Dominic de Nardo

Removing the B (cell) STING to improve cancer immunotherapy

Rajan Venkatraman, Dominic De Nardo

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Genistein Targets STING-Driven Antiviral Responses.

Tomalika R Ullah, Katherine R Balka, Rebecca L Ambrose, Geneviève Pépin, Matthew CJ Wilce, Jacqueline A Wilce, Belinda J Thomas, Dominic De Nardo, Bryan RG Williams, Michael P Gantier

Journal article  |  2022  |  mBio

Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synt..

Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12 macrophages.

Zhipeng Li, Manoj Gurung, Richard R Rodrigues, Jyothi Padiadpu, Nolan K Newman, Nathan P Manes, Jacob W Pederson, Renee L Greer, Stephany Vasquez-Perez, Hyekyoung You, Kaito A Hioki, Zoe Moulton, Anna Fel, Dominic De Nardo, Amiran K Dzutsev, Aleksandra Nita-Lazar, Giorgio Trinchieri, Natalia Shulzhenko, Andrey Morgun

Journal article  |  2022  |  J Exp Med

Microbiota contribute to the induction of type 2 diabetes by high-fat/high-sugar (HFHS) diet, but which organs/pathways are impact..

Deficiency in coatomer complex I causes aberrant activation of STING signalling

Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F Dagley, Michael J Mlodzianoski, Kelly L Rogers, Thomas Zillinger, Gunther Hartmann, Michael P Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L Masters

Journal article  |  2022  |  NATURE COMMUNICATIONS

Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi ..

Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations

Ee Shan Pang, Ghazal Daraj, Katherine R Balka, Dominic De Nardo, Christophe Macri, Hubertus Hochrein, Kelly-Anne Masterman, Peck S Tan, Angus Shoppee, Zoe Magill, Nazneen Jahan, Mariam Bafit, Yifan Zhan, Benjamin T Kile, Kate E Lawlor, Kristen J Radford, Mark D Wright, Meredith O'Keeffe

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Stimulator of Interferon Genes (STING) is a cytosolic sensor of cyclic dinucleotides (CDNs). The activation of dendritic cells (DC..

Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24

Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frederic Ebstein, Paul J Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J Calleja, Cassandra R Harapas, Katherine R Balka, Jacob Mitchell, Jacob T Jackson, Niall D Geoghegan, Fiona Moghaddas, Kelly L Rogers, Katrin D Mayer-Barber, Adriana A De Jesus, Dominic De Nardo, et al.

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signalin..

Activation of stimulator of interferon genes in dendritic cells induces interferon-lambda and subset- and species-specific dendritic cell death

Ee Shan Pang, Ghazal Daraj, Christophe Macri, Katherine Balka, Dominic de Nardo, Hubertus Hochrein, Kelly-Anne Masterman, Yifan Zhan, Benjamin Kile, Kate Lawlor, Kristen Radford, Mark Wright, Meredith O’Keeffe

Journal article  |  2021  |  The Journal of Immunology

Abstract Stimulator of Interferon (IFN) Genes (STING), a cytosolic DNA sensor that recognises cyclic dinucleotides ..

Molecular and spatial mechanisms governing STING signalling

Katherine R Balka, Dominic De Nardo

Journal article  |  2020  |  FEBS JOURNAL

Detection of microbial nucleic acids via innate immune receptors is critical for establishing host defence against pathogens. The ..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  CELL

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  IMMUNITY

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..