Natalie Hannan

Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model.

Natalie K Binder, Natasha de Alwis, Sally Beard, Elif Kadife, Alesia Harper, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Natalie J Hannan

Journal article  |  2023  |  Placenta

INTRODUCTION: Development of a therapeutic that targets the pathophysiological elements of preeclampsia would be a major advance f..

SLC38A4 Amino Acid Transporter Expression Is Significantly Lower in Early Preterm Intrauterine Growth Restriction Complicated Placentas

Elif Kadife, Alesia Harper, Natasha De Alwis, Keegan Chien, Natalie Hannan, Fiona CC Brownfoot

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrauterine growth restriction (IUGR), predominantly caused by placental insufficiency, affects partitioning of nutrients to the ..

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

Bridget M Arman, Natalie K Binder, Natasha de Alwis, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2023  |  REPRODUCTION

IN BRIEF: Preterm birth is the leading cause of perinatal morbidity and mortality; however, current therapies offer limited effica..

The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health

Natasha de Alwis, Natalie K Binder, Sally Beard, Yeukai Tm Mangwiro, Elif Kadife, James SM Cuffe, Emerson Keenan, Bianca R Fato, Tu'uhevaha J Kaituiu-Lino, Fiona C Brownfoot, Sarah A Marshall, Natalie J Hannan

Journal article  |  2022  |  LIFE SCIENCE ALLIANCE

Preeclampsia affects ∼2-8% of pregnancies worldwide. It is associated with increased long-term maternal cardiovascular disease ris..

Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction.

Faith Andres, Natalie J Hannan, Susan P Walker, Teresa M MacDonald, Georgia P Wong, Ciara Murphy, Ping Cannon, Manju Kandel, Joshua Masci, Tuong-Vi Nguyen, Alison Abboud, Danica Idzes, Valerie Kyritsis, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2022  |  FASEB J

Placental dysfunction is the leading cause of both preeclampsia and fetal growth restriction. This study aimed to characterize end..

The effect of metformin on cardiovascular markers in female mice consuming a high fat diet.

Natasha de Alwis, Natalie K Binder, Yeukai TM Mangwiro, Natasha Pritchard, Sally Beard, Tu'uhevaha J Kaitu'u-Lino, Fiona Brownfoot, Natalie J Hannan

Journal article  |  2022  |  Obes Res Clin Pract

BACKGROUND: Metformin, widely used to treat diabetes, is now considered a candidate therapeutic for treatment of cardiovascular di..

Placental galectin-3 is reduced in early-onset preeclampsia

Manju Kandel, Stephen Tong, Susan P Walker, Ping Cannon, Tuong-Vi Nguyen, Teresa M MacDonald, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Lucy A Bartho

Journal article  |  2022  |  FRONTIERS IN PHYSIOLOGY

Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside ..

RNA-Seq of amniotic fluid cell-free RNA: a discovery phase study of the pathophysiology of congenital cytomegalovirus infection

Lisa Hui, Luc De Catte, Sally Beard, Jovana Maksimovic, Neeta L Vora, Alicia Oshlack, Susan P Walker, Natalie J Hannan

Journal article  |  2022  |  AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

BACKGROUND: Congenital cytomegalovirus infection is the most common perinatal infection and a significant cause of sensorineural h..

Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction

Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Stephen Tong, Lisa Hui, Natalie J Hannan

Journal article  |  2022  |  ANTIOXIDANTS

Previously, we identified elevated transcripts for the gene Oleoyl-ACP Hydrolase (OLAH) in the maternal circulation of pregnancies..

Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease

Natasha de Alwis, Bianca R Fato, Sally Beard, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Kenji Onda, Natalie J Hannan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Previously, we demonstrated that the proton pump inhibitor, esomeprazole magnesium hydrate (MH), could have potential as a repurpo..