John Mariadason

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone.

Katie L Owen, Linden J Gearing, Damien J Zanker, Natasha K Brockwell, Weng Hua Khoo, Daniel L Roden, Marek Cmero, Stefano Mangiola, Matthew K Hong, Alex J Spurling, Michelle McDonald, Chia-Ling Chan, Anupama Pasam, Ruth J Lyons, Hendrika M Duivenvoorden, Andrew Ryan, Lisa M Butler, John M Mariadason, Tri Giang Phan, Vanessa M Hayes, et al.

Journal article  |  2020  |  EMBO reports

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in ..

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

David S Williams, Dmitri Mouradov, Clare Browne, Michelle Palmieri, Meg J Elliott, Rebecca Nightingale, Catherine G Fang, Rita Li, John M Mariadason, Ian Faragher, Ian T Jones, Leonid Churilov, Niall C Tebbutt, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  Modern Pathology

TP53 mutations drive colorectal cancer development, with missense mutations frequently leading to accumulation of abnormal TP53 pr..

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

David K Lau, Dmitri Mouradov, Wiphawan Wasenang, Ian Y Luk, Cameron M Scott, David S Williams, Yvonne H Yeung, Temduang Limpaiboon, George F Iatropoulos, Laura J Jenkins, Camilla M Reehorst, Fiona Chionh, Mehrdad Nikfarjam, Daniel Croagh, Amardeep S Dhillon, Andrew J Weickhardt, Toshihide Muramatsu, Yoshimasa Saito, Niall C Tebbutt, Oliver M Sieber, et al.

Journal article  |  2019  |  iScience

Biliary tract cancers (BTCs) currently have no approved targeted therapies. Although genomic profiling of primary BTCs has identif..

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Mercedes Davalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Togel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert, et al.

Journal article  |  2019  |  Nature Communications

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..

BRAF inhibitors synergize with BH3 mimetics to induce apoptosis in BRAF mutant colorectal cancer cells

Laura J Jenkins, Fiona Chionh, Ian Y Luk, Erinna F Lee, Amardeep S Dhillon, Niall Tebbutt, Walter D Fairlie, John M Mariadason

Conference Proceedings  |  2019  |  Molecular and Cellular Biology / Genetics

Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis

Sarah Bazzocco, Jose Higinio Dopeso, Agueda Martinez-Barriocanal, Estefania Anguita, Rocio Nieto, Alex Sanchez, John M Mariadason, Diego Arango

Conference Proceedings  |  2019  |  Molecular and Cellular Biology / Genetics

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Erinna F Lee, Tiffany J Harris, Sharon Tran, Marco Evangelista, Surein Arulananda, Thomas John, Celeste Ramnac, Chloe Hobbs, Haoran Zhu, Gency Gunasingh, David Segal, Andreas Behren, Jonathan Cebon, Alexander Dobrovic, John M Mariadason, Andreas Strasser, Leona Rohrbeck, Nikolas K Haass, Marco J Herold, W Douglas Fairlie

Journal article  |  2019  |  Cell Death & Disease

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin

D Rao, AB Mallick, T Augustine, C Daroqui, J Jiffry, A Merla, I Chaudhary, R Seetharam, A Sood, S Gajavelli, S Aparo, L Rajdev, A Kaubisch, J Chuy, A Negassa, JM Mariadason, R Maitra, S Goel

Journal article  |  2019  |  Oncotarget

Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles

Anand Kumar Meka, Laura J Jenkins, Mercedes Davalos-Salas, Naisarg Pujara, Kuan Yau Wong, Tushar Kumeria, John M Mariadason, Amirali Popat

Journal article  |  2018  |  Pharmaceutics

Effectiveness of tazemetostat as a novel epigenetic drug for cholangiocarcinoma

Wiphawan Wasenang, John Mariadason, Temduang Limpaiboon

Conference Proceedings  |  2018  |  CANCER SCIENCE

The prognostic impact of consensus molecular subtypes (CMS) and its predictive effects for bevacizumab benefit in metastatic colorectal cancer: molecular analysis of the AGITG MAX clinical trial

JK Mooi, P Wirapati, R Asher, CK Lee, P Savas, TJ Price, A Townsend, J Hardingham, D Buchanan, D Williams, S Tejpar, JM Mariadason, NC Tebbutt

Journal article  |  2018  |  Annals of Oncology

ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer

Ian Y Luk, Camilla M Reehorst, John M Mariadason

Journal article  |  2018  |  Molecules

Phase II study of everolimus (RAD001) monotherapy as first-line treatment in advanced biliary tract cancer with biomarker exploration: the RADiChol Study

David K Lau, Rebecca Y Tay, Yvonne H Yeung, Fiona Chionh, Jennifer Mooi, Carmel Murone, Effie Skrinos, Timothy J Price, John M Mariadason, Niall C Tebbutt

Journal article  |  2018  |  British Journal of Cancer

Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-gamma-Dependent Manner

Moritz F Eissmann, Christine Dijkstra, Merridee A Wouters, David Baloyan, Dmitri Mouradov, Paul M Nguyen, Mercedes Davalos-Salas, Tracy L Putoczki, Oliver M Sieber, John M Mariadason, Matthias Ernst, Frederick Masson

Journal article  |  2018  |  Cancer Immunology Research

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

Lars Togel, Rebecca Nightingale, Rui Wu, Anderly C Chueh, Sheren Al-Obaidi, Ian Luk, Mercedes Davalos-Salas, Fiona Chionh, Carmel Murone, Daniel D Buchanan, Zac Chatterton, Oliver M Sieber, Diego Arango, Niall C Tebbutt, David Williams, Amardeep S Dhillon, John M Mariadason

Journal article  |  2018  |  Scientific Reports

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer

Higinio Dopeso, Paulo Rodrigues, Josipa Bilic, Sarah Bazzocco, Fernando Carton-Garcia, Irati Macaya, Priscila Guimaraes de Marcondes, Estefania Anguita, Marc Masanas, Lizbeth M Jimenez-Flores, Augueda Martinez-Barriocanal, Rocio Nieto, Miguel F Segura, Simo Schwartz, John M Mariadason, Diego Arango

Journal article  |  2018  |  British Journal of Cancer

Cell Line Models of Molecular Subtypes of Colorectal Cancer.

Jennifer K Mooi, Ian Y Luk, John M Mariadason

Book Chapter  |  2018  |  Methods in Molecular Biology

Colorectal cancer (CRC) is a genetically diverse disease necessitating the need for well-characterized and reproducible models to ..

Aberrant DNA Methylation in Colorectal Cancer: What Should We Target?

Janson WT Tse, Laura J Jenkins, Fiona Chionh, John M Mariadason

Journal article  |  2017  |  Trends in Cancer

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity

Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Lisa J Zimmerman, Suhas Vasaikar, Christopher G Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert JC Coffey, Robbert JC Slebos, et al.

Journal article  |  2017  |  Gastroenterology

Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer

Anderly C Chueh, Mun-Sem Liew, Prudence A Russell, Marzena Walkiewicz, Aparna Jayachandran, Maud HW Starmans, Paul C Boutros, Gavin Wright, Stephen A Barnett, John M Mariadason, Thomas John

Journal article  |  2017  |  Oncotarget

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity toHDACInhibitors across Tumor Types

Anderly C Chueh, Janson WT Tse, Michael Dickinson, Paul Ioannidis, Laura Jenkins, Lars Togel, BeeShin Tan, Ian Luk, Mercedes Davalos-Salas, Rebecca Nightingale, Matthew R Thompson, Bryan RG Williams, Guillaume Lessene, Erinna F Lee, Walter D Fairlie, Amardeep S Dhillon, John M Mariadason

Journal article  |  2017  |  Clinical Cancer Research

K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines

Yvonne Yeung, David K Lau, Fiona Chionh, Hoanh Tran, Janson WT Tse, Andrew J Weickhardt, Mehrdad Nikfarjam, Andrew M Scott, Niall C Tebbutt, John M Mariadason

Journal article  |  2017  |  Molecular Oncology

PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

Candani SA Tutuka, Miles C Andrews, John M Mariadason, Paul Ioannidis, Christopher Hudson, Jonathan Cebon, Andreas Behren

Journal article  |  2017  |  Molecular Cancer

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis

Silvia Mateo-Lozano, Sarah Bazzocco, Paulo Rodrigues, Rocco Mazzolini, Elena Andretta, Higinio Dopeso, Yolanda Fernandez, Edgar del Llano, Josipa Bilic, Lucia Suarez-Lopez, Irati Macaya, Fernando Carton-Garcia, Rocio Nieto, Lizbeth M Jimenez-Flores, Priscila Guimaraes de Marcondes, Yaiza Nunez, Elsa Afonso, Karina Cacci, Javier Hernandez-Losa, Stefania Landolfi, et al.

Journal article  |  2017  |  Scientific Reports

Mechanisms of acquired resistance to the fibroblast growth factor receptor (FGFR) inhibitor BGJ398 in FGFR driven bladder cancer

M Hodgson-Garms, J Mariadason, A Weickhardt

Journal article  |  2016  |  Annals of Oncology

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

Lars Togel, Rebecca Nightingale, Anderly C Chueh, Aparna Jayachandran, Hoanh Tran, Toby Phesse, Rui Wu, Oliver M Sieber, Diego Arango, Amardeep S Dhillon, Mark A Dawson, Beatriz Diez-Dacal, Timothy C Gahman, Panagis Filippakopoulos, Andrew K Shiau, John M Mariadason

Journal article  |  2016  |  Molecular Cancer Therapeutics

By moonlighting in the nucleus, villin regulates epithelial plasticity

Srinivas Patnaik, Sudeep P George, Eric Pham, Swati Roy, Kanchan Singh, John M Mariadason, Seema Khurana

Journal article  |  2016  |  Molecular Biology of the Cell

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues

David Chisanga, Shivakumar Keerthikumar, Mohashin Pathan, Dinuka Ariyaratne, Hina Kalra, Stephanie Boukouris, Nidhi Abraham Mathew, Haidar Al Saffar, Lahiru Gangoda, Ching-Seng Ang, Oliver M Sieber, John M Mariadason, Ramanuj Dasgupta, Naveen Chilamkurti, Suresh Mathivanan

Journal article  |  2016  |  Nucleic Acids Research

Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment

Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez, Simo Schwartz, Josipa Bilic, John M Mariadason, Diego Arango

Journal article  |  2015  |  Clinical Cancer Research

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Mohashin Pathan, Shivakumar Keerthikumar, Ching-Seng Ang, Lahiru Gangoda, Camelia YJ Quek, Nicholas A Williamson, Dmitri Mouradov, Oliver M Sieber, Richard J Simpson, Agus Salim, Antony Bacic, Andrew F Hill, David A Stroud, Michael T Ryan, Johnson I Agbinya, John M Mariadason, Antony W Burgess, Suresh Mathivanan

Journal article  |  2015  |  PROTEOMICS

Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells

Anderly C Chueh, Janson WT Tse, Lars Toegel, John M Mariadason

Journal article  |  2015  |  Antioxidants & Redox Signaling

Vascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer

AJ Weickhardt, DS Williams, CK Lee, F Chionh, J Simes, C Murone, K Wilson, MM Parry, K Asadi, AM Scott, CJA Punt, ID Nagtegaal, TJ Price, JM Mariadason, NC Tebbutt

Journal article  |  2015  |  British Journal of Cancer

PR55 alpha-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

O Gilan, J Diesch, M Amalia, K Jastrzebski, AC Chueh, NM Verrills, RB Pearson, JM Mariadason, E Tulchinsky, RD Hannan, AS Dhillon

Journal article  |  2015  |  Oncogene

PR55 alpha-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity (vol 34, pg 1333, 2015)

O Gilan, J Diesch, M Amalia, K Jastrzebski, AC Chueh, NM Verrills, RB Pearson, JM Mariadason, E Tulchinsky, RD Hannan, AS Dhillon

Journal article  |  2015  |  Oncogene

Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer

Lloyd Pereira, John M Mariadason, Ross D Hannan, Amardeep S Dhillon

Journal article  |  2015  |  Frontiers in Oncology

Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer

TA Augustine, M Baig, A Sood, T Budagov, G Atzmon, JM Mariadason, S Aparo, R Maitra, S Goel

Journal article  |  2015  |  British Journal of Cancer

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer

Paulo Rodrigues, Irati Macaya, Sarah Bazzocco, Rocco Mazzolini, Elena Andretta, Higinio Dopeso, Silvia Mateo-Lozano, Josipa Bilic, Fernando Carton-Garcia, Rocio Nieto, Lucia Suarez-Lopez, Elsa Afonso, Stefania Landolfi, Javier Hernandez-Losa, Kazuto Kobayashi, Santiago Ramon y Cajal, Josep Tabernero, Niall C Tebbutt, John M Mariadason, Simo Schwartz, et al.

Journal article  |  2014  |  Nature Communications

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

Elisa Donnard, Paula F Asprino, Bruna R Correa, Fabiana Bettoni, Fernanda C Koyama, Fabio CP Navarro, Rodrigo O Perez, John Mariadason, Oliver M Sieber, Robert L Strausberg, Andrew JG Simpson, Denis LF Jardim, Luiz Fernando L Reis, Raphael B Parmigiani, Pedro AF Galante, Anamaria A Camargo

Journal article  |  2014  |  Oncotarget

The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) Is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent Manner

Joongho Shin, Azadeh Carr, Georgia A Corner, Lars Toegel, Mercedes Davaos-Salas, Tran Hoanh, Anderly C Chueh, Sheren Al-Obaidi, Fiona Chionh, Naseem Ahmed, Daniel DY Buchanan, Joanne P Young, Madhu S Malo, Richard A Hodin, Diego Arango, Oliver M Sieber, Leonard H Augenlicht, Amardeep S Dhillon, Thomas K Weber, John M Mariadason

Journal article  |  2014  |  Journal of Biological Chemistry

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

Dmitri Mouradov, Clare Sloggett, Robert N Jorissen, Christopher G Love, Shan Li, Antony W Burgess, Diego Arango, Robert L Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor, Jennifer L Wilding, David Bicknell, Ian PM Tomlinson, Walter F Bodmer, John M Mariadason, Oliver M Sieber

Journal article  |  2014  |  Cancer Research

Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

Radhashree Maitra, Raviraja Seetharam, Lydia Tesfa, Titto A Augustine, Lidija Klampfer, Matthew C Coffey, John M Mariadason, Sanjay Goel

Journal article  |  2014  |  Oncotarget

Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity

Nelson Ung, Tracy L Putoczki, Stanley S Stylli, Irvin Ng, John M Mariadason, Timothy A Chan, Hong-Jian Zhu, Rodney B Luwor

Journal article  |  2014  |  Cancer Biology & Therapy

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis

BeeShin Tan, Matthew Anaka, Siddhartha Deb, Claudia Freyer, Lisa M Ebert, Anderly C Chueh, Sheren Al-Obaidi, Andreas Behren, Aparna Jayachandran, Jonathan Cebon, Weisan Chen, John M Mariadason

Journal article  |  2014  |  Oncotarget

ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intratumoral Heterogeneity for Molecular Drivers

Dara L Aisner, Teresa T Nguyen, Diego D Paskulin, Anh T Le, Jerry Haney, Nathan Schulte, Fiona Chionh, Jenny Hardingham, John Mariadason, Niall Tebbutt, Robert C Doebele, Andrew J Weickhardt, Marileila Varella-Garcia

Journal article  |  2014  |  Molecular Cancer Research

BRAF Inhibitor-Driven Tumor Proliferation in a KRAS-Mutated Colon Carcinoma Is Not Overcome by MEK1/2 Inhibition

Miles C Andrews, Andreas Behren, Fiona Chionh, John Mariadason, Laura J Vella, Hongdo Do, Alexander Dobrovic, Niall Tebbutt, Jonathan Cebon

Journal article  |  2013  |  Journal of Clinical Oncology

Molecular Imaging of Death Receptor 5 Occupancy and Saturation Kinetics In Vivo by Humanized Monoclonal Antibody CS-1008

Ingrid JG Burvenich, Fook T Lee, Glenn A Cartwright, Graeme J O'Keefe, Dahna Makris, Diana Cao, Sylvia Gong, Anderly C Chueh, John M Mariadason, Martin W Brechbiel, Robert A Beckman, Kosaku Fujiwara, Reinhard von Roemeling, Andrew M Scott

Journal article  |  2013  |  Clinical Cancer Research

Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts

Sze Ting Lee, Hong Ji, David W Greening, Robert WH Speirs, Angela Rigopoulos, Vinochani Pillay, Carmel Murone, Angela Vitali, Kai Stuehler, Terrance G Johns, Georgia A Corner, John M Mariadason, Richard J Simpson, Andrew M Scott

Journal article  |  2013  |  Growth Factors

Regulation of EMT in Colorectal Cancer

Srinivas Patnaik, Sudeep P George, John M Mariadason, Seema Khurana

Conference Proceedings  |  2013  |  GASTROENTEROLOGY

Brush border myosin Ia inactivation in gastric but not endometrial tumors

Rocco Mazzolini, Paulo Rodrigues, Sarah Bazzocco, Higinio Dopeso, Ana M Ferreira, Silvia Mateo-Lozano, Elena Andretta, Stefan M Woerner, Hafid Alazzouzi, Stefania Landolfi, Javier Hernandez-Losa, Irati Macaya, Hiromu Suzuki, Santiago Ramon y Cajal, Mark S Mooseker, John M Mariadason, Johannes Gebert, Robert MW Hofstra, Jaume Reventos, Hiroyuki Yamamoto, et al.

Journal article  |  2013  |  International Journal of Cancer

Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

Muling Mao, Feng Tian, John M Mariadason, Chun C Tsao, Robert Lemos, Farshid Dayyani, YN Vashisht Gopal, Zhi-Qin Jiang, Ignacio I Wistuba, Xi M Tang, William G Bornman, Gideon Bollag, Gordon B Mills, Garth Powis, Jayesh Desai, Gary E Gallick, Michael A Davies, Scott Kopetz

Journal article  |  2013  |  Clinical Cancer Research

Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer

Missak Haigentz, Mimi Kim, Catherine Sarta, Juan Lin, Roger S Keresztes, Bruce Culliney, Anu G Gaba, Richard V Smith, Geoffrey I Shapiro, Lucian R Chirieac, John M Mariadason, Thomas J Belbin, John M Greally, John J Wright, Robert I Haddad

Journal article  |  2012  |  Oral Oncology

beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

HJM Smartt, A Greenhough, P Ordonez-Moran, M Al-Kharusi, TJ Collard, JM Mariadason, J Huelsken, AC Williams, C Paraskeva

Journal article  |  2012  |  British Journal of Cancer

beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

Helena JM Smartt, Alexander Greenhough, Paloma Ordonez-Moran, Elena Talero, Catherine A Cherry, Catherine A Wallam, Lee Parry, Manal Al Kharusi, Heather R Roberts, John M Mariadason, Alan R Clarke, Joerg Huelsken, Ann C Williams, Chris Paraskeva

Journal article  |  2012  |  Gut

Epigenetic Silencing of the Negative Feedback Regulator of Mitogen-activated Protein Kinase (MAPK) Signalling, DUSP5, in Colorectal Cancer

L Toegel, D Arango, AC Chueh, OM Sieber, JM Mariadason

Conference Proceedings  |  2012  |  EUROPEAN JOURNAL OF CANCER

PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer

Arjun Sood, Danielle McClain, Radhashree Maitra, Atrayee Basu-Mallick, Raviraja Seetharam, Andreas Kaubisch, Lakshmi Rajdev, John M Mariadason, Kathryn Tanaka, Sanjay Goel

Journal article  |  2012  |  Clinical Colorectal Cancer

The kinetics of the excision repair cross-complementing group-1 (ERCC1) gene in patients with colorectal cancer

Amartej Merla, Atrayee Basu Mallick, Titto A Augustine, Imran Chaudhary, Srikanth Gajavelli, Radhashree Maitra, Cecilia Daroqui, Santiago Aparo, Raviraja Seetharam, Lakshmi Rajdev, Andreas Kaubisch, Stephan Madajewicz, Abdissa Negassa, John Mariadason, Mohammad Haroon Ghalib, Sanjay Goel

Conference Proceedings  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

FOXP3 is not mutated in human melanoma

BeeShin Tan, Andreas Behren, Matthew Anaka, Laura Vella, Jonathan Cebon, John M Mariadason, Weisan Chen

Journal article  |  2012  |  Pigment Cell & Melanoma Research

Dual Targeting of the Epidermal Growth Factor Receptor Using the Combination of Cetuximab and Erlotinib: Preclinical Evaluation and Results of the Phase II DUX Study in Chemotherapy-Refractory, Advanced Colorectal Cancer

Andrew J Weickhardt, Tim J Price, Geoff Chong, Val Gebski, Nick Pavlakis, Terrance G Johns, Arun Azad, Effie Skrinos, Kate Fluck, Alexander Dobrovic, Renato Salemi, Andrew M Scott, John M Mariadason, Niall C Tebbutt

Journal article  |  2012  |  Journal of Clinical Oncology

Villin Expression Is Frequently Lost in Poorly Differentiated Colon Cancer

Diego Arango, Sheren Al-Obaidi, David S Williams, Higinio Dopeso, Rocco Mazzolini, Georgia Corner, Do-Sun Byun, Azadeh A Carr, Carmel Murone, Lars Toegel, Nikolajs Zeps, Lauri A Aaltonen, Barry Iacopetta, John M Mariadason

Journal article  |  2012  |  The American Journal of Pathology

A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells

JL Pakay, J Diesch, O Gilan, Y-Y Yip, E Sayan, W Kolch, JM Mariadason, RD Hannan, E Tulchinsky, AS Dhillon

Journal article  |  2012  |  Oncogene

Brush border Myosin Ia has tumor suppressor activity in the intestine

Rocco Mazzolini, Higinio Dopeso, Silvia Mateo-Lozano, Wakam Chang, Paulo Rodrigues, Sarah Bazzocco, Hafid Alazzouzi, Stefania Landolfi, Javier Hernandez-Losa, Elena Andretta, Pia Alhopuro, Eloy Espin, Manel Armengol, Josep Tabernero, Santiago Ramon y Cajal, Matthias Kloor, Johannes Gebert, John M Mariadason, Simo Schwartz, Lauri A Aaltonen, et al.

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Therapeutic targeting of the epidermal growth factor receptor in human cancer.

Nathalie S Dhomen, John Mariadason, Niall Tebbutt, Andrew M Scott

Journal article  |  2012  |  Critical Reviews™ in Oncogenesis

The epidermal growth factor receptor (EGFR; also referred to as HER1 or ERBB1), is a member of the type 1 receptor tyrosine kinase..

Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer

Donghai Wang, Karina Peregrina, Elena Dhima, Elaine Y Lin, John M Mariadason, Leonard H Augenlicht

Journal article  |  2011  |  Proceedings of the National Academy of Sciences

Biomarkers of 5-FU response in colon cancer

John M Mariadason, Niall C Tebbutt

Journal article  |  2011  |  Cancer Biology & Therapy

Strategies for Overcoming Inherent and Acquired Resistance to EGFR Inhibitors by Targeting Downstream Effectors in the RAS/PI3K Pathway

AJ Weickhardt, NC Tebbutt, JM Mariadason

Journal article  |  2010  |  Current Cancer Drug Targets

Intravenous administration of ReolysinA (R), a live replication competent RNA virus is safe in patients with advanced solid tumors

Radharani Gollamudi, Mohammad H Ghalib, Kavita K Desai, Imran Chaudhary, Benny Wong, Mark Einstein, Matthew Coffey, George M Gill, Karl Mettinger, John M Mariadason, Sridhar Mani, Sanjay Goel

Journal article  |  2010  |  Investigational New Drugs

Prediction and Testing of Biological Networks Underlying Intestinal Cancer

Vishal N Patel, Gurkan Bebek, John M Mariadason, Donghai Wang, Leonard H Augenlicht, Mark R Chance

Journal article  |  2010  |  PLoS ONE

Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer

Manickam Janakiraman, Efsevia Vakiani, Zhaoshi Zeng, Christine A Pratilas, Barry S Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Ricarte Filho, Yogindra Persaud, Douglas A Levine, James A Fagin, Suresh C Jhanwar, John M Mariadason, Alex Lash, Marc Ladanyi, Leonard B Saltz, Adriana Heguy, Philip B Paty, et al.

Journal article  |  2010  |  Cancer Research

Oxaliplatin Resistance Induced by ERCC1 Up-regulation Is Abrogated by siRNA-mediated Gene Silencing in Human Colorectal Cancer Cells

Raviraja N Seetharam, Arjun Sood, Atrayee Basu-Mallick, Leonard H Augenlicht, John M Mariadason, Sanjay Goel

Journal article  |  2010  |  Anticancer Research

Altered Dynamics of Intestinal Cell Maturation in Apc1638N/ Mice

Donghai Wang, Rossanna C Pezo, Georgia Corner, Cristina Sison, Martin L Lesser, Shailesh M Shenoy, John M Mariadason, Robert H Singer, Leonard H Augenlicht

Journal article  |  2010  |  Cancer Research

Aprataxin Tumor Levels Predict Response of Colorectal Cancer Patients to Irinotecan-based Treatment

Higinio Dopeso, Silvia Mateo-Lozano, Elena Elez, Stefania Landolfi, Francisco Javier Ramos Pascual, Javier Hernandez-Losa, Rocco Mazzolini, Paulo Rodrigues, Sarah Bazzocco, Maria Josep Carreras, Eloy Espin, Manel Armengol, Andrew J Wilson, John M Mariadason, Santiago Ramon y Cajal, Josep Tabernero, Simo Schwartz, Diego Arango

Journal article  |  2010  |  Clinical Cancer Research

Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling

S Guilmeau, M Flandez, JM Mariadason, LH Augenlicht

Journal article  |  2010  |  Oncogene

An A13 Repeat within the 3 '-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression (vol 69, pg 7811, 2009)

Z Yuan, J Shin, A Wilson, S Goel, Y-H Ling, N Ahmed, H Dopeso, M Jhawer, S Nasser, C Montagna, K Fordyce, LH Augenlicht, LA Aaltonen, D Arango, TK Weber, JM Mariadason

Journal article  |  2010  |  Cancer Research

Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction

Andrew J Wilson, Anderly C Chueh, Lars Toegel, Georgia A Corner, Naseem Ahmed, Sanjay Goel, Do-Sun Byun, Shannon Nasser, Michele A Houston, Minaxi Jhawer, Helena JM Smartt, Lucas B Murray, Courtney Nicholas, Barbara G Heerdt, Diego Arango, Leonard H Augenlicht, John M Mariadason

Journal article  |  2010  |  Cancer Research

Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors

Ganepola AP Ganepola, Robert M Mazziotta, Dilendra Weeresinghe, Georgia A Corner, Cheryl J Parish, David H Chang, Niall C Tebbutt, Carmel Murone, Naseem Ahmed, Leonard H Augenlicht, John M Mariadason

Journal article  |  2010  |  Clinical and Experimental Metastasis

PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab (vol 68, pg 1953, 2008)

M Jhawer, S Goel, AJ Wilson, C Montagna, Y-H Ling, D-S Byun, S Nasser, D Arango, J Shin, L Klampfer, LH Augenlicht, R Perez-Soler, JM Mariadason

Journal article  |  2009  |  Cancer Research

An A13 Repeat within the 3 '-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression

Ziqiang Yuan, Joongho Shin, Andrew Wilson, Sanjay Goel, Yi-He Ling, Naseem Ahmed, Higinio Dopeso, Minaxi Jhawer, Shannon Nasser, Cristina Montagna, Kenneth Fordyce, Leonard H Augenlicht, Lauri A Aaltonen, Diego Arango, Thomas K Weber, John M Mariadason

Journal article  |  2009  |  Cancer Research

The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis

Higinio Dopeso, Silvia Mateo-Lozano, Rocco Mazzolini, Paulo Rodrigues, Laura Lagares-Tena, Julian Ceron, Jordi Romero, Marielle Esteves, Stefania Landolfi, Javier Hernandez-Losa, Julio Castano, Andrew J Wilson, Santiago Ramon Y Cajal, John M Mariadason, Simo Schwartz, Diego Arango

Journal article  |  2009  |  Cancer Research

Proteomic changes during intestinal cell maturation in vivo

Jinsook Chang, Mark R Chance, Courtney Nicholas, Naseem Ahmed, Sandra Guilmeau, Marta Flandez, Donghai Wang, Do-Sun Byun, Shannon Nasser, Joseph M Albanese, Georgia A Comer, Barbara G Heerdt, Andrew J Wilson, Leonard H Augenlicht, John M Mariadason

Journal article  |  2008  |  Journal of Proteomics

Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer

Tianhong Li, Wancai Yang, Maomi Li, Do-Sun Byun, Chang Tong, Shannon Nasser, Min Zhuang, Diego Arango, John M Mariadason, Leonard H Augenlicht

Journal article  |  2008  |  Molecular Nutrition & Food Research

Making Sense of HDAC2 Mutations in Colon Cancer

John M Mariadason

Journal article  |  2008  |  Gastroenterology

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

Andrew J Wilson, Do-Sun Byun, Shannon Nasser, Lucas B Murray, Kanyalakshmi Ayyanar, Diego Arango, Maria Figueroa, Ari Melnick, Gary D Kao, Leonard H Augenlicht, John M Mariadason

Journal article  |  2008  |  Molecular Biology of the Cell

Dissecting HDAC3-mediated tumor progression

John M Mariadason

Journal article  |  2008  |  Cancer Biology & Therapy

De-differentiation of microsatellite unstable (MSI) colorectal cancer (CRC) is resistant to differentiation induction by the HDAC inhibitor butyrate as measured by intestinal alkaline phosphatase (ALPI) induction

Azadeh Azarbayejani, Joongho Shin, Victoria Lai, Naseem Ahmed, Thomas K Weber, John M Mariadason

Conference Proceedings  |  2008  |  Journal of the American College of Surgeons

A novel deletion A mutation within the 3 ' untranslated region of the EGFR gene contributes to EGFR overexpression in microsatellite unstable (MSI) colon cancer (CRC) that results from increased mRNA stability

Joongho Shin, Azadeh Azarbayejani, Ziqian Yuan, Minaxi Jhawer, Shannon Nasser, Kenneth Fordyce, Diego Arrango, John M Mariadason

Conference Proceedings  |  2008  |  Journal of the American College of Surgeons

Erratum: PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. (Cancer Res (2008) 68 (1953-61))

M Jhawer, S Goel, AJ Wilson, C Montagna, YH Ling, DS Byun, S Nasser, D Arango, J Shin, L Klampfer, LH Augenlicht, R Perez-Soler, JM Mariadason

Journal article  |  2008  |  Cancer Research

Meta-Analysis of Microarray Studies Reveals a Novel Hematopoietic Progenitor Cell Signature and Demonstrates Feasibility of Inter-Platform Data Integration

Davendra Sohal, Andrew Yeatts, Kenny Ye, Andrea Pellagatti, Li Zhou, Perry Pahanish, Yongkai Mo, Tushar Bhagat, John Mariadason, Jacqueline Boultwood, Ari Melnick, John Greally, Amit Verma

Journal article  |  2008  |  PLoS ONE

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

Isabelle Mercier, Magalis Vuolo, Jean-Francois Jasmin, Christina M Medina, Mark Williams, John M Mariadason, Hong Qian, Xiaonan Xue, Richard G Pestell, Michael P Lisanti, Richard N Kitsis

Journal article  |  2008  |  Cell Cycle

PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab

Minaxi Jhawer, Sanjay Goel, Andrew J Wilson, Cristina Montagna, Yi-He Ling, Do-Sun Byun, Shannon Nasser, Diego Arango, Joongho Shin, Lidija Klampfer, Leonard H Augenlicht, Roman Perez Soler, John M Mariadason

Journal article  |  2008  |  Cancer Research

Epidermal growth factor receptor (EGFR) over expression in microsatellite unstable (MSI) colorectal cancer (CRC) is characterized by a deletion mutation in the 3' UTR poly A (13) tract and is not associated with intron 1 CA repeat length variation

J Shin, Z Yuan, P Sreeramoju, K Fordyce, V Lai, N White, J Mariadason, TK Weber

Conference Proceedings  |  2008  |  ANNALS OF SURGICAL ONCOLOGY

HDACs and HDAC inhibitors in colon cancer

John M Mariadason

Journal article  |  2008  |  Epigenetics

Data mining of hematopoietic stem cell microarray studies reveals a novel stem cell gene expression signature and demonstrates feasibility of integrating data from different labs and different microarray platforms

D Sohal, A Yeatts, K Ye, A Pellagatti, L Zhou, P Pahanish, J Mariadason, A Melnick, J Greally, J Boultwood, A Verma

Conference Proceedings  |  2007  |  Blood

Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing

Nikolaus Gassler, Wilfried Roth, Benjamin Funke, Armin Schneider, Frank Herzog, Jens JW Tischendorf, Kerstin Grund, Roland Penzel, Ignacio G Bravo, John Mariadason, Volker Ehemann, Jaromir Sykora, Tobias L Haas, Henning Walczak, Tom Ganten, Hanswalter Zentgraf, Peter Erb, Angel Alonso, Frank Autschbach, Peter Schirmacher, et al.

Journal article  |  2007  |  Gastroenterology

P27(kip1) regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: Potential role in neoplasia

Helena JM Smartt, Sandra Guilmeau, Shannon V Nasser, Courtney Nicholas, Laura Bancroft, Sharon A Simpson, Nancy Yeh, Wancai Yang, John M Mariadason, Andrew Koff, Leonard H Augenlicht

Journal article  |  2007  |  Gastroenterology

c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

Chang Tong, Zhinan Yin, Zibo Song, Ashley Dockendorff, Chuanshu Huang, John Mariadason, Richard A Flavell, Roger J Davis, Leonard H Augenlicht, Wancai Yang

Journal article  |  2007  |  The American Journal of Pathology

Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth - Implications for therapy

Dineo Khabele, Deok-Soo Son, Angelika K Parl, Gary L Goldberg, Leonard H Augenlicht, John M Mariadason, Valerie Montgomery Rice

Journal article  |  2007  |  Cancer Biology & Therapy

Decreased CDK2-AP1 expression in microsatellite unstable (MSI) colorectal cancer (CRC) results from reduced mRNA stability

J Shin, Z Yuan, P Sreeramoju, T Kent, K Fordyce, J Kim, V Wang, D Schneyer, TK Weber

Conference Proceedings  |  2007  |  ANNALS OF SURGICAL ONCOLOGY

Increased epidermal growth factor receptor (EGFR) gene expression in microsatellite unstable (MSI) human colorectal cancer (CRC) is characterized by mutations in the poly A tract of the 3' untranslated region (UTR) of the EGFR gene

J Shin, J Mariadason, Z Yuan, M Jhawer, D Arango, S Nasser, K Fordyce, P Sreeramoju, T Kent, TK Weber

Conference Proceedings  |  2007  |  ANNALS OF SURGICAL ONCOLOGY

Genetics and Epigenetics in Cancer Biology

A Velcich, L Klampfer, J Mariadason, H Smartt, S Guilmeau, S Maier, W Yang, J Christman, B Heerdt, L Augenlicht

Book Chapter  |  2006

Meta-transcriptome of bone marrow stem cells demonstrates platform and lab dependant variability in gene expression and reveals a novel set of enriched genes.

Davendra Sohal, Andrew Yeatts, Joanna Opalinska, Li Zhou, Perry Pahanish, Kenny Ye, Maria Figueroa, John Mariadason, Ari Melnick, John Greally, Amit Verma

Conference Proceedings  |  2006  |  BLOOD

Interaction of genetic and dietary factors in mouse intestinal tumorigenesis

Leonard H Augenlicht, WanCai Yang, John Mariadason, Anna Velcich, Lidija Klampfer, Martin Lipkin, Kan Yang

Conference Proceedings  |  2006  |  The Journal of Nutrition

EPHB4 and survival of colorectal cancer patients

Veronica Davalos, Higinio Dopeso, Julio Castano, Andrew J Wilson, Felip Vilardell, Jordi Romero-Gimenez, Eloy Espin, Manel Armengol, Gabriel Capella, John M Mariadason, Lauri A Aaltonen, Simo Schwartz, Diego Arango

Journal article  |  2006  |  Cancer Research

Histone deacetylase 3 (HDAC3) and other class IHDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

AJ Wilson, DS Byun, N Popova, LB Murray, K L'Italien, Y Sowa, D Arango, A Velcich, LH Augenlicht, JM Mariadason

Journal article  |  2006  |  Journal of Biological Chemistry

Na /monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT

Viktoriya Paroder, Shelly R Spencer, Monika Paroder, Diego Arango, Simo Schwartz, John M Mariadason, Leonard H Augenlicht, Sepehr Eskandari, Nancy Carrasco

Journal article  |  2006  |  Proceedings of the National Academy of Sciences

Kaiso-deficient mice show resistance to intestinal cancer

A Prokhortchouk, O Sansom, J Selfridge, IM Caballero, S Salozhin, D Aithozhina, L Cerchietti, FG Meng, LH Augenlicht, JM Mariadason, B Hendrich, A Melnick, E Prokhortchouk, A Clarke, A Bird

Journal article  |  2006  |  Molecular and Cellular Biology

Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors

H Alazzouzi, V Davalos, A Kokko, E Domingo, SM Woerner, AJ Wilson, L Konrad, P Laiho, E Espin, M Armengol, K Imai, H Yamamoto, JM Mariadason, JF Gebert, LA Aaltonen, S Schwartz, D Arango

Journal article  |  2005  |  Cancer Research

Dietary components modify gene expression: Implications for carcinogenesis

K Yang, WC Yang, J Mariadason, A Velcich, M Lipkin, L Augenlicht

Conference Proceedings  |  2005  |  The Journal of Nutrition

Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis

JM Mariadason, C Nicholas, KE L'Italien, M Zhuang, HJM Smartt, BG Heerdt, WC Yang, GA Corner, AJ Wilson, L Klampfer, D Arango, LH Augenlicht

Journal article  |  2005  |  Gastroenterology

Quantitative rather than qualitative differences in gene expression predominate in intestinal cell maturation along distinct cell lineages

A Velcich, G Corner, D Paul, M Zhuang, JM Mariadason, C Laboisse, L Augenlicht

Journal article  |  2005  |  Experimental Cell Research

Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells

D Arango, AJ Wilson, Q Shi, GA Corner, MJ Aranes, C Nicholas, M Lesser, JM Mariadason, LH Augenlicht

Journal article  |  2004  |  British Journal of Cancer

Customizing chemotherapy for colon cancer: the potential of gene expression profiling

JM Mariadason, D Arango, LH Augenlicht

Journal article  |  2004  |  Drug Resistance Updates

Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin

JM Mariadason, D Arango, QH Shi, AJ Wilson, GA Corner, C Nicholas, MJ Aranes, M Lesser, EL Schwartz, LH Augenlicht

Journal article  |  2003  |  Cancer Research

Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression

L Klampfer, J Huang, G Corner, J Mariadason, D Arango, T Sasazuki, S Shirasawa, L Augenlicht

Journal article  |  2003  |  Journal of Biological Chemistry

c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis

D Arango, JM Mariadason, AJ Wilson, W Yang, GA Corner, C Nicholas, MJ Aranes, LH Augenlicht

Journal article  |  2003  |  British Journal of Cancer

TR3/Nur77 in colon cancer cell apoptosis

AJ Wilson, D Arango, JM Mariadason, BG Heerdt, LH Augenlicht

Journal article  |  2003  |  Cancer Research

Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation

L Augenlicht, L Shi, J Mariadason, C Laboisse, A Velcich

Journal article  |  2003  |  Oncogene

Application of gene expression profiling to colon cell maturation, transformation and chemoprevention

LH Augenlicht, A Velcich, L Klampfer, H Jie, G Corner, M Aranes, C Laboisse, B Rigas, M Lipkin, Y Kan, S Quihu, M Lesser, B Heerdt, D Arango, WC Yang, A Wilson, JM Mariadason

Conference Proceedings  |  2003  |  Journal of Nutrition

Application of gene expression profiling to colon cell maturation, transformation and chemoprevention

LH Augenlicht, A Velcich, L Klampfer, J Huang, G Corner, M Aranes, C Laboisse, B Rigas, M Lipkin, K Yang, QH Shi, M Lesser, B Heerdt, D Arango, WC Yang, A Wilson, JM Mariadason

Conference Proceedings  |  2003  |  The Journal of Nutrition

Microarray analysis in the clinical management of cancer

JM Mariadason, LH Augenlicht, D Arango

Journal article  |  2003  |  Hematology/Oncology Clinics of North America

Hereditary versus environmental factors in colorectal cancer

LH Augenlicht, W Yang, A Wilson, B Heerdt, J Mariadason, A Velcich

Conference Proceedings  |  2003  |  EXOGENOUS FACTORS IN COLONIC CARCINOGENESIS

Short chain fatty acids and colon cancer

LH Augenlicht, JM Mariadason, A Wilson, D Arango, WC Yang, BG Heerdt, A Velcich

Conference Proceedings  |  2002  |  The Journal of Nutrition

A gene expression profile that defines colon cell maturation in vitro

JM Mariadason, D Arango, GA Corner, MJ Aranes, KA Hotchkiss, WC Yang, LH Augenlicht

Journal article  |  2002  |  Cancer Research

Environment-gene interactions in intestinal cancer

LH Augenlicht, BG Heerdt, JM Mariadason, WC Yang, AJ Wilson, A Fragale, A Velcich

Conference Proceedings  |  2002  |  European Journal of Cancer Prevention

p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo

WC Yang, A Velcich, J Mariadason, C Nicholas, G Corner, M Houston, W Edelmann, R Kucherlapati, PR Holt, LH Augenlicht

Journal article  |  2001  |  Cancer Research

Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation

JM Mariadason, M Bordonaro, F Aslam, L Shi, M Kuraguchi, A Velcich, LH Augenlicht

Journal article  |  2001  |  Cancer Research

Dissociation of staurosporine-induced apoptosis from G(2)-M arrest in SW620 human colonic carcinoma cells: Initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (Delta psi(m))

BG Heerdt, MA Houston, JM Mariadason, LH Augenlicht

Journal article  |  2000  |  Cancer Research

Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: Comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer

JM Mariadason, GA Corner, LH Augenlicht

Journal article  |  2000  |  Cancer Research

Divergent phenotypic patterns and commitment to apoptosis of Caco-2 cells during spontaneous and butyrate-induced differentiation

JM Mariadason, KL Rickard, DH Barkla, LH Augenlicht, PR Gibson

Journal article  |  2000  |  Journal of Cellular Physiology

Divergent phenotypic patterns and commitment to apoptosis of Caco-2 cells during spontaneous and butyrate-induced differentiation

JM Mariadason, KL Rickard, DH Barkla, LH Augenlicht, PR Gibson

Journal article  |  2000  |  Journal of Cellular Physiology

Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells

KL Rickard, PR Gibson, NJ Wilson, JM Mariadason, WA Phillips

Journal article  |  2000  |  Journal of Cellular Physiology

Butyrate-induced apoptotic cascade in colonic carcinoma cells: Modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin a but not curcumin

M Bordonaro, JM Mariadason, F Aslam, BG Heerdt, LH Augenlicht

Journal article  |  1999  |  Cell Growth and Differentiation

Effect of butyrate on paracellular permeability in rat distal colonic mucosa ex vivo

JM Mariadason, D Kilias, A Catto-Smith, PR Gibson

Journal article  |  1999  |  Journal of Gastroenterology and Hepatology

Relationship of hydrolase activities to epithelial cell turnover in distal colonic mucosa of normal rats

PR Gibson, R Nov, M Fielding, A McIntyre, CF Finch, O Rosella, JM Mariadason, DH Barkla, GP Young

Journal article  |  1999  |  Journal of Gastroenterology and Hepatology

Colonic epithelial cell activation and the paradoxical effects of butyrate

PR Gibson, O Rosella, AJ Wilson, JM Mariadason, K Rickard, K Byron, DH Barkla

Journal article  |  1999  |  Carcinogenesis

Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats

JM Mariadason, A Catto-Smith, PR Gibson

Journal article  |  1999  |  Gut

Cellular mechanisms of risk and transformation

LH Augenlicht, M Bordonaro, BG Heerdt, J Mariadason, A Velcich

Conference Proceedings  |  1999  |  Annals of the New York Academy of Sciences

Colonic cell proliferation, differentiation, and apoptosis

L Augenlicht, A Velcich, J Mariadason, M Bordonaro, B Heerdt

Conference Proceedings  |  1999  |  Advances in Experimental Medicine and Biology

Resistance to butyrate-induced apoptosis and differentiation during spontaneous caco-2 cell differentiation.

JM Mariadason, KL Rickard, PR Gibson

Journal article  |  1998  |  Gastroenterology

Butyrate increases permeability and alters epithelial kinetics and brush border hydrolase activities in rat colon, ex vivo.

JM Mariadason, A CattoSmith, PR Gibson

Conference Proceedings  |  1997  |  GASTROENTEROLOGY

Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model.

JM Mariadason, DH Barkla, PR Gibson

Journal article  |  1997  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Control of paracellular permeability in the colonic epithelium is fundamental to its functional competence. This study examines th..

Butyrate induced cell differentiation in vitro is independent of its beta-oxidation.

JM Mariadason, PR Gibson

Conference Proceedings  |  1997  |  GASTROENTEROLOGY

Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model

JM Mariadason, DH Barkla, PR Gibson

Journal article  |  1997  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protective role of the epithelium of the small intestine and colon

PR Gibson, RP Anderson, JM Mariadason, AJ Wilson

Journal article  |  1996  |  Inflammatory Bowel Diseases

The effect of cell differentiation status on colonic epithelial barrier function, in vitro.

JM Mariadason, PR Gibson

Conference Proceedings  |  1996  |  GASTROENTEROLOGY

Dietary modulation of colonic barrier function.

JM Mariadason, A CattoSmith, PR Gibson

Conference Proceedings  |  1996  |  GASTROENTEROLOGY

Dietary modulation of urokinase and mucosal hydrolase activities.

PR Gibson, R Nov, M Fielding, A McIntyre, O Rosella, JM Mariadason, CF Finch, DH Barkla, GP Young

Conference Proceedings  |  1996  |  GASTROENTEROLOGY

THE EFFECT OF BUTYRATE ON PARACELLULAR PERMEABILITY IN THE CACO-2 MODEL OF COLONIC EPITHELIUM

JM MARIADASON, PR GIBSON

Conference Proceedings  |  1994  |  GASTROENTEROLOGY

LOCALIZATION AND RETRIEVAL OF BULLETS UNDER ULTRASOUND GUIDANCE

A YIENGPRUKSAWAN, J MARIADASON, GAP GANEPOLA, HP FREEMAN

Journal article  |  1987  |  Archives of Surgery