Malcolm McConville

The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring.

Gerard Wong, Jacquelyn M Weir, Priti Mishra, Kevin Huynh, Brunda Nijagal, Varsha Gupta, Birit FP Broekman, Mary Foong-Fong Chong, Shiao-Yng Chan, Kok Hian Tan, Dedreia Tull, Malcolm McConville, Philip C Calder, Keith M Godfrey, Yap Seng Chong, Peter D Gluckman, Michael J Meaney, Peter J Meikle, Neerja Karnani

Journal article  |  2021  |  Translational Psychiatry

While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determina..

The utilisation of glutamine and glucose by a 3-D tumour model trapped in quiescence.

Hannah Smith, David De Souza, Dedreia Tull, Malcolm McConville, Andrea Pellagatti, Jacqueline Boultwood, Mary Board, Richard Callaghan

Journal article  |  2021  |  The International Journal of Biochemistry & Cell Biology

Solid tumours modify their metabolic strategy to ensure sufficient biomass and energy to maintain a high rate of proliferation. Ho..

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.

Gillian M Fisher, Simon A Cobbold, Andrew Jezewski, Emma F Carpenter, Megan Arnold, Annie N Cowell, Erick T Tjhin, Kevin J Saliba, Tina S Skinner-Adams, Marcus CS Lee, Audrey Odom John, Elizabeth A Winzeler, Malcolm J McConville, Sally-Ann Poulsen, Katherine T Andrews

Journal article  |  2020  |  mBio

Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan, Jian Kang, Richard B Pearson

Journal article  |  2020  |  The EMBO Journal

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-i..

Modulation of acyl-carnitines, the broad mechanism behind Wolbachia-mediated inhibition of medically important flaviviruses in Aedes aegypti

Gayathri Manokaran, Heather A Flores, Conor T Dickson, Vinod K Narayana, Komal Kanojia, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie, Cameron P Simmons

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

Wolbachia-infected mosquitoes are refractory to flavivirus infections, but the role of lipids in Wolbachia-mediated virus blocking..

Immunometabolism ofLeishmaniagranulomas

Eleanor C Saunders, Malcolm J McConville

Journal article  |  2020  |  Immunology and Cell Biology

Leishmania are parasitic protists that cause a spectrum of diseases in humans characterized by the formation of granulomatous lesi..

Metabolomics in the study of spontaneous animal diseases

Helena Tran, Malcolm McConville, Panayiotis Loukopoulos

Journal article  |  2020  |  Journal of Veterinary Diagnostic Investigation

Using analytical chemistry techniques such as nuclear magnetic resonance (NMR) spectroscopy and liquid or gas chromatography-mass ..

The natural function of the malaria parasite's chloroquine resistance transporter

Sarah H Shafik, Simon A Cobbold, Kawthar Barkat, Sashika N Richards, Nicole S Lancaster, Manuel Llinas, Simon J Hogg, Robert L Summers, Malcolm J McConville, Rowena E Martin

Journal article  |  2020  |  Nature Communications

The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also esse..

A Sulfoglycolytic Entner-Doudoroff Pathway in Rhizobium leguminosarum bv. trifolii SRDI565

Jinling Li, Ruwan Epa, Nichollas E Scott, Dominik Skoneczny, Mahima Sharma, Alexander JD Snow, James P Lingford, Ethan D Goddard-Borger, Gideon J Davies, Malcolm J McConville, Spencer J Williams

Journal article  |  2020  |  Applied and Environmental Microbiology

Rhizobia are nitrogen-fixing bacteria that engage in symbiotic relationships with plant hosts but can also persist as free-living ..

Publisher Correction: Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality.

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.