Bruno Catimel

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Ruth N MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N Jorissen, Shan Li, Lachlan Whitehead, Tracy L Putoczki, Adele Preaudet, Cary Tsui, Cameron J Nowell, Robyn L Ward, Nicholas J Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, et al.

Journal article  |  2018  |  Cancer Discovery

ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by..

Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFR alpha signalling in vivo

Hong Li, Manuel Zeitelhofer, Ingrid Nilsson, Xicong Liu, Laura Allan, Benjamin Gloria, Angelo Perani, Carmel Murone, Bruno Catimel, A Munro Neville, Fiona E Scott, Andrew M Scott, Ulf Eriksson

Journal article  |  2018  |  PLoS One

PDGF-CC is a member of the platelet-derived growth factor (PDGF) family that stimulates PDGFRα phosphorylation and thereby activat..

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia LY Ng, Anderly C Chueh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E Turk, Thomas E Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng

Journal article  |  2017  |  Cell Communication and Signaling

BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases ..

Synthesis of a Tethered myo-Inositol (1,3,4,5,6)Pentakisphosphate (IP5) Derivative as a Probe for Biological Studies

Mark Gregory, Bruno Catimel, Meng-Xin Yin, Melanie Condron, Antony W Burgess, Andrew B Holmes

Journal article  |  2016  |  SYNLETT

There is sufficient evidence to suggest that myo-inositol pentakisphosphate is a vital intermediate species in higher inositol pho..

Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor

Ingrid JG Burvenich, William Farrugia, Fook T Lee, Bruno Catimel, Zhanqi Liu, Dahna Makris, Diana Cao, Graeme J O'Keefe, Martin W Brechbiel, Dylan King, Violeta Spirkoska, Laura C Allan, Paul A Ramsland, Andrew M Scott

Journal article  |  2016  |  mAbs

IgG has a long half-life through engagement of its Fc region with the neonatal Fc receptor (FcRn). The FcRn binding site on IgG1 h..

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate

Yeong-Chit Joel Chia, Bruno Catimel, Daisy Sio Seng Lio, Ching-Seng Ang, Benjamin Peng, Hong Wu, Hong-Jian Zhu, Heung-Chin Cheng

Journal article  |  2015  |  Archives of Biochemistry and Biophysics

Dephosphorylation of four major C-terminal tail sites and occupancy of the phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2]-bindi..

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites

Maya A Olshina, Fiona Angrisano, Danushka S Marapana, David T Riglar, Kartik Bane, Wilson Wong, Bruno Catimel, Meng-Xin Yin, Andrew B Holmes, Friedrich Frischknecht, David R Kovar, Jake Baum

Journal article  |  2015  |  Malaria Journal

BACKGROUND: Gliding motility in Plasmodium parasites, the aetiological agents of malaria disease, is mediated by an actomyosin mot..

Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives

Mark Gregory, Meng-Xin Yin, Malcolm J McConville, Eleanor Williams, Alex N Bullock, Stuart J Conway, Antony W Burgess, Bruno Catimel, Andrew B Holmes

Journal article  |  2015  |  Australian Journal of Chemistry

Phosphatidylinositol phosphates are key regulators of cell signalling pathways and membrane trafficking in eukaryotic cells, and t..

Activation of Src family tyrosine kinases by ferric ions

Graham S Baldwin, Daisy Sio-Seng Lio, Audrey Ferrand, Bruno Catimel, B Philip Shehan, Raymond S Norton, Heung-Chin Cheng

Journal article  |  2014  |  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Src-family tyrosine kinases (SFKs) are oncogenic enzymes that contribute to the initiation and progression of many types of ca..

A Mechanism for Actin Filament Severing by Malaria Parasite Actin Depolymerizing Factor 1 via a Low Affinity Binding Interface

Wilson Wong, Andrew I Webb, Maya A Olshina, Giuseppe Infusini, Yan Hong Tan, Eric Hanssen, Bruno Catimel, Cristian Suarez, Melanie Condron, Fiona Angrisano, Thomas Neb, David R Kovar, Jake Baum

Journal article  |  2014  |  Journal of Biological Chemistry

Actin depolymerizing factor (ADF)/cofilins are essential regulators of actin turnover in eukaryotic cells. These multifunctional p..