David Keizer

A solution NMR view of Lipidic Cubic Phases: Structure, dynamics, and beyond

Thomas G Meikle, David W Keizer, Frances Separovic, Shenggen Yao

Journal article  |  2022  |  BBA Advances

Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins an..

CSM-peptides: A computational approach to rapid identification of therapeutic peptides

Carlos HM Rodrigues, Anjali Garg, David Keizer, Douglas E Pires, David B Ascher

Journal article  |  2022  |  PROTEIN SCIENCE

Peptides are attractive alternatives for the development of new therapeutic strategies due to their versatility and low complexity..

NMR measurement of biomolecular translational and rotational motion for evaluating changes of protein oligomeric state in solution

Shenggen Yao, David W Keizer, Jeffrey J Babon, Frances Separovic

Journal article  |  2022  |  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Defining protein oligomeric state and/or its changes in solution is of significant interest for many biophysical studies carried o..

NMR spectroscopy of lipidic cubic phases.

Sunnia Rajput, Shenggen Yao, David W Keizer, Marc-Antoine Sani, Frances Separovic

Journal article  |  2022  |  Biophys Rev

Lipidic cubic phase (LCP) structures have been used for stabilisation and crystallisation of membrane proteins and show promising ..

Water diffusion in complex systems measured by PGSE NMR using chemical shift selective stimulated echo: Elimination of magnetization exchange effects

Thomas Meikle, David W Keizer, Frances Separovic, Shenggen Yao

Journal article  |  2021  |  JOURNAL OF CHEMICAL PHYSICS

The interpretation of molecular translational diffusion as measured by pulsed gradient spin-echo NMR (PGSE NMR) can be complicated..

Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

Sunnia Rajput, Marc-Antoine Sani, David W Keizer, Frances Separovic

Journal article  |  2021  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques p..

Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2021  |  JOURNAL OF PHYSICAL CHEMISTRY B

Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is..

O-aryl and Carbonyl Carbon Contents of Food Waste and Biosolid Predict P Availability in an Acidic Soil

Md Shahinur Rahman, Cassandra Schefe, Sunnia Rajput, David Keizer, Anthony Weatherley

Journal article  |  2021  |  Frontiers in Sustainable Food Systems

Organic waste streams, otherwise known as organic amendments (OA), contain potentially valuable nutrients which may additionally i..

The impact of size and charge on the pulmonary phatmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats

Shadabul Haque, Colin W Pouton, Michelle P McIntosh, David B Ascher, David W Keizer, Michael R Whittaker, Lisa M Kaminskas

Journal article  |  2020  |  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

Polylactide-co-glycolide (PLGA) nanoparticles are one of the most commonly explored biodegradable polymeric drug carriers for inha..

Physiochemical Characterization and Stability of Lipidic Cubic Phases by Solution NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2020  |  LANGMUIR

Lipidic inverse bicontinuous cubic phases (LCPs), formed via the spontaneous self-assembly of lipids such as monoolein, have found..