Leonid Churilov

Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion: An EXTEND-IA TNK Trials Analysis

Vignan Yogendrakumar, Leonid Churilov, Prodipta Guha, James Beharry, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Helen Brown, Helen M Dewey, Tissa Wijeratne, Bernard Yan, Gagan Sharma, Patricia M Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis, Bruce CV Campbell

Journal article  |  2023  |  STROKE

BACKGROUND: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that influence altepl..

Tenecteplase Improves Reperfusion across Time in Large Vessel Stroke.

Vignan Yogendrakumar, James Beharry, Leonid Churilov, Khairunnisa Alidin, Melissa Ugalde, Lauren Pesavento, Louise Weir, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Darshan G Shah, Helen M Dewey, Tissa Wijeratne, Bernard Yan, Patricia M Desmond, Gagan Sharma, Mark W Parsons, Geoffrey A Donnan, et al.

Journal article  |  2023  |  Ann Neurol

OBJECTIVE: Tenecteplase improves reperfusion compared to alteplase in patients with large vessel occlusions. To determine whether ..

Rates of Status Epilepticus and Sudden Unexplained Death in Epilepsy in People With Genetic Developmental and Epileptic Encephalopathies.

Alice M Donnan, Amy L Schneider, Sophie Russ-Hall, Leonid Churilov, Ingrid E Scheffer

Journal article  |  2023  |  Neurology

BACKGROUND AND OBJECTIVES: The genetic developmental and epileptic encephalopathies (DEEs) comprise a large group of severe epilep..

Tenecteplase versus alteplase for stroke thrombolysis evaluation (TASTE): A multicentre, prospective, randomized, open-label, blinded-endpoint, controlled phase III non-inferiority trial protocol

Andrew Bivard, Carlos Garcia-Esperon, Leonid Churilov, Neil Spratt, Michelle Russell, Bruce C Campbell, Philip Choi, Timothy Kleinig, Henry Ma, Hugh Markus, Carlos Molina, Chung Hsu, Chon-Haw Tsai, Atte Meretoja, Daniel Strbian, Kenneth Butcher, Teddy Wu, Stephen Davis, Geoffrey Donnan, Christopher Levi, et al.

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF STROKE

RATIONALE: Alteplase is the only approved thrombolytic agent for acute stroke. An alternative plasminogen activator, tenecteplase,..

Abstract WP56: Improvement In Motor And Language Domains Mediates Most Of The Effect Of 24h NIHSS Improvement On Functional Independence

Deep Pujara, Leonid Churilov, Ameer E Hassan, Michael G Abraham, clark sitton, Kelsey R Duncan, Faisal Al-Shaibi, Faris Shaker, Sophia Sundararajan, Cathy A Sila, Gregory W Albers, Bruce Campbell, Amrou Sarraj

Journal article  |  2023  |  Stroke

Introduction: Improvement in NIH stroke scale scores on 24h follow-up is considered a key prognostic element after end..

Abstract TMP54: Increased Thrombectomy Time Saving From Melbourne Mobile Stroke Unit Operation During Covid-19 Pandemic

Candice Menezes, Ahmed Haliem, Leonid Churilov, Karen L Smith, Belinda Delardes, Skye Coote, Damien Easton, Francesca Langenberg, James Beharry, Vignan Yogendrakumar, Louise C Weir, Peter J Mitchell, Geoff A Donnan, Stephen Davis, Bruce Campbell, Henry Zhao

Journal article  |  2023  |  Stroke

Introduction: Mobile stroke units (MSU) have demonstrated major time savings for thrombolysis but mixed evidence for e..

Abstract WMP47: Low Sensitivity Of Widely Used Emergency Dispatch Algorithm For Thrombectomy Patients - Implications For Mobile Stroke Units

Ahmed Haliem, Candice M Menezes, leonid churilov, Karen L Smith, Belinda Delardes, Skye Coote, Damien Easton, Francesca Langenberg, James Beharry, Vignan Yogendrakumar, Louise C Weir, Peter J Mitchell, Geoffrey A Donnan, Stephen Davis, Bruce Campbell, Henry Zhao

Journal article  |  2023  |  Stroke

Introduction: Widely used emergency dispatch algorithms such as the Advanced Medical Priority Dispatch System (AMPDS) ..

Abstract 92: Tenecteplase Treatment And Thrombus Characteristics Associated With Early Reperfusion - An EXTEND-IA TNK Trials Analysis

Vignan Yogendrakumar, Leonid Churilov, Prodipta Guha, James Beharry, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Helen Brown, Helen M Dewey, Tissa H Wijeratne, Bernard Yan, Gagan Sharma, Patricia Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen Davis, Bruce Campbell

Journal article  |  2023  |  Stroke

Background: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that infl..

Mediation of Successful Reperfusion Effect through Infarct Growth and Cerebral Edema: A Pooled, Patient-Level Analysis of EXTEND-IA Trials and SELECT Prospective Cohort

Amrou Sarraj, Deep K Pujara, Leonid Churilov, Clark W Sitton, Felix Ng, Ameer E Hassan, Michael G Abraham, Spiros L Blackburn, Gagan Sharma, Nawaf Yassi, Timothy Kleinig, Darshan Shah, Teddy Y Wu, Wondwossen G Tekle, Ronald F Budzik, William J Hicks, Nirav Vora, Randall C Edgell, Diogo Haussen, Santiago Ortega-Gutierrez, et al.

Journal article  |  2023  |  ANNALS OF NEUROLOGY

OBJECTIVE: Reperfusion therapy is highly beneficial for ischemic stroke. Reduction in both infarct growth and edema are plausible ..

Optimal CT perfusion thresholds for core and penumbra in acute posterior circulation infarction.

Leon Stephen Edwards, Cecilia Cappelen-Smith, Dennis Cordato, Andrew Bivard, Leonid Churilov, Longting Lin, Chushuang Chen, Carlos Garcia-Esperon, Kenneth Butcher, Tim Kleinig, Phillip MC Choi, Xin Cheng, Qiang Dong, Richard I Aviv, Mark William Parsons

Journal article  |  2023  |  Front Neurol

BACKGROUND: At least 20% of strokes involve the posterior circulation (PC). Compared to the anterior circulation, posterior circul..