Stephen Tonna

Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification

Stephen Tonna, Ingrid J Poulton, Farzin Taykar, Patricia WM Ho, Brett Tonkin, Blessing Crimeen-Irwin, Liliana Tatarczuch, Narelle E McGregor, Eleanor J Mackie, T John Martin, Natalie A Sims

Journal article  |  2016  |  DEVELOPMENT

The majority of the skeleton arises by endochondral ossification, whereby cartilaginous templates expand and are resorbed by osteo..

EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis

Stephen Tonna, Farzin M Takyar, Christina Vrahnas, Blessing Crimeen-Irwin, Patricia WM Ho, Ingrid J Poulton, Holly J Brennan, Narelle E McGregor, Elizabeth H Allan, Huynh Nguyen, Mark R Forwood, Liliana Tatarczuch, Eleanor J Mackie, T John Martin, Natalie AZ Sims

Journal article  |  2014  |  FASEB JOURNAL

Cells that form bone (osteoblasts) express both ephrinB2 and EphB4, and previous work has shown that pharmacological inhibition of..

Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast Lineage

Stephen Tonna, Natalie A Sims

Journal article  |  2014  |  CALCIFIED TISSUE INTERNATIONAL

While much research focuses on the range of signals detected by the osteoblast lineage that originate from endocrine influences, o..

EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone

Farzin M Takyar, Stephen Tonna, Patricia WM Ho, Blessing Crimeen-Irwin, Emma K Baker, T John Martin, Natalie A Sims

Journal article  |  2013  |  JOURNAL OF BONE AND MINERAL RESEARCH

Previous reports indicate that ephrinB2 expression by osteoblasts is stimulated by parathyroid hormone (PTH) and its related prote..

P03 L’étude par séquençage à haut débit des modifications épigénétiques dans les cellules endothéliales primaires démontre des changements majeurs sur la méthylation de l’ADN et l’acetylation des histones après exposition à l’hyperglycémie.

L Pirola, A Balcerczyk, R Tothill, I Haviv, A Kaspi, S Tonna, A Kowalczyk, B Beresford-Smith, G Macintyre, M Kelong, Z Hongyu, J Zhu, A Elosta

Journal article  |  2012  |  Diabetes & Metabolism

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

Luciano Pirola, Aneta Balcerczyk, Richard W Tothill, Izhak Haviv, Antony Kaspi, Sebastian Lunke, Mark Ziemann, Tom Karagiannis, Stephen Tonna, Adam Kowalczyk, Bryan Beresford-Smith, Geoff Macintyre, Kelong Ma, Hongyu Zhang, Jingde Zhu, Assam El-Osta

Journal article  |  2011  |  GENOME RESEARCH

Emerging evidence suggests that poor glycemic control mediates post-translational modifications to the H3 histone tail. We are onl..

A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

Giulio Genovese, Stephen J Tonna, Andrea U Knob, Gerald B Appel, Avi Katz, Andrea J Bernhardy, Alexander W Needham, Ross Lazarus, Martin R Pollak

Journal article  |  2010  |  Kidney Int

Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic ..

Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms

Stephen Tonna, Assam El-Osta, Mark E Cooper, Chris Tikellis

Journal article  |  2010  |  NATURE REVIEWS NEPHROLOGY

Many clinical studies have shown that intensive glycemic control in patients with diabetes can reduce the incidence and progressio..

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis.

Elizabeth J Brown, Johannes S Schlöndorff, Daniel J Becker, Hiroyasu Tsukaguchi, Stephen J Tonna, Andrea L Uscinski, Henry N Higgs, Joel M Henderson, Martin R Pollak

Journal article  |  2010  |  Nat Genet

Focal segmental glomerulosclerosis (FSGS) is a pattern of kidney injury observed either as an idiopathic finding or as a consequen..

Invited commentary: defining incident chronic kidney disease in epidemiologic study settings.

Stephen J Tonna

Journal article  |  2009  |  Am J Epidemiol

Chronic kidney disease affects an estimated 31 million Americans and potentially poses a significant global health and socioeconom..