A/Prof Natalie Hannan

A/Prof Natalie Hannan leads the Therapeutics Discovery and Vascular Function Group, within the broader Translational Obstetrics Group at the Mercy Hospital for Women, University of Melbourne. She is passionate about developing new approaches to combat major complication of pregnancy, especially preeclampsia.

Natalie’s research is focused on developing therapeutic strategies that are safe in pregnancy and novel approaches to deliver therapies directly to the placenta. Her pre-clinical research has led to a number of exciting clinical trials both internationally and nationally, on which she remained integral as the lead laboratory scientist.

Natalie’s research has been recognized by the award of a prestigious NHMRC CDF Fellowship and she currently holds two NHMRC Project Grants (as CIA), a further three as Co-CI and further philanthropic, University and commercial funded support schemes. She has a strong research profile with over 95 peer-reviewed publications in international journals.

Natalie is the President of the Australian New Zealand Placental Research Association (ANZPRA), and an executive member on The International Federation of Placental Associations (IFPA) executive committee.

Natalie is well known for her engagement and passion to communicate her research to the public, she was selected as a Fresh Scientist and awarded a Young Tall Poppy award. As a VESKI Inspiring Women Fellow, Natalie is a staunch ambassador for Women in STEM and is involved in initiatives to reduce the gender inequity in STEM.

She is the Faculty of Medicine, Dentistry and Health Sciences Associate Dean, Diversity and Inclusion.

Find out more about Natalie Hannan's experience

Natalie Hannan's highlights

FEATURED Journal article

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.

Natalie Hannan's selected work

Developing Novel Therapeutic Strategies To Reduce Spontaneous Pre-Term Birth

Research Grant

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe ear..

Journal article

Single Cell Rna Sequencing Of Amniotic Fluid: A Novel Approach To Understanding Fetal Deve..

Research Grant

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic f..

Journal article

Is Elevated Endothelin-1 A Reliable Marker Of Preeclampsia And Fetal Growth Restriction

Research Grant

Circulating mRNAs are differentially expressed in pregnancies with severe placental insuff..

Journal article

Projects

Displaying the 24 most recent projects by Natalie Hannan.

Developing Novel Therapeutic Strategies To Reduce Spontaneous Pre-Term Birth

2020 - 2022

Active

Single Cell Rna Sequencing Of Amniotic Fluid: A Novel Approach To Understanding Fetal Development

2020 - 2021

Active

Is Elevated Endothelin-1 A Reliable Marker Of Preeclampsia And Fetal Growth Restriction

2019 - 2020

Active

Anti-Thrombotic Therapy And Trophoblast Cell-Free Dna: Exploring Mechanisms For Failed Cfdna Screening And Therapeutic Potential

2018 - 2019

Completed

Novel Therapeutic Agents To Treat Preeclampsia In Obese Mice Models

2018 - 2020

Active

Development Of Novel Therapeutics To Prevent Or Treat Preeclampsia

Preeclampsia, a major pregnancy complication, affects ~3-8% of pregnancies. There is no cure. We have developed new strategies to tackle the..

2018 - 2021

Active

New Generation Antiplatelet Therapy To Prevent Preeclampsia

Preeclampsia, a major complication of pregnancy, affects around 3-8% of pregnancies. Sadly, there is no way to prevent or delay disease. We ..

2017 - 2019

Completed

Nanomedicine Targeted Delivery Of Therapeutics To The Placenta To Treat Preeclampsia

Preeclampsia, one of the most serious complications of pregnancy, affects around 3-8% of all pregnancies. Sadly, there is no treatment. We h..

2017 - 2020

Active

From Pathogenesis To Therapeutics: Targeting Two Signalling Pathways As A Therapeutic Strategy To Treat Preeclampsia

Preeclampsia is a serious complication of pregnancy that claims the lives of thousands of mothers and babies each year. There is no efficaci..

2017 - 2020

Active

Preeclampsia Therapeutics Screening Of Gsk Small Molecules

2016 - 2017

Completed

Investigating Mechanisms Of Preeclampsia And Developing Novel Therapeutics

2016 - 2020

Completed

Noninvasive Prenatal Testing (Nipt) To Detect Early Stage Ovarian Cancer (The Neo Study)

2016 - 2018

Completed

Systematic Screening Approach To Identify New Therapeutics For Preeclampsia

Preeclampsia is a pregnancy complication where factors are released from the placenta into the mum's bloodstream, causing widespread blood v..

2016 - 2019

Completed

Purchase Of The Floid Cell Imaging Station

2014 - 2014

Completed

Developing A Clinical Blood Test For Women With Preterm Ruptured Membranes (<32 Weeks Gestation) To Identify Those Developing Chorioamnionitis

2014 - 2015

Completed

Targeted Placental Therapeutic Delivery To Treat Preeclampsia

2014 - 2015

Completed

Development Of A Novel Animal Model To Examine Preeclampsia Therapeutics

2014 - 2014

Completed

Corin, A Cardiac Enzyme, Is Critical To Pregnancy Success

Most pregnancy complications, including miscarriage, pre-eclampsia, fetal growth restriction and stillbirth, stem from poor development of t..

2014 - 2017

Completed

Lansoprazole As A Novel Therapeutic For Preeclampsia

2014 - 2015

Completed

Early Career Research Grant 2010

2011 - 2011

Completed

Mother And Baby Communication During Early Pregnancy, The Key To Establishing A Healthy Pregnancy

nan

2010 - 2015

Completed

24

Projects

Project Types

Research Grant

Internal Research Grant

Research Contracts

Additional Information

Baker-Melbourne Cardiometabolic Department Seed Fund (CIA;

00,000) 2020
Risk of heart failure in women following preeclampsia: is prevention possible?
University of Melbourne Innovation Grant (CIA; $23,000) 2020
Transcriptomics to assess the effects of prasugrel on placental signalling in a mouse model of preeclampsia
University of Melbourne Innovation Grant (CIB; $20,000) 2020
Placental targeting of nanoliposomes to silence pathogenic anti-angiogenic factors to treat preeclampsia

Mercy Perinatal Foundation (

00,000) 2020
Novel Therapeutic development for the prevention of preterm birth
University of Melbourne Innovation Grant (CIA;

5,000) 2020 Post-partum maternal cardiovascular disease risk associated with preeclampsia: is prevention possible?
University of Melbourne Innovation Grant (CIB; $20,000) 2020
Developing an animal model for fetal growth restriction
University of Melbourne Innovation Grant (CIB; $20,000) 2020
Prevention of fetal CMV infection after maternal infection: developing novel therapeutic approaches using primary trophoblast and placental explant cultures

Strategic Grant for Outstanding Women, Melbourne Medical School (CIA; $88,780) 2019
Trevor B Kilvington Bequest (CIA; $49,500) 2019 Long term maternal cardiovascular disease risk associated with preeclampsia: is prevention possible?

Melbourne Medical School Mid Career Seed Grant Scheme 2018 (CIA; $24,550) 2019
Placental targeted nanomedicine to silence toxins of preeclampsia
Melbourne Medical School Department of Obstetrics & Gynaecology, University of Melbourne, Equipment Grant (CIA;

14,545) 2018
Vascular Pressure Myograph System for assessment of whole vessels

University of Melbourne Research Grant Support Scheme (CIA; $42,000) 2016

University of Melbourne C R Roper Fellowship (CIA; $433,000) 2015
Investigating the mechanisms of preeclampsia and developing novel therapeutics

Scholarly Works

Displaying the 158 most recent scholarly works by Natalie Hannan.

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.

Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article | 2020 | Pregnancy Hypertension

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction

Sally Beard, Natasha Pritchard, Natalie Binder, Karen Schindler, Natasha De Alwis, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan

Journal article | 2020 | Placenta

INTRODUCTION: Oxidative damage and biochemical ageing are implicated in placental dysfunction and potentially fetal death. Cellula..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2020 | Placenta

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

Journal article | 2020 | BMC Medicine

BACKGROUND: Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricte..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

Journal article | 2020 | Nature Communications

Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental ins..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

Journal article | 2020 | Pregnancy Hypertension

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

GDF15 is Increased in Preeclampsia and May be Regulated via Transcription Factors EGR1 and SP1.

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Damanpreet Singh, Ping Cannon, Alesia Harper, Murray Elizabeth, Tuong-Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings | 2020 | REPRODUCTIVE SCIENCES

Syndecan-1 is Reduced in Fetal Growth Restriction and Cleaved by Matrix Metalloproteinases.

Damanpreet Singh, Teresa M MacDonald, Susan P Walker, Tess Cruickshank, Natalie J Hannan, Ping Cannon, Alesia Harper, Elizabeth Murray, Nguyen Tuong-Vi, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings | 2020 | REPRODUCTIVE SCIENCES

The New Generation Antiplatelet Agent Prasugrel Represents an Exciting Novel Candidate Therapy for Preeclampsia.

Natasha De Alwis, Natalie Binder, Sally Beard, Nguyen Vi, Kaitu'u-Lino Tu'uhevaha, Stephen Tong, Natalie Hannan

Conference Proceedings | 2020 | REPRODUCTIVE SCIENCES

Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin

Teresa M MacDonald, Susan P Walker, Richard Hiscock, Ping Cannon, Alesia Harper, Elizabeth Murray, Lisa Hui, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Natasha de Alwis, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2020 | Placenta

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

Cameron Yung, Teresa M MacDonald, Susan P Walker, Ping Cannon, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2019 | Placenta

INTRODUCTION: Death associated protein kinase-1 (DAPK-1) is highly expressed in the placenta relative to all other human tissues. ..

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

Roxanne Hastie, Fiona C Brownfoot, Ping Cannon, Nguyen Vi, Laura Tuohey, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Placenta

OBJECTIVES: Preeclampsia is a hypertensive disorder of pregnancy with no available medical treatment. We recently reported sulfasa..

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Placenta

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and..

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery

Christiane Albrecht, Larry Chamley, D Stephen Charnock-Jones, Sally Collins, Hiroshi Fujiwara, Thaddeus Golos, Solene Grayo, Natalie Hannan, Lynda Harris, Kiyotake Ichizuka, Nicholas P Illsley, Mitsutoshi Iwashita, Sampada Kallol, Abdulla Al-Khan, Gendie Lash, Takeshi Nagamatsu, Akitoshi Nakashima, Kaoru Niimi, Masataka Nomoto, Christopher Redman, et al.

Journal article | 2019 | Placenta

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 201..

NOVEL APPROACHES TO TREAT PREECLAMPSIA: FROM NEW DRUGS TO INNOVATIVE DELIVERY.

Natalie Hannan

Conference Proceedings | 2019 | Placenta

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women A Swedish Population Register-Based Cohort Study

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikstrom, Stephen Tong, Susanne Hesselman

Journal article | 2019 | Hypertension

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women.

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikström, Stephen Tong, Susanne Hesselman

Journal article | 2019 | Hypertension

Preeclampsia is a hypertensive disorder of pregnancy with a high rate of maternal and neonatal morbidity and mortality. The only d..

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Roxanne Hastie, Natasha De Alwis, Ping Cannon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Journal article | 2019 | Pregnancy Hypertension

Epidermal Growth Factor and Mitochondrial Respiration-Two Pathways That Regulate Placental Growth Factor Secretion from Placental Cells.

Carole-Anne Whigham, Roxanne Hastie, Natalie Hannan, Ping Canon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Vi, Roxanne Hastie, Laura J Parry, Sevvandi Senadheera, Laura Tuohey, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | EBioMedicine

Gonadotrophin Releasing Hormone Receptor Antagonists are a Potential Targeted Treatment for Ectopic Pregnancy.

Lisa Campbell, Natalie Hannan, Stephen Tong, Mohamed Bedaiwy, Nicola Gray, Andrew W Horne

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Comparing the Ability of Pravastatin, Simvastatin and Rosuvastatin to Quench Markers of Endothelial Dysfunction in Pregnancy.

Natasha de Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Stephen Tong, Natalie Hannan

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

New Generation Antiplatelet Agents Mitigate Pathophysiological Aspects of Preeclampsia in Both Human and Mouse Models of Preeclampsia, Representing Exciting Novel Candidate Therapeutics.

Natalie Hannan, Sally Beard, Natalie Binder, Natasha De Alwis, Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Esomeprazole to treat women with preeclampsia: possible implications in the nitric oxide homeostasis Reply

Catherine Cluver, Natalie Hannan, Stephen Tong

Journal article | 2019 | American Journal of Obstetrics and Gynecology

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Ping Cannon, Vi Nguyen Tuong, Roxanne Hastie, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Scientific Reports

A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension

Manarangi De Silva, Fiona Brownfoot, Natalie J Hannan, Susan P Walker, Catherine A Cluver, Anthea Lindquist, Stephen Tong, Roxanne Hastie

Journal article | 2019 | Open Journal of Obstetrics and Gynecology

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar-Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael Dw Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

Journal article | 2019 | EMBO Molecular Medicine

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in soli..

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

Clare L Whitehead, Tu'uhevaha J Kaitu'u-Lino, Natalie K Binder, Sally Beard, Natasha De Alwis, Fiona Brownfoot, Stephen Tong, Natalie J Hannan

Journal article | 2018 | Pregnancy Hypertension

Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial

Catherine A Cluver, Natalie J Hannan, Erika van Papendorp, Richard Hiscock, Sally Beard, Ben W Mol, Gerhard B Theron, David R Hall, Eric H Decloedt, Marietjie Stander, Kim T Adams, Megan Rensburg, Pawel Schubert, Susan P Walker, Stephen Tong

Journal article | 2018 | American Journal of Obstetrics and Gynecology

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

Roxanne Hastie, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2018 | Pregnancy Hypertension

AURORA KINASE EXPRESSION IS NOT ALTERED IN GROWTH RESTRICTED OR PREECLAMPTIC PLACENTAS, AND IS NOT CHANGED WITH PLACENTAL AGING

Natasha Pritchard, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Stephen Tong, Natalie Hannan

Conference Proceedings | 2018 | PLACENTA

WATER-SOLUBLE EXTRACT OF CINNAMOMUM CASSIA AND ZINGIBER OFFICINALE INCREASE PLACENTAL GROWTH FACTOR AND DECREASE SFLT-1 SECRETED FROM ENDOTHELIAL AND PLACENTAL CELLS

Kenji Onda, Sally Beard, Rhotaro Shiota, Masaru Sakamaki, Stephen Tong, Toshihiko Hirano, Natalie J Hannan

Conference Proceedings | 2018 | PLACENTA

TWO PARALLEL PATHWAYS REGULATING SFLT-1 SECRETION FROM PLACENTA

Roxanne Hastie, Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Tuong-Vi, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings | 2018 | PLACENTA

NOVEL STRATEGIES TO TREAT PREECLAMPSIA: FROM NEW DRUGS TO NEW DELIVERY

Natalie Hannan, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2018 | PLACENTA

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Ping Cannon, Nguyen Vi, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2018 | Pregnancy Hypertension

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

Natalie J Hannan, Natalie K Binder, Sally Beard, Nguyen Tuong-Vi, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2018 | PLOS ONE

IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction

Ganesh Acharya, John Aplin, Paul Brownbill, Judith Bulmer, Graham Burton, Larry Chamley, Igor Chernyavsky, Alys Clark, Sally Collins, Elizabeth Cottrell, Mark Dilworth, David Elad, Marcel Filoche, Natalie Hannan, Alexander EP Heazell, Oliver Jensen, Edward D Johnstone, Lopa Leach, Rohan Lewis, Terry Morgan, et al.

Journal article | 2018 | Placenta

Animal models of preeclampsia: translational failings and why

Sarah A Marshall, Natalie J Hannan, Maria Jelinic, Thy PH Nguyen, Jane E Girling, Laura J Parry

Journal article | 2018 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Targeted Nanoparticles for Delivery of sFlt-1e15a-Specific siRNA to the Placental Syncytiotrophoblast; a Novel Therapy for Pre-Eclampsia?

Chloe Logue, Susan Greenwood, Stephen Tong, Natalie Hannan, Lynda K Harris

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Circulating mRNA Coding Adrenomedullin is Decreased in Women Destined to Develop Pre-Eclampsia and May Be of Placental and/or Endothelial Origin.

Carole-Anne Whigham, Teresa MacDonald, Sue Walker, Natalie Hannan, Ping Canon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

sFlt-1 Transcription and Secretion is Regulated through the Mitochondrial Electron Transport Chain - A New Mechanism to Target for Treating Preeclampsia.

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Nguyen Tuong-Vi, Stephen Tong

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Combination Sulfasalazine and Metformin Are Additive in Reducing Placental Anti-Angiogenic Factor Secretion and Up-Regulating Angiogenic Factors.

Fiona C Brownfoot, Stephen Tong, Ping Cannon, Nguyen Vi, Natalie Hannan, Roxanne Hastie, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Altered Placental Expression of Candidate Blood Markers of Severe Fetal Growth Restriction is Driven by Hypoxia.

Natasha De Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Susan Walker, Stephen Tong, Natalie J Hannan

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

Roxanne Hastie, Elgene Lim, Pavel Sluka, Lisa Campbell, Andrew W Horne, Lenore Ellett, Natalie J Hannan, Fiona Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2018 | EBioMedicine

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan

Journal article | 2018 | PLOS ONE

Measuring fetal brain and lung transcripts in amniotic fluid supernatant: a comparison of digital PCR and RT-qPCR methods

Lisa Hui, Sally Beard, Natalie J Hannan

Journal article | 2018 | The Journal of Maternal-Fetal & Neonatal Medicine

Th Pre-eclampsia Intervention with Esomeprazole trial (PIE trial)

Catherine Cluver, Natalie Hannan, Erika van Papendorp, Richard Hiscock, Ben Mol, Gerhard Theron, David Hall, Megan Rensburg, Sally Beard, Pawel Schubert, Susan Walker, Stephen Tong

Conference Proceedings | 2018 | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Severe placental insufficiency, acidemia and imminent stillbirth are associated with changes in circulating levels of mRNA coding NR4A2, RCBTB2 and EMP1

Stephen Tong, Clare Whitehead, Susan Walker, Gordon Lavinia, Jo Said, Katie Groom, Scott Petersen, Sean Seeho, Amanda Henry, Stefan Kane, Natalie Hannan, Owen Stock

Conference Proceedings | 2018 | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Roxanne Hastie, Ashwini Chand, Ping Cannon, Minh Deo, Laura Tuohey, Clare Whitehead, Natalie J Hannan, Stephen Tong

Journal article | 2017 | Hypertension

sFlt-1 and soluble endoglin concentrations in serum vs plasma in preterm preeclampsia: Are they interchangeable for biomarker studies?

Fiona Brownfoot, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Stephen Tong, Natalie Hannan

Journal article | 2017 | Pregnancy Hypertension

NOVEL TREATMENT OPTIONS FOR ECTOPIC PREGNANCY: THE EFFECTS OF GONADOTROPHIN RELEASING HORMONE RECEPTOR ANTAGONISTS ON TROPHOBLAST

Lisa Campbell, Natalie Hannan, Stephen Tong, Nicola Gray, Andrew Horne

Conference Proceedings | 2017 | Placenta

CIRCULATING ENDOTHELIAL TRANSCRIPTION FACTOR GATA2 IS DECREASED IN PREECLAMPSIA AND MAY CONTRIBUTE TO MATERNAL ENDOTHELIAL DYSFUNCTION

Carole-Anne Whigham, Teresa MacDonald, Sue Walker, Lisa Hui, Natalie Hannan, Ping Cannon, Tuong Vi Nguyen, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2017 | Placenta

EFFECT OF KAMPO EXTRACT FORMULATION (JAPANESE TRADITIONAL MEDICINE) ON PRO- AND ANTI-ANGIOGENIC FACTORS SECRETED FROM PRIMARY ENDOTHELIAL CELLS AND PLACENTAL CELLS

Kenji Onda, Kei Uchiyama, Chika Ohi, Sally Beard, Haruki Yamada, Stephen Tong, Toshihiko Hirano, Natalie Hannan

Conference Proceedings | 2017 | Placenta

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

Roxanne Hastie, Stephen Tong, Natalie J Hannan, Fiona Brownfoot, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2017 | Reproductive Sciences

Evidence of proteinuria, but no other characteristics of pre-eclampsia, in relaxin-deficient mice

Kelly P O'Sullivan, Sarah A Marshall, Scott Cullen, Tahnee Saunders, Natalie J Hannan, Sevvandi N Senadheera, Laura J Parry

Journal article | 2017 | Reproduction, Fertility and Development

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment

Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Minh Deo, Sally Beard, Tuong V Nguyen, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2017 | Scientific Reports

Relaxin treatment reduces angiotensin II-induced vasoconstriction in pregnancy and protects against endothelial dysfunction

Sarah A Marshall, Chen Huei Leo, Jane E Girling, Marianne Tare, Sally Beard, Natalie J Hannan, Laura J Parry

Journal article | 2017 | Biology of Reproduction

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma

Rhiannon Coulson, Seng H Liew, Angela A Connelly, Nicholas S Yee, Siddhartha Deb, Beena Kumar, Ana C Vargas, Sandra A O'Toole, Adam C Parslow, Ashleigh Poh, Tracy Putoczki, Riley J Morrow, Mariah Alorro, Kyren A Lazarus, Evie FW Yeap, Kelly L Walton, Craig A Harrison, Natalie J Hannan, Amee J George, Colin D Clyne, et al.

Journal article | 2017 | ONCOTARGET

Relaxin Reduces Vascular Sensitivity to Angiotensin II in Pregnant Relaxin-Deficient Mice and Prevents Onset of Vascular Dysfunction in Mouse and Human Arteries

Sarah A Marshall, Chen H Leo, Kelly O'Sullivan, Marianne Tare, Natalie J Hannan, Jane E Girling, Laura J Parry

Conference Proceedings | 2017 | REPRODUCTIVE SCIENCES

The circulating microRNA-200 family in whole blood are potential biomarkers for high-grade serous epithelial ovarian cancer

Adam Pendlebury, Natalie J Hannan, Natalie Binder, Sally Beard, Monica Mcgauran, Peter Grant, Stephen Tong, Clare L Whitehead

Journal article | 2017 | Biomedical Reports

Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial

Katie M Groom, Lesley M McCowan, Laura K Mackay, Arier C Lee, Joanne M Said, Stefan C Kane, Susan P Walker, Thijs E van Mens, Natalie J Hannan, Stephen Tong, Larry W Chamley, Peter R Stone, Claire McLintock

Journal article | 2017 | American Journal of Obstetrics and Gynecology

Could Gonadotrophin-Releasing Hormone Receptor Antagonists Be Repurposed to Treat Ectopic Pregnancy?

Lisa L Campbell, Natalie J Hannan, Mohamed A Bedaiwy, Nicola Gray, Stephen Tong, Andrew W Horne

Conference Proceedings | 2017 | REPRODUCTIVE SCIENCES

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

Natalie J Hannan, Sally Beard, Natalie K Binder, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino, Qi Chen, Laura Tuohey, Manarangi De Silva, Stephen Tong

Journal article | 2017 | Placenta

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

Kenji Onda, Stephen Tong, Sally Beard, Natalie Binder, Masanaga Muto, Sevvandi N Senadheera, Laura Parry, Mark Dilworth, Lewis Renshall, Fiona Brownfoot, Roxanne Hastie, Laura Tuohey, Kirsten Palmer, Toshihiko Hirano, Masahito Ikawa, Tu'uhevaha Kaitu'u-Lino, Natalie J Hannan

Journal article | 2017 | Hypertension

Targeted Nanoparticle Delivery of Short Interfering RNAs to Treat Preeclampsia.

Natalie J Hannan, Scott Pattison, Sally Beard, Natalie K Binder, Jennifer MacDiarmid, Himanshu Brahmbhatt, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2017 | REPRODUCTIVE SCIENCES

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta

Louie Ye, Amy Gratton, Natalie J Hannan, Ping Cannon, Minh Deo, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot

Journal article | 2016 | PLACENTA

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia

Amy M Gratton, Louie Ye, Fiona C Brownfoot, Natalie J Hannan, Clare Whitehead, Ping Cannon, Minh Deo, Peter J Fuller, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | Placenta

Placental Growth Factor Is Secreted by the Human Endometrium and Has Potential Important Functions during Embryo Development and Implantation

Natalie K Binder, Jemma Evans, Lois A Salamonsen, David K Gardner, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article | 2016 | PLOS ONE

MITOCHONDRIAL BIOGENESIS MOLECULES AMPK, SIRT1 AND PGC1 alpha AND THEIR RELATIONSHIP TO sFLT1 RELEASE IN PREECLAMPSIA

Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Roxanne Hastie, Natalie Hannan, Ping Cannon, Minh Deo, Stephen Tong

Conference Proceedings | 2016 | Placenta

Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening

Paul A Cohen, Nicola Flowers, Stephen Tong, Natalie Hannan, Mark D Pertile, Lisa Hui

Journal article | 2016 | BMC MEDICINE

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid.

Lisa Hui, Stephen Tong, Tu'Uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article | 2016 | BMC Research Notes

BACKGROUND: Cell-free RNA (cfRNA) transcripts known to be expressed by the fetal brain are detectable by quantitative reverse tran..

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | BMC PREGNANCY AND CHILDBIRTH

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation

Clare L Whitehead, Helen McNamara, Susan P Walker, Maria Alexiadis, Peter J Fuller, Daniel K Vickers, Natalie J Hannan, Roxanne Hastie, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2016 | American Journal of Obstetrics and Gynecology

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta

Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Fiona Brownfoot, Manarangi De Silva, Ping Cannon, Laura Tuohey, Stephen Tong

Journal article | 2016 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Metformin: A Novel Candidate Therapeutic for Preeclampsia.

Fiona C Brownfoot, Tu'uhevaha Kaitu'u-Lino, Natalie Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Laura Parry, Sevvandi Senadheera, Stephen Tong

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production

Kirsten R Palmer, Stephen Tong, Laura Tuohey, Ping Cannon, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | Biology of Reproduction

Reduced Placental ATF3 Increases sFlt1 Export via the Cargo Proteins Rab11a and Arf1.

Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Laura Tuohey, Stephen Tong

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

Epidermal Growth Factor Receptor Positively Regulates Sflt1 Secretion.

Roxanne Hastie, Stephen Tong, Natalie Hannan, Fiona Brownfoot, Kenji Onda, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

New Generation, Orally Available Antiplatelet Agents as Novel Therapeutic Candidates for Preeclampsia.

Natalie J Hannan, Sally Beard, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Laura Tuohey, Laura J Parry, Sevvandi Senadheera, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2016 | American Journal of Obstetrics and Gynecology

Early ovarian cancer detection in non pregnant women using a clinical NIPT platform: Implications for cancer screening

Paul Cohen, Nicola Flowers, Stephen Tong, Natalie Hannan, Mark Pertile, Lisa Hui

Conference Proceedings | 2016

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

Kirsten R Palmer, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Louie Ye, Natalie Binder, Ping Cannon, Laura Tuohey, Terrance G Johns, Alexis Shub, Stephen Tong

Journal article | 2015 | HYPERTENSION

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion

Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Kenji Onda, Sally Beard, Roxanne Hastie, Natalie K Binder, Cathy Cluver, Laura Tuohey, Clare Whitehead, Fiona Brownfoot, Manarangi De Silva, Natalie J Hannan

Journal article | 2015 | HYPERTENSION

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan, Manarangi De Silva, Natalie Binder, Laura Tuohey, Ping Cannon, Stephen Tong

Journal article | 2015 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2015 | Molecular and Cellular Endocrinology

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Natalie K Binder, Susan P Walker, Ping Cannon, Roxanne Hastie, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2015 | HYPERTENSION

EGF DECREASES SFLT1 SECRETION AND ENDOTHELIAL DYSFUNCTION: A POTENTIAL THERAPEUTIC FOR PREECIAMPSIA

Roxanne Hastie, Stephen Tong, Ping Cannon, Fiona Brownfoot, Natalie Hannan, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2015 | Placenta

ACTIVATING TRANSCRIPTION FACTOR 3-A KEY MOLECULE IN THE PATHOGENESIS OF PREECLAMPSIA

Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Natalie Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Stephen Tong

Conference Proceedings | 2015 | Placenta

Invitro embryo outgrowth is a bioassay of invivo embryo implantation and development

NK Binder, NJ Hannan, DK Gardner

Journal article | 2015 | Asian Pacific Journal of Reproduction

PROTON PUMP INHIBITORS QUENCH THE PATHOPHYSIOLOGICAL CHARACTERISTICS OF PREECLAMPSIA IN BOTH HUMAN AND MOUSE MODELS AND REPRESENT AN EXCITING NOVEL CANDIDATE THERAPEUTIC

Kenji Onda, Stephen Tong, Natalie Binder, Sally Beard, Tu'uhevaha Kaitu'u-Lino, Masanaga Muto, Masahito Ikawa, Mark Dilworth, Lewis Renshal, Sevvandi Senadheera, Laura Parry, Roxanne Hastie, Fiona Brownfoot, Laura Tuohey, Kirsten Palmer, Natalie Hannan

Conference Proceedings | 2015 | Placenta

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14

TJ Kaitu'u-Lino, R Hastie, P Cannon, H Nguyen, S Lee, NJ Hannan, S Tong

Journal article | 2015 | Placenta

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

Owen Stock, Lavinia Gordon, Jada Kapoor, Susan P Walker, Clare Whitehead, Tu'uhevaha J Kaitu'u-Lino, Gabrielle Pell, Natalie J Hannan, Stephen Tong

Journal article | 2015 | REPRODUCTIVE SCIENCES

Fathers That Are Born Small Program Alterations in the Next-Generation Preimplantation Rat Embryos

Jordanna S Master, George A Thouas, Alexandra J Harvey, John R Sheedy, Natalie J Hannan, David K Gardner, Mary E Wlodek

Journal article | 2015 | The Journal of Nutrition

Low female birth weight and advanced maternal age programme alterations in next-generation blastocyst development

Jordanna S Master, George A Thouas, Alexandra J Harvey, John R Sheedy, Natalie J Hannan, David K Gardner, Mary E Wlodek

Journal article | 2015 | REPRODUCTION

Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model

Natalie K Binder, John R Sheedy, Natalie J Hannan, David K Gardner

Journal article | 2015 | Molecular Human Reproduction

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner

Natalie K Binder, Sally A Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan, David K Gardner

Journal article | 2015 | REPRODUCTION

Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms-Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction Potential Therapeutic for Preeclampsia

Kenji Onda, Stephen Tong, Anzu Nakahara, Mei Kondo, Hideaki Monchusho, Toshihiko Hirano, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Natalie Binder, Laura Tuohey, Fiona Brownfoot, Natalie J Hannan

Journal article | 2015 | HYPERTENSION

Pravastatin quenches pre-eclampsia in humans: a potential therapeutic

FC Brownfoot, T Kaitu'u-Lino, NJ Hannan, N Binder, SP Walker, P Cannon, R Astie, K Onda, S Tong

Conference Proceedings | 2015 | BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

GM-CSF and EGF Enhance Trophoblast Proliferation and Decrease Sflt1 Secretion: Potential Therapeutics for Preeclampsia

Roxanne M Hastie, Stephen Tong, Ping Cannon, Fiona Brownfoot, Natalie J Hannan, Tu'uhevaha J Kaitu'uLino