Hongjian Zhu

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis.

Sijia Liu, Román González-Prieto, Mengdi Zhang, Paul P Geurink, Raymond Kooij, Prasanna Vasudevan Iyengar, Maarten van Dinther, Erik Bos, Xiaobing Zhang, Sylvia E Le Dévédec, Bob van de Water, Roman I Koning, Hong-Jian Zhu, Wilma E Mesker, Alfred CO Vertegaal, Huib Ovaa, Long Zhang, John WM Martens, Peter Ten Dijke

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Therapies directed to specific molecular targets are still unmet for patients with triple-negative breast cancer (TNBC). ..

USP26 regulates TGF-beta signalling by deubiquitinating and stabilizing SMAD7; not applicable in glioblastoma

Thomas MB Ware, Hong-Jian Zhu

Journal article  |  2020  |  EMBO reports

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

Jiang Ren, Marcel Smid, Josephine Iaria, Daniela CF Salvatori, Hans van Dam, Hong Jian Zhu, John WM Martens, Peter ten Dijke

Journal article  |  2019  |  Breast Cancer Research

Petchiether A attenuates obstructive nephropathy by suppressing TGF-ss/Smad3 and NF-kappa B signalling

Yong-Ke You, Qi Luo, Wei-Feng Wu, Jiao-Jiao Zhang, Hong-Jian Zhu, Lixing Lao, Hui Y Lan, Hai-Yong Chen, Yong-Xian Cheng

Journal article  |  2019  |  Journal of Cellular and Molecular Medicine

Obstructive nephropathy is the end result of a variety of diseases that block drainage from the kidney(s). Transforming growth fac..

Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

Fiona H Tan, Tracy L Putoczki, Jieqiong Lou, Elizabeth Hinde, Frederic Hollande, Julie Giraud, Stanley S Stylli, Lucia Paradiso, Hong-Jian Zhu, Oliver M Sieber, Rodney B Luwor

Journal article  |  2018  |  Cancers

Live Cell Imaging of the TGF-beta/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System

Hao Chen, Thomas MB Ware, Josephine Iaria, Hong-Jian Zhu

Journal article  |  2018  |  Journal of Visualized Experiments

Ras enhances TGF-beta signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1

Sheng Liu, Josephine Iaria, Richard J Simpson, Hong-Jian Zhu

Journal article  |  2018  |  Cell Communication and Signaling

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia LY Ng, Anderly C Chueh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E Turk, Thomas E Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng

Journal article  |  2017  |  Cell Communication and Signaling

YAP IS ESSENTIAL FOR GLIOBLASTOMA PROLIFERATION AND SURVIVAL IN VITRO AND IN VIVO

AJ Gogos, H Zhu, K Drummond, AP Morokoff, AH Kaye, AW Burgess

Conference Proceedings  |  2017  |  NEURO-ONCOLOGY

Mathematical model of TGF-beta signalling: feedback coupling is consistent with signal switching

Shabnam Khatibi, Hong-Jian Zhu, John Wagner, Chin Wee Tan, Jonathan H Manton, Antony W Burgess

Journal article  |  2017  |  BMC Systems Biology

TGF-beta and IL-6 family signalling crosstalk: an integrated model

Shabnam Khatibi, Jeff Babon, John Wagner, Jonathan H Manton, Chin Wee Tan, Hong-Jian Zhu, Sam Wormald, Antony W Burgess

Journal article  |  2017  |  Growth Factors

Extracellular vesicles: their role in cancer biology and epithelial-mesenchymal transition

Shashi K Gopal, David W Greening, Alin Rai, Maoshan Chen, Rong Xu, Adnan Shafiq, Rommel A Mathias, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2017  |  Biochemical Journal

The emergent role of exosomes in glioma

J Gourlay, AP Morokoff, RB Luwor, HJ Zhu, AH Kaye, SS Stylli

Journal article  |  2017  |  Journal of Clinical Neuroscience

Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis

Shashi K Gopal, David W Greening, Hong-Jian Zhu, Richard J Simpson, Rommel A Mathias

Journal article  |  2016  |  Scientific Reports

Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells

Shashi K Gopal, David W Greening, Eric G Hanssen, Hong-Jian Zhu, Richard J Simpson, Rommel A Mathias

Journal article  |  2016  |  Oncotarget

Extracellular vesicle isolation and characterization: toward clinical application

Rong Xu, David W Greening, Hong-Jian Zhu, Nobuhiro Takahashi, Richard J Simpson

Journal article  |  2016  |  Journal of Clinical Investigation

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate

Yeong-Chit Joel Chia, Bruno Catimel, Daisy Sio Seng Lio, Ching-Seng Ang, Benjamin Peng, Hong Wu, Hong-Jian Zhu, Heung-Chin Cheng

Journal article  |  2015  |  Archives of Biochemistry and Biophysics

SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-beta Signaling Pathway Targeting the Type II Receptor

Sheng Liu, Thao Nheu, Rodney Luwor, Sandra E Nicholson, Hong-Jian Zhu

Journal article  |  2015  |  Journal of Biological Chemistry

YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment

Shashi K Gopal, David W Greening, Rommel A Mathias, Hong Ji, Alin Rai, Maoshan Chen, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2015  |  Oncotarget

The immune suppressive function of transforming growth factor-beta (TGF-beta) in human diseases

Jingyi Sheng, Weisan Chen, Hong-Jian Zhu

Journal article  |  2015  |  Growth Factors

Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression

David W Greening, Shashi K Gopal, Rommel A Mathias, Lin Liu, Jingyi Sheng, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2015  |  Seminars in Cell & Developmental Biology

Single live cell TGF-beta signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-beta-Smad3 activity

Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson, Hong-Jian Zhu

Journal article  |  2015  |  Molecular Cancer

Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NF kappa B-mediated induction of MMP2

Maree Bilandzic, Yao Wang, Nuzhat Ahmed, Rodney B Luwor, Hong Jian Zhu, Jock K Findlay, Kaye L Stenvers

Journal article  |  2014  |  Cancer Letters

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

Khalid Abubaker, Rodney B Luwor, Hongjian Zhu, Orla McNally, Michael A Quinn, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2014  |  BMC Cancer

Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity

Nelson Ung, Tracy L Putoczki, Stanley S Stylli, Irvin Ng, John M Mariadason, Timothy A Chan, Hong-Jian Zhu, Rodney B Luwor

Journal article  |  2014  |  Cancer Biology & Therapy

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-beta signalling

FangFang Zhou, Yvette Drabsch, Tim JA Dekker, Amaya Garcia de Vinuesa, Yihao Li, Lukas JAC Hawinkels, Kelly-Ann Sheppard, Marie-Jose Goumans, Rodney B Luwor, Carlie J de Vries, Wilma E Mesker, Rob AEM Tollenaar, Peter Devilee, Chris X Lu, Hongjian Zhu, Long Zhang, Peter ten Dijke

Journal article  |  2014  |  Nature Communications

Retrograde, antegrade, and laparoscopic approaches to the management of large upper ureteral stones after shockwave lithotripsy failure: a four-year retrospective study.

Hongjian Zhu, Xiongjun Ye, Xuren Xiao, Xianglong Chen, Qingjiang Zhang, Hua Wang

Journal article  |  2014  |  Journal of Endourology

PURPOSE: We compare the success rate and complications of retrograde ureteroscopy, laparoscopic ureterolithotomy, and percutaneous..

Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition

Bow J Tauro, Rommel A Mathias, David W Greening, Shashi K Gopal, Hong Ji, Eugene A Kapp, Bradley M Coleman, Andrew F Hill, Ulrike Kusebauch, Janice L Hallows, David Shteynberg, Robert L Moritz, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2013  |  Molecular and Cellular Proteomics

Targeting Stat3 and Smad7 to restore TGF-beta cytostatic regulation of tumor cells in vitro and in vivo

RB Luwor, B Baradaran, LE Taylor, J Iaria, TV Nheu, N Amiry, CM Hovens, B Wang, AH Kaye, H-J Zhu

Journal article  |  2013  |  Oncogene

Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components

Hong Ji, David W Greening, Thomas W Barnes, Justin W Lim, Bow J Tauro, Alin Rai, Rong Xu, Christopher Adda, Suresh Mathivanan, Wei Zhao, Yanhong Xue, Tao Xu, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2013  |  Proteomics

Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden

Khalid Abubaker, Ardian Latifi, Rod Luwor, Simon Nazaretian, Hongjian Zhu, Michael A Quinn, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2013  |  Molecular Cancer

TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers

Benjamin J Shields, Florian Wiede, Esteban N Gurzov, Kenneth Wee, Christine Hauser, Hong-Jian Zhu, Timothy J Molloy, Sandra A O'Toole, Roger J Daly, Robert L Sutherland, Christina A Mitchell, Catriona A McLean, Tony Tiganis

Journal article  |  2013  |  Molecular and Cellular Biology

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

Nicholas I Fleming, Robert N Jorissen, Dmitri Mouradov, Michael Christie, Anuratha Sakthianandeswaren, Michelle Palmieri, Fiona Day, Shan Li, Cary Tsui, Lara Lipton, Jayesh Desai, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Hong-Jian Zhu, John M Mariadason, Antony W Burgess, et al.

Journal article  |  2013  |  Cancer Research

Laparoscopic pyeloplasty: a comparison between the transperitoneal and retroperitoneal approach during the learning curve.

Hongjian Zhu, Cheng Shen, Xuesong Li, Xuren Xiao, Xianglong Chen, Qingjiang Zhang, Hua Wang, Zhisong He, Liqun Zhou

Journal article  |  2013  |  Urologia Internationalis

PURPOSE: To compare the transperitoneal and the retroperitoneal approach in the laparoscopic management of pelviureteric junction ..

Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors

Ardian Latifi, Rodney B Luwor, Maree Bilandzic, Simon Nazaretian, Kaye Stenvers, Jan Pyman, Hongjian Zhu, Erik W Thompson, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2012  |  PLoS One

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Robert JJ O'Donoghue, Darryl A Knight, Carl D Richards, Cecilia M Prele, Hui Ling Lau, Andrew G Jarnicki, Jessica Jones, Steven Bozinovski, Ross Vlahos, Stefan Thiem, Brent S McKenzie, Bo Wang, Philip Stumbles, Geoffrey J Laurent, Robin J McAnulty, Stefan Rose-John, Hong Jian Zhu, Gary P Anderson, Matthias R Ernst, Steven E Mutsaers

Journal article  |  2012  |  EMBO Molecular Medicine

Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation

Rodney B Luwor, Xiaowen Chin, Andrew B McGeachie, Phillip J Robinson, Hong-Jian Zhu

Journal article  |  2012  |  Growth Factors

New reagents for improved in vitro and in vivo examination of TGF-beta signalling

Rodney B Luwor, Bo Wang, Thao V Nheu, Josephine Iaria, Evelyn Tsantikos, Margaret L Hibbs, Oliver M Sieber, Hong-Jian Zhu

Journal article  |  2011  |  Growth Factors

Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of beta-Synuclein as a Potential CHK Physiological Substrate

Kim K Ia, Grace R Jeschke, Yang Deng, Mohd Aizuddin Kamaruddin, Nicholas A Williamson, Denis B Scanlon, Janetta G Culvenor, Mohammed Iqbal Hossain, Anthony W Purcell, Sheng Liu, Hong-Jian Zhu, Bruno Catimel, Benjamin E Turk, Heung-Chin Cheng

Journal article  |  2011  |  Biochemistry

Tandem application of cationic colloidal silica and Triton X-114 for plasma membrane protein isolation and purification: Towards developing an MDCK protein database

Rommel A Mathias, Yuan-Shou Chen, Robert JA Goode, Eugene A Kapp, Suresh Mathivanan, Robert L Moritz, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2011  |  Proteomics

Proteomics Profiling of Madin-Darby Canine Kidney Plasma Membranes Reveals Wnt-5a Involvement during Oncogenic H-Ras/TGF-beta-mediated Epithelial-Mesenchymal Transition

Yuan-Shou Chen, Rommel A Mathias, Suresh Mathivanan, Eugene A Kapp, Robert L Moritz, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2011  |  Molecular and Cellular Proteomics

Regulation and function of protein kinases and phosphatases.

Heung-Chin Cheng, Robert Z Qi, Hemant Paudel, Hong-Jian Zhu

Journal article  |  2011  |  Enzyme Research

Cell division autoantigen 1 enhances signaling and the profibrotic effects of transforming growth factor-beta in diabetic nephropathy

Yugang Tu, Tieqiao Wu, Aozhi Dai, Yen Pham, Phyllis Chew, Judy B de Haan, Yu Wang, Ban-Hock Toh, Hongjian Zhu, Zemin Cao, Mark E Cooper, Zhonglin Chai

Journal article  |  2011  |  Kidney International

Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-Demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN

Joel Yeong-Chit Chia, Joanna E Gajewski, Yi Xiao, Hong-Jian Zhu, Heung-Chin Cheng

Journal article  |  2010  |  Biochimica et Biophysica Acta-Proteins and Proteomics

Extracellular Remodelling During Oncogenic Ras-Induced Epithelial-Mesenchymal Transition Facilitates MDCK Cell Migration

Rommel A Mathias, Yuan-Shou Chen, Bo Wang, Hong Ji, Eugene A Kapp, Robert L Moritz, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2010  |  Journal of Proteome Research

Perturbation of the CD4 T Cell Compartment and Expansion of Regulatory T Cells in Autoimmune-Prone Lyn-Deficient Mice

Evelyn Tsantikos, Cathy Quilici, Kenneth W Harder, Bo Wang, Hong-Jian Zhu, Gary P Anderson, David M Tarlinton, Margaret L Hibbs

Journal article  |  2009  |  Journal of Immunology

Secretome-Based Proteomic Profiling of Ras-Transformed MDCK Cells Reveals Extracellular Modulators of Epithelial-Mesenchymal Transition

Rommel A Mathias, Bo Wang, Hong Ji, Eugene A Kapp, Robert L Moritz, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2009  |  Journal of Proteome Research

Transforming growth factor-beta (TGF-beta) and brain tumours

Rodney B Luwor, Andrew H Kaye, Hong-Han Zhu

Journal article  |  2008  |  Journal of Clinical Neuroscience

Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes

Hong Ji, Nasrollah Erfani, Bow J Tauro, Eugene A Kapp, Hong-Jian Zhu, Robert L Moritz, Justin WE Lim, Richard J Simpson

Journal article  |  2008  |  Electrophoresis

Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase

Joanna E Gajewski, Megan J Bird, Meredith O Crowhurst, Daisy Sio-Seng Lio, Junjun Liu, Richard EH Wettenhall, Hong-Jian Zhu, Heung-Chin Cheng

Journal article  |  2007  |  Protein Expression and Purification

PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid - Mechanistic analysis of a familial Cowden disease-associated PTEN mutation

Yi Xiao, Joel Yeong Chit Chia, Joanna E Gajewski, Daisy Sio Seng Lio, Terrence D Mulhern, Hong-Jian Zhu, Harshal Nandurkar, Heung-Chin Cheng

Journal article  |  2007  |  Cellular Signaling

Analysis of Ras-induced oncogenic transformation of NIH-3T3 cells using differential-display 2-DE proteomics

Hong Ji, Robert L Moritz, Yu-Sam Kim, Hong-Jian Zhu, Richard J Simpson

Journal article  |  2007  |  Electrophoresis

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

Yumiko Hirokawa, Alexander Levitzki, Guillaume Lessene, Jonathan Baell, Yi Xiao, Hongjian Zhu, Hiroshi Maruta

Journal article  |  2007  |  Cancer Letters

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

BJ Jenkins, D Grail, T Nheu, M Najdovska, B Wang, P Waring, M Inglese, RM McLoughlin, SA Jones, N Topley, H Baumann, LM Judd, AS Giraud, A Boussioutas, HJ Zhu, M Ernst

Journal article  |  2005  |  Nature Medicine

Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta 1 in rat proximal tubular cells and mouse fibroblasts

T Nakagawa, HY Lan, O Glushakova, HJ Zhu, DH Kang, GF Schreiner, EP Bottinger, RJ Johnson, YY Sautin

Journal article  |  2005  |  Journal of the American Society of Nephrology

Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells

T Nakagawa, HY Lan, HJ Zhu, DH Kang, GF Schreiner, RJ Johnson

Journal article  |  2004  |  American Journal of Physiology: Renal Physiology

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR

RB Luwor, HJ Zhu, F Walker, AA Vitali, RM Perera, AW Burgess, AM Scott, TG Johns

Journal article  |  2004  |  Oncogene

TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

T Nakagawa, JH Li, G Garcia, W Mu, E Piek, EP Bottinger, Y Chen, HJ Zhu, DH Kang, GF Schreiner, HY Lan, RJ Johnson

Journal article  |  2004  |  Kidney International

Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction

NS Cheung, MS Choy, B Halliwell, TS Teo, BH Bay, AYW Lee, RZ Qi, VH Koh, M Whiteman, ESC Koay, LL Chiu, HJ Zhu, KP Wong, PM Beart, HC Cheng

Journal article  |  2004  |  Cellular and Molecular Life Sciences

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor

F Walker, SG Orchard, RN Jorissen, NE Hall, HH Zhang, PA Hoyne, TE Adams, TG Johns, C Ward, TPJ Garrett, HJ Zhu, M Nerrie, AM Scott, EC Nice, AW Burgess

Journal article  |  2004  |  Journal of Biological Chemistry

A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity

YP Chong, TD Mulhern, HJ Zhu, DJ Fujita, JD Bjorge, JP Tantiongco, N Sotirellis, DSS Lio, G Scholz, HC Cheng

Journal article  |  2004  |  Journal of Biological Chemistry

Advanced glycation end products activate Smad signaling via TGF-beta-dependent and -independent mechanisms: implications for diabetic renal and vascular disease

JH Li, XR Huang, HJ Zhu, M Oldfield, M Cooper, LD Truong, RJ Johnson, HY Lan

Journal article  |  2004  |  FASEB Journal

Erratum: Smad7 inhibits fibrotic effect of TGF-β on renal tubular epithelial cells by blocking Smad2 activation (Journal in The American Society of Neurology (2002) 13 (1464-1472))

JH Li, HJ Zhu, XR Huang, KN Lai, RJ Johnson, HY Lan

Journal article  |  2003  |  Journal of the American Society of Nephrology

Heart and liver defects and reduced transforming growth factor beta 2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

KL Stenvers, ML Tursky, KW Harder, N Kountouri, S Amatayakul-Chantler, D Grail, C Small, RA Weinberg, AM Sizeland, HJ Zhu

Journal article  |  2003  |  Molecular and Cellular Biology

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

HY Lan, W Mu, N Tomita, XR Huang, JH Li, HJ Zhu, R Morishita, RJ Johnson

Journal article  |  2003  |  Journal of the American Society of Nephrology

Role of TGF-beta signaling in extracellular matrix production under high glucose conditions

JH Li, XR Huang, HJ Zhu, R Johnson, HY Lan

Journal article  |  2003  |  Kidney International

Epidermal growth factor receptor: Association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand

HJ Zhu, J Iaria, S Orchard, F Walker, AW Burgess

Journal article  |  2003  |  Growth Factors

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

TPJ Garrett, NM McKern, MZ Lou, TC Elleman, TE Adams, GO Lovrecz, HJ Zhu, F Walker, MJ Frenkel, PA Hoyne, RN Jorissen, EC Nice, AW Burgess, CW Ward

Journal article  |  2002  |  Cell

Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation

JH Li, HJ Zhu, XR Huang, KN Lai, RJ Johnson, HY Lan

Journal article  |  2002  |  Journal of the American Society of Nephrology

Regulation of transforming growth factor-beta signaling.

HJ Zhu, AW Burgess

Journal article  |  2001  |  Molecular Cell Biology Research Communications

Members of transforming growth factor beta (TGF-beta) family are potent regulators of multiple cellular functions, including cell ..

Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases

H He, A Levitzki, HJ Zhu, F Walker, A Burgess, H Maruta

Journal article  |  2001  |  Journal of Biological Chemistry

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.

T Nakagawa, H Zhu, N Morishima, E Li, J Xu, BA Yankner, J Yuan

Journal article  |  2000  |  Nature

Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis c..

Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways.

HJ Zhu, J Iaria, AM Sizeland

Journal article  |  1999  |  Journal of Biological Chemistry

Smad7 has been identified as a negative regulator of transforming growth factor beta (TGF-beta) signaling by interfering with the ..

Extracellular domain of the transforming growth factor-beta receptor negatively regulates ligand-independent receptor activation.

HJ Zhu, AM Sizeland

Journal article  |  1999  |  Journal of Biological Chemistry

We have previously proposed that transforming growth factor (TGF)-beta receptor activation occurs via a relative rotation between ..

A pivotal role for the transmembrane domain in transforming growth factor-beta receptor activation.

HJ Zhu, AM Sizeland

Journal article  |  1999  |  Journal of Biological Chemistry

Transforming growth factor-beta (TGF-beta) delivers diverse growth and differentiation signals by binding two distantly related tr..