Steven Stacker

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

Tevin CY Chau, Sungmin Baek, Baptiste Coxam, Renae Skoczylas, Maria Rondon-Galeano, Neil I Bower, Elanor N Wainwright, Steven A Stacker, Helen M Cooper, Peter A Koopman, Anne K Lagendijk, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

Journal article  |  2021  |  DEVELOPMENTAL DYNAMICS

BACKGROUND: Lymphatic vascular development is regulated by well-characterized signaling and transcriptional pathways. These pathwa..

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Michael Y He, Michael M Halford, Ruofei Liu, James P Roy, Zoe L Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A Dawson, Marc G Achen, Steven A Stacker

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant an..

Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis

Valeria Arcucci, Steven A Stacker, Marc G Achen

Journal article  |  2021  |  BIOMOLECULES

Abstract: Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumo..

RYK-mediated filopodial pathfinding facilitates midgut elongation

Sha Wang, James P Roy, Abigail J Tomlinson, Ellen B Wang, Yu-Hwai Tsai, Lisa Cameron, Julie Underwood, Jason R Spence, Katherine D Walton, Steven A Stacker, Deborah L Gumucio, Terry Lechler

Journal article  |  2020  |  DEVELOPMENT

Between embryonic days 10.5 and 14.5, active proliferation drives rapid elongation of the murine midgut epithelial tube. Within th..

Soothing a Broken Heart Can Therapeutic Cross-Talk Between Lymphatics and the Immune Response Improve Recovery From Myocardial Infarction?

Rae H Farnsworth, Steven A Stacker

Journal article  |  2020  |  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons

Melissa G McKenzie, Lucy Cobbs, Patrick D Dummer, Timothy J Petros, Michael M Halford, Steven A Stacker, Yimin Zou, Gord J Fishell, Edmund Au

Journal article  |  2019  |  NEURON

GABAergic interneurons have many important functions in cortical circuitry, a reflection of their cell diversity. The developmenta..

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Adam J Vogrin, Neil Bower, Menachem J Gunzburg, Sally Roufail, Kazuhide S Okuda, Scott Paterson, Stephen J Headey, Steven A Stacker, Benjamin M Hogan, Marc G Achen

Journal article  |  2019  |  CELL REPORTS

Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebr..

The Interplay Between Lymphatic Vessels and Chemokines

Rae H Farnsworth, Tara Karnezis, Simon J Maciburko, Scott N Mueller, Steven A Stacker

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Chemokines are a family of small protein cytokines that act as chemoattractants to migrating cells, in particular those of the imm..

CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells

Tara Karnezis, Rae H Farnsworth, Nicole C Harris, Steven P Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Yazar, Simon J Takouridis, Craig Gerard, Stephen B Fox, Marc G Achen, Steven A Stacker

Journal article  |  2019  |  CANCER RESEARCH

Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymph..

Consensus guidelines for the use and interpretation of angiogenesis assays

Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C Aplin, Robert Auerbach, Hellmut G Augustin, David O Bates, Judy R van Beijnum, R Hugh F Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C Boeck, Peter C Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M Cimpean, et al.

Journal article  |  2018  |  ANGIOGENESIS

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, ti..