Brian Le

Establishing a Longitudinal Opioid Pharmacogenomic Registry for Cancer Patients: Feasibility and Acceptability

Jennifer Philip, Aaron Wong, Leeanne Pasanen, Andrew A Somogyi, Justin Rubio, Pal Klepstad, Anna Collins, Peter Gibbs, Brian Le

Journal article  |  2022  |  JOURNAL OF PALLIATIVE MEDICINE

Purpose: Individual genetic variation can affect both pain expression and opioid response. Large cohort datasets are required to v..

Symptom burden in malignant and non-malignant disease on admission to a palliative care unit

David See, Brian Le, Alexandra Gorelik, Peter Eastman

Journal article  |  2022  |  BMJ SUPPORTIVE & PALLIATIVE CARE

BACKGROUND: There is increasing recognition that patients with non-malignant diseases have comparable physical and psychosocial sy..

ENhANCE trial protocol: A multi-centre, randomised, phase IV trial comparing the efficacy of oxycodone/naloxone prolonged release (OXN PR) versus oxycodone prolonged release (Oxy PR) tablets in patients with advanced cancer

Aaron K Wong, Anneke Grobler, Brian Le

Journal article  |  2022  |  CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS

BACKGROUND: Oxycodone is a frequently used opioid in cancer. Opioid-induced constipation (OIC) is common. Oxycodone/Naloxone Prolo..

The feasibility of triggers for the integration of Standardised, Early Palliative (STEP) Care in advanced cancer: A phase II trial

Anna Collins, Vijaya Sundararajan, Brian Le, Linda Mileshkin, Susan Hanson, Jon Emery, Jennifer Philip

Journal article  |  2022  |  FRONTIERS IN ONCOLOGY

BACKGROUND: While multiple clinical trials have demonstrated benefits of early palliative care for people with cancer, access to t..

Do Patient Demographics and Performance Status Influence Opioid Dose in Cancer Pain?

Catherine E Rowe, Aaron K Wong, Luke Buizen, Justin Hawke, Brian Le

Journal article  |  2022  |  AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE

Context: There is limited evidence on the role of objective parameters in influencing analgesic use in cancer pain management.Obje..

A multi-centre study on patients dying from COVID-19: communication between clinicians, patients and their families

Rachel Everitt, Aaron K Wong, Olivia Wawryk, Brian Le, Jaclyn Yoong, Maria Pisasale, Ruwani Mendis, Jennifer Philip

Journal article  |  2022  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: COVID-19 has led to challenges in providing effective and timely communication in healthcare. Services have been requi..

Is the use of palliative care services increasing? A comparison of current versus historical palliative care access using health service datasets for patients with cancer

Jennifer Philip, Anna Collins, Olivia Warwyk, Vijaya Sundararajan, Brian Le

Journal article  |  2022  |  PALLIATIVE MEDICINE

BACKGROUND: Mature evidence exists supporting the integration of palliative care in cancer care, but translation of evidence into ..

Spiritual distress in dialysis: A case report

Hannah Douglass-Molloy, Mandy M Law, Brian Le, Naomi Katz

Journal article  |  2022  |  PROGRESS IN PALLIATIVE CARE

The dialysis cohort in Australia, as in other parts of the world, is becoming increasingly elderly and frail. The incidence of dia..

The Palliative Approach and Terminal Heart Failure Admissions - Are We

Vithoosharan Sivanathan, Natasha Smallwood, Alexander Strathmore, Douglas Johnson, Brian Le, Dominica Zentner

Journal article  |  2022  |  HEART LUNG AND CIRCULATION

BACKGROUND: Chronic heart failure has a high mortality and early provision of palliative care supports complex decision-making and..

Attitudes of Palliative Care Practitioners Towards Enrolling Patients in Clinical Trials

Ahmed Nagla, Brian Le, Clare White, Katerina Kiburg, Jennifer Philip

Journal article  |  2022  |  JOURNAL OF PALLIATIVE CARE

Background: Recruitment of participants for clinical trials remains a key consideration for investigators. This is particularly re..