Jan Schroeder

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schroder, Chad K Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced regenerative potential and loss of quiesce..

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

Xiaodong Liu, Jia Ping Tan, Jan Schroder, Asma Aberkane, John F Ouyang, Monika Mohenska, Sue Mei Lim, Yu BY Sun, Joseph Chen, Guizhi Sun, Yichen Zhou, Daniel Poppe, Ryan Lister, Amander T Clark, Owen JL Rackham, Jennifer Zenker, Jose M Polo

Journal article  |  2021  |  NATURE

Human pluripotent and trophoblast stem cells have been essential alternatives to blastocysts for understanding early human develop..

Multi-level remodelling of chromatin underlying activation of human T cells

Naiara G Bediaga, Hannah D Coughlan, Timothy M Johanson, Alexandra L Garnham, Gaetano Naselli, Jan Schroeder, Liam G Fearnley, Esther Bandala-Sanchez, Rhys S Allan, Gordon K Smyth, Leonard C Harrison

Journal article  |  2021  |  SCIENTIFIC REPORTS

Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage develop..

TINC-A Method to Dissect Regulatory Complexes at Single-Locus Resolution-Reveals an Extensive Protein Complex at the Nanog Promoter

Anja S Knaupp, Monika Mohenska, Michael R Larcombe, Ethan Ford, Sue Mei Lim, Kayla Wong, Joseph Chen, Jaber Firas, Cheng Huang, Xiaodong Liu, Nguyen Trung, Yu BY Sun, Melissa L Holmes, Pratibha Tripathi, Jahnvi Pflueger, Fernando J Rossello, Jan Schroder, Kathryn C Davidson, Christian M Nefzger, Partha P Das, et al.

Journal article  |  2020  |  STEM CELL REPORTS

Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory elements (REs) to control gen..

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Xiaodong Liu, John F Ouyang, Fernando J Rossello, Jia Ping Tan, Kathryn C Davidson, Daniela S Valdes, Jan Schroeder, Yu BY Sun, Joseph Chen, Anja S Knaupp, Guizhi Sun, Hun S Chy, Ziyi Huang, Jahnvi Pflueger, Jaber Firas, Vincent Tano, Sam Buckberry, Jacob M Paynter, Michael R Larcombe, Daniel Poppe, et al.

Journal article  |  2020  |  Nature

The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early embry..

A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture.

Alexandra Grubman, Teresa H Vandekolk, Jan Schröder, Guizhi Sun, Jessica Hatwell-Humble, Jonathan Chan, Minna Oksanen, Sarka Lehtonen, Cameron Hunt, Jari E Koistinaho, Susan K Nilsson, John M Haynes, Colin W Pouton, Jose M Polo

Journal article  |  2020  |  Stem Cell Reports

Multiple protocols have been published for generation of iMGLs from hESCs/iPSCs. To date, there are no guides to assist researcher..

Inferring structural variant cancer cell fraction

Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, undefined PCAWG Evolution and Heterogeneity Working Group, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whol..

Overview of Fusion Detection Strategies Using Next-Generation Sequencing

Jan Schroeder, Amit Kumar, Stephen Q Wong

Book Chapter  |  2019  |  Methods in Molecular Biology

Structural gene fusion rearrangements leading to aberrant signaling are frequently detected in many cancer types. Gene fusions hav..

The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate

Joseph HA Vissers, Francesca Froldi, Jan Schroder, Anthony T Papenfuss, Louise Y Cheng, Kieran F Harvey

Journal article  |  2018  |  CELL REPORTS

The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scallo..

An orthotopic mouse model of gastric cancer invasion and metastasis

Rita A Busuttil, David S Liu, Natasha Di Costanzo, Jan Schroder, Catherine Mitchell, Alex Boussioutas

Journal article  |  2018  |  SCIENTIFIC REPORTS

Gastric cancer is a leading cause of cancer death worldwide, with advanced stage being correlated to the level of tumour invasion ..