Malcolm McConville

Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii

Stephen J Fairweather, Esther Rajendran, Martin Blume, Kiran Javed, Birte Steinhofel, Malcolm J McConville, Kiaran Kirk, Stefan Broer, Giel G van Dooren

Journal article  |  2021  |  PLOS PATHOGENS

Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We pr..

Metabolic stringent response in intracellular stages of Leishmania.

Eleanor C Saunders, Marijke F Sernee, Julie E Ralton, Malcolm J McConville

Journal article  |  2021  |  Curr Opin Microbiol

Leishmania are unusual in being able to survive long-term in the mature phagolysosome compartment of macrophages and other phagocy..

Evolution and function of carbohydrate reserve biosynthesis in parasitic protists.

Julie E Ralton, M Fleur Sernee, Malcolm J McConville

Journal article  |  2021  |  Trends Parasitol

Nearly all eukaryotic cells synthesize carbohydrate reserves, such as glycogen, starch, or low-molecular-weight oligosaccharides. ..

Malaria thriving on steroids

Malcolm J McConville, Christian R Engwerda

Journal article  |  2021  |  NATURE METABOLISM

The utilisation of glutamine and glucose by a 3-D tumour model trapped in quiescence

Hannah Smith, David De Souza, Dedreia Tull, Malcolm McConville, Andrea Pellagatti, Jacqueline Boultwood, Mary Board, Richard Callaghan

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Solid tumours modify their metabolic strategy to ensure sufficient biomass and energy to maintain a high rate of proliferation. Ho..

Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics

Simon A Cobbold, Madel Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville

Journal article  |  2021  |  MOLECULAR SYSTEMS BIOLOGY

The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..

P62.05 Identifying Therapeutic Approaches to Treat KEAP1-Mutant Lung Adenocarcinoma

S Best, S Ding, A Kersbergen, B Reljic, G Wright, V Rathi, D Desouza, M Mcconville, M Ritchie, K Sutherland

Journal article  |  2021  |  Journal of Thoracic Oncology

Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry

Joachim Kloehn, Berin A Boughton, Eleanor C Saunders, Sean O'Callaghan, Katrina J Binger, Malcolm J McConville

Journal article  |  2021  |  MBIO

Leishmania are sandfly-transmitted protists that induce granulomatous lesions in their mammalian host. Although infected host cell..

The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring

Gerard Wong, Jacquelyn M Weir, Priti Mishra, Kevin Huynh, Brunda Nijagal, Varsha Gupta, Birit FP Broekman, Mary Foong-Fong Chong, Shiao-Yng Chan, Kok Hian Tan, Dedreia Tull, Malcolm McConville, Philip C Calder, Keith M Godfrey, Yap Seng Chong, Peter D Gluckman, Michael J Meaney, Peter J Meikle, Neerja Karnani

Journal article  |  2021  |  TRANSLATIONAL PSYCHIATRY

While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determina..

The Structure and Biosynthesis of Glycans in the Parasitic Protists

MF Sernee, JE Ralton, MJ McConville

Book Chapter  |  2021