Steven Stacker

Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons

Melissa G McKenzie, Lucy Cobbs, Patrick D Dummer, Timothy J Petros, Michael M Halford, Steven A Stacker, Yimin Zou, Gord J Fishell, Edmund Au

Journal article  |  2019  |  Neuron

GABAergic interneurons have many important functions in cortical circuitry, a reflection of their cell diversity. The developmenta..

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Adam J Vogrin, Neil Bower, Menachem J Gunzburg, Sally Roufail, Kazuhide S Okuda, Scott Paterson, Stephen J Headey, Steven A Stacker, Benjamin M Hogan, Marc G Achen

Journal article  |  2019  |  Cell Reports

The Interplay Between Lymphatic Vessels and Chemokines

Rae H Farnsworth, Tara Karnezis, Simon J Maciburko, Scott N Mueller, Steven A Stacker

Journal article  |  2019  |  Frontiers in Immunology

CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells

Tara Karnezis, Rae H Farnsworth, Nicole C Harris, Steven P Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Yazar, Simon J Takouridis, Craig Gerard, Stephen B Fox, Marc G Achen, Steven A Stacker

Journal article  |  2019  |  Cancer Research

Consensus guidelines for the use and interpretation of angiogenesis assays

Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C Aplin, Robert Auerbach, Hellmut G Augustin, David O Bates, Judy R van Beijnum, R Hugh F Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C Boeck, Peter C Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M Cimpean, et al.

Journal article  |  2018  |  Angiogenesis

The evolving role of lymphatics in cancer metastasis

Rae H Farnsworth, Marc G Achen, Steven A Stacker

Journal article  |  2018  |  Current Opinion in Immunology

Exit Stage Left: A Tumor Cell's Journey from Lymph Node to Beyond

Marc G Achen, Steven A Stacker

Journal article  |  2018  |  Trends in Cancer

A kinome-wide CRISPR screen reveals BET inhibition-associated endothelial cell resistance to anti-angiogenic therapy

Michael Y He, Michael M Halford, Marc G Achen, Steven A Stacker

Conference Proceedings  |  2018  |  Tumor Biology

Emerging Roles for VEGF-D in Human Disease

Steven A Stacker, Marc G Achen

Journal article  |  2018  |  Biomolecules

Deficiency of the Wnt receptor Ryk causes multiple cardiac and outflow tract defects

Kumudhini Kugathasan, Michael M Halford, Peter G Farlie, Damien Bates, Darrin P Smith, You Fang Zhang, James P Roy, Maria L Macheda, Dong Zhang, James L Wilkinson, Margaret L Kirby, Donald F Newgreen, Steven A Stacker

Journal article  |  2018  |  Growth Factors

The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases

James P Roy, Michael M Halford, Steven A Stacker

Journal article  |  2018  |  Growth Factors

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling

Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, et al.

Journal article  |  2017  |  Science Signaling

Counting nuclei released from microcarrier-based cultures using pro-fluorescent nucleic acid stains and volumetric flow cytometry

Michael YC He, Steven A Stacker, Ralph Rossi, Michael M Halford

Journal article  |  2017  |  BioTechniques

Data Descriptor: Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology

Steven P Williams, Cathryn M Gould, Cameron J Nowell, Tara Karnezis, Marc G Achen, Kaylene J Simpson, Steven A Stacker

Journal article  |  2017  |  Scientific Data

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development

Neil I Bower, Adam J Vogrin, Ludovic Le Guen, Huijun Chen, Steven A Stacker, Marc G Achen, Benjamin M Hogan

Journal article  |  2017  |  Development

The fibrinolysis inhibitor alpha(2)-antiplasmin restricts lymphatic remodelling and metastasis in a mouse model of cancer

Sophie Paquet-Fifield, Sally Roufail, You-Fang Zhang, Trifina Sofian, David J Byrne, Paul B Coughlin, Stephen B Fox, Steven A Stacker, Marc G Achen

Journal article  |  2017  |  Growth Factors

A Three-Dimensional Lymphatic Endothelial Cell Tube Formation Assay to Identify Novel Kinases Involved in Lymphatic Vessel Remodeling

T Jessica Gambino, Steven P Williams, Carol Caesar, Daniel Resnick, Cameron J Nowell, Rae H Farnsworth, Marc G Achen, Steven A Stacker, Tara Karnezis

Journal article  |  2017  |  ASSAY and Drug Development Technologies

Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D

Natalia Davydova, Nicole C Harris, Sally Roufail, Sophie Paquet-Fifield, Musarat Ishaq, Victor A Streltsov, Steven P Williams, Tara Karnezis, Steven A Stacker, Marc G Achen

Journal article  |  2016  |  J Biol Chem

The Role of the Tumor vasculature in the Host immune Response: implications for Therapeutic Strategies Targeting the Tumor Microenvironment

Shona A Hendry, Rae H Farnsworth, Benjamin Solomon, Marc G Achen, Steven A Stacker, Stephen B Fox

Journal article  |  2016  |  Frontiers in Immunology

VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury

Teruhiko Sato, Sophie Paquet-Fifield, Nicole C Harris, Sally Roufail, Debra J Turner, Yinan Yuan, You-Fang Zhang, Stephen B Fox, Margaret L Hibbs, Jennifer L Wilkinson-Berka, Richard A Williams, Steven A Stacker, Peter D Sly, Marc G Achen

Journal article  |  2016  |  The Journal of Pathology

Intestinal-specific activatable Myb initiates colon tumorigenesis in mice

J Malaterre, L Pereira, T Putoczki, R Millen, S Paquet-Fifield, M Germann, J Liu, D Cheasley, S Sampurno, SA Stacker, MG Achen, RL Ward, P Waring, T Mantamadiotis, M Ernst, RG Ramsay

Journal article  |  2016  |  Oncogene

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Caroline P Le, Cameron J Nowell, Corina Kim-Fuchs, Edoardo Botteri, Jonathan G Hiller, Hilmy Ismail, Matthew A Pimentel, Ming G Chai, Tara Karnezis, Nicole Rotmensz, Giuseppe Renne, Sara Gandini, Colin W Pouton, Davide Ferrari, Andreas Moeller, Steven A Stacker, Erica K Sloan

Journal article  |  2016  |  Nature Communications

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Steven A Stacker, Michael M Halford, Sally Roufail, Carol Caesar, Marc G Achen

Journal article  |  2016  |  Journal of Visualized Experiments

Growth factors: the journey continues

Steven A Stacker

Journal article  |  2016  |  Growth Factors

The RYK receptor family

MM Halford, ML Macheda, SA Stacker

Book Chapter  |  2015

A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma

J Lewin, KK Khamly, RJ Young, C Mitchell, RJ Hicks, GC Toner, SYK Ngan, S Chander, GJ Powell, A Herschtal, L Te Marvelde, J Desai, PFM Choong, SA Stacker, MG Achen, N Ferris, S Fox, J Slavin, DM Thomas

Journal article  |  2014  |  British Journal of Cancer

Exploring the role of endothelium in the tumour response to anti-angiogenic therapy

Yi-Chao He, Michael M Halford, Marc G Achen, Steven A Stacker

Journal article  |  2014  |  Biochemical Society Transactions

Vascular remodeling in cancer

RH Farnsworth, M Lackmann, MG Achen, SA Stacker

Journal article  |  2014  |  Oncogene

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, Anne-Marie Orfila, Jessica Voisin, Sonia Hernandez, Nicolas Offner, J Alex Parker, Sophie Menet, Jinho Kim, Jungmok Lyu, Si Ho Choi, Kerry Cormier, Christina K Edgerly, Olivia L Bordiuk, Karen Smith, Anne Louise, Michael Halford, Steven Stacker, Jean-Philippe Vert, et al.

Journal article  |  2014  |  PLoS Biology

Expression and purification of bioactive, low-endotoxin recombinant human vitronectin

Michael M Halford, Yi-Chao He, Steven A Stacker

Journal article  |  2014  |  Biotechniques

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis

Ludovic Le Guen, Terhi Karpanen, Dorte Schulte, Nicole C Harris, Katarzyna Koltowska, Guy Roukens, Neil I Bower, Andreas van Impel, Steven A Stacker, Marc G Achen, Stefan Schulte-Merker, Benjamin M Hogan

Journal article  |  2014  |  Development

Lymphangiogenesis and lymphatic vessel remodelling in cancer

Steven A Stacker, Steven P Williams, Tara Karnezis, Ramin Shayan, Stephen B Fox, Marc G Achen

Journal article  |  2014  |  Nature Reviews Cancer

Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development

Joelle Kartopawiro, Neil I Bower, Tara Karnezis, Jan Kazenwadel, Kelly L Betterman, Emmanuelle Lesieur, Katarzyna Koltowska, Jonathan Astin, Philip Crosier, Sonja Vermeren, Marc G Achen, Steven A Stacker, Kelly A Smith, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

Journal article  |  2014  |  Human Molecular Genetics

VEGFD regulates blood vascular development by modulating SOX18 activity

Tam Duong, Katarzyna Koltowska, Cathy Pichol-Thievend, Ludovic Le Guen, Frank Fontaine, Kelly A Smith, Truong Vy, Renae Skoczylas, Steven A Stacker, Marc G Achen, Peter Koopman, Benjamin M Hogan, Mathias Francois

Journal article  |  2014  |  Blood

Wnt5a induces Ryk-dependent and -independent effects on callosal axon and dendrite growth

Charlotte EJ Clark, Linda J Richards, Steven A Stacker, Helen M Cooper

Journal article  |  2014  |  Growth Factors

Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy

Christel Devaud, Jennifer A Westwood, Liza B John, Jacqueline K Flynn, Sophie Paquet-Fifield, Connie PM Duong, Carmen SM Yong, Hollie J Pegram, Steven A Stacker, Marc G Achen, Trina J Stewart, Linda A Snyder, Michele WL Teng, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  Molecular Therapy

Lymphovascular and neural regulation of metastasis: shared tumour signalling pathways and novel therapeutic approaches.

Caroline P Le, Tara Karnezis, Marc G Achen, Steven A Stacker, Erica K Sloan

Journal article  |  2013  |  Best Practice and Research in Clinical Anaesthesiology

The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including i..

A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK

Michael M Halford, Maria L Macheda, Clare L Parish, Elena A Takano, Stephen Fox, Daniel Layton, Edouard Nice, Steven A Stacker

Journal article  |  2013  |  PLoS One

Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis

Sophie Paquet-Fifield, Sidney M Levy, Teruhiko Sato, Ramin Shayan, Tara Karnezis, Natalia Davydova, Cameron J Nowell, Sally Roufail, Gerry Zhi-Ming Ma, You-Fang Zhang, Steven A Stacker, Marc G Achen

Journal article  |  2013  |  Journal of Investigative Dermatology

Ryk, a Receptor Regulating Wnt5a-Mediated Neurogenesis and Axon Morphogenesis of Ventral Midbrain Dopaminergic Neurons

Brette D Blakely, Christopher R Bye, Chathurini V Fernando, Asheeta A Prasad, R Jeroen Pasterkamp, Maria L Macheda, Steven A Stacker, Clare L Parish

Journal article  |  2013  |  Stem Cells and Development

Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis

Masataka Matsumoto, Sally Roufail, Rachael Inder, Carol Caesar, Tara Karnezis, Ramin Shayan, Rae H Farnsworth, Teruhiko Sato, Marc G Achen, G Bruce Mann, Steven A Stacker

Journal article  |  2013  |  Clinical and Experimental Metastasis

The VEGF signaling pathway in cancer: the road ahead

Steven A Stacker, Marc G Achen

Journal article  |  2013  |  Chinese Journal of Cancer

The Propeptides of VEGF-D Determine Heparin Binding, Receptor Heterodimerization, and Effects on Tumor Biology

Nicole C Harris, Natalia Davydova, Sally Roufail, Sophie Paquet-Fifield, Karri Paavonen, Tara Karnezis, You-Fang Zhang, Teruhiko Sato, Julie Rothacker, Edouard C Nice, Steven A Stacker, Marc G Achen

Journal article  |  2013  |  Journal of Biological Chemistry

Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis

Ramin Shayan, Rachael Inder, Tara Karnezis, Carol Caesar, Karri Paavonen, Mark W Ashton, G Bruce Mann, G Ian Taylor, Marc G Achen, Steven A Stacker

Journal article  |  2013  |  Clinical and Experimental Metastasis

The Wnt Coreceptor Ryk Regulates Wnt/Planar Cell Polarity by Modulating the Degradation of the Core Planar Cell Polarity Component Vangl2

Philipp Andre, Qianyi Wang, Na Wang, Bo Gao, Arielle Schilit, Michael M Halford, Steven A Stacker, Xuemin Zhang, Yingzi Yang

Journal article  |  2012  |  Journal of Biological Chemistry

Remodeling of the Lymphatic Vasculature during Mouse Mammary Gland Morphogenesis Is Mediated via Epithelial-Derived Lymphangiogenic Stimuli

Kelly L Betterman, Sophie Paquet-Fifield, Marie-Liesse Asselin-Labat, Jane E Visvader, Lisa M Butler, Steven A Stacker, Marc G Achen, Natasha L Harvey

Journal article  |  2012  |  American Journal of Pathology

Lymphatic vessel density in primary melanomas predicts sentinel lymph node status and risk of metastasis

Ramin Shayan, Tara Karnezis, Rajmohan Murali, James S Wilmott, Mark W Ashton, G Ian Taylor, John F Thompson, Peter Hersey, Marc G Achen, Richard A Scolyer, Steven A Stacker

Journal article  |  2012  |  Histopathology

Vascular endothelial growth factor-D: signaling mechanisms, biology, and clinical relevance

Marc G Achen, Steven A Stacker

Journal article  |  2012  |  Growth Factors

The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling

Maria L Macheda, Willy W Sun, Kumudhini Kugathasan, Benjamin M Hogan, Neil I Bower, Michael M Halford, You Fang Zhang, Bonnie E Jacques, Graham J Lieschke, Alain Dabdoub, Steven A Stacker

Journal article  |  2012  |  Journal of Biological Chemistry

The connection between lymphangiogenic signalling and prostglandin biology: A missing link in the metastatsic pathway

Tara Karnezis, Ramin Shayan, Stephen Fox, Marc G Achen, Steven A Stacker

Journal article  |  2012  |  Oncotarget

Towards the biomarker-guided rational use of antiangiogenic agents in the treatment of metastatic colorectal cancer

Michael M Halford, Niall C Tebbutt, Jayesh Desai, Marc G Achen, Steven A Stacker

Journal article  |  2012  |  Colorectal Cancer

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies

Natalia Davydova, Victor A Streltsov, Sally Roufail, George O Lovrecz, Steven A Stacker, Timothy E Adams, Marc G Achen

Journal article  |  2012  |  Protein Expression and Purification

VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

Tara Karnezis, Ramin Shayan, Carol Caesar, Sally Roufail, Nicole C Harris, Kathryn Ardipradja, You Fang Zhang, Steven P Williams, Rae H Farnsworth, Ming G Chai, Thusitha WT Rupasinghe, Dedreia L Tull, Megan E Baldwin, Erica K Sloan, Stephen B Fox, Marc G Achen, Steven A Stacker

Journal article  |  2012  |  Cancer Cell

A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth

Rae H Farnsworth, Tara Kamezis, Ramin Shayan, Masataka Matsumoto, Cameron J Nowell, Marc G Achen, Steven A Stacker

Journal article  |  2011  |  Cancer Research

Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer

Nicole C Harris, Karri Paavonen, Natalia Davydova, Sally Roufail, Teruhiko Sato, You-Fang Zhang, Tara Karnezis, Steven A Stacker, Marc G Achen

Journal article  |  2011  |  FASEB Journal

The VD1 Neutralizing Antibody to Vascular Endothelial Growth Factor-D: Binding Epitope and Relationship to Receptor Binding

Natalia Davydova, Sally Roufail, Victor A Streltsov, Steven A Stacker, Marc G Achen

Journal article  |  2011  |  Journal of Molecular Biology

Wnt5a Regulates Midbrain Dopaminergic Axon Growth and Guidance

Brette D Blakely, Christopher R Bye, Chathurini V Fernando, Malcolm K Horne, Maria L Macheda, Steven A Stacker, Ernest Arenas, Clare L Parish

Journal article  |  2011  |  PLoS One

Targeting lymphatic vessel functions through tyrosine kinases.

Steven P Williams, Tara Karnezis, Marc G Achen, Steven A Stacker

Journal article  |  2010  |  Journal of Angiogenesis Research

The lymphatic vascular system is actively involved in tissue fluid homeostasis, immune surveillance and fatty acid transport. Path..

Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer

Jane E Girling, Jacqueline F Donoghue, Fiona L Lederman, Leonie M Cann, Marc G Achen, Steven A Stacker, Peter AW Rogers

Journal article  |  2010  |  Reproductive Biology and Endocrinology

Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/beta-Catenin Pathway In Vivo

Michael Buchert, Dimitris Athineos, Helen E Abud, Zoe D Burke, Maree C Faux, Michael S Samuel, Andrew G Jarnicki, Catherine E Winbanks, Ian P Newton, Valerie S Meniel, Hiromu Suzuki, Steven A Stacker, Inke S Nathke, David Tosh, Joerg Huelsken, Alan R Clarke, Joan K Heath, Owen J Sansom, Matthias Ernst

Journal article  |  2010  |  PLoS Genetics

Elevated level of inhibin-alpha subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer

P Balanathan, ED Williams, H Wang, JS Pedersen, LG Horvath, MG Achen, SA Stacker, GP Risbridger

Journal article  |  2009  |  British Journal of Cancer

LYMPHANGIOGENESIS IN HEALTH AND DISEASE - AN OVERVIEW

Steven A Stacker, Marc G Achen, Paula Haiko, Kari Alitalo

Book Chapter  |  2009  |  Cancer Metastasis - Biology and Treatment

Sox18 induces development of the lymphatic vasculature in mice

Mathias Francois, Andrea Caprini, Brett Hosking, Fabrizio Orsenigo, Dagmar Wilhelm, Catherine Browne, Karri Paavonen, Tara Karnezis, Ramin Shayan, Meredith Downes, Tara Davidson, Desmond Tutt, Kathryn SE Cheah, Steven A Stacker, George EO Muscat, Marc G Achen, Elisabetta Dejana, Peter Koopman

Journal article  |  2008  |  Nature

Importance of Wnt Signaling in the Tumor Stroma Microenvironment

Maria L Macheda, Steven A Stacker

Journal article  |  2008  |  Current Cancer Drug Targets

Deletion of Vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos

Paula Haiko, Taija Makinen, Salla Keskitalo, Jussi Taipale, Marika J Karkkainen, Megan E Baldwin, Steven A Stacker, Marc G Achen, Kari Alitalo

Journal article  |  2008  |  Molecular and Cellular Biology

Molecular control of lymphatic metastasis

Marc G Achen, Steven A Stacker

Journal article  |  2008  |  Annals of The New York Academy of Sciences

From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy.

Steven A Stacker, Marc G Achen

Journal article  |  2008  |  Lymphatic Research and Biology

The theory that angiogenesis could support tumor growth and therefore be a target for cancer therapy was explored in publications ..

A system for quantifying the patterning of the lymphatic vasculature

Ramin Shayan, Tara Karnezis, Evelyn Tsantikos, Steven P Williams, Andrew S Runting, Mark W Ashton, Marc G Achen, Margaret L Hibbs, Steven A Stacker

Journal article  |  2007  |  Growth Factors

Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis

Lucie Kopfstein, Tanja Veikkola, Valentin G Djonov, Vanessa Baeriswyl, Tibor Schomber, Karin Strittmatter, Steven A Stacker, Marc G Achen, Kari Alitalo, Gerhard Christofori

Journal article  |  2007  |  American Journal of Pathology

Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.

BK McColl, K PAAVONEN, T KARNEZIS, NC HARRIS, N DAVYDOVA, J Rothacker, E NICE, K HARDER, S Roufail, M HIBBS, PAW Rogers, K Alitalo, S STACKER, M ACHEN

Journal article  |  2007  |  FASEB Journal

Molecular pathways for lymphangiogenesis and their role in human disease.

Steven A Stacker, Rae H Farnsworth, Tara Karnezis, Ramin Shayan, Darrin P Smith, Karri Paavonen, Natalia Davydova, Carol Caesar, Rachael Inder, Megan E Baldwin, Bradley K McColl, Sally Roufail, Richard A Williams, Richard A Hughes, Kari Alitalo, Marc G Achen

Conference Proceedings  |  2007  |  Decoding the genomic control of immune reactions

The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth fa..

Tumor lymphangiogenesis and metastatic spread - New players begin to emerge

Marc G Achen, Steven A Stacker

Journal article  |  2006  |  International Journal of Cancer

Lymphatic vessels in cancer metastasis: bridging the gaps

Ramin Shayan, Marc G Achen, Steven A Stacker

Journal article  |  2006  |  Carcinogenesis

Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation

Terhi Karpanen, Maria Wirzenius, Taija Makinen, Tanja Veikkola, Hidde J Haisma, Marc G Achen, Steven A Stacker, Bronislaw Pytowski, Seppo Yla-Herttuala, Kari Alitalo

Journal article  |  2006  |  American Journal of Pathology

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

Thomas R Keeble, Michael M Halford, Clare Seaman, Nigel Kee, Maria Macheda, Richard B Anderson, Steven A Stacker, Helen M Cooper

Journal article  |  2006  |  Journal of Neuroscience

Targeting lymphangiogenesis to prevent tumour metastasis

MG Achen, GB Mann, SA Stacker

Journal article  |  2006  |  British Journal of Cancer

Lymphatic endothelium: An important interactive surface for malignant cells

RH Farnsworth, MG Achen, SA Stacker

Journal article  |  2006  |  Pulmonary Pharmacology and Therapeutics

Current strategies for modulating lymphangiogenesis signalling pathways in human disease

SA Stacker, RA Hughes, RA Williams, MG Achen

Journal article  |  2006  |  Current Medicinal Chemistry

Mechanisms of Lymphangiogenesis: Targets for Blocking the Metastatic Spread of Cancer

Bradley McColl, Stephen Loughran, Natalia Davydova, Steven Stacker, Marc Achen

Journal article  |  2005  |  Current Cancer Drug Targets

Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer

Z Von Marschall, A Scholz, SA Stacker, MG Achen, DG Jackson, F Alves, M Schirner, M Haberey, KH Thierauch, B Wiedenmann, S Rosewicz

Journal article  |  2005  |  International Journal of Oncology

Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism

J Rutanen, AM Turunen, M Teittinen, TT Rissanen, T Heikura, JK Koponen, M Gruchala, M Inkala, S Jauhiainen, MO Hiltunen, MP Turunen, SA Stacker, MG Achen, S Yla-Herttuala

Journal article  |  2005  |  Gene Therapy

Vascular endothelial growth factor d is dispensable for development of the lymphatic system

ME Baldwin, MA Halford, S Roufail, RA Williams, ML Hibbs, D Grail, H Kubo, SA Stacker, MG Achen

Journal article  |  2005  |  Molecular and Cellular Biology

Focus on lymphangiogenesis in tumor metastasis

MG Achen, BK McColl, SA Stacker

Journal article  |  2005  |  Cancer Cell

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation Journal of Clinical Investigation

P BALUK, T TAMMELA, E ATOR, N LYUBYNSKA, MG ACHEN, DJ HICKLIN, M JELTSCH, TV PETROVA, B PYTOWSKI, SA STACKER, S YLA-HERTTUALA, H JACKSON, K ALITALO, undefined MCDONALD

Journal article  |  2005  |  Journal of Clinical Investigation

Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer

YP Zeng, K Opeskin, ME Baldwin, LG Horvath, MG Achen, SA Stacker, RL Sutherland, ED Williams

Journal article  |  2004  |  Clinical Cancer Research

Lymphangiogenic growth factors as markers of tumor metastasis

SA Stacker, RA Williams, MG Achen

Journal article  |  2004  |  APMIS

Molecular regulation of the VEGF family - inducers of angiogenesis and lymphangiogenesis

BK McColl, SA Stacker, MG Achen

Journal article  |  2004  |  APMIS

Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart

J Rutanen, TT Rissanen, JE Markkanen, M Gruchala, P Silvennoinen, A Kivela, A Hedman, M Hedman, T Heikura, MR Orden, SA Stacker, MG Achen, J Hartikainen, S Yla-Herttuala

Journal article  |  2004  |  Circulation

A study of VEGF and its receptors in two rat models of proteinuria.

John Kanellis, Vicki Levidiotis, Tiffany Khong, Alison J Cox, Steven A Stacker, Richard E Gilbert, Mark E Cooper, David A Power

Journal article  |  2004  |  Nephron

BACKGROUND: The high level of expression of vascular endothelial growth factor (VEGF) in normal podocyte foot processes suggests t..

Molecular targeting of lymphatics for therapy

SA Stacker, RA Hughes, MG Achen

Journal article  |  2004  |  Current Pharmaceutical Design

Vascular endothelial growth factor-D expression in human atherosclerotic lesions

J Rutanen, P Leppanen, TT Tuomisto, TT Rissanen, MO Hiltunen, I Vajanto, M Niemi, T Hakkinen, K Karkola, SA Stacker, MG Achen, K Alitalo, S Yla-Herttuala

Journal article  |  2003  |  Cardiovascular Research

Angiogenic responses of vascular endothelial growth factors in periadventitial tissue

S Bhardwaj, H Roy, M Gruchala, H Viita, I Kholova, I Kokina, MG Achen, SA Stacker, M Hedman, K Alitalo, S Yla-Herttuala

Journal article  |  2003  |  Human Gene Therapy

Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens

LM Wise, N Ueda, NH Dryden, SB Fleming, C Caesar, S Roufail, MG Achen, SA Stacker, AA Mercer

Journal article  |  2003  |  Journal of Biological Chemistry

Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D

BK McColl, ME Baldwin, S Roufail, C Freeman, RL Moritz, RJ Simpson, K Alitalo, SA Stacker, MG Achen

Journal article  |  2003  |  Journal of Experimental Medicine

VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses

TT Rissanen, JE Markkanen, M Gruchala, T Heikura, A Puranen, MI Kettunen, I Kholova, RA Kauppinen, MG Achen, SA Stacker, K Alitalo, S Yla-Herttuala

Journal article  |  2003  |  Circulation Research

EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma

B Solomon, J Hagekyriakou, MK Trivett, SA Stacker, GA McArthur, C Cullinane

Journal article  |  2003  |  International Journal of Radiation: Oncology - Biology - Physics

Pseudocowpox virus encodes a homolog of vascular endothelial growth factor

N Ueda, LM Wise, SA Stacker, SB Fleming, AA Mercer

Journal article  |  2003  |  Virology

Regenerating lizard tails: a new model for investigating lymphangiogenesis.

CB Daniels, BC Lewis, C Tsopelas, SL Munns, S Orgeig, ME Baldwin, SA Stacker, MG Achen, BE Chatterton, RD Cooter

Journal article  |  2003  |  FASEB Journal

Molecular control of lymphangiogenesis

ME Baldwin, SA Stacker, MG Achen

Journal article  |  2002  |  Bioessays

Lymphangiogenesis and cancer metastasis

Steven A Stacker, Marc G Achen, Lotta Jussila, Megan E Baldwin, Kari Alitalo

Journal article  |  2002  |  Nature Reviews Cancer

The role of tumor lymphangiogenesis in metastatic spread

SA Stacker, ME Baldwin, MG Achen

Journal article  |  2002  |  FASEB Journal

Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo

TV Byzova, CK Goldman, J Jankau, JH Chen, G Cabrera, MG Achen, SA Stacker, KA Carnevale, M Slemionow, SR Deitcher, PE DiCorleto

Journal article  |  2002  |  Blood

The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer

MG Achen, RA Williams, ME Baldwin, P Lai, S Roufail, K Alitalo, SA Stacker

Journal article  |  2002  |  Growth Factors

Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression

J Kanellis, K Paizis, AJ Cox, SA Stacker, RE Gilbert, ME Cooper, DA Power

Journal article  |  2002  |  Kidney International

Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis

ME Baldwin, S Roufail, MM Halford, K Alitalo, SA Stacker, MG Achen

Journal article  |  2001  |  Journal of Biological Chemistry

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

T Makinen, T Veikkola, S Mustjoki, T Karpanen, B Catimel, EC Nice, L Wise, A Mercer, H Kowalski, D Kerjaschki, SA Stacker, MG Achen, K Alitalo

Journal article  |  2001  |  EMBO Journal

VEGF-D is an x-linked/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme

W Debinski, B Slagle-Webb, MG Achen, SA Stacker, E Tulchinsky, GY Gillespie, DM Gibo

Journal article  |  2001  |  Molecular Medicine

The specificity of receptor binding by vascular endothelial growth factor-D is different in mouse and man

ME Baldwin, B Catimel, EC Nice, S Roufail, NE Hall, KL Stenvers, MJ Karkkainen, K Alitalo, SA Stacker, MG Achen

Journal article  |  2001  |  Journal of Biological Chemistry

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

T Veikkola, L Jussila, T Makinen, T Karpanen, M Jeltsch, TV Petrova, H Kubo, G Thurston, DM McDonald, MG Achen, SA Stacker, K Alitalo

Journal article  |  2001  |  EMBO Journal

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

SA Stacker, C Caesar, ME Baldwin, GE Thornton, RA Williams, R Prevo, DG Jackson, S Nishikawa, H Kubo, MG Achen

Journal article  |  2001  |  Nature Medicine

Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis

MG Achen, RA Williams, MP Minekus, GE Thornton, K Stenvers, PAW Rogers, F Lederman, S Roufail, SA Stacker

Journal article  |  2001  |  Journal of Pathology

Revelations of the RYK receptor

MM Halford, SA Stacker

Journal article  |  2001  |  Bioessays