John Mariadason

Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.

Surein Arulananda, Megan O'Brien, Marco Evangelista, Tiffany J Harris, Nikita S Steinohrt, Laura J Jenkins, Marzena Walkiewicz, Robert JJ O'Donoghue, Ashleigh R Poh, Bibhusal Thapa, David S Williams, Trishe Leong, John M Mariadason, Xia Li, Jonathan Cebon, Erinna F Lee, Thomas John, W Douglas Fairlie

Journal article  |  2021  |  Cell Death Discov

The original version of this article unfortunately contained an error in the name of one of the authors (WD Fairlie). This has bee..

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis

Camilla M Reehorst, Rebecca Nightingale, Ian Y Luk, Laura Jenkins, Frank Koentgen, David S Williams, Charbel Darido, Fiona Tan, Holly Anderton, Michael Chopin, Kael Schoffer, Moritz F Eissmann, Michael Buchert, Dmitri Mouradov, Oliver M Sieber, Matthias Ernst, Amardeep S Dhillon, John M Mariadason

Journal article  |  2021  |  DEVELOPMENT

Ets homologous factor (EHF) is a member of the epithelial-specific Ets (ESE) family of transcription factors. To investigate its r..

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma

Surein Arulananda, Megan O'Brien, Marco Evangelista, Laura J Jenkins, Ashleigh R Poh, Marzena Walkiewicz, Trishe Leong, John M Mariadason, Jonathan Cebon, Srividya B Balachander, Justin R Cidado, Erinna F Lee, Thomas John, Walter D Fairlie

Journal article  |  2021  |  CELL DEATH DISCOVERY

Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Rece..

Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis

Sarah Bazzocco, Higinio Dopeso, Agueda Martinez-Barriocanal, Estefania Anguita, Rocio Nieto, Jing Li, Elia Garcia-Vidal, Valentina Maggio, Paulo Rodrigues, Priscila Guimaraes de Marcondes, Simo Schwartz, Lauri A Aaltonen, Alex Sanchez, John M Mariadason, Diego Arango

Journal article  |  2021  |  CLINICAL EPIGENETICS

BACKGROUND: Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has s..

Dual Antiangiogenesis Agents Bevacizumab Plus Trebananib, without Chemotherapy, in First-line Treatment of Metastatic Colorectal Cancer: Results of a Phase II Study

Jennifer Mooi, Fiona Chionh, Peter Savas, Jessica Da Gama Duarte, Geoffrey Chong, Stephen Brown, Rachel Wong, Timothy J Price, Alysson Wann, Effie Skrinos, John M Mariadason, Niall C Tebbutt

Journal article  |  2021  |  CLINICAL CANCER RESEARCH

PURPOSE: To assess the efficacy and safety of dual antiangiogenesis agents, bevacizumab plus trebananib, without chemotherapy, in ..

Rapid Resistance of FGFR-driven Gastric Cancers to Regorafenib and Targeted FGFR Inhibitors can be Overcome by Parallel Inhibition of MEK

David K Lau, Ian Y Luk, Laura J Jenkins, Andrew Martin, David S Williams, Kael L Schoffer, Fiona Chionh, Michael Buchert, Katrin Sjoquist, Alex Boussioutas, Sarah A Hayes, Matthias Ernst, Andrew J Weickhardt, Nick Pavlakis, Niall C Tebbutt, John M Mariadason

Journal article  |  2021  |  MOLECULAR CANCER THERAPEUTICS

Amplification or overexpression of the FGFR family of receptor tyrosine kinases occurs in a significant proportion of gastric canc..

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

Anderly C Chueh, Gahana Advani, Momeneh Foroutan, Jai Smith, Nadia Ng, Harshal Nandurkar, Daisy S Lio, Hong-Jian Zhu, Yuh-Ping Chong, Heather Verkade, Donald J Fujita, Jeffrey Bjorge, Faiza Basheer, Jet Phey Lim, Ian Luk, Amardeep Dhillon, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver Sieber, Frederic Hollande, et al.

Journal article  |  2021  |  ONCOGENE

Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC..

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma

Surein Arulananda, Megan O'Brien, Marco Evangelista, Tiffany J Harris, Nikita S Steinohrt, Laura J Jenkins, Marzena Walkiewicz, Robert JJ O'Donoghue, Ashleigh R Poh, Bibhusal Thapa, David S Williams, Trishe Leong, John M Mariadason, Xia Li, Jonathan Cebon, Erinna F Lee, Thomas John, W Douglas Fairlie

Journal article  |  2020  |  CELL DEATH DISCOVERY

Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant pleural m..

Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?

Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery

Journal article  |  2020  |  BIOCHEMICAL PHARMACOLOGY

The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Katie L Owen, Linden J Gearing, Damien J Zanker, Natasha K Brockwell, Weng Hua Khoo, Daniel L Roden, Marek Cmero, Stefano Mangiola, Matthew K Hong, Alex J Spurling, Michelle McDonald, Chia-Ling Chan, Anupama Pasam, Ruth J Lyons, Hendrika M Duivenvoorden, Andrew Ryan, Lisa M Butler, John M Mariadason, Tri Giang Phan, Vanessa M Hayes, et al.

Journal article  |  2020  |  EMBO REPORTS

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in ..