Robin Anderson

Microbeam Radiation Therapy Controls Local Growth of Radioresistant Melanoma and Treats Out-of-Field Locoregional Metastasis.

Verdiana Trappetti, Marine Potez, Cristian Fernandez-Palomo, Vladislav Volarevic, Nahoko Shintani, Paolo Pellicioli, Alexander Ernst, David Haberthür, Jennifer M Fazzari, Michael Krisch, Jean A Laissue, Robin L Anderson, Olga A Martin, Valentin G Djonov

Journal article  |  2022  |  Int J Radiat Oncol Biol Phys

PURPOSE: Synchrotron-generated microbeam radiation therapy (MRT) represents an innovative preclinical type of cancer radiation the..

Fusing ToF-SIMS Images for Spatial-Spectral Resolution Enhancement using a Convolutional Neural Network

Wil Gardner, David A Winkler, Ruqaya Maliki, Suzanne M Cutts, Sarah Ellis, Robin L Anderson, Benjamin W Muir, Paul J Pigram

Journal article  |  2022  |  ADVANCED MATERIALS INTERFACES

Hyperspectral data sets generated by time-of-flight secondary ion mass spectrometry (ToF-SIMS) contain valuable spatial-spectral i..

MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms

Lap Hing Chi, Ryan SN Cross, Richard P Redvers, Melissa Davis, Soroor Hediyeh-zadeh, Suresh Mathivanan, Monisha Samuel, Erin C Lucas, Kellie Mouchemore, Philip A Gregory, Cameron N Johnstone, Robin L Anderson

Journal article  |  2022  |  ONCOGENESIS

MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 ..

Abstract 6232: Defining the cellular composition and associated molecular phenotypes of malignant and non-malignant cells in breast cancer pleural effusions

Holly J Whitfield, Jean Berthelet, Stefano Mangiola, Caroline Bell, Robin L Anderson, Bhupinder Pal, Anthony T Papenfuss, Belinda Yeo, Delphine Merino, Melissa J Davis

Journal article  |  2022  |  Cancer Research

Abstract Malignant pleural effusions (MPE) are a common complication of advanced cancers, particularly those adjace..

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

Ian Y Luk, Laura J Jenkins, Kael L Schoffer, Irvin Ng, Janson WT Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D Burrows, Robin L Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F Richardson, Oliver M Sieber, Yang Liao, Jennifer K Mooi, Natalia Vukelic, Camilla M Reehorst, Shoukat Afshar-Sterle, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnin..

Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin

Jean Berthelet, Momeneh Foroutan, Dharmesh D Bhuva, Holly J Whitfield, Farrah El-Saafin, Joseph Cursons, Antonin Serrano, Michal Merdas, Elgene Lim, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Matthias Ernst, Frederic Hollande, Robin L Anderson, Bhupinder Pal, Belinda Yeo, Melissa J Davis, Delphine Merino

Journal article  |  2022  |  CANCERS

The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast can..

Can preclinical drug development help to predict adverse events in clinical trials?

Lap Hing Chi, Allan D Burrows, Robin L Anderson

Journal article  |  2021  |  DRUG DISCOVERY TODAY

The development of novel therapeutics is associated with high rates of attrition, with unexpected adverse events being a major cau..

Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis

Raymond KH Yip, Joel S Rimes, Bianca D Capaldo, Francois Vaillant, Kellie A Mouchemore, Bhupinder Pal, Yunshun Chen, Elliot Surgenor, Andrew J Murphy, Robin L Anderson, Gordon K Smyth, Geoffrey J Lindeman, Edwin D Hawkins, Jane E Visvader

Journal article  |  2021  |  NATURE COMMUNICATIONS

Bone marrow is a preferred metastatic site for multiple solid tumours and is associated with poor prognosis and significant morbid..

Mouse Breast Carcinoma Monocytic/Macrophagic Myeloid-Derived Suppressor Cell Infiltration as a Consequence of Endothelial Dysfunction in Shb-Deficient Endothelial Cells Increases Tumor Lung Metastasis

Qi He, Maria Jamalpour, Eric Bergquist, Robin L Anderson, Karin Gustafsson, Michael Welsh

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metastasis reflects both the inherent properties of tumor cells and the response of the stroma to the presence of the tumor. Vascu..

PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling.

Yassir Al-Zubaidi, Yongjuan Chen, Md Khalilur Rahman, Bala Umashankar, Hassan Choucair, Kirsi Bourget, Long Chung, Yanfei Qi, Paul K Witting, Robin L Anderson, Geraldine M O'Neill, Colin R Dunstan, Tristan Rawling, Michael Murray

Journal article  |  2021  |  Biochem Pharmacol

Migration and invasion promote tumor cell metastasis, which is the leading cause of cancer death. At present there are no effectiv..