Amy Hampson

The Effect of Different Round Window Sealants on Cochlear Mechanics Over Time

Timothy Mclean, Philip Clamp, Luke Campbell, Amy Hampson, Scott Chambers, Aaron Collins, Christofer Bester, Stephen O'Leary

Journal article  |  2021  |  OTOLOGY & NEUROTOLOGY

BACKGROUND: This project investigated the effects of round window membrane (RWM) sealants after surgical incision, with a focus on..

Cochlear microphonic latency predicts outer hair cell function in animal models and clinical populations

Christofer Bester, Stefan Weder, Aaron Collins, Adrian Dragovic, Kate Brody, Amy Hampson, Stephen O'Leary

Journal article  |  2020  |  HEARING RESEARCH

As recently reported, electrocochleography recorded in cochlear implant recipients showed reduced amplitude and shorter latency in..

A new method for three-dimensional immunofluorescence study of the cochlea

Kate M Brody, Amy J Hampson, Hyun-jung Cho, Prudence Johnson, Stephen J O'Leary

Journal article  |  2020  |  HEARING RESEARCH

Visualisation of cochlear histopathology in three-dimensions has been long desired in the field of hearing research. This paper ou..

Nanomechanical mapping reveals localized stiffening of the basilar membrane after cochlear implantation

Jessica K Choong, Amy J Hampson, Kate M Brody, Jonathon Lo, Christofer W Bester, Anthony W Gummer, Nicholas P Reynolds, Stephen J O'Leary

Journal article  |  2020  |  HEARING RESEARCH

Cochlear implantation leads to many structural changes within the cochlea which can impair residual hearing. In patients with pres..

Intracochlear tPA infusion may reduce fibrosis caused by cochlear implantation surgery

Jessica Ky-Lee Choong, Jonathon Lo, Scott Andrew Chambers, Amy Judith Hampson, Hayden Timothy Eastwood, Stephen John O'Leary

Journal article  |  2019  |  ACTA OTO-LARYNGOLOGICA

BACKGROUND: Experiments show that the extent of ongoing fibrotic change within the cochlea can be determined by the volume and pat..

Adjuvant agents enhance round window membrane permeability to dexamethasone and modulate basal to apical cochlear gradients

Nathan J Creber, Hayden T Eastwood, Amy J Hampson, Justin Tan, Stephen J O'Leary

Journal article  |  2019  |  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Glucocorticoids have direct anti-inflammatory, anti-oxidant and anti-apoptotic effects on cochlear hair cells. Cochlear glucocorti..

A comparison of cochlear distribution and glucocorticoid receptor activation in local and systemic dexamethasone drug delivery regimes

Nathan J Creber, Hayden T Eastwood, Amy J Hampson, Justin Tan, Stephen J O'Leary

Journal article  |  2018  |  HEARING RESEARCH

Local and systemically delivered glucocorticoids are commonly administered to protect the cochlea against damage associated with a..

Effect of cochlear implantation on middle ear function: A three-month prospective study

Joseph D Wasson, Luke Campbell, Scott Chambers, Amy Hampson, Robert JS Briggs, Stephen J O'Leary

Journal article  |  2018  |  LARYNGOSCOPE

OBJECTIVES/HYPOTHESIS: To determine if cochlear implantation has a delayed effect on the middle ear conductive hearing mechanism b..

Intraoperative force and electrocochleography measurements in an animal model of cochlear implantation

J Lo, C Bester, A Collins, C Newbold, A Hampson, S Chambers, H Eastwood, S O'Leary

Journal article  |  2018  |  HEARING RESEARCH

To preserve residual hearing, techniques for monitoring and reducing the effects of trauma during cochlear implant surgery are bei..

Cannula-based drug delivery to the guinea pig round window causes a lasting hearing loss that may be temporarily mitigated by BDNF

Phillip JP Sale, Aaron Uschakov, Tasfia Saief, David P Rowe, Carla J Abbott, Chi D Luu, Amy J Hampson, Stephen J O'Leary, David J Sly

Journal article  |  2017  |  HEARING RESEARCH

Sustained local delivery of drugs to the inner ear may be required for future regenerative and protective strategies. The round wi..