Anne Verhagen

Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques

Andreas Pannek, Fiona J Houghton, Anne M Verhagen, Steven K Dower, Elizabeth Hinde, Paul A Gleeson

Journal article  |  2022  |  MOLECULAR BIOLOGY OF THE CELL

The neonatal Fc receptor (FcRn) is responsible for the recycling of endocytosed albumin and IgG, and contributes to their long pla..

FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages

Wei Hong Toh, Jade Louber, Ismail S Mahmoud, Jenny Chia, Greg T Bass, Steve K Dower, Anne M Verhagen, Paul A Gleeson

Journal article  |  2020  |  JOURNAL OF CELL SCIENCE

The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life o..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A

Vincent P Diego, Bernadette W Luu, Marco Hofmann, Long V Dinh, Marcio Almeida, Jerry S Powell, Raja Rajalingam, Juan M Peralta, Satish Kumar, Joanne E Curran, Zuben E Sauna, Roberta Kellerman, Yara Park, Nigel S Key, Miguel A Escobar, Huynh Huy, Anne M Verhagen, Sarah Williams-Blangero, Paul V Lehmann, Eugene Maraskovsky, et al.

Journal article  |  2020  |  JOURNAL OF THROMBOSIS AND HAEMOSTASIS

BACKGROUND: Plasma-derived (pd) or recombinant (r) therapeutic factor VIII proteins (FVIIIs) are infused to arrest/prevent bleedin..

Half-life-extended recombinant coagulation factor IX-albumin fusion protein is recycled via the FcRn-mediated pathway

Jenny Chia, Jade Louber, Isabelle Glauser, Shirley Taylor, Greg T Bass, Steve K Dower, Paul A Gleeson, Anne M Verhagen

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The neonatal Fc receptor (FcRn) has a pivotal role in albumin and IgG homeostasis. Internalized IgG captured by FcRn under acidic ..

Reduced Lymphocyte Longevity and Homeostatic Proliferation in Lamin B Receptor-Deficient Mice Results in Profound and Progressive Lymphopenia

Anne M Verhagen, Carolyn A de Graaf, Tracey M Baldwin, Ankita Goradia, Janelle E Collinge, Benjamin T Kile, Donald Metcalf, Robyn Starr, Douglas J Hilton

Journal article  |  2012  |  JOURNAL OF IMMUNOLOGY

The lamin B receptor (LBR) is a highly unusual inner nuclear membrane protein with multiple functions. Reduced levels are associat..