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Dr

Hongjian Zhu

Senior Research Fellow
Surgery - Royal Melbourne Hospital
science & technology
life sciences & biomedicine
animals
humans
mice
signal transduction
transforming growth factor beta
biochemistry & molecular biology
cell biology
Hongjian Zhu's Profile Picture
Dr

Hongjian Zhu

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Cancer Research
Hongjian Zhu's Profile Picture
Dr

Hongjian Zhu

 
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Hongjian's  Short Profile
 

Find out more about Hongjian Zhu's experience

Hongjian Zhu's highlights

Projects

Displaying the 10 most recent projects by Hongjian Zhu.

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Discovering TGF-b signaling-driven tumourigenesis in receptor-defective (TGFBR2) colorectal cancers with microsatellite instability (MSI) by exosomes

2018 - 2018
Completed
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Role of MACROD2 Deficiency in DNA Repair, Chromosomal Instability and Evolution of Colorectal Cancer: Clinical and Therapeutic Implications

2014 - 2018
Completed
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Dynamic TGF-b Signaling Regulation of Tumor Cell Dissemination, Circulation and Metastatic Seeding

2014 - 2015
Completed
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APC and TGF-beta in colon cancer

Colon cancer is one of the leading causes of death of all cancers. Two molecular pathways have been independently implicated in colon cancer..

2010 - 2011
Completed
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LOSS OF CYTOSTATIC REGULATION BY TGF-BETA DURING EGFR-DRIVEN TUMOR DEVELOPMENT

Growth factor and cytokine signalling networks control many aspects of cell behaviour such as proliferation, survival, migration, invasive c..

2007 - 2010
Completed
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EXPANSION OF TGF-BETA-SMAD SIGNALING NETWORK AND INTRINSIC EPITHELIAL-MESENCHYMAL TRANSITION

The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be ..

2007 - 2010
Completed
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DIFFERENTIAL COOPERATION OF MAPK WITH TGF-BETA SIGNALING IN EPITHELIAL-MESENCHYMAL TRANSITION

Tumor metastasis - the spread of tumor cells from the original site of growth to other sites in the body, is the biggest threat to survival ..

2006 - 2006
Completed
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THE ROLE OF TGF-BETA SIGNALING IN SUPPRESSION OF STAT3-MEDIATED TUMORIGENESIS

Stomach cancer is the third most prevalent cancer in the Western World and result in the yearly death of several thousand people in Australi..

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Novel upstream regulatory and down-stream signaling mechanisms of the Src-family protein kinases

Normal cell growth and division are governed by the balanced action of two groups of enzymes - the enzymes encoded by the proto-oncogenes (p..

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Novel upstream regulatory and down-stream signaling mechanisms of the Src-family protein kinases

Normal cell growth and division are governed by the balanced action of two groups of enzymes - the enzymes encoded by the proto-oncogenes (p..

11

Projects

Project Types

8

Research Grant

2

Internal Research Grant

1

Research Contracts

Scholarly Works

Displaying the 10 most recent scholarly works by Hongjian Zhu.

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Reactivation of BMP signaling by suboptimal concentrations of MEK inhibitor and FK506 reduces organ-specific breast cancer metastasis

Jiang Ren, Yanhong Wang, Thomas Ware, Josephine Iaria, Peter ten Dijke, Hong-Jian Zhu

Journal article  |  2020  |  Cancer Letters

TGFβ-SMAD3 signaling is a major driving force for cancer metastasis, while BMP-SMAD1/5 signaling can counteract this response. Ana..

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On-Target Anti-TGF-beta Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?

Adilson Fonseca Teixeira, Peter ten Dijke, Hong-Jian Zhu

Journal article  |  2020  |  Frontiers in Cell and Developmental Biology

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Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF beta-Induced Breast Cancer Metastasis

Sijia Liu, Roman Gonzalez-Prieto, Mengdi Zhang, Paul P Geurink, Raymond Kooij, Prasanna Vasudevan Iyengar, Maarten van Dinther, Erik Bos, Xiaobing Zhang, Sylvia E Le Devedec, Bob van de Water, Roman I Koning, Hong-Jian Zhu, Wilma E Mesker, Alfred CO Vertegaal, Huib Ovaa, Long Zhang, John WM Martens, Peter ten Dijke

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Therapies directed to specific molecular targets are still unmet for patients with triple-negative breast cancer (TNBC). ..

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Therapeutic Reversal of Radiotherapy Injury to Pro-fibrotic Dysfunctional Fibroblasts In Vitro Using Adipose-derived Stem Cells

Lipi Shukla, Rodney Luwor, Matthew E Ritchie, Shiva Akbarzadeh, Hong-Jian Zhu, Wayne Morrison, Tara Karnezis, Ramin Shayan

Journal article  |  2020  |  Plastic and Reconstructive Surgery Global Open

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USP26 regulates TGF-beta signalling by deubiquitinating and stabilizing SMAD7; not applicable in glioblastoma

Thomas MB Ware, Hong-Jian Zhu

Journal article  |  2020  |  EMBO Reports

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In vitro and in vivo studies of ganoderma lucidum in cancer

KG Heah, SN Bt Suhaimi, NR Bt Mohd Shobri, HJ Zhu, GRA Froemming

Journal article  |  2020  |  Journal of International Dental and Medical Research

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DEF6 expression and regulation in cancer, chronic inflammatory diseases and autoimmune diseases: A review

NMS Purwaningsih, KG Heah, HJ Zhu, MNM Rosdy, E Omar

Journal article  |  2020  |  Journal of International Dental and Medical Research

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Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

Jiang Ren, Marcel Smid, Josephine Iaria, Daniela CF Salvatori, Hans van Dam, Hong Jian Zhu, John WM Martens, Peter ten Dijke

Journal article  |  2019  |  Breast Cancer Research

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Petchiether A attenuates obstructive nephropathy by suppressing TGF-ss/Smad3 and NF-kappa B signalling

Yong-Ke You, Qi Luo, Wei-Feng Wu, Jiao-Jiao Zhang, Hong-Jian Zhu, Lixing Lao, Hui Y Lan, Hai-Yong Chen, Yong-Xian Cheng

Journal article  |  2019  |  Journal of Cellular and Molecular Medicine

Obstructive nephropathy is the end result of a variety of diseases that block drainage from the kidney(s). Transforming growth fac..

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Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

Fiona H Tan, Tracy L Putoczki, Jieqiong Lou, Elizabeth Hinde, Frederic Hollande, Julie Giraud, Stanley S Stylli, Lucia Paradiso, Hong-Jian Zhu, Oliver M Sieber, Rodney B Luwor

Journal article  |  2018  |  CANCERS

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Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Oncology and Carcinogenesis
Biochemistry and Cell Biology
Clinical (organs, Diseases and Abnormal Conditions)
Clinical Sciences
Expanding Knowledge
Medical Biochemistry and Clinical Chemistry
Artificial Intelligence and Image Processing
Cardiovascular Medicine and Haematology
Medical Biochemistry and Metabolomics

Honours, Awards and Fellowships

2000

Deakin University
1998

1st Electronic Lorne Cancer Conference
1990

Commonwealth Government of Australia
1990

Deakin University

4

Awards

Credentials

Positions

Senior Research Fellow

Surgery - Royal Melbourne Hospital

Australian Society For Biochemistry And Molecular Biology

ASBMB

Australian Society For Medical Research

ASMR

American Association For Cancer Research

AACR

Education

PhD

Deakin University

Msc Chemistry

Nanjing University

BSc Dept of Chemistry

Nanjing University

Links

International Linkages

Baylor College of Medicine

United States

Leiden University

Netherlands

Ludwig Institute for Cancer Research

Sweden