Paul Hertzog

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.

Sarang Tartey, Prajwal Gurung, Rajendra Karki, Amanda Burton, Paul Hertzog, Thirumala-Devi Kanneganti

Journal article  |  2021  |  Cell Mol Immunol

The SHP-1 protein encoded by the Ptpn6 gene has been extensively studied in hematopoietic cells in the context of inflammation. A ..

KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8( ) T cell differentiation

Jasmine Li, Kristine Hardy, Moshe Olshansky, Adele Barugahare, Linden J Gearing, Julia E Prier, Xavier YX Sng, Michelle Ly Thai Nguyen, Dana Piovesan, Brendan E Russ, Nicole L La Gruta, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article  |  2021  |  CELL REPORTS

Naive CD8+ T cell activation results in an autonomous program of cellular proliferation and differentiation. However, the mechanis..

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.

Jennifer K Dowling, Remsha Afzal, Linden J Gearing, Mariana P Cervantes-Silva, Stephanie Annett, Gavin M Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J Gough, Glenn R Bantug, Fidinny I Hamid, Frances K Nally, Conor P Duffy, Aoife L Gorman, Alex M Liddicoat, Ed C Lavelle, Christoph Hess, Peter J Oefner, David K Finlay, et al.

Journal article  |  2021  |  Nature Communications

Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155)..

10th Lorne Infection and Immunity Conference 2020

Rebecca E Smith, Heidi E Drummer, Paul J Hertzog

Journal article  |  2020  |  Immunology and Cell Biology

The December 2020 issue contains a Special Feature on Infection and Immunity, featuring selected presentations from the 10th Lorne..

Structural integrity with functional plasticity: what type I IFN receptor polymorphisms reveal.

Nicole A de Weerd, Julian P Vivian, San S Lim, Stephanie U-Shane Huang, Paul J Hertzog

Journal article  |  2020  |  Journal of Leukocyte Biology

The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind their cognate receptors, IFNα/β recep..

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Katie L Owen, Linden J Gearing, Damien J Zanker, Natasha K Brockwell, Weng Hua Khoo, Daniel L Roden, Marek Cmero, Stefano Mangiola, Matthew K Hong, Alex J Spurling, Michelle McDonald, Chia-Ling Chan, Anupama Pasam, Ruth J Lyons, Hendrika M Duivenvoorden, Andrew Ryan, Lisa M Butler, John M Mariadason, Tri Giang Phan, Vanessa M Hayes, et al.

Journal article  |  2020  |  EMBO Reports

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in ..

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

Renee M Van der Sluis, Jennifer M Zerbato, Jake W Rhodes, Rachel D Pascoe, Ajantha Solomon, Nitasha A Kumar, Ashanti I Dantanarayana, Surekha Tennakoon, Jeremy Dufloo, James McMahon, Judy J Chang, Vanessa A Evans, Paul J Hertzog, Martin R Jakobsen, Andrew N Harman, Sharon R Lewin, Paul U Cameron

Journal article  |  2020  |  PLoS Pathogens

HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus per..

Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer

Damien J Zanker, Alex J Spurling, Natasha K Brockwell, Katie L Owen, Jasmine M Zakhour, Tina Robinson, Hendrika M Duivenvoorden, Paul J Hertzog, Stefanie R Mullins, Robert W Wilkinson, Belinda S Parker

Journal article  |  2020  |  Clinical and Translational Immunology

Objectives: Loss of tumor-inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progressio..

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa

Yu-Wei Lin, Mei-Ling Han, Jinxin Zhao, Yan Zhu, Gauri Rao, Alan Forrest, Jiangning Song, Keith S Kaye, Paul Hertzog, Anthony Purcell, Darren Creek, Qi Tony Zhou, Tony Velkov, Jian Li

Journal article  |  2019  |  FRONTIERS IN PHARMACOLOGY

Polymyxins are used as a last-resort class of antibiotics against multidrug-resistant (MDR) Gram-negative Pseudomonas aeruginosa. ..

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.

Nicholas Hernandez, Giorgia Bucciol, Leen Moens, Jérémie Le Pen, Mohammad Shahrooei, Ekaterini Goudouris, Afshin Shirkani, Majid Changi-Ashtiani, Hassan Rokni-Zadeh, Esra Hazar Sayar, Ismail Reisli, Alain Lefevre-Utile, Dick Zijlmans, Andrea Jurado, Ruben Pholien, Scott Drutman, Serkan Belkaya, Aurelie Cobat, Robbert Boudewijns, Dirk Jochmans, et al.

Journal article  |  2019  |  J Exp Med

Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live attenuated viruses can rarely cause life-thr..