Pavel Lobachevsky

Monitoring DNA Damage and Repair in Peripheral Blood Mononuclear Cells of Lung Cancer Radiotherapy Patients

Pavel N Lobachevsky, Nicholas W Bucknell, Joel Mason, Diane Russo, Xiaoyu Yin, Lisa Selbie, David L Ball, Tomas Kron, Michael Hofman, Shankar Siva, Olga A Martin

Journal article  |  2020  |  CANCERS

Thoracic radiotherapy (RT) is required for the curative management of inoperable lung cancer, however, treatment delivery is limit..

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

Arcadi Cipponi, David L Goode, Justin Bedo, Mark J McCabe, Marina Pajic, David R Croucher, Alvaro Gonzalez Rajal, Simon R Junankar, Darren N Saunders, Pavel Lobachevsky, Anthony T Papenfuss, Danielle Nessem, Max Nobis, Sean C Warren, Paul Timpson, Mark Cowley, Ana C Vargas, Min R Qiu, Daniele G Generali, Shivakumar Keerthikumar, et al.

Journal article  |  2020  |  Science

In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesi..

A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect

Michael J McKay, Jeffery Craig, Paul Kalitsis, Sergei Kozlov, Sandra Verschoor, Phillip Chen, Pavel Lobachevsky, Raja Vasireddy, Yuqian Yan, Jacinta Ryan, George McGillivray, Ravi Savarirayan, Martin F Lavin, Robert G Ramsay, Huiling Xu

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: Roberts syndrome (RBS) is a rare, recessively transmitted developmental disorder characterized by growth retardation, cra..

A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation

Pavel N Lobachevsky, Jessica Ventura, Lina Giannakandropoulou, Helen Forrester, Jason S Palazzolo, Nicole M Haynes, Andrew W Stevenson, Christopher J Hall, Joel Mason, Gerasimos Pollakis, Ioannis S Pateras, Vassilis Gorgoulis, Georgia I Terzoudi, John A Hamilton, Carl N Sprung, Alexandros G Georgakilas, Olga A Martin

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: Nontargeted effects of ionizing radiation, by which unirradiated cells and tissues are also damaged, are a relatively new..

Systemic effects of synchrotron radiation

J Ventura, CN Sprung, HB Forrester, JS Palazzolo, A Ivashkevich, AW Stevenson, CJ Hall, AG Georgakilas, PN Lobachevsky, OA Martin

Conference Proceedings  |  2019  |  Journal of Physics: Conference Series

A change in an organ or tissue distant from the irradiated region was termed the radiation-induced abscopal effect (RIAE). It is n..

Radiation Therapy Modulates DNA Repair Efficiency in Peripheral Blood Mononuclear Cells of Patients With Non-Small Cell Lung Cancer

Xiaoyu Yin, Joel Mason, Pavel N Lobachevsky, Laura Munforte, Lisa Selbie, David L Ball, Roger F Martin, Trevor Leong, Shankar Siva, Olga A Martin

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: There is growing interest in developing individually tailored cancer radiation therapy (RT), wherein patients with high i..

A Bayesian Approach for Prediction of Patient Radiosensitivity

Alan Herschtal, Roger F Martin, Trevor Leong, Pavel Lobachevsky, Olga A Martin

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: A priori identification of the small proportion of radiation therapy patients who prove to be severely radiosensitive is ..

Localized synchrotron radiation in mice induces persistent systemic genotoxic events mediated by the functional immune system

Jessica Ventura, Pavel Lobachevsky, Jason Palazzolo, Helen Forrester, Nicole Haynes, Alesia Ivashkevich, Andrew Stevenson, Christopher Hall, Vassilis Gorgoulis, John Hamilton, Alexandros Georgakilas, Calr Sprung, Olga A Martin

Conference Proceedings  |  2018  |  CANCER RESEARCH

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses

Jessica Ventura, Pavel N Lobachevsky, Jason S Palazzolo, Helen Forrester, Nicole M Haynes, Alesia Ivashkevich, Andrew W Stevenson, Christopher J Hall, Andreas Ntargaras, Vasilis Kotsaris, Gerasimos Ch Pollakis, Gianna Potsi, Konstantinos Skordylis, Georgia Terzoudi, Ioannis S Pateras, Vassilis G Gorgoulis, Alexandros G Georgakilas, Carl N Sprung, Olga A Martin

Journal article  |  2017  |  CANCER RESEARCH

The importance of nontargeted (systemic) effects of ionizing radiation is attracting increasing attention. Exploiting synchrotron ..

Compromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity

Pavel Lobachevsky, Trevor Leong, Patricia Daly, Jai Smith, Nickala Best, Jonathan Tomaszewski, Ella R Thompson, Na Li, Ian G Campbell, Roger F Martin, Olga A Martin

Journal article  |  2016  |  CANCER LETTERS

A small percentage of cancer radiotherapy patients develop abnormally severe side effects as a consequence of intrinsic radiosensi..