Paul Hertzog

TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma.

Joanne Lundy, Linden J Gearing, Hugh Gao, Alison C West, Louise McLeod, Virginie Deswaerte, Liang Yu, Sean Porazinski, Marina Pajic, Paul J Hertzog, Daniel Croagh, Brendan J Jenkins

Journal article  |  2021  |  Oncogene

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and is plagued by a paucity of targeted treatment options..

Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses.

Christina F Budden, Linden J Gearing, Romina Kaiser, Lena Standke, Paul J Hertzog, Eicke Latz

Journal article  |  2021  |  J Extracell Vesicles

Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammation and adaptive immunity. Thes..

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.

Sarang Tartey, Prajwal Gurung, Rajendra Karki, Amanda Burton, Paul Hertzog, Thirumala-Devi Kanneganti

Journal article  |  2021  |  Cell Mol Immunol

The SHP-1 protein encoded by the Ptpn6 gene has been extensively studied in hematopoietic cells in the context of inflammation. A ..

KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8( ) T cell differentiation

Jasmine Li, Kristine Hardy, Moshe Olshansky, Adele Barugahare, Linden J Gearing, Julia E Prier, Xavier YX Sng, Michelle Ly Thai Nguyen, Dana Piovesan, Brendan E Russ, Nicole L La Gruta, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article  |  2021  |  CELL REPORTS

Naive CD8+ T cell activation results in an autonomous program of cellular proliferation and differentiation. However, the mechanis..

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.

Jennifer K Dowling, Remsha Afzal, Linden J Gearing, Mariana P Cervantes-Silva, Stephanie Annett, Gavin M Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J Gough, Glenn R Bantug, Fidinny I Hamid, Frances K Nally, Conor P Duffy, Aoife L Gorman, Alex M Liddicoat, Ed C Lavelle, Christoph Hess, Peter J Oefner, David K Finlay, et al.

Journal article  |  2021  |  Nat Commun

Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155)..

10th Lorne Infection and Immunity Conference 2020

Rebecca E Smith, Heidi E Drummer, Paul J Hertzog

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

The December 2020 issue contains a Special Feature on Infection and Immunity, featuring selected presentations from the 10th Lorne..

Structural integrity with functional plasticity: what type I IFN receptor polymorphisms reveal.

Nicole A de Weerd, Julian P Vivian, San S Lim, Stephanie U-Shane Huang, Paul J Hertzog

Journal article  |  2020  |  J Leukoc Biol

The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind their cognate receptors, IFNα/β recep..

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Katie L Owen, Linden J Gearing, Damien J Zanker, Natasha K Brockwell, Weng Hua Khoo, Daniel L Roden, Marek Cmero, Stefano Mangiola, Matthew K Hong, Alex J Spurling, Michelle McDonald, Chia-Ling Chan, Anupama Pasam, Ruth J Lyons, Hendrika M Duivenvoorden, Andrew Ryan, Lisa M Butler, John M Mariadason, Tri Giang Phan, Vanessa M Hayes, et al.

Journal article  |  2020  |  EMBO REPORTS

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in ..

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

Renee M Van der Sluis, Jennifer M Zerbato, Jake W Rhodes, Rachel D Pascoe, Ajantha Solomon, Nitasha A Kumar, Ashanti I Dantanarayana, Surekha Tennakoon, Jeremy Dufloo, James McMahon, Judy J Chang, Vanessa A Evans, Paul J Hertzog, Martin R Jakobsen, Andrew N Harman, Sharon R Lewin, Paul U Cameron

Journal article  |  2020  |  PLOS PATHOGENS

HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus per..

Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer

Damien J Zanker, Alex J Spurling, Natasha K Brockwell, Katie L Owen, Jasmine M Zakhour, Tina Robinson, Hendrika M Duivenvoorden, Paul J Hertzog, Stefanie R Mullins, Robert W Wilkinson, Belinda S Parker

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Loss of tumor-inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progressio..