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A/Prof

Akhter Hossain

Principal Research Fellow
Florey Department of Neuroscience and Mental Health
science & technology
life sciences & biomedicine
biochemistry & molecular biology
chemistry
physical sciences
1 underpinning research
1.1 normal biological development and functioning
chemistry, multidisciplinary
in-vitro
Akhter Hossain's Profile Picture
A/Prof

Akhter Hossain

 
Division
Medicine, Dentistry and Health Sciences
Akhter Hossain's Profile Picture
A/Prof

Akhter Hossain

 
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Akhter's  Short Profile
 

Projects

Displaying the 10 most recent projects from 10 for Akhter Hossain.

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Developing novel peptide-based therapeutics and technologies to mitigate fibrosis

Fibrosis (tissue scarring) is an unmet medical problem that adversely affects both human health and medical devices. It causes organ (e.g. h..

2021 - 2024
Active
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DEVELOPING G PROTEIN-COUPLED RECEPTOR, RXFP4, AGONISTS AS NOVEL THERAPEUTICS FOR CHRONIC CONSTIPATION

Insulin-like peptide 5 (INSL5) is a gut hormone that promotes colon motility. Therefore, modulating the INSL5 axis represents a new strategy..

2020 - 2023
Active
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Novel chemoenzymatic synthesis and bioconjugation of peptides and proteins

This project aims to solve the critical difficulty of producing the complex peptide insulin and related insulin-like peptides (INSLs) and th..

2019 - 2023
Active
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Novel chemoenzymatic synthesis and bioconjugation of peptides and proteins

This project aims to solve the critical difficulty of producing the complex peptide insulin and related insulin-like peptides (INSLs) and th..

2019 - 2023
Active
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NOVEL GREEN SCALABLE CHEMICAL PEPTIDE SYNTHESIS AND ENZYME IMMOBILIZATION

The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industr..

2019 - 2022
Completed
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NOVEL GREEN SCALABLE CHEMICAL PEPTIDE SYNTHESIS AND ENZYME IMMOBILIZATION

The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industr..

2019 - 2022
Completed
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Treatment of vascular dysfunction in preeclampsia

2015 - 2018
Completed
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Pharmacological targeting of the G protein-coupled receptor, RXFP1, for treating heart failure

2016 - 2016
Completed
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Novel insulin to treat diabetes

The glucose regulatory hormone, insulin, remains the only treatment for type I diabetes and up to 30% of type II diabetes, both of which are..

2012 - 2015
Completed
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Towards the development of orally active antimicrobial peptides with distinctive mode of action

This project aims to design and develop novel antibacterial compounds to address one of humankind's greatest health concerns, that of antiba..

2012 - 2014
Completed

10

Projects

Project Types

9

Research Grant

1

Internal Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works from 191 for Akhter Hossain.

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The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy.

Fariha Alam, Tracey A Gaspari, Barbara K Kemp-Harper, Edward Low, Aaron Aw, Dorota Ferens, Iresha Spizzo, Ann-Maree Jefferis, Praveen Praveen, Robert E Widdop, Ross AD Bathgate, Mohammed Akhter Hossain, Chrishan S Samuel

Journal article  |  2023  |  Biomed Pharmacother

The hormone, relaxin (RLX), exerts various organ-protective effects independently of etiology. However, its complex two-chain and ..

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The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency

Bruce Lin, Andrew Hung, William Singleton, Kevion K Darmawan, Rachael Moses, Bicheng Yao, Hongkang Wu, Anders Barlow, Marc‐Antoine Sani, Alastair J Sloan, Mohammed Akhter Hossain, John D Wade, Yuning Hong, Neil M O'Brien‐Simpson, Wenyi Li

Journal article  |  2023  |  Aggregate

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Understanding VPAC receptor family peptide binding and selectivity

Sarah J Piper, Giuseppe Deganutti, Jessica Lu, Peishen Zhao, Yi-Lynn Liang, Yao Lu, Madeleine M Fletcher, Mohammed Akhter Hossain, Arthur Christopoulos, Christopher A Reynolds, Radostin Danev, Patrick M Sexton, Denise Wootten

Journal article  |  2022  |  NATURE COMMUNICATIONS

The vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are key regulator..

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The cell cycle, cancer development and therapy

Elaheh Jamasbi, Mona Hamelian, Mohammed Akhter Hossain, Kambiz Varmira

Journal article  |  2022  |  MOLECULAR BIOLOGY REPORTS

The process of cell division plays a vital role in cancer progression. Cell proliferation and error-free chromosomes segregation d..

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Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

Felipe Tapia Caceres, Tracey A Gaspari, Mohammed Akhter Hossain, Chrishan S Samuel

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic NLRP3 inflammasome activation can promote fibrosis through its production of interleukin (IL)-1β and IL-18. Conversely, re..

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Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine

Ada Koo, Ruslan Pustovit, Orla RM Woodward, Jo E Lewis, Fiona M Gribble, Mohammed Akhter Hossain, Frank Reimann, John B Furness

Journal article  |  2022  |  CELL AND TISSUE RESEARCH

The gastrointestinal hormone, insulin-like peptide 5 (INSL5), is found in large intestinal enteroendocrine cells (EEC). One of its..

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Evaluation of Potential DnaK Modulating Proline-Rich Antimicrobial Peptides Identified by Computational Screening

Thomas NG Handley, Wenyi Li, Nicholas G Welch, Neil M O'Brien-Simpson, Mohammed Akhter Hossain, John D Wade

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

The day is rapidly approaching where current antibiotic therapies will no longer be effective due to the development of multi-drug..

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Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker

Wenyi Li, Feng Lin, Andrew Hung, Anders Barlow, Marc-Antoine Sani, Rita Paolini, William Singleton, James Holden, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2022  |  CHEMICAL SCIENCE

Antimicrobial peptides (AMPs) are host defense peptides, and unlike conventional antibiotics, they possess potent broad spectrum a..

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Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens

Bruce Lin, Andrew Hung, Rong Li, Anders Barlow, William Singleton, Tamara Matthyssen, Marc-Antoine D Sani, Mohammed Akhter Hossain, John Wade, Neil M O'Brien-Simpson, Wenyi Li

Journal article  |  2022  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The World Health Organisation has deemed several multi-drug resistant (MDR) nosocomial bacterial pathogens to be of significant th..

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Engineering of a Biologically Active Insulin Dimer

Mengjie Liu, Barbara F White, Praveen Praveen, Wenyi Li, Feng Lin, Hongkang Wu, Rong Li, Carlie Delaine, Briony E Forbes, John D Wade, Mohammed Akhter Hossain

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

The growing epidemic of diabetes means that there is a need for therapies that are more efficacious, safe, and convenient. Here, w..

191

Scholarly Works

Keyword Analysis

Expanding Knowledge
Medicinal and Biomolecular Chemistry
Biochemistry and Cell Biology
Clinical Health
Neurosciences
Pharmacology and Pharmaceutical Sciences
Other Health
Medical Biochemistry and Metabolomics
Clinical Sciences
Other Chemical Sciences

Credentials

Positions

Principal Research Fellow

Florey Department of Neuroscience and Mental Health

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