Robert O'Donoghue

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma

Surein Arulananda, Megan O'Brien, Marco Evangelista, Tiffany J Harris, Nikita S Steinohrt, Laura J Jenkins, Marzena Walkiewicz, Robert JJ O'Donoghue, Ashleigh R Poh, Bibhusal Thapa, David S Williams, Trishe Leong, John M Mariadason, Xia Li, Jonathan Cebon, Erinna F Lee, Thomas John, W Douglas Fairlie

Journal article  |  2020  |  Cell Death Discovery

Abstract Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant ..

Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice

Ashleigh R Poh, Amy R Dwyer, Moritz F Eissmann, Ashwini L Chand, David Baloyan, Louis Boon, Michael W Murrey, Lachlan Whitehead, Megan O'Brien, Clifford A Lowell, Tracy L Putoczki, Fiona J Pixley, Robert JJ O'Donoghue, Matthias Ernst

Journal article  |  2020  |  Cancer Immunology Research

Persistent activation of the latent transcription factor STAT3 is observed in gastric tumor epithelial and immune cells and is ass..

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Moritz F Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D Huntington, Margaret L Hibbs, Alex Boussioutas, Michele A Grimbaldeston, Michael Buchert, Robert JJ O'Donoghue, Frederick Masson, Matthias Ernst

Journal article  |  2019  |  Nature Communications

CD52 inhibits Toll-like receptor activation of NF-kappa B and triggers apoptosis to suppress inflammation

Maryam Rashidi, Esther Bandala-Sanchez, Kate E Lawlor, Yuxia Zhang, Alana M Neale, Swarna L Vijayaraj, Robert O'Donoghue, John M Wentworth, Timothy E Adams, James E Vince, Leonard C Harrison

Journal article  |  2018  |  Cell Death & Differentiation

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Ashleigh R Poh, Christopher G Love, Frederick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessene, Oliver Sieber, Clifford Lowell, Tracy L Putoczki, Robert JJ O'Donoghue, Matthias Ernst

Journal article  |  2017  |  Cancer Cell

Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells

Ashleigh R Poh, Robert JJ O'Donoghue, Matthias Ernst

Journal article  |  2015  |  Oncotarget

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

IA Elsum, LL Yates, HB Pearson, TJ Phesse, F Long, R O'Donoghue, M Ernst, C Cullinane, PO Humbert

Journal article  |  2014  |  Oncogene

TGF-beta signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung

Jonathan L McQualter, Rosa C McCarty, Joanne Van der Velden, Robert JJ O'Donoghu, Marie-Liesse Asselin-Labat, Steven Bozinovski, Ivan Bertoncello

Journal article  |  2013  |  STEM CELL RESEARCH

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Robert JJ O'Donoghue, Darryl A Knight, Carl D Richards, Cecilia M Prele, Hui Ling Lau, Andrew G Jarnicki, Jessica Jones, Steven Bozinovski, Ross Vlahos, Stefan Thiem, Brent S McKenzie, Bo Wang, Philip Stumbles, Geoffrey J Laurent, Robin J McAnulty, Stefan Rose-John, Hong Jian Zhu, Gary P Anderson, Matthias R Ernst, Steven E Mutsaers

Journal article  |  2012  |  EMBO Molecular Medicine

STAT3: a central mediator of pulmonary fibrosis?

Cecilia M Prêle, Eric Yao, Robert JJ O'Donoghue, Steven E Mutsaers, Darryl A Knight

Conference Proceedings  |  2012  |  Annals of the American Thoracic Society

Pulmonary fibrosis is a devastating, relentlessly progressive, and lethal disease. There is a significant unmet need for effective..