Akhter Hossain

The Chemical Synthesis of Insulin: An Enduring Challenge.

John A Karas, John D Wade, Mohammed Akhter Hossain

Journal article  |  2021  |  Chemical Reviews

The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential for glycemic control and is used as a..

Human Insulin-like Peptide 5 (INSL5). Identification of a Simplified Version of Two-Chain Analog A13

Xiaozhou Zhang, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2020  |  ACS Medicinal Chemistry Letters

The receptor for insulin-like peptide 5 (INSL5), RXFP4, is a potential pharma target for treating human conditions such as constip..

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Mengjie Liu, Emily A Whitfield, Linda J Fothergill, John B Furness, John D Wade, Sebastian GB Furness, Mohammed Akhter Hossain

Journal article  |  2020  |  Biochemical and Biophysical Research Communications

Human ghrelin receptor (GHSR) is a recognized prospective target in the diagnosis and therapy of multiple cancer types. To gain a ..

Effects of C-Terminal B-Chain Modifications in a Relaxin 3 Agonist Analogue

Praveen Praveen, Julien Tailhades, K Johan Rosengren, Mengjie Liu, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2020  |  ACS Medicinal Chemistry Letters

The receptor for the neuropeptide relaxin 3, relaxin family peptide 3 (RXFP3) receptor, is an attractive pharmacological target fo..

Antiviral Peptides as Promising Therapeutics against SARS-CoV-2

Surid Mohammad Chowdhury, Shafi Ahmad Talukder, Akib Mahmud Khan, Nadia Afrin, Md Ackas Ali, Rajib Islam, Rimon Parves, Abdulla Al Mamun, Md Abu Sufian, Md Nayeem Hossain, Mohammed Akhter Hossain, Mohammad A Halim

Journal article  |  2020  |  The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter

Over 50 peptides, which were known to inhibit SARS-CoV-1, were computationally screened against the receptor-binding domain (RBD) ..

Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists

Han Siean Lee, Shu Hui Wang, James T Daniel, Mohammed Akhter Hossain, Richard J Clark, Ross AD Bathgate, K Johan Rosengren

Journal article  |  2020  |  Biomedicines

Relaxin-3 is a highly conserved two-chain neuropeptide that acts through its endogenous receptor the Relaxin Family Peptide-3 (RXF..

Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor

Shanti Diwakarla, Ross AD Bathgate, Xiaozhou Zhang, Mohammed Akhter Hossain, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Insulin-like peptide 5 (INSL5) is a hormone stored in colonic enteroendocrine cells that also contain the unrelated ho..

B7-33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction-Related Adverse Cardiac Remodeling in Mice

Teja Devarakonda, Adolfo G Mauro, Geronimo Guzman, Sahak Hovsepian, Chad Cain, Anindita Das, Praveen Praveen, Mohammed Akhter Hossain, Fadi N Salloum

Journal article  |  2020  |  Journal of the American Heart Association

Background Human relaxin-2 is a peptide hormone capable of pleiotropic effects in several organ systems. Its recombinant formulati..

The anti-fibrotic actions of relaxin are mediated through AT(2)R-associated protein phosphatases via RXFP1-AT(2)R functional crosstalk in human cardiac myofibroblasts

Chao Wang, Anita A Pinar, Robert E Widdop, Mohammed A Hossain, Ross AD Bathgate, Kate M Denton, Barbara K Kemp-Harper, Chrishan S Samuel

Journal article  |  2020  |  The FASEB Journal

Fibrosis is a hallmark of several cardiovascular diseases. The relaxin family peptide receptor 1 (RXFP1) agonist, relaxin, has rap..

An insulin-like peptide 5 related agonist, INSL5-A13, stimulates colorectal propulsion via the relaxin family peptide 4 receptor

John B Furness, Shanti Diwakarla, Ross AD Bathgate, Xiaozhou Zhang, Mohammed Akhter Hossain

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY