoboinik, Gunnar Pejler, Ricky W Johnstone, Daniel M Andrews, Joseph A Trapani
Journal article | 2016 | FEBS Journal
Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time
Misty R Jenkins, Jesse A Rudd-Schmidt, Jamie A Lopez, Kelly M Ramsbottom, Stuart I Mannering, Daniel M Andrews, Ilia Voskoboinik, Joseph A Trapani
Journal article | 2015 | Journal of Experimental Medicine
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
Jamie A Lopez, Olivia Susanto, Misty R Jenkins, Natalya Lukoyanova, Vivien R Sutton, Ruby HP Law, Angus Johnston, Catherina H Bird, Phillip I Bird, James C Whisstock, Joseph A Trapani, Helen R Saibil, Ilia Voskoboinik
Journal article | 2013 | Blood
Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8( ) T cells
Misty R Jenkins, Justine Mintern, Nicole L La Gruta, Katherine Kedzierska, Peter C Doherty, Stephen J Turner
Journal article | 2008 | Journal of Immunology
Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8( ) T cell memory
Katherine Kedzierska, John Stambas, Misty R Jenkins, Rachael Keating, Stephen J Turner, Peter C Doherty
Journal article | 2007 | Proceedings of the National Academy of Sciences of the United States of America
A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel
Ruwei Xu, Evan A Thomas, Misty Jenkins, Elena V Gazina, Cindy Chiu, Sarah E Heron, John C Mulley, Ingrid E Scheffer, Samuel F Berkovic, Steven Petrou
Journal article | 2007 | Molecular and Cellular Neurosciences
GABRD encoding a protein for extra- or peri-synaptic GABA(A) receptors is a susceptibility locus for generalized epilepsies
LM Dibbens, HJ Feng, LA Harkin, BL Hodgson, D Scott, M Jenkins, S Petrou, GR Sutherland, IE Scheffer, SF Berkovic, RL Macdonald, JC Mulley
Journal article | 2004 | Human Molecular Genetics
Displaying the 2 most recent news articles by Misty Jenkins.
Honours, Awards and Fellowships
Medical Biology (W.E.H.I.)
Doctor of Philosophy
University of Melbourne
Bachelor of Science (Honours)
University of Melbourne