Malcolm McConville

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565.

Jinling Li, Ruwan Epa, Nichollas E Scott, Dominik Skoneczny, Mahima Sharma, Alexander JD Snow, James P Lingford, Ethan D Goddard-Borger, Gideon J Davies, Malcolm J McConville, Spencer J Williams

Journal article  |  2020  |  Applied and Environmental Microbiology

Rhizobia are nitrogen fixing bacteria that engage in symbiotic relationships with plant hosts but can also persist as free-living ..

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii.

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  Infection and Immunity

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal.

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

MtrP, a putative methyltransferase in Corynebacteria, is required for optimal membrane transport of trehalose mycolates

Arek K Rainczuk, Stephan Klatt, Yoshiki Yamaryo-Botte, Rajini Brammananth, Malcolm J McConville, Ross L Coppel, Paul K Crellin

Journal article  |  2020  |  Journal of Biological Chemistry

Metabolomics Provide Sensitive Insights into the Impacts of Low Level Environmental Contamination on Fish Health-A Pilot Study

Sara M Long, Dedreia L Tull, David P De Souza, Konstantinos A Kouremenos, Saravanan Dayalan, Malcolm J McConville, Kathryn L Hassell, Vincent J Pettigrove, Marthe Monique Gagnon

Journal article  |  2020  |  Metabolites

This exploratory study aims to investigate the health of sand flathead (Platycephalus bassensis) sampled from five sites in Port P..

Metabolomic Analysis of Toxoplasma gondii Tachyzoites.

Elizabeth FB King, Simon A Cobbold, Alessandro D Uboldi, Christopher J Tonkin, Malcolm J McConville

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

This protocol describes the use of 13C-stable isotope labeling, combined with metabolite profiling, to investigate the metabolism ..

Analysis of the Physiological and Metabolic State of Leishmania Using Heavy Water Labeling.

Joachim Kloehn, Malcolm J McConville

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

This protocol describes the use of heavy water (2H2O) labeling to determine the growth rate and metabolic state of Leishmania para..

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565

Jinling Li, Ruwan Epa, Nichollas Scott, Dominic Skoneczny, Mahima Sharma, Alexander JD Snow, James Lingford, Ethan Goddard-Borger, Gideon Davies, Malcolm McConville, Spencer Williams

Journal article  |  2019

Abstract Rhizobia are nitrogen fixing bacteria that engage in symbiotic relationships with plant hosts but can also persist as fre..

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  Cell Reports

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, KT Chan, DP De Souza, MJ McConville, GA McArthur, G Thomas, E Sanij, G Poortinga, RD Hannan, KM Hannan, J Kang, RB Pearson

Journal article  |  2019  |  bioRxiv

Abstract Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-i..

Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjaerg syndrome

Yilin Kang, Alexander J Anderson, Thomas Daniel Jackson, Catherine S Palmer, David P De Souza, Kenji M Fujihara, Tegan Stait, Ann E Frazier, Nicholas J Clemons, Deidreia Tull, David R Thorburn, Malcolm J McConville, Michael T Ryan, David A Stroud, Diana Stojanovski

Journal article  |  2019  |  eLife

Human Tim8a and Tim8b are members of an intermembrane space chaperone network, known as the small TIM family. Mutations in TIMM8A ..

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

Laure Dumont, Mark B Richardson, Phillip van der Peet, Danushka S Marapana, Tony Triglia, Matthew WA Dixon, Alan F Cowman, Spencer J Williams, Leann Tilley, Malcolm J McConville, Simon A Cobbold

Journal article  |  2019  |  mBio

Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathway..

The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium

Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Iain D Hay, Simon A Cobbold, Mark R Davies, Malcolm J McConville, Trevor Lithgow, Richard A Strugnell

Journal article  |  2019  |  Biochemical Journal

Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimi..

Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters

Miku Kuba, Nitika Neha, David P De Souza, Saravanan Dayalan, Joshua PM Newson, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2019  |  Biochemical Journal

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  Journal of Clinical Investigation

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Marcel A Vieira-Lara, Simon A Cobbold, Lauren Stanton, Douglas EV Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M Bastidas, Phillip L van der Peet, Michael W Parker, David B Ascher, Spencer J Williams, Gideon J Davies, Malcolm J McConville

Journal article  |  2019  |  Cell Host & Microbe

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article  |  2019  |  Immunity

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J McConville, Stuart A Ralph

Journal article  |  2019  |  PLOS Biology

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeepi..

Changes in plasma lipids predict pravastatin efficacy in secondary prevention

Kaushala S Jayawardana, Piyushkumar A Mundra, Corey Giles, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Ian C Marschner, Gerard Wong, Bronwyn A Kingwell, et al.

Journal article  |  2019  |  JCI Insight

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2 signaling and motility in Toxoplasma gondii

Luning Yang, Alessandro D Uboldi, Simona Seizova, Mary-Louise Wilde, Michael J Coffey, Nicholas J Katris, Yoshiki Yamaryo-Botte, Martina Kocan, Ross AD Bathgate, Rebecca J Stewart, Malcolm J McConville, Philip E Thompson, Cyrille Y Botte, Christopher J Tonkin

Journal article  |  2019  |  Journal of Biological Chemistry

High Spare Respiratory Capacity is a Canonical Feature of Virtual Memory, but not Conventional Memory CD8 T Cells, and is Driven by IL-15 Signalling

Nicole L La Gruta, Kylie M Quinn, Felix Kraus, Luke Formosa, Michael Dagley, Eleanor Saunders, Tabinda Hussain, Lisa Assmus, Adam Costin, Joan Clark, Georg Ramm, Kim Good-Jacobson, Malcolm McConville, Michael Ryan

Conference Proceedings  |  2019  |  JOURNAL OF IMMUNOLOGY

Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome

Kim R Simpfendorfer, Nancy Wang, Dedreia L Tull, David P De Souza, Amsha Nahid, Andre Mu, Dianna M Hocking, John S Pedersen, Odilia LC Wijburg, Malcolm J McConville, Richard A Strugnell

Journal article  |  2019  |  Molecular Medicine

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

Phurpa Wangchuk, Catherine Shepherd, Constantin Constantinoiu, Rachael YM Ryan, Konstantinos A Kouremenos, Luke Becker, Linda Jones, Geraldine Buitrago, Paul Giacomin, David Wilson, Norelle Daly, Malcolm J McConville, John J Miles, Alex Loukas

Journal article  |  2019  |  Infection and Immunity

Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis

Leilah K Grant, Suzanne Ftouni, Brunda Nijagal, David P De Souza, Dedreia Tull, Malcolm J McConville, Shantha MW Rajaratnam, Steven W Lockley, Clare Anderson

Journal article  |  2019  |  Scientific Reports

Establishing a distributed national research infrastructure providing bioinformatics support to life science researchers in Australia

Maria Victoria Schneider, Philippa C Griffin, Sonika Tyagi, Madison Flannery, Saravanan Dayalan, Simon Gladman, Nathan Watson-Haigh, Philipp E Bayer, Michael Charleston, Ira Cooke, Rob Cook, Richard J Edwards, David Edwards, Dominique Gorse, Malcolm McConville, David Powell, Marc R Wilkins, Andrew Lonie

Journal article  |  2019  |  Briefings in Bioinformatics

Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation

Jhih-Hang Jiang, Md Saruar Bhuiyan, Hsin-Hui Shen, David R Cameron, Thusitha WT Rupasinghe, Chun-Ming Wu, Anton P Le Brun, Xenia Kostoulias, Carmen Domene, Alex J Fulcher, Malcolm J McConville, Benjamin P Howden, Graham J Lieschke, Anton Y Peleg

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family

Kathryn ER Parker, Stephen J Fairweather, Esther Rajendran, Martin Blume, Malcolm J McConville, Stefan Broer, Kiaran Kirk, Giel G van Dooren

Journal article  |  2019  |  PLOS Pathogens

Determining the Mode of Action of Antimalarial Drugs Using Time-Resolved LC-MS-Based Metabolite Profiling.

Simon A Cobbold, Malcolm J McConville

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Methods for assessing the mode of action of new antimalarial compounds identified in high throughput phenotypic screens are needed..

Synergy Between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small Cell Lung Cancer with an Altered Metabolism

S Best, D Desouza, A Kersbergen, A Policheni, S Dayalan, D Tull, V Rathi, D Gray, M Ritchie, M Mcconyille, K Sutherland

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, et al.

Journal article  |  2018  |  Nature Communications

Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention

Piyushkumar A Mundra, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Kaushala S Jayawardana, Corey Giles, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Gerard Wong, Bronwyn A Kingwell, John Simes, et al.

Journal article  |  2018  |  JCI Insight

Protein kinase A negatively regulates Ca2 signalling in Toxoplasma gondii

Alessandro D Uboldi, Mary-Louise Wilde, Emi A McRae, Rebecca J Stewart, Laura F Dagley, Luning Yang, Nicholas J Katris, Sanduni Hapuarachchi, Michael J Coffey, Adele M Lehane, Cyrille Y Botte, Ross F Waller, Andrew Webb, Malcolm J McConville, Christopher J Tonkin

Journal article  |  2018  |  PLOS Biology

Identification of novel lipid modifications and intermembrane dynamics in Corynebacterium glutamicum using high-resolution mass spectrometry

Stephan Klatt, Rajini Brammananth, Sean O'Callaghan, Konstantinos A Kouremenos, Dedreia Tull, Paul K Crellin, Ross L Coppel, Malcolm J McConville

Journal article  |  2018  |  Journal of Lipid Research

Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium

Asma Ul Husna, Nancy Wang, Simon A Cobbold, Hayley J Newton, Dianna M Hocking, Jonathan J Wilksch, Timothy A Scott, Mark R Davies, Jay C Hinton, Jai J Tree, Trevor Lithgow, Malcolm J McConville, Richard A Strugnell

Journal article  |  2018  |  Journal of Biological Chemistry

DExSI: a new tool for the rapid quantitation of C-13-labelled metabolites detected by GC-MS

Michael J Dagley, Malcolm J McConville

Journal article  |  2018  |  Bioinformatics

Characterization of the apicomplexan amino acid transporter (ApiAT) family in Toxoplasma gondii

Kathryn Parker, Stephen Fairweather, Esther Rajendran, Martin Blume, Malcolm McConville, Stefan Bröer, Kiaran Kirk, Giel van Dooren

Journal article  |  2018

Abstract Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their host cells, either th..

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Sarah A Best, David P De Souza, Ariena Kersbergen, Antonia N Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H Gray, Matthew E Ritchie, Malcolm J McConville, Kate D Sutherland

Journal article  |  2018  |  Cell Metabolism

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models

Eleanor C Saunders, Thomas Naderer, Jenny Chambers, Scott M Landfear, Malcolm J McConville

Journal article  |  2018  |  Molecular Microbiology

Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus

Susann Liebscher, Rebecca L Ambrose, Turgut E Aktepe, Andrea Mikulasova, Julia E Prier, Leah K Gillespie, Adam J Lopez-Denman, Thusitha WT Rupasinghe, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie

Journal article  |  2018  |  PLOS Pathogens

Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis

Samantha J Emery, Louise Baker, Brendan RE Ansell, Mehdi Mirzaei, Paul A Haynes, Malcom J McConville, Staffan G Svard, Aaron R Jex

Journal article  |  2018  |  GigaScience

The &ITPlasmodium falciparum &ITtranscriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding &ITvar &ITgenes

Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Simon A Cobbold, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham Brown, Karen P Day, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Michael F Duffy

Journal article  |  2018  |  PLOS Biology

Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages

Kylie J Boyce, David P De Souza, Saravanan Dayalan, Shivani Pasricha, Dedreia Tull, Malcolm J McConville, Alex Andrianopoulos

Journal article  |  2018  |  mSphere

Comparative Metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum Reveals Fundamental Differences in Active Metabolic Pathways and Suggests Novel Gene Annotations

Y Masukagami, DP De Souza, S Dayalan, C Bowen, S O'Callaghan, K Kouremenos, B Nijagal, D Tull, KA Tivendale, PF Markham, MJ McConville, GF Browning, FM Sansom

Journal article  |  2017  |  mSystems

Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei

Shivani Pasricha, James I MacRae, Hwa H Chua, Jenny Chambers, Kylie J Boyce, Malcolm J McConville, Alex Andrianopoulos

Journal article  |  2017  |  Frontiers in Cellular and Infection Microbiology

Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

Yilin Kang, David A Stroud, Michael J Baker, David P De Souza, Ann E Frazier, Michael Liem, Dedreia Tull, Suresh Mathivanan, Malcolm J McConville, David R Thorburn, Michael T Ryan, Diana Stojanovski

Journal article  |  2017  |  Molecular Cell

Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS)

Lenka A Vodstrcil, Thusitha WT Rupasinghe, Fabian YS Kong, Dedreia Tull, Karen Worthington, Marcus Y Chen, Wilhelmina M Huston, Peter Timms, Malcolm J McConville, Christopher K Fairley, Catriona S Bradshaw, Sepehr N Tabrizi, Jane S Hocking

Journal article  |  2017  |  PLOS ONE

Analysis of Ca2 mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules

Rebecca J Stewart, Lachlan Whitehead, Brunda Nijagal, Brad E Sleebs, Guillaume Lessene, Malcolm J McConville, Kelly L Rogers, Christopher J Tonkin

Journal article  |  2017  |  Cellular Microbiology

Pharmacokinetics of a single 1 g dose of azithromycin in rectal tissue in men

Fabian YS Kong, Thusitha W Rupasinghe, Julie A Simpson, Lenka A Vodstrcil, Christopher K Fairley, Malcolm J McConville, Jane S Hocking

Journal article  |  2017  |  PLOS ONE

Identification of a Membrane Protein Required for Lipomannan Maturation and Lipoarabinomannan Synthesis in Corynebacterineae

Tamaryn J Cashmore, Stephan Klatt, Yoshiki Yamaryo-Botte, Rajini Brammananth, Arek K Rainczuk, Malcolm J McConville, Paul K Crellin, Ross L Coppel

Journal article  |  2017  |  Journal of Biological Chemistry

Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines

Brendan RE Ansell, Louise Baker, Samantha J Emery, Malcolm J McConville, Staffan G Svard, Robin B Gasser, Aaron R Jex

Journal article  |  2017  |  Frontiers in Microbiology

MASTR-MS: a web-based collaborative laboratory information management system (LIMS) for metabolomics

Adam Hunter, Saravanan Dayalan, David De Souza, Brad Power, Rodney Lorrimar, Tamas Szabo, Nguyen Thu, Sean O'Callaghan, Jeremy Hack, James Pyke, Amsha Nahid, Roberto Barrero, Ute Roessner, Vladimir Likic, Dedreia Tull, Antony Bacic, Malcolm McConville, Matthew Bellgard

Journal article  |  2017  |  Metabolomics

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

Sanduni V Hapuarachchi, Simon A Cobbold, Sarah H Shafik, Adelaide SM Dennis, Malcolm J McConville, Rowena E Martin, Kiaran Kirk, Adele M Lehane

Journal article  |  2017  |  PLOS Pathogens

Characterization of the Plasmodium falciparum and P-berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast

Melanie J Shears, James I MacRae, Vanessa Mollard, Christopher D Goodman, Angelika Sturm, Lindsey M Orchard, Manuel Llins, Malcolm J McConville, Cyrille Y Botte, Geoffrey I McFadden

Journal article  |  2017  |  Cellular Microbiology

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

Anubhav Srivastava, Nisha Philip, Katie R Hughes, Konstantina Georgiou, James I MacRae, Michael P Barrett, Darren J Creek, Malcolm J McConville, Andrew P Waters

Journal article  |  2016  |  PLOS Pathogens

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

Victoria C Foletta, Michelle Palmieri, Joachim Kloehn, Shaun Mason, Stephen F Previs, Malcolm J McConville, Oliver M Sieber, Clinton R Bruce, Greg M Kowalski

Journal article  |  2016  |  Metabolites

Plasma Lipidomic Profiles Improve on Traditional Risk Factors for the Prediction of Cardiovascular Events in Type 2 Diabetes Mellitus

Zahir H Alshehry, Piyushkumar A Mundra, Christopher K Barlow, Natalie A Mellett, Gerard Wong, Malcolm J McConville, John Simes, Andrew M Tonkin, David R Sullivan, Elizabeth H Barnes, Paul J Nestel, Bronwyn A Kingwell, Michel Marre, Bruce Neal, Neil R Poulter, Anthony Rodgers, Bryan Williams, Sophia Zoungas, Graham S Hillis, John Chalmers, et al.

Journal article  |  2016  |  Circulation

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

Benjamin K Dickerman, Brendan Elsworth, Simon A Cobbold, Catherine Q Nie, Malcolm J McConville, Brendan S Crabb, Paul R Gilson

Journal article  |  2016  |  Scientific Reports

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

Darren J Creek, Hwa H Chua, Simon A Cobbold, Brunda Nijagal, James I MacRae, Benjamin K Dickerman, Paul R Gilson, Stuart A Ralph, Malcolm J McConville

Journal article  |  2016  |  Antimicrobial Agents and Chemotherapy

Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis

Brendan RE Ansell, Malcolm J McConville, Louise Baker, Pasi K Korhonen, Samantha J Emery, Staffan G Svard, Robin B Gasser, Aaron R Jex

Journal article  |  2016  |  Antimicrobial Agents and Chemotherapy

Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice

Elinor Hortle, Brunda Nijagal, Denis C Bauer, Lora M Jensen, Seong Beom Ahn, Ian A Cockburn, Shelley Lampkin, Dedreia Tull, Malcolm J McConville, Brendan J McMorran, Simon J Foote, Gaetan Burgio

Journal article  |  2016  |  Blood

Metabolic Crosstalk between Leishmania and the Macrophage Host

Malcolm J McConville

Journal article  |  2016  |  Trends in Parasitology

Using metabolomics to dissect host-parasite interactions

J Kloehn, M Blume, SA Cobbold, EC Saunders, MJ Dagley, MJ McConville

Journal article  |  2016  |  Current Opinion in Microbiology

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase

Souad Amiar, James I MacRae, Damien L Callahan, David Dubois, Giel G van Dooren, Melanie J Shears, Marie-France Cesbron-Delauw, Eric Marechal, Malcolm J McConville, Geoffrey I McFadden, Yoshiki Yamaryo-Botte, Cyrille Y Botte

Journal article  |  2016  |  PLOS Pathogens

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo [4,5-b]pyridine-2-yl)anilide

Daniel Stoessel, Cameron J Nowell, Amy J Jones, Lori Ferrins, Katherine M Ellis, Jennifer Riley, Raphael Rahmani, Kevin D Read, Malcolm J McConville, Vicky M Avery, Jonathan B Baell, Darren J Creek

Journal article  |  2016  |  Metabolomics

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis

Greg M Kowalski, Steven Hamley, Ahrathy Selathurai, Joachim Kloehn, David P De Souza, Sean O'Callaghan, Brunda Nijagal, Dedreia L Tull, Malcolm J McConville, Clinton R Bruce

Journal article  |  2016  |  Scientific Reports

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema

Lisa M Sedger, Dedreia L Tull, Malcolm J McConville, David P De Souza, Thusitha WT Rupasinghe, Spencer J Williams, Saravanan Dayalan, Daniel Lanzer, Helen Mackie, Thomas C Lam, John Boyages

Journal article  |  2016  |  PLOS ONE

Carbon metabolism of parasitic protozoa: strategies for surviving in intracellular niches

Malcolm McConville, Eleanor Saunders, Fleur Sernee, Martin Blume, Joachim Kloehn, Julie Ralton

Conference Proceedings  |  2016  |  FASEB JOURNAL

Carbon metabolism of parasitic protozoa: strategies for surviving in intracellular niches

Malcolm McConville, Eleanor Saunders, Fleur Sernee, Martin Blume, Joachim Kloehn, Julie Ralton

Conference Proceedings  |  2016  |  FASEB JOURNAL

Towards Improving Point-of-Care Diagnosis of Non-malaria Febrile Illness: A Metabolomics Approach

Saskia Decuypere, Jessica Maltha, Stijn Deborggraeve, Nicholas JW Rattray, Guiraud Issa, Kabore Berenger, Palpouguini Lompo, Marc C Tahita, Thusitha Ruspasinghe, Malcolm McConville, Royston Goodacre, Halidou Tinto, Jan Jacobs, Jonathan R Carapetis

Journal article  |  2016  |  PLOS Neglected Tropical Diseases

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Monica Rolando, Pedro Escoll, Tamara Nora, Joelle Botti, Valarie Boitez, Carmen Bedia, Craig Daniels, Gilu Abraham, Peter J Stogios, Tatiana Skarina, Charlotte Christophe, Delphine Dervins-Ravault, Christel Cazalet, Hubert Hilbi, Thusitha WT Rupasinghe, Dedreia Tull, Malcolm J McConville, Sze Ying Ong, Elizabeth L Hartland, Patrice Codogno, et al.

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Overexpression of Striated Muscle Activator of Rho Signaling (STARS) Increases C2C12 Skeletal Muscle Cell Differentiation

Marita A Wallace, Paula A Della Gatta, Bilal Ahmad Mir, Greg M Kowalski, Joachim Kloehn, Malcom J McConville, Aaron P Russell, Severine Lamon

Journal article  |  2016  |  Frontiers in Physiology

Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs

Simon A Cobbold, Hwa H Chua, Brunda Nijagal, Darren J Creek, Stuart A Ralph, Malcolm J McConville

Journal article  |  2016  |  Journal of Infectious Diseases

Using metabolomic approaches to characterize the human pathogen Leishmania in macrophages

J Kloehn, EC Saunders, MJ McConville

Book Chapter  |  2016

Regulation of Starch Stores by a Ca2 -Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii

Alessandro D Uboldi, James M McCoy, Martin Blume, Motti Gerlic, David JP Ferguson, Laura F Dagley, Cherie T Beahan, David I Stapleton, Paul R Gooley, Antony Bacic, Seth L Masters, Andrew I Webb, Malcolm J McConville, Christopher J Tonkin

Journal article  |  2015  |  Cell Host & Microbe

A tandem liquid chromatography-mass spectrometry (LC-MS) method for profiling small molecules in complex samples

James S Pyke, Damien L Callahan, Komal Kanojia, Jairus Bowne, Sheena Sahani, Dedreia Tull, Antony Bacic, Malcolm J McConville, Ute Roessner

Journal article  |  2015  |  Metabolomics

Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites

Brendan RE Ansell, Malcolm J McConville, Louise Baker, Pasi K Korhonen, Neil D Young, Ross S Hall, Cristian AA Rojas, Staffan G Svard, Robin B Gasser, Aaron R Jex

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

Drug resistance in Giardia duodenalis

Brendan RE Ansell, Malcolm J McConville, Showgy Y Ma'ayeh, Michael J Dagley, Robin B Gasser, Staffan G Svard, Aaron R Jex

Journal article  |  2015  |  Biotechnology Advances

Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target

Stacey M Allen, Erin E Lim, Esther Jortzik, Janina Preuss, Hwa Huat Chua, James I MacRae, Stefan Rahlfs, Kristina Haeussler, Matthew T Downton, Malcolm J McConville, Katja Becker, Stuart A Ralph

Journal article  |  2015  |  FEBS Journal

Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages

Thomas Naderer, Joanne Heng, Eleanor C Saunders, Joachim Kloehn, Thusitha W Rupasinghe, Tracey J Brown, Malcolm J McConville

Journal article  |  2015  |  PLOS Pathogens

High-Content Assay for Measuring Intracellular Growth of Leishmania in Human Macrophages

Michael J Dagley, Eleanor C Saunders, Kaylene J Simpson, Malcolm J McConville

Journal article  |  2015  |  ASSAY and Drug Development Technologies

A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and Virulence

Martin Blume, Richard Nitzsche, Ulrich Sternberg, Motti Gerlic, Seth L Masters, Nishith Gupta, Malcolm J McConville

Journal article  |  2015  |  Cell Host & Microbe

In vivo cardiac glucose metabolism in the high-fat fed mouse: Comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach

Greg M Kowalski, David P De Souza, Steve Risis, Micah L Burch, Steven Hamley, Joachim Kloehn, Ahrathy Selathurai, Robert S Lee-Young, Dedreia Tull, Sean O'Callaghan, Malcolm J McConville, Clinton R Bruce

Journal article  |  2015  |  Biochemical and Biophysical Research Communications

High risk prostate cancer is associated with distinct transcriptional and lipid profiles in adipose tissue

Ryan Stuchbery, Stefano Mangiola, Yuen Tan, Thusita Rupasinghe, Saravanan Dayalan, Dedreia Tull, Malcolm McConville, Geoff Macintyre, Tony Costello, Christopher Hovens, Niall Corcoran

Conference Proceedings  |  2015  |  BJU INTERNATIONAL

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell

Srinivasan Ramakrishnan, Melissa D Docampo, James I MacRae, Julie E Ralton, Thusitha Rupasinghe, Malcolm J McConville, Boris Striepen

Journal article  |  2015  |  Molecular Microbiology

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse

Greg M Kowalski, David P De Souza, Micah L Burch, Steven Hamley, Joachim Kloehn, Ahrathy Selathurai, Dedreia Tull, Sean O'Callaghan, Malcolm J McConville, Clinton R Bruce

Journal article  |  2015  |  Biochemical and Biophysical Research Communications

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites

Anubhav Srivastava, Darren J Creek, Krystal J Evans, David De Souza, Louis Schofield, Sylke Mueller, Michael P Barrett, Malcolm J McConville, Andrew P Waters

Journal article  |  2015  |  PLOS Pathogens

An Efficient Single Phase Method for the Extraction of Plasma Lipids

Zahir H Alshehry, Christopher K Barlow, Jacquelyn M Weir, Youping Zhou, Malcolm J McConville, Peter J Meikle

Journal article  |  2015  |  Metabolites

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Alison N Thorburn, Craig I McKenzie, Sj Shen, Dragana Stanley, Laurence Macia, Linda J Mason, Laura K Roberts, Connie HY Wong, Raymond Shim, Remy Robert, Nina Chevalier, Jian K Tan, Eliana Marino, Rob J Moore, Lee Wong, Malcolm J McConville, Dedreia L Tull, Lisa G Wood, Vanessa E Murphy, Joerg Mattes, et al.

Journal article  |  2015  |  Nature Communications

Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate

Sebastian G Gornik, undefined Febrimarsa, Andrew M Cassin, James I MacRae, Abhinay Ramaprasad, Zineb Rchiad, Malcolm J McConville, Antony Bacic, Geoffrey I McFadden, Arnab Pain, Ross F Waller

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

A multi-platform metabolomics approach demonstrates changes in energy metabolism and the transsulfuration pathway in Chironomus tepperi following exposure to zinc

Sara M Long, Dedreia L Tull, Katherine J Jeppe, David P De Souza, Saravanan Dayalan, Vincent J Pettigrove, Malcolm J McConville, Ary A Hoffmann

Journal article  |  2015  |  Aquatic Toxicology

Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae

Yoshiki Yamaryo-Botte, Arek K Rainczuk, David J Lea-Smith, Rajini Brammananth, Phillip L van der Peet, Peter Meikle, Julie E Ralton, Thusita WT Rupasinghe, Spencer J Williams, Ross L Coppel, Paul K Crellin, Malcolm J McConville

Journal article  |  2015  |  ACS Chemical Biology

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

Greg M Kowalski, Joachim Kloehn, Micah L Burch, Ahrathy Selathurai, Steven Hamley, Stephanie AM Bayol, Severine Lamon, Matthew J Watt, Robert S Lee-Young, Malcolm J McConville, Clinton R Bruce

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling

Joachim Kloehn, Eleanor C Saunders, Sean O'Callaghan, Michael J Dagley, Malcolm J McConville

Journal article  |  2015  |  PLOS Pathogens

Leishmania carbon metabolism in the macrophage phagolysosome- feast or famine?

Malcolm J McConville, Eleanor C Saunders, Joachim Kloehn, Michael J Dagley

Journal article  |  2015  |  F1000Research

A number of medically important microbial pathogens target and proliferate within macrophages and other phagocytic cells in their ..

Use of C-13 Stable Isotope Labelling for Pathway and Metabolic Flux Analysis in Leishmania Parasites

Eleanor C Saunders, David R de Souza, Jennifer M Chambers, Milica Ng, James Pyke, Malcolm J McConville

Journal article  |  2015  |  Methods in Molecular Biology

Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives

Mark Gregory, Meng-Xin Yin, Malcolm J McConville, Eleanor Williams, Alex N Bullock, Stuart J Conway, Antony W Burgess, Bruno Catimel, Andrew B Holmes

Journal article  |  2015  |  Australian Journal of Chemistry

Using Fat to Turbo-Charge Intracellular Parasite Growth

Malcolm J McConville

Journal article  |  2014  |  Cell Host & Microbe

Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence

Fiona M Sansom, Julie E Ralton, M Fleur Sernee, Alice M Cohen, David J Hooker, Elizabeth L Hartland, Thomas Naderer, Malcolm J McConville

Journal article  |  2014  |  PLoS Neglected Tropical Diseases

H-1-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium-vitamin-D-3 supplementation in older men

John R Sheedy, Paul R Gooley, Amsha Nahid, Dedreia L Tull, Malcolm J McConville, Sonja Kukuljan, Caryl A Nowson, Robin M Daly, Peter R Ebeling

Journal article  |  2014  |  Applied Physiology, Nutrition and Metabolism

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

Rebecca D Oppenheim, Darren J Creek, James I Macrae, Katarzyna K Modrzynska, Paco Pino, Julien Limenitakis, Valerie Polonais, Frank Seeber, Michael P Barrett, Oliver Billker, Malcolm J McConville, Dominique Soldati-Favre

Journal article  |  2014  |  PLoS Pathogens

Open questions: microbes, metabolism and host-pathogen interactions

Malcolm McConville

Journal article  |  2014  |  BMC Biology

Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses

Kheng H Tan, Christine A Seers, Stuart G Dashper, Helen L Mitchell, James S Pyke, Vincent Meuric, Nada Slakeski, Steven M Cleal, Jenny L Chambers, Malcolm J McConville, Eric C Reynolds

Journal article  |  2014  |  PLoS Pathogens

Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity

James I MacRae, Sash Lopaticki, Alexander G Maier, Thusitha Rupasinghe, Amsha Nahid, Alan F Cowman, Malcolm J McConville

Journal article  |  2014  |  Molecular Microbiology

Letter to the Glycoforum Transforming Glycoscience: An Australian Perspective

Deirdre R Coombe, Christopher Davis, Geoff Fincher, Malcolm J McConville, Nicolle Packer, Keith A Stubbs, Spencer J Williams, Anne Dell

Journal article  |  2014  |  Glycobiology

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

Eleanor C Saunders, William W Ng, Joachim Kloehn, Jennifer M Chambers, Milica Ng, Malcolm J McConville

Journal article  |  2014  |  PLoS Pathogens

Chronic arsenic exposure and microbial drug resistance

Malcolm J McConville, Stuart A Ralph

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

MALARIA Sensing when it's time for sex

Leann Tilley, Malcolm McConville

Journal article  |  2013  |  Nature

POST-TREATMENT DETECTION OF AZITHROMYCIN IN HIGH-VAGINAL SWABS USING LIQUID CHROMATOGRAPHY AND TANDEM MASS SPECTROMETRY (LC-MS/MS)

LA Vodstrcil, T Rupasinghe, D Tull, K Worthington, MY Chen, WM Huston, CK Fairley, M McConville, SN Tabrizi, JS Hocking

Conference Proceedings  |  2013  |  Sexually Transmitted Infections

Membrane targeting of the small myristoylated protein 2 (SMP-2) in Leishmania major

Joanne Heng, Eleanor C Saunders, Paul R Gooley, Malcolm J McConville, Thomas Naderer, Dedreia Tull

Journal article  |  2013  |  Molecular and Biochemical Parasitology

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

James I MacRae, Matthew WA Dixon, Megan K Dearnley, Hwa H Chua, Jennifer M Chambers, Shannon Kenny, Iveta Bottova, Leann Tilley, Malcolm J McConville

Journal article  |  2013  |  BMC Biology

Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites

Cyrille Y Botte, Yoshiki Yamaryo-Botte, Thusitha WT Rupasinghe, Kylie A Mullin, James I MacRae, Timothy P Spurck, Ming Kalanon, Melanie J Shears, Ross L Coppel, Paul K Crellin, Eric Marechal, Malcolm J McConville, Geoffrey I McFadden

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Synthesis, Structural Elucidation, And Biochemical Analysis of Immunoactive Glucuronosyl Diacylglycerides of Mycobacteria and Corynebacteria

Benjamin Cao, Xingqiang Chen, Yoshiki Yamaryo-Botte, Mark B Richardson, Kirstee L Martin, George N Khairallah, Thusita WT Rupasinghe, Roisin M O'Flaherty, Richard AJ O'Hair, Julie E Ralton, Paul K Crellin, Ross L Coppel, Malcolm J McConville, Spencer J Williams

Journal article  |  2013  |  Journal of Organic Chemistry

Leishmania major Methionine Sulfoxide Reductase A Is Required for Resistance to Oxidative Stress and Efficient Replication in Macrophages

Fiona M Sansom, Leonie Tang, Julie E Ralton, Eleanor C Saunders, Thomas Naderer, Malcolm J McConville

Journal article  |  2013  |  PLoS One

Alveolate Mitochondrial Metabolic Evolution: Dinoflagellates Force Reassessment of the Role of Parasitism as a Driver of Change in Apicomplexans

Jillian C Danne, Sebastian G Gornik, James I MacRae, Malcolm J McConville, Ross F Waller

Journal article  |  2013  |  Molecular Biology and Evolution

Cross-Platform Urine Metabolomics of Experimental Hyperglycemia in Type 2 Diabetes

Liesbet Temmerman

Journal article  |  2013  |  Journal of Diabetes and Metabolism

Normalizing and Integrating Metabolomics Data

Alysha M De Livera, Daniel A Dias, David De Souza, Thusitha Rupasinghe, James Pyke, Dedreia Tull, Ute Roessner, Malcolm McConville, Terence P Speed

Journal article  |  2012  |  Analytical Chemistry

The Lipoprotein LpqW Is Essential for the Mannosylation of Periplasmic Glycolipids in Corynebacteria

Arek K Rainczuk, Yoshiki Yamaryo-Botte, Rajini Brammananth, Timothy P Stinear, Torsten Seemann, Ross L Coppel, Malcolm J McConville, Paul K Crellin

Journal article  |  2012  |  Journal of Biological Chemistry

MR1 presents microbial vitamin B metabolites to MAIT cells

Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jerome Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard AJ O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Nature

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

James I MacRae, Lilach Sheiner, Amsha Nahid, Christopher Tonkin, Boris Striepen, Malcolm J McConville

Journal article  |  2012  |  Cell Host & Microbe

PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools

Sean O'Callaghan, David P De Souza, Andrew Isaac, Qiao Wang, Luke Hodkinson, Moshe Olshansky, Tim Erwin, Bill Appelbe, Dedreia L Tull, Ute Roessner, Antony Bacic, Malcolm J McConville, Vladimir A Likic

Journal article  |  2012  |  BMC Bioinformatics

Biosynthesis and transport of cell wall glycolipids in mycobacteria

Malcolm John McConville, Areck Rainczuk, Yoshiki Yamaryo-Botte, James Pyke, Ross Coppel, Paul Crellin

Conference Proceedings  |  2012  |  FASEB JOURNAL

Acylation-dependent and-independent membrane targeting and distinct functions of small myristoylated proteins (SMPs) in Leishmania major

Dedreia Tull, Joanne Heng, Paul R Gooley, Thomas Naderer, Malcolm J McConville

Journal article  |  2012  |  International Journal for Parasitology

Discovery of Inhibitors of Leishmania beta-1,2-Mannosyltransferases Using a Click-Chemistry-Derived Guanosine Monophosphate Library

Phillip van der Peet, Julie E Ralton, Malcolm J McConville, Spencer J Williams

Journal article  |  2012  |  PLoS One

Apicoplast and Endoplasmic Reticulum Cooperate in Fatty Acid Biosynthesis in Apicomplexan Parasite Toxoplasma gondii

Srinivasan Ramakrishnan, Melissa D Docampo, James I MacRae, Francois M Pujol, Carrie F Brooks, Giel G van Dooren, J Kalervo Hiltunen, Alexander J Kastaniotis, Malcolm J McConville, Boris Striepen

Journal article  |  2012  |  Journal of Biological Chemistry

Metabolomic analysis of trypanosomatid protozoa

Darren J Creek, Jana Anderson, Malcolm J McConville, Michael P Barrett

Journal article  |  2012  |  Molecular and Biochemical Parasitology

LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data.

Eleanor C Saunders, James I MacRae, Thomas Naderer, Milica Ng, Malcolm J McConville, Vladimir A Likić

Journal article  |  2012  |  Methods in Molecular Biology

The complexity of the metabolic networks in even the simplest organisms has raised new challenges in organizing metabolic informat..

LeishCyc: A guide to building a metabolic pathway database and visualization of metabolomic data

EC Saunders, JI MacRae, T Naderer, M Ng, MJ McConville, VA Likić

Journal article  |  2012  |  Methods in Molecular Biology

FAD286, an Aldosterone Synthase Inhibitor, Reduces Retinal Neovascularization

Devy Deliyanti, Antonia G Miller, Katrina J Binger, Genevieve Tan, Lainie Sutton, M Jayamanne, Thusita Rupasinghe, Deedjra L Tull, Malcolm McConville, Jennifer L Wilkinson-Berka

Conference Proceedings  |  2011  |  HYPERTENSION

Comprehensive Profiling and Quantitation of Amine Group Containing Metabolites

Berm A Boughton, Damien L Callahan, Claudio Silva, Jairus Bowne, Amsha Nahid, Thusita Rupasinghe, Dedreja L Tull, Malcolm J McConville, Antony Bacic, Ute Roessner

Journal article  |  2011  |  Analytical Chemistry

FAD286, an aldosterone synthase inhibitor, reduces retinal neovascularisation

D Deliyanti, AG Miller, KJ Binger, G Tan, L Sutton, M Jayamanne, T Rupasinghe, DL Tull, M McConville, JL Wilkinson-Berka

Conference Proceedings  |  2011  |  DIABETOLOGIA

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites

Cyrille Y Botte, Yoshiki Yamaryo-Botte, Jan Janouskovec, Thusita Rupasinghe, Patrick J Keeling, Paul Crellin, Ross L Coppel, Eric Marechal, Malcolm J McConville, Geoffrey I McFadden

Journal article  |  2011  |  Journal of Biological Chemistry

Isotopomer Profiling of Leishmania mexicana Promastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

Eleanor C Saunders, William W Ng, Jennifer M Chambers, Milica Ng, Thomas Naderer, Jens O Kroemer, Vladimir A Likic, Malcolm J McConville

Journal article  |  2011  |  Journal of Biological Chemistry

Inositol lipid metabolism in mycobacteria: Biosynthesis and regulatory mechanisms

Yasu S Morita, Takeshi Fukuda, Chubert BC Sena, Yoshiki Yamaryo-Botte, Malcolm J McConville, Taroh Kinoshita

Journal article  |  2011  |  Biochimica et Biophysica Acta - General Subjects

Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner

James E Vince, Dedreia Tull, Scott Landfear, Malcolm J McConville

Journal article  |  2011  |  International Journal for Parasitology

Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host

Thomas Naderer, Orwa Dandash, Malcolm J McConville

Journal article  |  2011  |  Molecular Microbiology

Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2

Michael J Dagley, Ian E Gentle, Traude H Beilharz, Filomena A Pettolino, Julianne T Djordjevic, Tricia L Lo, Nathalie Uwamahoro, Thusitha Rupasinghe, Dedreja L Tull, Malcolm McConville, Cecile Beaurepaire, Andre Nantel, Trevor Lithgow, Aaron P Mitchell, Ana Traven

Journal article  |  2011  |  Molecular Microbiology

A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments

MD Robinson, DP De Souza, WW Keen, EC Saunders, MJ McConville, TP Speed, VA Likić

Book Chapter  |  2011

Metabolic Pathways Required for the Intracellular Survival of Leishmania

Malcolm J McConville, Thomas Naderer

Journal article  |  2011  |  Annual Review of Microbiology

Intracellular growth and pathogenesis of Leishmania parasites

Thomas Naderer, Malcolm J McConville

Journal article  |  2011  |  Essays in Biochemistry

Evidence That Intracellular Stages of Leishmania major Utilize Amino Sugars as a Major Carbon Source

Thomas Naderer, Joanne Heng, Malcolm J McConville

Journal article  |  2010  |  PLoS Pathogens

Central carbon metabolism of Leishmania parasites

Eleanor C Saunders, David P de Souza, Thomas Naderer, Marijke F Sernee, Julie E Ralton, Maria A Doyle, James I MacRae, Jenny L Chambers, Joanne Heng, Amsha Nahid, Vladimir A Likic, Malcolm J McConville

Journal article  |  2010  |  Parasitology

Recognition and Detoxification of the Insecticide DDT by Drosophila melanogaster Glutathione S-Transferase D1

Wai Yee Low, Susanne C Feil, Hooi Ling Ng, Michael A Gorman, Craig J Morton, James Pyke, Malcolm J McConville, Michael Bieri, Yee-Foong Mok, Charles Robin, Paul R Gooley, Michael W Parker, Philip Batterham

Journal article  |  2010  |  Journal of Molecular Biology

Stress-induced Synthesis of Phosphatidylinositol 3-Phosphate in Mycobacteria

Yasu S Morita, Yoshiki Yamaryo-Botte, Kana Miyanagi, Judy M Callaghan, John H Patterson, Paul K Crellin, Ross L Coppel, Helen Billman-Jacobe, Taroh Kinoshita, Malcolm J McConville

Journal article  |  2010  |  Journal of Biological Chemistry

A sample preparation protocol for H-1 nuclear magnetic resonance studies of water-soluble metabolites in blood and urine

John R Sheedy, Peter R Ebeling, Paul R Gooley, Malcolm J McConville

Journal article  |  2010  |  Analytical Biochemistry

Membrane protein SMP-1 is required for normal flagellum function in Leishmania

Dedreia Tull, Thomas Naderer, Timothy Spurck, Haydyn DT Mertens, Joanne Heng, Geoffrey I McFadden, Paul R Gooley, Malcolm J McConville

Journal article  |  2010  |  Journal of Cell Science

Systems biology: the next frontier for bioinformatics.

Vladimir A Likić, Malcolm J McConville, Trevor Lithgow, Antony Bacic

Journal article  |  2010  |  Advances in Bioinformatics

Biochemical systems biology augments more traditional disciplines, such as genomics, biochemistry and molecular biology, by champi..

LeishCyc: a biochemical pathways database for Leishmania major

Maria A Doyle, James I MacRae, David P De Souza, Eleanor C Saunders, Malcolm J McConville, Vladimir A Likic

Journal article  |  2009  |  BMC Systems Biology

A combined technological metabolomic strategy for the identification of metabolites in human urine

JR Sheedy, PR Ebeling, REH Wettenhall, PR Gooley, M McConville

Conference Proceedings  |  2009  |  Bone

Oocyst wall formation and composition in coccidian parasites

Kelly Mai, Philippa A Sharman, Robert A Walker, Marilyn Katrib, David De Souza, Malcolm J McConville, Michael G Wallach, Sabina I Belli, David JP Ferguson, Nicholas C Smith

Journal article  |  2009  |  Memorias do Instituto Oswaldo Cruz

Glycosylated compounds of parasitic protozoa

Joanne Heng, Thomas Naderer, Stuart A Ralph, Malcolm J McConville

Book Chapter  |  2009

Role of hexosamine biosynthesis in Leishmania growth and virulence

Thomas Naderer, Edmund Wee, Malcolm J McConville

Journal article  |  2008  |  Molecular Microbiology

Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host

James E Vince, Dedreia L Tull, Timothy Spurck, Merran C Derby, Geoffrey I McFadden, Paul A Gleeson, Suzanne Gokool, Malcolm J McConville

Journal article  |  2008  |  Eukaryotic Cell

Humans lack iGb3 due to the absence of functional iGb3-synthase: Implications for NKT cell development and transplantation

Dale Christiansen, Julie Milland, Effie Mouhtouris, Hilary Vaughan, Daniel G Pellicci, Malcolm J McConville, Dale I Godfrey, Mauro S Sandrin

Journal article  |  2008  |  PLoS Biology

Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutant

Paul K Crellin, Svetozar Kovacevic, Kirstee L Martin, Rajini Brammananth, Yasu S Morita, Helen Billman-Jacobe, Malcolm J McConville, Ross L Coppell

Journal article  |  2008  |  Journal of Bacteriology

Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae

David J Lea-Smith, Kirstee L Martin, James S Pyke, Dedreia Tull, Malcolm J McConville, Ross L Coppel, Paul K Crellin

Journal article  |  2008  |  Journal of Biological Chemistry

Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfamates by aryl sulfatase

Pavla Bojarova, Emma Denehy, Ian Walker, Karen Loft, David P De Souza, LW Lawrence Woo, Barry VL Potter, Malcolm J McConville, Spencer J Williams

Journal article  |  2008  |  ChemBioChem

The Leishmania-macrophage interaction: a metabolic perspective

Thomas Naderer, Malcolm J McConville

Journal article  |  2008  |  Cellular Microbiology

Metabolite profiling of Plasmodium falciparum.

James MacRae, David De Souza, Vladimir Likic, Sash Lopatieki, Alan Cowman, Malcolm J McConville

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Analysis of the Leishmania Metabolome

M MCCONVILLE, D DE SOUZA, E SAUNDERS, J PYKE, T NADERER, undefined Ellis, M SERNEE, J RALTON, V LIKIC

Book Chapter  |  2008

A high-resolution solution structure of a trypanosomatid FYVE domain

Haydyn DT Mertens, Judy M Callaghan, James D Swarbrick, Malcolm J Mcconville, Paul R Gooley

Journal article  |  2007  |  Protein Science

A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments

Mark D Robinson, David P De Souza, Woon Wai Keen, Eleanor C Saunders, Malcolm J McConville, Terence P Speed, Vladimir A Likic

Journal article  |  2007  |  BMC Bioinformatics

Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications

Cameron R Stewart, Antonio Haw, Roland Lopez, Thomas O McDonald, Judy M Callaghan, Malcolm J McConville, Kathryn J Moore, Geoffrey J Howlett, Kevin D O'Brien

Journal article  |  2007  |  Journal of Lipid Research

Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins

Yaniv Lustig, Yaron Vagima, Hanoch Goldshmidt, Avigail Erlanger, Vered Ozeri, James Vince, Malcolm J McConville, Dennis M Dwyer, Scott M Landfear, Shulamit Michaeli

Journal article  |  2007  |  Eukaryotic Cell

The molecular basis of Leishmania pathogenesis

Malcolm J McConville, Emanuela Handman

Journal article  |  2007  |  International Journal for Parasitology

Living in a phagolysosome; metabolism of Leishmania amastigotes

Malcolm J McConville, David de Souza, Eleanor Saunders, Vladimir A Likic, Thomas Naderer

Journal article  |  2007  |  Trends in Parasitology

WITHDRAWN: The molecular basis of Leishmania pathogenesis.

Malcolm J McConville, Emanuela Handman

Journal article  |  2007  |  International Journal for Parasitology

The Publisher regrets that this article was an accidental duplication of an article that has already been published in PARA 37/10 ..

Molecular mimicry in Campylobacter jejuni: role of the lipo-oligosaccharide core oligosaccharide in inducing anti-ganglioside antibodies

Viraj N Perera, Irving Nachamkin, Huong Ung, John H Patterson, Malcolm J McConville, Peter J Coloe, Benjamin N Fry

Journal article  |  2007  |  FEMS Immunology and Medical Microbiology

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides

Abigail Clements, Dedreia Tull, Adam W Jenney, Jacinta L Farn, Sang-Hyun Kim, Russell E Bishop, Joseph B McPhee, Robert EW Hancock, Elizabeth L Hartland, Martin J Pearse, Odilia LC Wijburg, David C Jackson, Malcolm J McConville, Richard A Strugnell

Journal article  |  2007  |  Journal of Biological Chemistry

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space

Ian E Gentle, Andrew J Perry, Felicity H Alcock, Vladimir A Likic, Pavel Dolezal, Ee Ting Ng, Anthony W Purcell, Malcolm McConnville, Thomas Naderer, Anne-Laure Chanez, Fabien Charriere, Caroline Aschinger, Andre Schneider, Kostas Tokatlidis, Trevor Lithgow

Journal article  |  2007  |  Molecular Biology and Evolution

A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15

Daniel HD Gray, Dedreia Tull, Tomoo Ueno, Natalie Seach, Brendan J Classon, Ann Chidgey, Malcolm J McConville, Richard L Boyd

Journal article  |  2007  |  Journal of Immunology

The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan

David J Lea-Smith, James S Pyke, Dedreia Tull, Malcolm J McConville, Ross L Coppel, Paul K Crellin

Journal article  |  2007  |  Journal of Biological Chemistry

Galactose-derived phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria

Zoran Dinev, Carlie T Gannon, Caroline Egan, Jacinta A Watt, Malcolm J McConville, Spencer J Williams

Journal article  |  2007  |  Organic & Biomolecular Chemistry

Chewing the fat on natural killer T cell development

Dale I Godfrey, Malcolm J McConville, Daniel G Pellicci

Journal article  |  2006  |  Journal of Experimental Medicine

PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria

Yasu S Morita, Chubert BC Sena, Ross F Waller, Ken Kurokawa, M Fleur Sernee, Fumiki Nakatani, Ruth E Haites, Helen Billman-Jacobe, Malcolm J McConville, Yusuke Maeda, Taroh Kinoshita

Journal article  |  2006  |  Journal of Biological Chemistry

Use of click chemistry to define the substrate specificity of Leishmania beta-1,2-mannosyltransferases

Phillip van der Peet, Carlie T Gannon, Ian Walker, Zoran Dinev, Marcus Angelin, Shanna Tam, Julie E Ralton, Malcolm J McConville, Spencer J Williams

Journal article  |  2006  |  ChemBioChem

Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer

M Fleur Sernee, Julie E Ralton, Zoran Dinev, George N Khairallah, Richard A O'Hair, Spencer J Williams, Malcolm J McConville

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

Progressive peak clustering in GC-MS metabolomic experiments applied to Leishmania parasites

David P De Souza, Eleanor C Saunders, Malcolm J McConville, Vladimir A Likic

Journal article  |  2006  |  Bioinformatics

Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria

S Kovacevic, D Anderson, YS Morita, J Patterson, R Haites, BNI McMillan, R Coppel, MJ McConville, H Billman-Jacobe

Journal article  |  2006  |  Journal of Biological Chemistry

Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase

T Naderer, MA Ellis, MF Sernee, DP De Souza, J Curtis, E Handman, MJ McConville

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

Role and regulation of glycosylation pathways in leishmania parasites

MJ McConville, F Sernee, JE Ralton, T Naderer, M Ellis, D De Souza, E Saunders, V Likic

Conference Proceedings  |  2006  |  FASEB JOURNAL

H-1, C-13 and N-15 resonance assignments of SMP-1: A small myristoylated protein from Leishmania major

Paul R Gooley, Haydyn DT Mertens, Dedreia Tull, Malcolm J McConville

Journal article  |  2006  |  Journal of Biomolecular NMR

Cyanogenic glycosides from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae)

RE Miller, MJ McConville, IE Woodrow

Journal article  |  2006  |  Phytochemistry

Distinct protein classes including novel merozoite surface antigens in raft-like membranes of Plasmodium falciparum

PR Sanders, PR Gilson, GT Cantin, DC Greenbaum, T Nebl, DJ Carucci, MJ McConville, L Schofield, AN Hodder, JR Yates, BS Crabb

Journal article  |  2005  |  Journal of Biological Chemistry

Compartmentalization of lipid biosynthesis in mycobacteria

YS Morita, R Velasquez, E Taig, RF Waller, JH Patterson, D Tull, SJ Williams, H Billman-Jacobe, MJ McConville

Journal article  |  2005  |  Journal of Biological Chemistry

Function of phosphatidylinositol in mycobacteria

RE Haites, YS Morita, MJ McConville, HB Jacobe

Journal article  |  2005  |  Journal of Biological Chemistry

SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania

D Tull, JE Vince, JM Callaghan, T Naderer, T Spurck, GI McFadden, G Currie, K Ferguson, A Bacic, MJ McConville

Journal article  |  2004  |  Molecular Biology of the Cell

Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium avium

D Jeevarajah, JH Patterson, E Taig, T Sargeant, MJ McConville, H Billman-Jacobe

Journal article  |  2004  |  Journal of Bacteriology

Purification, characterization of O-acetylated sialoglycoconjugates-specific IgM, and development of an enzyme-linked immunosorbent assay for diagnosis and follow-up of Indian visceral leishmaniasis patients

S Bandyopadhyay, M Chatterjee, S Pal, RF Waller, S Sundar, MJ McConville, C Mandal

Journal article  |  2004  |  Diagnostic Microbiology and Infectious Disease

Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host

T Naderer, JE Vince, MJ McConville

Journal article  |  2004  |  Current Molecular Medicine

Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites

MA Dodge, RF Waller, LMC Chow, MM Zaman, LM Cotton, MJ McConville, DF Wirth

Journal article  |  2004  |  Molecular Microbiology

Biosynthesis of mycobacterial phosphatidylinositol mannosides

YS Morita, JH Patterson, H Billman-Jacobe, MJ McConville

Journal article  |  2004  |  Biochemical Journal

Biosynthesis of mycobacterial phosphatidylinositol mannosides.

Yasu S Morita, John H Patterson, Helen Billman-Jacobe, Malcolm J McConville

Journal article  |  2004  |  The Biochemical journal

All mycobacterial species, including pathogenic Mycobacterium tuberculosis, synthesize an abundant class of phosphatidylinositol m..

More plastids in human parasites?

RF Waller, MJ McConville, GI McFadden

Journal article  |  2004  |  Trends in Parasitology

Evidence that intracellular beta 1-2 mannan is a virulence factor in Leishmania parasites

JE Ralton, T Naderer, HL Piraino, TA Bashtannyk, JM Callaghan, MJ McConville

Journal article  |  2003  |  Journal of Biological Chemistry

MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling

MJ de Veer, JM Curtis, TM Baldwin, JA DiDonato, A Sexton, MJ McConville, E Handman, L Schofield

Journal article  |  2003  |  European Journal of Immunology

Mannose metabolism is required for mycobacterial growth

JH Patterson, RF Waller, D Jeevarajah, H Billman-Jacobe, MJ McConville

Journal article  |  2003  |  Biochemical Journal

Leishmania major proteophosphoglycans exist as membrane-bound and soluble forms and localise to the cell membrane, the flagellar pocket and the lysosome

B Foth, A Piani, JM Curtis, T Ilg, M McConville, E Handman

Journal article  |  2002  |  International Journal for Parasitology

Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids

T Naderer, MJ McConville

Journal article  |  2002  |  Molecular and Biochemical Parasitology

Developmental changes in lysosome morphology and function Leishmania parasites

RF Waller, MJ McConville

Journal article  |  2002  |  International Journal for Parasitology

Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatis

D Jeevarajah, JH Patterson, MJ McConville, H Billman-Jacobe

Journal article  |  2002  |  Microbiology

Targeting of the GRIP domain to the trans-Golgi network is conserved from protists to animals

MJ McConville, SC Ilgoutz, RD Teasdale, BJ Foth, A Matthews, KA Mullin, PA Gleeson

Journal article  |  2002  |  European Journal of Cell Biology

Intracellular trafficking of glycosylphosphatidylinositol (GPI)-anchored proteins and free GPIs in Leishmania mexicana

JE Ralton, KA Mullin, MJ McConville

Journal article  |  2002  |  Biochemical Journal

Secretory pathway of trypanosomatid parasites

MJ McConville, KA Mullin, SC Ilgoutz, RD Teasdale

Journal article  |  2002  |  Microbiology and Molecular Biology Reviews

Compartmentalisation and regulation of ER glycosylation machinery in Leishmania parasites

RF Waller, MJ McConville

Journal article  |  2001  |  MOLECULAR BIOLOGY OF THE CELL

Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana

KA Mullin, BJ Foth, SC Ilgoutz, JM Callaghan, JL Zawadzki, GI McFadden, MJ McConville

Journal article  |  2001  |  Molecular Biology of the Cell

Function and assembly of the Leishmania surface coat

SC Ilgoutz, MJ McConville

Journal article  |  2001  |  International Journal for Parasitology

Identification of a methyltransferase from Mycobacterium smegmatis involved in glycopeptidolipid synthesis

JH Patterson, MJ McConville, RE Haites, RL Coppel, H Billman-Jacobe

Journal article  |  2000  |  Journal of Biological Chemistry

Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.

JD Hilley, JL Zawadzki, MJ McConville, GH Coombs, JC Mottram

Journal article  |  2000  |  Molecular Biology of the Cell

The major surface proteins of the parasitic protozoon Leishmania mexicana are anchored to the plasma membrane by glycosylphosphati..

The major surface antigens of Entamoeba histolytica trophozoites are GPI-anchored proteophosphoglycans.

S Moody-Haupt, JH Patterson, D Mirelman, MJ McConville

Journal article  |  2000  |  Journal of Molecular Biology

Trophozoites of the parasitic protozoa, Entamoeba histolytica, synthesize a cell surface lipoglycoconjugate, termed lipophosphogly..

Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids (review).

MJ McConville, AK Menon

Journal article  |  2000  |  Molecular Membrane Biology

Glycosylphosphatidylinositols (GPIs) represent an abundant and ubiquitous class of eukaryotic glycolipids. Although these structur..

Identification of a peptide synthetase involved in the biosynthesis of glycopeptidolipids of Mycobacterium smegmatis

H Billman-Jacobe, MJ McConville, RE Haites, S Kovacevic, RL Coppel

Journal article  |  1999  |  Molecular Microbiology

Glycosylphosphatidylinositol biosynthetic enzymes are localized to a stable tubular subcompartment of the endoplasmic reticulum in Leishmania mexicana.

SC Ilgoutz, KA Mullin, BR Southwell, MJ McConville

Journal article  |  1999  |  The EMBO Journal

Glycosylphosphatidylinositols (GPI) are essential components in the plasma membrane of the protozoan parasite Leishmania mexicana,..

Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.

SC Ilgoutz, JL Zawadzki, JE Ralton, MJ McConville

Journal article  |  1999  |  The EMBO Journal

The cell surface of the parasitic protozoan Leishmania mexicana is coated by glycosylphosphatidylinositol (GPI)-anchored glycoprot..

Characterization of a novel GDP-mannose : Serine-protein mannose-l-phosphotransferase from Leishmania mexicana

JM Moss, GE Reid, KA Mullin, JL Zawadzki, RJ Simpson, MJ McConville

Journal article  |  1999  |  Journal of Biological Chemistry

CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.

L Schofield, MJ McConville, D Hansen, AS Campbell, B Fraser-Reid, MJ Grusby, SD Tachado

Journal article  |  1999  |  Science

Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by con..

Subcellular location and composition of the wall and secreted extracellular sulphated polysaccharides/proteoglycans of the diatom Stauroneis amphioxys Gregory

MJ McConville, R Wetherbee, A Bacic

Journal article  |  1998  |  Protoplasma

The glycoinositolphospholipids from Leishmania panamensis contain unusual glycan and lipid moieties.

J Zawadzki, C Scholz, G Currie, GH Coombs, MJ McConville

Journal article  |  1998  |  Journal of Molecular Biology

The cell surface of Leishmania parasites is coated by glycosylphosphatidylinositol (GPI)-anchored macromolecules (glycoproteins an..

Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling.

JE Ralton, MJ McConville

Journal article  |  1998  |  Journal of Biological Chemistry

Glycosylphosphatidylinositol (GPI) glycolipids are major cell surface constituents in the Leishmania parasites. Distinct classes o..

Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties.

SD Tachado, P Gerold, R Schwarz, S Novakovic, M McConville, L Schofield

Journal article  |  1997  |  Proceedings of the National Academy of Sciences

The perturbation of various glycosylphosphatidylinositol (GPI)-anchored surface proteins imparts profound regulatory signals to ma..

Developmentally regulated changes in the cell surface architecture of Leishmania parasites.

MJ McConville, JE Ralton

Journal article  |  1997  |  Behring Institute Mitteilungen

The cell surface of Leishmania parasites is coated by a highly unusual glycocalyx which varies markedly during the parasite life c..

The variant-specific surface protein of Giardia, VSP4A1, is a glycosylated and palmitoylated protein.

P Papanastasiou, MJ McConville, J Ralton, P Köhler

Journal article  |  1997  |  Biochemical Journal

The variant-specific surface proteins (VSPs) of the ancient protist Giardia duodenalis (syn.: Giardia intestinalis, Giardia lambli..

The lipophosphoglycan-like molecules of virulent and avirulent E. histolytica as well as of E. dispar differ in both composition and abundance.

S Moody, S Becker, Y Nuchamowitz, MJ McConville, D Mirelman

Conference Proceedings  |  1997  |  Archives of Medical Research

Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction.

L Schofield, S Novakovic, P Gerold, RT Schwarz, MJ McConville, SD Tachado

Journal article  |  1996  |  Journal of Immunology

In this study we demonstrate that glycosylphosphatidylinositol (GPI) of malaria parasite origin directly increases cell adhesion m..

Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway.

SD Tachado, P Gerold, MJ McConville, T Baldwin, D Quilici, RT Schwarz, L Schofield

Journal article  |  1996  |  Journal of Immunology

In this study, we demonstrate that glycosylphosphatidylinositol (GPI) is a major toxin of Plasmodium falciparum origin responsible..

Structural studies on a lipoarabinogalactan of Crithidia fasciculata.

P Schneider, A Treumann, KG Milne, MJ McConville, N Zitzmann, MA Ferguson

Journal article  |  1996  |  Biochemical Journal

The monosaccharide D-arabinopyranose has only been found in glycoconjugates of the trypanasomatid parasites Leishmania major, Endo..

The surface glycoconjugates of parasitic protozoa: potential targets for new drugs.

MJ McConville

Journal article  |  1995  |  Australian and New Zealand Journal of Medicine

Protozoan parasites are the cause of many disease in humans and their domestic livestock. Glycoconjugates (i.e. glycoproteins, gly..

Structure of Leishmania lipophosphoglycan: inter- and intra-specific polymorphism in Old World species.

MJ McConville, LF Schnur, C Jaffe, P Schneider

Journal article  |  1995  |  Biochemical Journal

The most abundant surface macromolecule on the promastigote stage of leishmanial parasites is a polymorphic lipophosphoglycan (LPG..

Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major.

L Proudfoot, P Schneider, MA Ferguson, MJ McConville

Journal article  |  1995  |  Biochemical Journal

The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a gl..

Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan.

DL Sacks, PF Pimenta, MJ McConville, P Schneider, SJ Turco

Journal article  |  1995  |  The Journal of Experimental Medicine

The life cycle of Leishmania parasites within the sand fly vector includes the development of extracellular promastigotes from a n..

Purification, partial characterization and immunolocalization of a proteophosphoglycan secreted by Leishmania mexicana amastigotes.

T Ilg, YD Stierhof, MJ McConville, P Overath

Journal article  |  1995  |  European Journal of Cell Biology

The intracellular amastigote form of the parasitic protozoon Leishmania mexicana expresses a high-molecular weight phosphoglycan, ..

Glycoinositol-phospholipid profiles of four serotypically distinct Old World Leishmania strains.

P Schneider, LF Schnur, CL Jaffe, MA Ferguson, MJ McConville

Journal article  |  1994  |  Biochemical Journal

Glycoinositol-phospholipids (GIPLs) are the major glycolipid class and prominant surface antigens of leishmanial parasites. The GI..

O- and N-glycosylation of the Leishmania mexicana-secreted acid phosphatase. Characterization of a new class of phosphoserine-linked glycans.

T Ilg, P Overath, MA Ferguson, T Rutherford, DG Campbell, MJ McConville

Journal article  |  1994  |  Journal of Biological Chemistry

The protozoan parasite Leishmania mexicana secretes a heavily glycosylated 100-kDa acid phosphatase (sAP) which is associated with..

Surface antigens of Leishmania mexicana amastigotes: characterization of glycoinositol phospholipids and a macrophage-derived glycosphingolipid.

G Winter, M Fuchs, MJ McConville, YD Stierhof, P Overath

Journal article  |  1994  |  Journal of Cell Science

Amastigotes of the protozoan parasite Leishmania proliferate in phagolysosomes of macrophages. They abundantly express glycoinosit..

Solution structure and dynamics of a glycoinositol phospholipid (GIPL-6) from Leishmania major.

CT Weller, M McConville, SW Homans

Journal article  |  1994  |  Biopolymers

By use of a combination of 1H nuclear Overhauser effect measurements, restrained molecular dynamics simulations, and 13C spin-latt..

Recognition of the major cell surface glycoconjugates of Leishmania parasites by the human serum mannan-binding protein.

PJ Green, T Feizi, MS Stoll, S Thiel, A Prescott, MJ McConville

Journal article  |  1994  |  Molecular and Biochemical Parasitology

Activation of complement on the surface of parasitic protozoa of the genus Leishmania appears to be important for parasite infecti..

Characterization of GDP-alpha-D-arabinopyranose, the precursor of D-Arap in Leishmania major lipophosphoglycan.

P Schneider, MJ McConville, MA Ferguson

Journal article  |  1994  |  Journal of Biological Chemistry

Protozoan parasites of the genus Leishmania synthesize a complex lipophosphoglycan (LPG), which is the major cell surface macromol..

The developmental regulation and biosynthesis of GPI-related structures in Leishmania parasites.

MJ McConville, P Schneider, L Proudfoot, C Masterson, MA Ferguson

Journal article  |  1994  |  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]

Most macromolecules on the surface of Leishmania parasites, including the major surface proteins and a complex lipophosphoglycan (..