Robert MacInnis

Heritable methylation marks associated with prostate cancer risk.

James G Dowty, Chenglong Yu, Mahnaz Hosseinpour, Jihoon Eric Joo, Ee Ming Wong, Tu Nguyen-Dumont, Joseph Rosenbluh, Graham G Giles, Roger L Milne, Robert J MacInnis, Pierre-Antoine Dugué, Melissa C Southey

Journal article  |  2023  |  Fam Cancer

DNA methylation marks that are inherited from parents to offspring are known to play a role in cancer risk and could explain part ..

Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men.

Anqi Wang, Yili Xu, Yao Yu, Kevin T Nead, TaeBeom Kim, Keren Xu, Tokhir Dadaev, Ed Saunders, Xin Sheng, Peggy Wan, Loreall Pooler, Lucy Y Xia, Stephen Chanock, Sonja I Berndt, Susan M Gapstur, Victoria Stevens, Demetrius Albanes, Stephanie J Weinstein, Vincent Gnanapragasam, Graham G Giles, et al.

Journal article  |  2023  |  Hum Mol Genet

Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate potential (CHIP), which is..

The future burden of oesophageal and stomach cancers attributable to modifiable behaviours in Australia: a pooled cohort study

Maarit A Laaksonen, Siqi E Li, Karen J Canfell, Robert JE MacInnis, Graham GK Giles, Emily Banks, Julie LG Byles, Dianna J Magliano, Jonathan E Shaw, Tiffany K Gill, Vasant Hirani, Robert GW Cumming, Paul Mitchell, Michelle M Bonello, Claire M Vajdic, Barbara-Ann Adelstein, Anne W Taylor, Kay Price, Canc PAF Cohort consortium Australian

Journal article  |  2022  |  BRITISH JOURNAL OF CANCER

BACKGROUND: We quantified the individual and joint contribution of contemporaneous causal behavioural exposures on the future burd..

Australian genome-wide association study confirms higher female risk for adult glioma associated with variants in the region of CCDC26

Karen Alpen, Claire M Vajdic, Robert J MacInnis, Roger L Milne, Eng-Siew Koh, Elizabeth Hovey, Rosemary Harrup, Fiona Bruinsma, Tuong L Nguyen, Shuai Li, David Joseph, Geza Benke, Pierre-Antoine Dugue, Melissa C Southey, Graham G Giles, Mark Rosenthal, Katharine J Drummond, Anna K Nowak, John L Hopper, Miroslaw Kapuscinski, et al.

Journal article  |  2022  |  NEURO-ONCOLOGY

BACKGROUND: Glioma accounts for approximately 80% of malignant adult brain cancer and its most common subtype, glioblastoma, has o..

Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction

Shuai Li, Robert J MacInnis, Andrew Lee, Tu Nguyen-Dumont, Leila Dorling, Sara Carvalho, Gillian S Dite, Mitul Shah, Craig Luccarini, Qin Wang, Roger L Milne, Mark A Jenkins, Graham G Giles, Alison M Dunning, Paul DP Pharoah, Melissa C Southey, Douglas F Easton, John L Hopper, Antonis C Antoniou

Journal article  |  2022  |  AMERICAN JOURNAL OF HUMAN GENETICS

Rare pathogenic variants in known breast cancer-susceptibility genes and known common susceptibility variants do not fully explain..

Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis

Eleanor L Watts, Aurora Perez-Cornago, Georgina K Fensom, Karl Smith-Byrne, Urwah Noor, Colm D Andrews, Marc J Gunter, Michael Holmes, Richard M Martin, Konstantinos K Tsilidis, Demetrius Albanes, Aurelio Barricarte, H Bas Bueno-de-Mesquita, Barbara A Cohn, Melanie Deschasaux-Tanguy, Niki L Dimou, Luigi Ferrucci, Leon Flicker, Neal D Freedman, Graham G Giles, et al.

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

BACKGROUND: Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IG..

Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia

Eleanor L Watts, Aurora Perez-Cornago, Georgina K Fensom, Karl Smith-Byrne, Urwah Noor, Colm D Andrews, Marc J Gunter, Michael Holmes, Richard M Martin, Konstantinos K Tsilidis, Demetrius Albanes, Aurelio Barricarte, Bas Bueno-de-Mesquita, Chu Chen, Barbara A Cohn, Niki L Dimou, Luigi Ferrucci, Leon Flicker, Neal D Freedman, Graham G Giles, et al.

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF CANCER

Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Furth..

Cigarette smoking and risk of second primary cancer: a systematic review and meta-analysis.

Zhi Jing Phua, Robert J MacInnis, Harindra Jayasekara

Journal article  |  2022  |  Cancer Epidemiol

Approximately 5% of the population are living with a diagnosis of cancer. Recent improvements in survival following a diagnosis of..

Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women.

Xiaoliang Wang, Pooja Middha Kapoor, Paul L Auer, Joe Dennis, Alison M Dunning, Qin Wang, Michael Lush, Kyriaki Michailidou, Manjeet K Bolla, Kristan J Aronson, Rachel A Murphy, Angela Brooks-Wilson, Derrick G Lee, Emilie Cordina-Duverger, Pascal Guénel, Thérèse Truong, Claire Mulot, Lauren R Teras, Alpa V Patel, Laure Dossus, et al.

Journal article  |  2022  |  Sci Rep

Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and ..

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.

Fernanda Morales Berstein, Daniel L McCartney, Ake T Lu, Konstantinos K Tsilidis, Emmanouil Bouras, Philip Haycock, Kimberley Burrows, Amanda I Phipps, Daniel D Buchanan, Iona Cheng, undefined PRACTICAL consortium, Richard M Martin, George Davey Smith, Caroline L Relton, Steve Horvath, Riccardo E Marioni, Tom G Richardson, Rebecca C Richmond

Journal article  |  2022  |  Elife

BACKGROUND: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear ..