David Keizer

Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

Sunnia Rajput, Marc-Antoine Sani, David W Keizer, Frances Separovic

Journal article  |  2021  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques p..

Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2021  |  JOURNAL OF PHYSICAL CHEMISTRY B

Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is..

O-aryl and Carbonyl Carbon Contents of Food Waste and Biosolid Predict P Availability in an Acidic Soil

Md Shahinur Rahman, Cassandra Schefe, Sunnia Rajput, David Keizer, Anthony Weatherley

Journal article  |  2021  |  Frontiers in Sustainable Food Systems

Organic waste streams, otherwise known as organic amendments (OA), contain potentially valuable nutrients which may additionally i..

The impact of size and charge on the pulmonary phatmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats

Shadabul Haque, Colin W Pouton, Michelle P McIntosh, David B Ascher, David W Keizer, Michael R Whittaker, Lisa M Kaminskas

Journal article  |  2020  |  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

Polylactide-co-glycolide (PLGA) nanoparticles are one of the most commonly explored biodegradable polymeric drug carriers for inha..

Physiochemical Characterization and Stability of Lipidic Cubic Phases by Solution NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2020  |  LANGMUIR

Lipidic inverse bicontinuous cubic phases (LCPs), formed via the spontaneous self-assembly of lipids such as monoolein, have found..

In-cell Solid-State NMR Studies of Antimicrobial Peptides

Frances Separovic, David W Keizer, Marc-Antoine Sani

Journal article  |  2020  |  Frontiers in Medical Technology

Antimicrobial peptides (AMPs) have attracted attention as alternatives to classic antibiotics due to their expected limited pressu..

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

Thomas G Meikle, Ashish Sethi, David W Keizer, Jeffrey J Babon, Frances Separovic, Paul R Gooley, Charlotte E Conn, Shenggen Yao

Journal article  |  2019  |  JOURNAL OF MAGNETIC RESONANCE

Lipidic cubic phases, which form spontaneously via the self-assembly of certain lipids in an aqueous environment, are highly prosp..

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

Erinna F Lee, Nicholas A Smith, Tatiana P Soares da Costa, Nastaran Meftahi, Shenggen Yao, Tiffany J Harris, Sharon Tran, Anne Pettikiriarachchi, Matthew A Perugini, David W Keizer, Marco Evangelista, Brian J Smith, W Douglas Fairlie

Journal article  |  2019  |  AUTOPHAGY

BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation ..

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Robert G Brinson, John P Marino, Frank Delaglio, Luke W Arbogast, Ryan M Evans, Anthony Kearsley, Genevieve Gingras, Houman Ghasriani, Yves Aubin, Gregory K Pierens, Xinying Jia, Mehdi Mobli, Hamish G Grant, David W Keizer, Kristian Schweimer, Jonas Stahle, Goran Widmalm, Edward R Zartler, Chad W Lawrence, Patrick N Reardon, et al.

Journal article  |  2019  |  mAbs

The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new anal..

Nuclear Magnetic Resonance Study of the Peptide FRANCESSEPAROVIC

JA Karas, DW Keizer, MA Sani

Journal article  |  2019  |  Australian Journal of Chemistry

As an eminent ambassador of STEM and renowned NMR spectroscopist, Frances Separovic is an internationally famous name, but could i..