Akhter Hossain

Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor

Shanti Diwakarla, Ross AD Bathgate, Xiaozhou Zhang, Mohammed Akhter Hossain, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Insulin-like peptide 5 (INSL5) is a hormone stored in colonic enteroendocrine cells that also contain the unrelated ho..

The anti-fibrotic actions of relaxin are mediated through AT(2)R-associated protein phosphatases via RXFP1-AT(2)R functional crosstalk in human cardiac myofibroblasts

Chao Wang, Anita A Pinar, Robert E Widdop, Mohammed A Hossain, Ross AD Bathgate, Kate M Denton, Barbara K Kemp-Harper, Chrishan S Samuel

Journal article  |  2020  |  The FASEB Journal

Fibrosis is a hallmark of several cardiovascular diseases. The relaxin family peptide receptor 1 (RXFP1) agonist, relaxin, has rap..

An insulin-like peptide 5 related agonist, INSL5-A13, stimulates colorectal propulsion via the relaxin family peptide 4 receptor

John B Furness, Shanti Diwakarla, Ross AD Bathgate, Xiaozhou Zhang, Mohammed Akhter Hossain

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Total Chemical Synthesis of a Nonfibrillating Human Glycoinsulin

Mohammed Akhter Hossain, Rio Okamoto, John A Karas, Praveen Praveen, Mengjie Liu, Briony E Forbes, John D Wade, Yasuhiro Kajihara

Journal article  |  2020  |  Journal of the American Chemical Society

Glycosylation is an accepted strategy to improve the therapeutic value of peptide and protein drugs. Insulin and its analogues are..

Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat

Werner I Furuya, Rishi R Dhingra, Andrew L Gundlach, Mohammad Akhter Hossain, Mathias Dutschmann

Journal article  |  2020  |  Respiratory Physiology & Neurobiology

The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal..

The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis - Its Past, Present, and Future

Wenyi Li, Neil M O'Brien-Simpson, Mohammed Akhter Hossain, John D Wade

Journal article  |  2020  |  Australian Journal of Chemistry

The chemical formation of the peptide bond has long fascinated and challenged organic chemists. It requires not only the activatio..

Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation

Nicholas G Welch, Shayanti Mukherjee, Mohammed A Hossain, Praveen Praveen, Jerome A Werkmeister, John D Wade, Ross AD Bathgate, David A Winkler, Helmut Thissen

Journal article  |  2019  |  ACS Applied Materials & Interfaces

Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4

Praveen Praveen, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2019  |  Scientific Reports

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Herve Bourhy, Gregory W Moseley, Paul R Gooley

Journal article  |  2019  |  Cell Reports

To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of path..

Adsorption of Amyloidogenic Peptides to Functionalized Surfaces Is Biased by Charge and Hydrophilicity

Torsten John, George W Greene, Nitin A Patil, Tiara JA Dealey, Mohammed A Hossain, Bernd Abel, Lisandra L Martin

Journal article  |  2019  |  Langmuir

Surfaces are abundant in living systems, such as in the form of cellular membranes, and govern many biological processes. In this ..

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2019  |  Journal of the American Society of Nephrology

BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..

Characterization of the relaxin family peptide receptor 3 system in the mouse bed nucleus of the stria terminalis

Sarah S Ch'ng, Jingjing Fu, Robyn M Brown, Craig M Smith, Mohammed Akhter Hossain, Stuart J McDougall, Andrew J Lawrence

Journal article  |  2019  |  Journal of Comparative Neurology

The bed nucleus of the stria terminalis (BNST) is a critical node involved in stress and reward-related behaviors. Relaxin family ..

B7-33,a Functionally Selective Relaxin Receptor 1 Agonist, Exerts Protective Effects Against Myocardial ischemia-Reperfusion Injury in Mice

Teja Devarakonda, Adolfo G Mauro, Geronimo Guzman, Chad Cain, Anindita Das, Praveen Praveen, MA Hossain, Fadi N Salloum

Conference Proceedings  |  2019  |  CIRCULATION RESEARCH

Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides

Nitin A Patil, John A Karas, John D Wade, Mohammed Akhter Hossain, Julien Tailhades

Journal article  |  2019  |  Chemistry – A European Journal

NOVEL PEPTIDE B7-33 AND RELAXIN HORMONES PROTECT CYTOTROPHOBLASTS FROM PREECLAMPSIA PHENOTYPE

Syeda H Afroze, Ahmed F Pantho, David C Zawieja, Ross Bathgate, Thomas J Kuehl, Mohammed A Hossain, Mohammad N Uddin

Conference Proceedings  |  2019  |  JOURNAL OF INVESTIGATIVE MEDICINE

Single chain peptide agonists of relaxin receptors

Praveen Praveen, Martina Kocan, Adam Valkovic, Ross Bathgate, Mohammed Akhter Hossain

Journal article  |  2019  |  Molecular and Cellular Endocrinology

H-1, N-15 and C-13 resonance assignments of the C-terminal domain of the P protein of the Nishigahara strain of rabies virus

Jingyu Zhan, Md Alamgir Hossain, Ashish Sethi, Toyoyuki Ose, Gregory W Moseley, Paul R Gooley

Journal article  |  2019  |  Biomolecular NMR Assignments

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

Bradley L Hoare, Shoni Bruell, Ashish Sethi, Paul R Gooley, Michael J Lew, Mohammed A Hossain, Asuka Inoue, Daniel J Scott, Ross AD Bathgate

Journal article  |  2019  |  iScience

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

Lilian LL Wong, Daniel James Scott, Mohammed Akhter Hossain, Quentin Kaas, K Johan Rosengren, Ross AD Bathgate

Journal article  |  2018  |  Journal of Biological Chemistry

Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3

Linda M Haugaard-Kedstrom, Han Siean Lee, Maryon V Jones, Angela Song, Vishaal Rathod, Mohammed Akhter Hossain, Ross AD Bathgate, K Johan Rosengren

Journal article  |  2018  |  Journal of Biological Chemistry

Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor

Adam L Valkovic, Miranda B Leckey, Alice R Whitehead, Mohammed A Hossain, Asuka Inoue, Martina Kocan, Ross AD Bathgate

Journal article  |  2018  |  Pharmacology Research & Perspectives

Fluorescence imaging of the interaction of amyloid beta 40 peptides with live cells and model membrane

Elaheh Jamasbi, Mohammed Akhter Hossain, Marsha Tan, Frances Separovic, Giuseppe D Ciccotosto

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Effect of dimerized melittin on gastric cancer cells and antibacterial activity

Elaheh Jamasbi, Sasidharan S Lucky, Wenyi Li, Mohammed Akhter Hossain, Ponnampalam Gopalakrishnakone, Frances Separovic

Journal article  |  2018  |  AMINO ACIDS

The relaxin receptor as a therapeutic target - perspectives from evolution Cheek for updates and drug targeting

Ross AD Bathgate, Martina Kocan, Daniel J Scott, M Akhter Hossain, Sara V Good, Sergey Yegorov, Jan Bogerd, Paul R Gooley

Journal article  |  2018  |  Pharmacology & Therapeutics

Challenges in the design of insulin and relaxin/insulin-like peptide mimetics

Mohammed Akhter Hossain, Ross AD Bathgate

Journal article  |  2018  |  Bioorganic & Medicinal Chemistry

Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core

Wenyi Li, Neil M O'Brien-Simpson, James A Holden, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2018  |  PEPTIDE SCIENCE

Amyloid aggregation and membrane activity of the antimicrobial peptide uperin 3.5

Lisandra L Martin, Clemens Kubeil, Stefania Piantavigna, Tarun Tikkoo, Nicholas P Gray, Torsten John, Antonio N Calabrese, Yanqin Liu, Yuning Hong, Mohammed A Hossain, Nitin Patil, Bernd Abel, Ralf Hoffmann, John H Bowie, John A Carver

Journal article  |  2018  |  Peptide Science

Inorganic-organic based novel nano-conjugate material for effective cobalt(II) ions capturing from wastewater

Md Rabiul Awual, Nabeel H Alharthi, Md Munjur Hasan, Mohammad Rezaul Karim, Aminul Islam, Hussein Znad, Mohammed Akhter Hossain, Md Ershad Halim, Mohammed M Rahman, Md Abdul Khaleque

Journal article  |  2017  |  Chemical Engineering Journal

Novel Methods for the Chemical Synthesis of Insulin Superfamily Peptides and of Analogues Containing Disulfide Isosteres

Mohammed Akhter Hossain, John D Wade

Journal article  |  2017  |  Accounts of Chemical Research

Phosphorylation of a full length amyloid-beta peptide modulates its amyloid aggregation, cell binding and neurotoxic properties

Elaheh Jamasbi, Frances Separovic, Mohammed Akhter Hossain, Giuseppe Donato Ciccotosto

Journal article  |  2017  |  Molecular BioSystems

B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin)

Sarah A Marshall, Kelly O'Sullivan, Hooi Hooi Ng, Ross AD Bathgate, Laura J Parry, Mohammed Akhter Hossain, Chen Huei Leo

Journal article  |  2017  |  European Journal of Pharmacology

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J Petrie, Paul R Gooley, Ross AD Bathgate

Journal article  |  2017  |  Scientific Reports

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Martina Kocan, Mohsin Sarwar, Sheng Y Ang, Jingbo Xiao, Juan J Marugan, Mohammed A Hossain, Chao Wang, Dana S Hutchinson, Chrishan S Samuel, Alexander I Agoulnik, Ross AD Bathgate, Roger J Summers

Journal article  |  2017  |  Scientific Reports

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

Sheng Y Ang, Dana S Hutchinson, Nitin Patil, Bronwyn A Evans, Ross AD Bathgate, Michelle L Halls, Mohammed A Hossain, Roger J Summers, Martina Kocan

Journal article  |  2017  |  British Journal of Pharmacology

Relaxin family peptides: structure-activity relationship studies

Nitin A Patil, K Johan Rosengren, Frances Separovic, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2017  |  British Journal of Pharmacology

NOVEL PEPTIDE B7-33, A SINGLE-CHAIN DERIVATIVE OF THE RELAXIN HORMONE, PROTECTS CYTOTROPHOBLASTS FROM ANTI-ANGIOGENIC MILIEU IN CELLULAR MODELS OF PREECLAMPSIA

AF Pantho, S Afroze, DM Dean, MA Hossain, R Bathgate, DC Zawieja, TJ Kuehl, MN Uddin

Conference Proceedings  |  2017  |  JOURNAL OF INVESTIGATIVE MEDICINE

The Effect of Selective D- or N-alpha-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

Wenyi Li, Zhe Sun, Neil M O'Brien-Simpson, Laszlo Otvos, Eric C Reynolds, Mohammed A Hossain, Frances Separovic, John D Walde

Journal article  |  2017  |  FRONTIERS IN CHEMISTRY

C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide

Wenyi Li, Neil M O'Brien-Simpson, Shenggen Yao, Julien Tailhades, Eric C Reynolds, Raymond M Dawson, Laszlo Otvos, Mohammed Akhter Hossain, Frances Separovic, John D Wade

Journal article  |  2017  |  Chemistry - A European Journal

Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2)

Feng Lin, Mohammed Akhter Hossain, Stephanie Post, Galina Karashchuk, Marc Tatar, Pierre De Meyts, John D Wade

Journal article  |  2017  |  Australian Journal of Chemistry

Fluorescent Ion Efflux Screening Assay for Determining Membrane-Active Peptides

Neil M O'Brien-Simpson, Wenyi Li, Namfon Pantarat, Mohammed Akhter Hossain, Frances Separovic, John D Wade, Eric C Reynolds

Journal article  |  2017  |  AUSTRALIAN JOURNAL OF CHEMISTRY

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

Sheng Y Ang, Dana S Hutchinson, Bronwyn A Evans, Mohammed A Hossain, Nitin Patil, Ross AD Bathgate, Martina Kocan, Roger J Summers

Journal article  |  2017  |  Naunyn-Schmiedeberg's Archives of Pharmacology

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

John A Karas, Nitin A Patil, Julien Tailhades, Marc-Antoine Sani, Denis B Scanlon, Briony E Forbes, James Gardiner, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie

Despite recent advances in the treatment of diabetes mellitus, storage of insulin formulations at 4 °C is still necessary to minim..

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

John A Karas, Nitin A Patil, Julien Tailhades, Marc-Antoine Sani, Denis B Scanlon, Briony E Forbes, James Gardiner, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

Keiko Hojo, Mohammed Akhter Hossain, Julien Tailhades, Fazel Shabanpoor, Lilian LL Wong, Emma EK Ong-Palsson, Hanna E Kastman, Sherie Ma, Andrew L Gundlach, K Johan Rosengren, John D Wade, Ross AD Bathgate

Journal article  |  2016  |  Journal of Medicinal Chemistry

Direct Measurement of Pore Dynamics and Leakage Induced by a Model Antimicrobial Peptide in Single Vesicles and Cells

Matthew G Burton, Qi M Huang, Mohammed A Hossain, John D Wade, Enzo A Palombo, Michelle L Gee, Andrew HA Clayton

Journal article  |  2016  |  Langmuir

Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers

Wenyi Li, Marc-Antoine Sani, Elaheh Jamasbi, Laszlo Otvos, Mohammed Akhter Hossain, John D Wade, Frances Separovic

Journal article  |  2016  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J Scott, Emma J Petrie, Ross AD Bathgate, Paul R Gooley

Journal article  |  2016  |  Nature Communications

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

Nitin A Patil, Ross AD Bathgate, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger Summers, Johannes Grosse, Richard A Hughes, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  AMINO ACIDS

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

Nitin A Patil, Richard A Hughes, K Johan Rosengren, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger J Summers, Johannes Grosse, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2016  |  Journal of Medicinal Chemistry

Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

Julien Tailhades, Ashish Sethi, Emma J Petrie, Paul R Gooley, Ross A Bathgate, John D Wade, Mohammed A Hossain

Journal article  |  2016  |  Chemistry - A European Journal

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Christopher Siwek, Nitin A Patil, Ian P Harrison, K Johan Rosengren, Stavros Selemidis, Roger J Summers, John D Wade, Ross AD Bathgate, Chrishan S Samuel

Journal article  |  2016  |  Chemical Science

Amyloid Beta (A beta) Peptide and Factors that Play Important Roles in Alzheimer's Disease

Elaheh Jamasbi, John D Wade, Frances Separovic, Mohammed A Hossain

Journal article  |  2016  |  Current Medicinal Chemistry

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

Cary Zhang, Berenice E Chua, Annie Yang, Faze Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Craig M Smith, Andrew L Gundlach

Journal article  |  2015  |  Behavioural Brain Research

Site of fluorescent label modifies interaction of melittin with live cells and model membranes

Elaheh Jamasbi, Giuseppe D Ciccotosto, Julien Tailhades, Roy M Robins-Browne, Cathryn L Ugalde, Robyn A Sharples, Nitin Patil, John D Wade, Mohammed Akhter Hossain, Frances Separovic

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane

Wenyi Li, Neil M O'Brien-Simpson, Julien Tailhades, Namfon Pantarat, Raymond M Dawson, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  Chemistry & Biology

Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria

Anna Mularski, Jonathan J Wilksch, Huabin Wang, Mohammed Akhter Hossain, John D Wade, Frances Separovic, Richard A Strugnell, Michelle L Gee

Journal article  |  2015  |  Langmuir

ChemInform Abstract: Intramolecular Acyl Transfer in Peptide and Protein Ligation and Synthesis

Julien Tailhades, Nitin A Patil, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  ChemInform

ChemInform Abstract: Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds

Fazel Shabanpoor, Mohammed Akhter Hossain, Feng Lin, John D Wade

Journal article  |  2015  |  ChemInform

Solution Structure, Aggregation Behavior, and Flexibility of Human Relaxin-2

Linda M Haugaard-Kedstrom, Mohammed Akhter Hossain, Norelle L Daly, Ross AD Bathgate, Ernst Rinderknecht, John D Wade, David J Craik, K Johan Rosengren

Journal article  |  2015  |  ACS Chemical Biology

Intramolecular acyl transfer in peptide and protein ligation and synthesis

Julien Tailhades, Nitin A Patil, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  Journal of Peptide Science

C-Terminal Modifications Broaden Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

Wenyi Li, Julien Tailhades, M Akhter Hossain, Neil M O'Brien-Simpson, Eric C Reynolds, Laszlo Otvos, Frances Separovic, John D Wade

Journal article  |  2015  |  Australian Journal of Chemistry

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B Nair, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  BIOMED RESEARCH INTERNATIONAL

Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins

Nitin A Patil, Julien Tailhades, Richard Anthony Hughes, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2015  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

Mohammed Akhter Hossain, Linda M Haugaard-Kedstroem, K Johan Rosengren, Ross AD Bathgate, John D Wade

Journal article  |  2015  |  Organic & Biomolecular Chemistry

Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)

Natalie A Diepenhorst, Emma J Petrie, Catherine Z Chen, Amy Wang, Mohammed Akhter Hossain, Ross AD Bathgate, Paul R Gooley

Journal article  |  2014  |  Journal of Biological Chemistry

Melittin peptides exhibit different activity on different cells and model membranes

Elaheh Jamasbi, Steven Batinovic, Robyn A Sharples, Marc-Antoine Sani, Roy Michael Robins-Browne, John D Wade, Frances Separovic, Mohammed Akhter Hossain

Journal article  |  2014  |  AMINO ACIDS

Synthetic relaxins

Mohammed Akhter Hossain, John D Wade

Journal article  |  2014  |  CURRENT OPINION IN CHEMICAL BIOLOGY

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

Wenyi Li, Julien Tailhades, Neil M O'Brien-Simpson, Frances Separovic, Laszlo Otvos, M Akhter Hossain, John D Wade

Journal article  |  2014  |  AMINO ACIDS

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

Johannes Grosse, Helen Heffron, Keith Burling, Mohammed Akhter Hossain, Abdella M Habib, Gareth J Rogers, Paul Richards, Rachel Larder, Debra Rimmington, Alice A Adriaenssens, Laura Parton, Justin Powell, Matteo Binda, William H Colledge, Joanne Doran, Yukio Toyoda, John D Wade, Samuel Aparicio, Mark BL Carlton, Anthony P Coll, et al.

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin

John A Karas, Denis B Scanlon, Briony E Forbes, Irina Vetter, Richard J Lewis, James Gardiner, Frances Separovic, John D Wade, Mohammed A Hossain

Journal article  |  2014  |  CHEMISTRY-A EUROPEAN JOURNAL

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice

Craig M Smith, Berenice E Chua, Cary Zhang, Andrew W Walker, Mouna Haidar, David Hawkes, Fazel Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Andrew L Gundlach

Journal article  |  2014  |  BEHAVIOURAL BRAIN RESEARCH

Signalling profiles of H3 relaxin, H2 relaxin and R3(B.23-27) R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

M Kocan, M Sarwar, MA Hossain, JD Wade, RJ Summers

Journal article  |  2014  |  BRITISH JOURNAL OF PHARMACOLOGY

Relaxin and its role in fibrotic diseases

Linda Jiaying Chan, Chrishan S Samuel, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Book Chapter  |  2014  |  Amino Acids, Peptides and Proteins

Relaxin-3/RXFP3 system regulates alcohol-seeking

Philip J Ryan, Hanna E Kastman, Elena V Krstew, K Johan Rosengren, Mohammed Akhter Hossain, Leonid Churilov, John D Wade, Andrew L Gundlach, Andrew J Lawrence

Journal article  |  2013  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-Terminus of the B-Chain of Relaxin-3 Is Important for Receptor Activity

Fazel Shabanpoor, Ross AD Bathgate, John D Wade, Mohammed Akhter Hossain

Journal article  |  2013  |  PLOS ONE

Long-Time-Scale Interaction Dynamics between a Model Antimicrobial Peptide and Giant Unilamellar Vesicles

Matthew G Burton, Qi M Huang, Mohammed A Hossain, John D Wade, Andrew HA Clayton, Michelle L Gee

Journal article  |  2013  |  Langmuir

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

Mohammed Akhter Hossain, Craig M Smith, Philip J Ryan, Elena Buechler, Ross AD Bathgate, Andrew L Gundlach, John D Wade

Journal article  |  2013  |  AMINO ACIDS

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

Philip J Ryan, Elena Buechler, Fazel Shabanpoor, Mohammed Akhter Hossain, John D Wade, Andrew J Lawrence, Andrew L Gundlach

Journal article  |  2013  |  BEHAVIOURAL BRAIN RESEARCH

Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

Anna Blasiak, Tomasz Blasiak, Marian H Lewandowski, Mohammed Akhter Hossain, John D Wade, Andrew L Gundlach

Journal article  |  2013  |  European Journal of Neuroscience

Imaging the action of antimicrobial peptides on living bacterial cells

Michelle L Gee, Matthew Burton, Alistair Grevis-James, Mohammed Akhter Hossain, Sally McArthur, Enzo A Palombo, John D Wade, Andrew HA Clayton

Journal article  |  2013  |  Scientific Reports

Preliminary Structure-Function Relationship Studies on Insulin-Like Peptide 5 (INSL5)

Alessia Belgi, Ross AD Bathgate, Geoffrey W Tregear, John D Wade, Mohammed Akhter Hossain

Journal article  |  2013  |  INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS

Sequential formation of regioselective disulfide bonds in synthetic peptides with multiple disulfide bonds

F Shabanpoor, MA Hossain, F Lin, JD Wade

Journal article  |  2013  |  Methods in Molecular Biology

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization

Linda J Chan, Craig M Smith, Berenice E Chua, Feng Lin, Ross AD Bathgate, Frances Separovic, Andrew L Gundlach, Mohammed Akhter Hossain, John D Wade

Journal article  |  2013  |  FRONTIERS IN CHEMISTRY

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

Ross AD Bathgate, Maria HY Oh, WJ Jason Ling, Quentin Kaas, M Akhter Hossain, Paul R Gooley, K Johan Rosengren

Journal article  |  2013  |  Frontiers in Endocrinology

Relaxin-3 is a highly conserved neuropeptide in vertebrate species and binds to the Class A G protein-coupled receptor (GPCR) RXFP..

Amino Acids, Peptides and Proteins

Book Chapter  |  2013

Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds

Fazel Shabanpoor, Mohammed Akhter Hossain, Feng Lin, John D Wade

Book  |  2013  |  Methods in Molecular Biology

Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.

Craig M Smith, Ihaia T Hosken, Natalie L Downer, Berenice E Chua, Mohammad Akhter Hossain, John D Wade, Andrew L Gundlach

Journal article  |  2013  |  Italian Journal of Anatomy and Embryology

The neuropeptide relaxin-3 and its cognate G-protein-coupled receptor, RXFP3, have been implicated in the control of feeding behav..

Chemical synthesis and biological evaluation of an antimicrobial peptide gonococcal growth inhibitor

John D Wade, Feng Lin, Mohammed Akhter Hossain, Raymond M Dawson

Journal article  |  2012  |  AMINO ACIDS

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J Chan, K Johan Rosengren, Sharon L Layfield, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed A Hossain, John D Wade

Journal article  |  2012  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Human relaxin-2: historical perspectives and role in cancer biology

Vinojini B Nair, Chrishan S Samuel, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2012  |  AMINO ACIDS

Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin

Mohammed Akhter Hossain, John D Wade, Ross AD Bathgate

Journal article  |  2012  |  Peptides

Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone

Fazel Shabanpoor, Ross AD Bathgate, Alessia Belgi, Linda J Chan, Vinojini B Nair, John D Wade, Mohammed Akhter Hossain

Journal article  |  2012  |  Biochemical and Biophysical Research Communications

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Fazel Shabanpoor, Mohammad Alchter Hossain, Philip J Ryan, Alessia Belgi, Sharon Layfield, Martina Kocan, Suode Zhang, Chrishan S Samuel, Andrew L Gundlach, Ross AD Bathgate, Frances Separovic, John D Wade

Journal article  |  2012  |  Journal of Medicinal Chemistry

Slow Insertion Kinetics during Interaction of a Model Antimicrobial Peptide with Unilamellar Phospholipid Vesicles

Zubaidah Ningsih, Mohammed Akhter Hossain, John D Wade, Andrew HA Clayton, Michelle L Gee

Journal article  |  2012  |  Langmuir

Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity.

MI Hossain, MA Kamaruddin, HC Cheng

Journal article  |  2012  |  Clinical and Experimental Pharmacology and Physiology

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

F Shabanpoor, M Hossain, PJ Ryan, A Belgi, SL Layfield, undefined Kocan, undefined Zhang, C Samuel, AL Gundlach, R Bathgate, F Separovic, JD Wade

Journal article  |  2012  |  Journal of Medicinal Chemistry

ChemInform Abstract: The Relaxin Peptide Family - Structure, Function and Clinical Applications

Linda Jiaying Chan, Mohammed Akhter Hossain, Chrishan S Samuel, Frances Separovic, John D Wade

Journal article  |  2011  |  ChemInform

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

Linda M Haugaard-Kedstrom, Fazel Shabanpoor, Mohammed Akhter Hossain, Richard J Clark, Philip J Ryan, David J Craik, Andrew L Gundlach, John D Wade, Ross AD Bathgate, K Johan Rosengren

Journal article  |  2011  |  Journal of the American Chemical Society

Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa

Mohammed Akhter Hossain, Laure Guilhaudis, Agnes Sonnevend, Samir Attoub, Bianca J van Lierop, Andrea J Robinson, John D Wade, J Michael Conlon

Journal article  |  2011  |  European Biophysics Journal

Structural Dynamics of a Lytic Peptide Interacting with a Supported Lipid Bilayer

Andrew C Rapson, Mohammed Akhter Hossain, John D Wade, Edouard C Nice, Trevor A Smith, Andrew HA Clayton, Michelle L Gee

Journal article  |  2011  |  Biophysical Journal

H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor

Mohammed Akhter Hossain, Bryna Chow Suet Man, Chongxin Zhao, Qi Xu, Xiao-Jun Du, John D Wade, Chrishan S Samuel

Journal article  |  2011  |  Biochemistry

The chemical synthesis of insulin: From the past to the present

A Belgi, MA Hossain, GW Tregear, JD Wade

Journal article  |  2011  |  Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry

The Relaxin Peptide Family-Structure, Function and Clinical Applications

Linda Jiaying Chan, Mohammed Akhter Hossain, Chrishan S Samuel, Frances Separovic, John D Wade

Journal article  |  2011  |  Protein and Peptide Letters

The Roles of the A- and B-Chains of Human Relaxin-2 and-3 on Their Biological Activity

Mohammed Akhter Hossain, John D Wade

Journal article  |  2010  |  Current Protein & Peptide Science

Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2

Suode Zhang, Richard A Hughes, Ross AD Bathgate, Fazel Shabanpoor, M Akhter Hossain, Feng Lin, Bianca van Lierop, Andrea J Robinson, John D Wade

Journal article  |  2010  |  Peptides

Solid Phase Synthesis of an Analogue of Insulin, A0:R glargine, That Exhibits Decreased Mitogenic Activity

Seon-Yeong Kwak, Briony E Forbes, Yoon-Sik Lee, Alessia Belgi, John D Wade, Mohammed Akhter Hossain

Journal article  |  2010  |  International Journal of Peptide Research and Therapeutics

Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3

Fazel Shabanpoor, Richard A Hughes, Suode Zhang, Ross AD Bathgate, Sharon Layfield, Mohammed Akhter Hossain, Geoffrey W Tregear, Frances Separovic, John D Wade

Journal article  |  2010  |  Amino Acids

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, Norelle L Daly, David J Craik, John D Wade, K Johan Rosengren

Journal article  |  2009  |  Biochemical Journal

De Novo Design and Synthesis of Cyclic and Linear Peptides to Mimic the Binding Cassette of Human Relaxin

Mohammed Akhter Hossain, Ross AD Bathgate, Geoffery Tregear, John D Wade

Journal article  |  2009  |  Annals of the New York Academy of Sciences

Structural Properties of Relaxin Chimeras NMR Characterization of the R3/I5 Relaxin Peptide

Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, Norelle L Daly, Ross AD Bathgate, John D Wade, David J Craik, K Johan Rosengren

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7

Changlu Liu, Chester Kuei, Steven Sutton, Jonathan Shelton, Jessica Zhu, Diane Nepomuceno, Mohammed Akhter Hossain, John D Wade, Ross AD Bathgate, Pascal Bonaventure, Timothy Lovenberg

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

Mohammed Akhter Hossain, K Johan Rosengren, Suode Zhang, Ross AD Bathgate, Geoffrey W Tregear, Bianca J van Lierop, Andrea J Robinson, John D Wade

Journal article  |  2009  |  Organic & Biomolecular Chemistry

Structural Insights into the Function of Relaxins

K Johan Rosengren, Ross AD Bathgate, David J Craik, Norelle L Daly, Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, John D Wade

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

Simultaneous Post-cysteine(S-Acm) Group Removal Quenching of Iodine and Isolation of Peptide by One Step Ether Precipitation

Suode Zhang, Feng Lin, Mohammed Akhter Hossain, Fazel Shabanpoor, Geoffrey W Tregear, John D Wade

Conference Proceedings  |  2008  |  International Journal of Peptide Research and Therapeutics

Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist

Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, Norelle L Daly, Ross AD Bathgate, John D Wade, David J Craik, K Johan Rosengren

Journal article  |  2008  |  Journal of Biological Chemistry

Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: Pore formation mechanism in various lipid compositions

Seong-Cheol Park, Mi-Hyun Kim, Mohammed Akhter Hossain, Song Yub Shin, Yangmee Kim, Lorenzo Stella, John D Wade, Yoonkyung Park, Kyung-Soo Hahm

Journal article  |  2008  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

R3(B Delta 23-27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7 - In vitro and in vivo characterization

Chester Kuei, Steven Sutton, Pascal Bonaventure, Cindy Pudiak, Jonathan Shelton, Jessica Zhu, Diane Nepomuceno, Jiejun Wu, Jingcai Chen, Fredrik Kamme, Mark Seierstad, Michael D Hack, Ross AD Bathgate, Mohammed Akhter Hossain, John D Wade, John Atack, Timothy W Lovenberg, Changlu Liu

Journal article  |  2007  |  Journal of Biological Chemistry

Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin

Chrishan S Samuel, Feng Lin, Mohammed Akhter Hossain, Chongxin Zhao, Tania Ferraro, Ross AD Bathgate, Geoffrey W Tregear, John D Wade

Journal article  |  2007  |  Biochemistry

Cyclodecapeptides to mimic the radical site of tyrosyl-containing proteins

Mohammed Akhter Hossain, Fabrice Thomas, Sylvain Hamman, Eric Saint-Aman, Didier Boturyn, Pascal Dumy, Jean-Louis Pierre

Journal article  |  2006  |  Journal of Peptide Science

Regioselective disulfide solid phase synthesis, chemical characterization and in vitro receptor binding activity of equine relaxin

Mohammed Akhter Hossain, Feng Lin, Soude Zhang, Tania Ferraro, Ross A Bathgate, Geoffrey W Tregear, John D Wade

Conference Proceedings  |  2006  |  International Journal of Peptide Research and Therapeutics

Fluorescence resonance energy transfer in a novel cyclodextrin-peptide conjugate for detecting steroid molecules

MA Hossain, H Mihara, A Ueno

Journal article  |  2003  |  Bioorganic & Medicinal Chemistry Letters

Novel peptides bearing pyrene and coumarin units with or without beta-cyclodextrin in their side chains exhibit intramolecular fluorescence resonance energy transfer

MA Hossain, H Mihara, A Ueno

Journal article  |  2003  |  Journal of the American Chemical Society

Molecule-responsive fluorescent sensors of alpha-helix peptides bearing alpha-cyclodextrin, pyrene and nitrobenzene units in their side chains

MA Hossain, K Takahashi, H Mihara, A Ueno

Journal article  |  2002  |  Journal of Inclusion Phenomena and Macrocyclic Chemistry

Guest-induced diminishment in fluorescence quenching and molecule sensing ability of a novel cyclodextrin-peptide conjugate

MA Hossain, K Hamasaki, K Takahashi, H Mihara, A Ueno

Journal article  |  2001  |  Journal of the American Chemical Society

Association and guest-induced dissociation of a novel alpha-helix peptide bearing pyrene and gamma-cyclodextrin in the side chains

MA Hossain, K Hamasaki, H Mihara, A Ueno

Journal article  |  2000  |  Chemistry Letters

Association of alpha-helix peptides that have gamma-cyclodextrin and pyrene units in their side chain, and induction of dissociation of the association dimer by external stimulant molecules

MA Hossain, S Matsumura, T Kanai, K Hamasaki, H Mihara, A Ueno

Journal article  |  2000  |  Journal of the Chemical Society, Perkin Transactions 2

Inside Cover: A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides (Angew. Chem. Int. Ed. 47/2016)

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Figure  |  Angewandte Chemie International Edition

Preparation of canine relaxin by Fmoc-solid phase synthesis and regioselective disulfide bond formation within the A- and B-chains

Feng Lin, Julien Tailhades, Linda J Chan, Ross AD Bathgate, Mohammed Akhter Hossain, John D Wade

Journal article  |  Biochemical Compounds

Innentitelbild: A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides (Angew. Chem. 47/2016)

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Figure  |  Angewandte Chemie International Edition