Anne Verhagen

FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages

Wei Hong Toh, Jade Louber, Ismail S Mahmoud, Jenny Chia, Greg T Bass, Steve K Dower, Anne M Verhagen, Paul A Gleeson

Journal article  |  2020  |  JOURNAL OF CELL SCIENCE

The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life o..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A

Vincent P Diego, Bernadette W Luu, Marco Hofmann, Long V Dinh, Marcio Almeida, Jerry S Powell, Raja Rajalingam, Juan M Peralta, Satish Kumar, Joanne E Curran, Zuben E Sauna, Roberta Kellerman, Yara Park, Nigel S Key, Miguel A Escobar, Huynh Huy, Anne M Verhagen, Sarah Williams-Blangero, Paul V Lehmann, Eugene Maraskovsky, et al.

Journal article  |  2020  |  JOURNAL OF THROMBOSIS AND HAEMOSTASIS

BACKGROUND: Plasma-derived (pd) or recombinant (r) therapeutic factor VIII proteins (FVIIIs) are infused to arrest/prevent bleedin..

Half-life-extended recombinant coagulation factor IX-albumin fusion protein is recycled via the FcRn-mediated pathway

Jenny Chia, Jade Louber, Isabelle Glauser, Shirley Taylor, Greg T Bass, Steve K Dower, Paul A Gleeson, Anne M Verhagen

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The neonatal Fc receptor (FcRn) has a pivotal role in albumin and IgG homeostasis. Internalized IgG captured by FcRn under acidic ..

Reduced Lymphocyte Longevity and Homeostatic Proliferation in Lamin B Receptor-Deficient Mice Results in Profound and Progressive Lymphopenia

Anne M Verhagen, Carolyn A de Graaf, Tracey M Baldwin, Ankita Goradia, Janelle E Collinge, Benjamin T Kile, Donald Metcalf, Robyn Starr, Douglas J Hilton

Journal article  |  2012  |  JOURNAL OF IMMUNOLOGY

The lamin B receptor (LBR) is a highly unusual inner nuclear membrane protein with multiple functions. Reduced levels are associat..