Michael Murray

Netrins: Evolutionarily Conserved Regulators of Epithelial Fusion and Closure in Development and Wound Healing

Vishal Chaturvedi, Michael J Murray

Journal article  |  2021  |  CELLS TISSUES ORGANS

Epithelial remodelling plays a crucial role during development. The ability of epithelial sheets to temporarily lose their integri..

Exploiting Drosophila melanogaster Wing Imaginal Disc Eversion to Screen for New EMT Effectors

Sofia Golenkina, Rosemary Manhire-Heath, Michael J Murray

Journal article  |  2021  |  EPITHELIAL-TO MESENCHYMAL TRANSITION

In the early stages of Drosophila melanogaster (Drosophila) metamorphosis, a partial epithelial-mesenchymal transition (pEMT) take..

Maintenance of Cell Fate by the Polycomb Group Gene Sex Combs Extra Enables a Partial Epithelial Mesenchymal Transition in Drosophila

Grace Jefferies, Jason Somers, Isabelle Lohrey, Vishal Chaturvedi, Jacob Calabria, Owen J Marshall, Tony D Southall, Robert Saint, Michael J Murray

Journal article  |  2020  |  G3-GENES GENOMES GENETICS

Epigenetic silencing by Polycomb group (PcG) complexes can promote epithelial-mesenchymal transition (EMT) and stemness and is ass..

Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response

Vishal Chaturvedi, Alexandre Fournier-Level, Helen M Cooper, Michael J Murray

Journal article  |  2019  |  SCIENTIFIC REPORTS

Neogenin1 (NEO1) is a receptor of the Deleted in Colorectal Carcinoma (DCC)/Frazzled/UNC-40 family, which regulates axon guidance ..

Frazzled can act through distinct molecular pathways in epithelial cells to regulate motility, apical constriction, and localisation of E-Cadherin

Sofia Golenkina, Vishal Chaturvedi, Robert Saint, Michael J Murray

Journal article  |  2018  |  PLOS ONE

Netrin receptors of the DCC/NEO/UNC-40/Frazzled family have well established roles in cell migration and axon guidance but can als..

The Role of Netrins and Their Receptors in Epithelial Mesenchymal Plasticity during Development

Michael J Murray

Journal article  |  2017  |  CELLS TISSUES ORGANS

Transitions between mesenchymal and epithelial cells are underpinned by changes in motility, adhesion, and polarity. Netrins and t..

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila

Karen Doggett, Nezaket Turkel, Lee F Willoughby, Jason Ellul, Michael J Murray, Helena E Richardson, Anthony M Brumby

Journal article  |  2015  |  PLOS ONE

During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endo..

Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells

Melissa Pert, Miao Gan, Robert Saint, Michael J Murray

Journal article  |  2015  |  BIOLOGY OPEN

Mesenchymal-epithelial transitions (METs) are important in both development and the growth of secondary tumours. Although the mole..

Drosophila models of metastasis

Michael J Murray

Journal article  |  2015  |  AIMS GENETICS

AbstractAn important goal in the fight against cancer is to understand how tumors become invasive and metastatic. A crucial early ..

In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos

David A Simpson, Amelia J Thompson, Mark Kowarsky, Nida F Zeeshan, Michael SJ Barson, Liam T Hall, Yan Yan, Stefan Kaufmann, Brett C Johnson, Takeshi Ohshima, Frank Caruso, Robert E Scholten, Robert B Saint, Michael J Murray, Lloyd CL Hollenberg

Journal article  |  2014  |  BIOMEDICAL OPTICS EXPRESS

In this work, we incorporate and image individual fluorescent nanodiamonds in the powerful genetic model system Drosophila melanog..