Prof Stacker is Head of the Tumour Angiogenesis Program at Peter MacCallum Cancer Centre in Melbourne. Previously he worked for two decades at the Melbourne branch of the Ludwig Institute for Cancer Research, where he was Associate Director and Joint-Head of the Angiogenesis Laboratory.
He received his PhD from the University of Melbourne on work characterising mucins associated with breast cancer and subsequently developing serum markers for the diagnosis of breast cancer. He undertook post-doctoral training with Dr Timothy Springer at the Dana-Farber Cancer Institute and Centre for Blood Research, Harvard Medical School, Boston, in 1988-1991. He has published more than 100 articles and 15 patents in the area of vascular biology, cell adhesion and tumour detection. He is recognised internationally for his work on identifying new members of the VEGF family. He demonstrated that the tumour lymphangiogenic properties of VEGF-D result in lymphatic metastasis and their inhibition blocks tumour metastasis. His work has contributed to the formation of three companies, Integrated Medical Technologies, Lymphatix Ltd and Vegenics Ltd. which focused on developing therapeutics and biomarkers for vascular disease and cancer. Prof Stacker was the inaugural holder of the Pfizer Australia Senior Research Fellowship and is currently supported by an NHMRC Research Fellowship and NHMRC Program Grant. His current work tries to understand the unique signalling pathways in lymphatic endothelial cells with the aim of identifying new targets for therapeutics in vascular disease and cancer.
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Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics ..
Defining The Heterogeneity Of Signaling Networks That Drive Remodeling Of Lymphatic Vessel..
Soothing a Broken Heart Can Therapeutic Cross-Talk Between Lymphatics and the Immune Respo..
Displaying the 8 most recent projects by Steven Stacker.
Displaying the 114 most recent scholarly works by Steven Stacker.
Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons
Melissa G McKenzie, Lucy Cobbs, Patrick D Dummer, Timothy J Petros, Michael M Halford, Steven A Stacker, Yimin Zou, Gord J Fishell, Edmund Au
Journal article | 2019 | Neuron
GABAergic interneurons have many important functions in cortical circuitry, a reflection of their cell diversity. The developmenta..
Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis
Adam J Vogrin, Neil Bower, Menachem J Gunzburg, Sally Roufail, Kazuhide S Okuda, Scott Paterson, Stephen J Headey, Steven A Stacker, Benjamin M Hogan, Marc G Achen
Journal article | 2019 | Cell Reports
CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
Tara Karnezis, Rae H Farnsworth, Nicole C Harris, Steven P Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Yazar, Simon J Takouridis, Craig Gerard, Stephen B Fox, Marc G Achen, Steven A Stacker
Journal article | 2019 | Cancer Research
Consensus guidelines for the use and interpretation of angiogenesis assays
Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C Aplin, Robert Auerbach, Hellmut G Augustin, David O Bates, Judy R van Beijnum, R Hugh F Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C Boeck, Peter C Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M Cimpean, et al.
Journal article | 2018 | Angiogenesis
Deficiency of the Wnt receptor Ryk causes multiple cardiac and outflow tract defects
Kumudhini Kugathasan, Michael M Halford, Peter G Farlie, Damien Bates, Darrin P Smith, You Fang Zhang, James P Roy, Maria L Macheda, Dong Zhang, James L Wilkinson, Margaret L Kirby, Donald F Newgreen, Steven A Stacker
Journal article | 2018 | Growth Factors
Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling
Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, et al.
Journal article | 2017 | Science Signaling
The fibrinolysis inhibitor alpha(2)-antiplasmin restricts lymphatic remodelling and metastasis in a mouse model of cancer
Sophie Paquet-Fifield, Sally Roufail, You-Fang Zhang, Trifina Sofian, David J Byrne, Paul B Coughlin, Stephen B Fox, Steven A Stacker, Marc G Achen
Journal article | 2017 | Growth Factors
A Three-Dimensional Lymphatic Endothelial Cell Tube Formation Assay to Identify Novel Kinases Involved in Lymphatic Vessel Remodeling
T Jessica Gambino, Steven P Williams, Carol Caesar, Daniel Resnick, Cameron J Nowell, Rae H Farnsworth, Marc G Achen, Steven A Stacker, Tara Karnezis
Journal article | 2017 | ASSAY and Drug Development Technologies
Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D
Natalia Davydova, Nicole C Harris, Sally Roufail, Sophie Paquet-Fifield, Musarat Ishaq, Victor A Streltsov, Steven P Williams, Tara Karnezis, Steven A Stacker, Marc G Achen
Journal article | 2016 | J Biol Chem
VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury
Teruhiko Sato, Sophie Paquet-Fifield, Nicole C Harris, Sally Roufail, Debra J Turner, Yinan Yuan, You-Fang Zhang, Stephen B Fox, Margaret L Hibbs, Jennifer L Wilkinson-Berka, Richard A Williams, Steven A Stacker, Peter D Sly, Marc G Achen
Journal article | 2016 | The Journal of Pathology
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
Caroline P Le, Cameron J Nowell, Corina Kim-Fuchs, Edoardo Botteri, Jonathan G Hiller, Hilmy Ismail, Matthew A Pimentel, Ming G Chai, Tara Karnezis, Nicole Rotmensz, Giuseppe Renne, Sara Gandini, Colin W Pouton, Davide Ferrari, Andreas Moeller, Steven A Stacker, Erica K Sloan
Journal article | 2016 | NATURE COMMUNICATIONS
A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma
J Lewin, KK Khamly, RJ Young, C Mitchell, RJ Hicks, GC Toner, SYK Ngan, S Chander, GJ Powell, A Herschtal, L Te Marvelde, J Desai, PFM Choong, SA Stacker, MG Achen, N Ferris, S Fox, J Slavin, DM Thomas
Journal article | 2014 | British Journal of Cancer
The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, Anne-Marie Orfila, Jessica Voisin, Sonia Hernandez, Nicolas Offner, J Alex Parker, Sophie Menet, Jinho Kim, Jungmok Lyu, Si Ho Choi, Kerry Cormier, Christina K Edgerly, Olivia L Bordiuk, Karen Smith, Anne Louise, Michael Halford, Steven Stacker, Jean-Philippe Vert, et al.
Journal article | 2014 | PLoS Biology
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis
Ludovic Le Guen, Terhi Karpanen, Dorte Schulte, Nicole C Harris, Katarzyna Koltowska, Guy Roukens, Neil I Bower, Andreas van Impel, Steven A Stacker, Marc G Achen, Stefan Schulte-Merker, Benjamin M Hogan
Journal article | 2014 | Development
Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development
Joelle Kartopawiro, Neil I Bower, Tara Karnezis, Jan Kazenwadel, Kelly L Betterman, Emmanuelle Lesieur, Katarzyna Koltowska, Jonathan Astin, Philip Crosier, Sonja Vermeren, Marc G Achen, Steven A Stacker, Kelly A Smith, Natasha L Harvey, Mathias Francois, Benjamin M Hogan
Journal article | 2014 | Human Molecular Genetics
VEGFD regulates blood vascular development by modulating SOX18 activity
Tam Duong, Katarzyna Koltowska, Cathy Pichol-Thievend, Ludovic Le Guen, Frank Fontaine, Kelly A Smith, Truong Vy, Renae Skoczylas, Steven A Stacker, Marc G Achen, Peter Koopman, Benjamin M Hogan, Mathias Francois
Journal article | 2014 | Blood
Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy
Christel Devaud, Jennifer A Westwood, Liza B John, Jacqueline K Flynn, Sophie Paquet-Fifield, Connie PM Duong, Carmen SM Yong, Hollie J Pegram, Steven A Stacker, Marc G Achen, Trina J Stewart, Linda A Snyder, Michele WL Teng, Mark J Smyth, Phillip K Darcy, Michael H Kershaw
Journal article | 2014 | Molecular Therapy
Lymphovascular and neural regulation of metastasis: shared tumour signalling pathways and novel therapeutic approaches.
Caroline P Le, Tara Karnezis, Marc G Achen, Steven A Stacker, Erica K Sloan
Journal article | 2013 | Best Pract Res Clin Anaesthesiol
The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including i..
Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis
Sophie Paquet-Fifield, Sidney M Levy, Teruhiko Sato, Ramin Shayan, Tara Karnezis, Natalia Davydova, Cameron J Nowell, Sally Roufail, Gerry Zhi-Ming Ma, You-Fang Zhang, Steven A Stacker, Marc G Achen
Journal article | 2013 | Journal of Investigative Dermatology
Ryk, a Receptor Regulating Wnt5a-Mediated Neurogenesis and Axon Morphogenesis of Ventral Midbrain Dopaminergic Neurons
Brette D Blakely, Christopher R Bye, Chathurini V Fernando, Asheeta A Prasad, R Jeroen Pasterkamp, Maria L Macheda, Steven A Stacker, Clare L Parish
Journal article | 2013 | Stem Cells and Development
Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis
Masataka Matsumoto, Sally Roufail, Rachael Inder, Carol Caesar, Tara Karnezis, Ramin Shayan, Rae H Farnsworth, Teruhiko Sato, Marc G Achen, G Bruce Mann, Steven A Stacker
Journal article | 2013 | CLINICAL & EXPERIMENTAL METASTASIS
The Propeptides of VEGF-D Determine Heparin Binding, Receptor Heterodimerization, and Effects on Tumor Biology
Nicole C Harris, Natalia Davydova, Sally Roufail, Sophie Paquet-Fifield, Karri Paavonen, Tara Karnezis, You-Fang Zhang, Teruhiko Sato, Julie Rothacker, Edouard C Nice, Steven A Stacker, Marc G Achen
Journal article | 2013 | Journal of Biological Chemistry
The Wnt Coreceptor Ryk Regulates Wnt/Planar Cell Polarity by Modulating the Degradation of the Core Planar Cell Polarity Component Vangl2
Philipp Andre, Qianyi Wang, Na Wang, Bo Gao, Arielle Schilit, Michael M Halford, Steven A Stacker, Xuemin Zhang, Yingzi Yang
Journal article | 2012 | Journal of Biological Chemistry
Remodeling of the Lymphatic Vasculature during Mouse Mammary Gland Morphogenesis Is Mediated via Epithelial-Derived Lymphangiogenic Stimuli
Kelly L Betterman, Sophie Paquet-Fifield, Marie-Liesse Asselin-Labat, Jane E Visvader, Lisa M Butler, Steven A Stacker, Marc G Achen, Natasha L Harvey
Journal article | 2012 | American Journal of Pathology
Lymphatic vessel density in primary melanomas predicts sentinel lymph node status and risk of metastasis
Ramin Shayan, Tara Karnezis, Rajmohan Murali, James S Wilmott, Mark W Ashton, G Ian Taylor, John F Thompson, Peter Hersey, Marc G Achen, Richard A Scolyer, Steven A Stacker
Journal article | 2012 | Histopathology
The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling
Maria L Macheda, Willy W Sun, Kumudhini Kugathasan, Benjamin M Hogan, Neil I Bower, Michael M Halford, You Fang Zhang, Bonnie E Jacques, Graham J Lieschke, Alain Dabdoub, Steven A Stacker
Journal article | 2012 | Journal of Biological Chemistry
VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium
Tara Karnezis, Ramin Shayan, Carol Caesar, Sally Roufail, Nicole C Harris, Kathryn Ardipradja, You Fang Zhang, Steven P Williams, Rae H Farnsworth, Ming G Chai, Thusitha WT Rupasinghe, Dedreia L Tull, Megan E Baldwin, Erica K Sloan, Stephen B Fox, Marc G Achen, Steven A Stacker
Journal article | 2012 | Cancer Cell
Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer
Nicole C Harris, Karri Paavonen, Natalia Davydova, Sally Roufail, Teruhiko Sato, You-Fang Zhang, Tara Karnezis, Steven A Stacker, Marc G Achen
Journal article | 2011 | FASEB Journal
Targeting lymphatic vessel functions through tyrosine kinases.
Steven P Williams, Tara Karnezis, Marc G Achen, Steven A Stacker
Journal article | 2010 | Journal of Angiogenesis Research
The lymphatic vascular system is actively involved in tissue fluid homeostasis, immune surveillance and fatty acid transport. Path..
Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer
Jane E Girling, Jacqueline F Donoghue, Fiona L Lederman, Leonie M Cann, Marc G Achen, Steven A Stacker, Peter AW Rogers
Journal article | 2010 | REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/beta-Catenin Pathway In Vivo
Michael Buchert, Dimitris Athineos, Helen E Abud, Zoe D Burke, Maree C Faux, Michael S Samuel, Andrew G Jarnicki, Catherine E Winbanks, Ian P Newton, Valerie S Meniel, Hiromu Suzuki, Steven A Stacker, Inke S Nathke, David Tosh, Joerg Huelsken, Alan R Clarke, Joan K Heath, Owen J Sansom, Matthias Ernst
Journal article | 2010 | PLoS Genetics
Sox18 induces development of the lymphatic vasculature in mice
Mathias Francois, Andrea Caprini, Brett Hosking, Fabrizio Orsenigo, Dagmar Wilhelm, Catherine Browne, Karri Paavonen, Tara Karnezis, Ramin Shayan, Meredith Downes, Tara Davidson, Desmond Tutt, Kathryn SE Cheah, Steven A Stacker, George EO Muscat, Marc G Achen, Elisabetta Dejana, Peter Koopman
Journal article | 2008 | Nature
Deletion of Vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos
Paula Haiko, Taija Makinen, Salla Keskitalo, Jussi Taipale, Marika J Karkkainen, Megan E Baldwin, Steven A Stacker, Marc G Achen, Kari Alitalo
Journal article | 2008 | Molecular and Cellular Biology
From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy.
Steven A Stacker, Marc G Achen
Journal article | 2008 | Lymphatic Research and Biology
The theory that angiogenesis could support tumor growth and therefore be a target for cancer therapy was explored in publications ..
Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis
Lucie Kopfstein, Tanja Veikkola, Valentin G Djonov, Vanessa Baeriswyl, Tibor Schomber, Karin Strittmatter, Steven A Stacker, Marc G Achen, Kari Alitalo, Gerhard Christofori
Journal article | 2007 | American Journal of Pathology
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
BK McColl, K PAAVONEN, T KARNEZIS, NC HARRIS, N DAVYDOVA, J Rothacker, E NICE, K HARDER, S Roufail, M HIBBS, PAW Rogers, K Alitalo, S STACKER, M ACHEN
Journal article | 2007 | FASEB Journal
Molecular pathways for lymphangiogenesis and their role in human disease.
Steven A Stacker, Rae H Farnsworth, Tara Karnezis, Ramin Shayan, Darrin P Smith, Karri Paavonen, Natalia Davydova, Carol Caesar, Rachael Inder, Megan E Baldwin, Bradley K McColl, Sally Roufail, Richard A Williams, Richard A Hughes, Kari Alitalo, Marc G Achen
Conference Proceedings | 2007 | Decoding the genomic control of immune reactions
The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth fa..
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation
Terhi Karpanen, Maria Wirzenius, Taija Makinen, Tanja Veikkola, Hidde J Haisma, Marc G Achen, Steven A Stacker, Bronislaw Pytowski, Seppo Yla-Herttuala, Kari Alitalo
Journal article | 2006 | American Journal of Pathology
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer
Z Von Marschall, A Scholz, SA Stacker, MG Achen, DG Jackson, F Alves, M Schirner, M Haberey, KH Thierauch, B Wiedenmann, S Rosewicz
Journal article | 2005 | International Journal of Oncology
Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism
J Rutanen, AM Turunen, M Teittinen, TT Rissanen, T Heikura, JK Koponen, M Gruchala, M Inkala, S Jauhiainen, MO Hiltunen, MP Turunen, SA Stacker, MG Achen, S Yla-Herttuala
Journal article | 2005 | Gene Therapy
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation Journal of Clinical Investigation
P BALUK, T TAMMELA, E ATOR, N LYUBYNSKA, MG ACHEN, DJ HICKLIN, M JELTSCH, TV PETROVA, B PYTOWSKI, SA STACKER, S YLA-HERTTUALA, H JACKSON, K ALITALO, undefined MCDONALD
Journal article | 2005 | Journal of Clinical Investigation
Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart
J Rutanen, TT Rissanen, JE Markkanen, M Gruchala, P Silvennoinen, A Kivela, A Hedman, M Hedman, T Heikura, MR Orden, SA Stacker, MG Achen, J Hartikainen, S Yla-Herttuala
Journal article | 2004 | Circulation
A study of VEGF and its receptors in two rat models of proteinuria.
John Kanellis, Vicki Levidiotis, Tiffany Khong, Alison J Cox, Steven A Stacker, Richard E Gilbert, Mark E Cooper, David A Power
Journal article | 2004 | Nephron
BACKGROUND: The high level of expression of vascular endothelial growth factor (VEGF) in normal podocyte foot processes suggests t..
Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens
LM Wise, N Ueda, NH Dryden, SB Fleming, C Caesar, S Roufail, MG Achen, SA Stacker, AA Mercer
Journal article | 2003 | Journal of Biological Chemistry
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
TT Rissanen, JE Markkanen, M Gruchala, T Heikura, A Puranen, MI Kettunen, I Kholova, RA Kauppinen, MG Achen, SA Stacker, K Alitalo, S Yla-Herttuala
Journal article | 2003 | Circulation Research
EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma
B Solomon, J Hagekyriakou, MK Trivett, SA Stacker, GA McArthur, C Cullinane
Journal article | 2003 | International Journal of Radiation: Oncology - Biology - Physics
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
T Makinen, T Veikkola, S Mustjoki, T Karpanen, B Catimel, EC Nice, L Wise, A Mercer, H Kowalski, D Kerjaschki, SA Stacker, MG Achen, K Alitalo
Journal article | 2001 | EMBO Journal
Honours, Awards and Fellowships
NH&MRC Senior Research Fellow
NH&MRC Senior Research Fellow
Pharmacia/Pfizer Foundation Senior Research Fellow
Project Leader, CRC for Cellular Growth factors
The Sir Peter Maccallum Department Of Oncology
Surgery - Royal Melbourne Hospital
Honorary Fellow Faculty Of Medicine
Dentistry and Health Sciences
Australian Society for Medical Research
Doctor of Philosophy
University of Melbourne
University of Melbourne
University of Melbourne