Anthony Hodder

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity

Lachlan W Richardson, Trent D Ashton, Madeline G Dans, Nghi Nguyen, Paola Favuzza, Tony Triglia, Anthony N Hodder, Anna Ngo, Kate E Jarman, Alan F Cowman, Brad E Sleebs

Journal article  |  2022  |  CHEMMEDCHEM

Plasmepsin X (PMX) is an aspartyl protease that processes proteins essential for Plasmodium parasites to invade and egress from ho..

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax

Anthony N Hodder, Janni Christensen, Stephen Scally, Tony Triglia, Anna Ngo, Richard W Birkinshaw, Brodie Bailey, Paola Favuzza, Melanie H Dietrich, Wai-Hong Tham, Peter E Czabotar, Kym Lowes, Zhuyan Guo, Nicholas Murgolo, Manuel de Lera Ruiz, John A McCauley, Brad E Sleebs, David Olsen, Alan F Cowman

Journal article  |  2022  |  STRUCTURE

Plasmepsins IX (PMIX) and X (PMX) are essential aspartyl proteases for Plasmodium spp. egress, invasion, and development. WM4 and ..

Structure of thePlasmodium falciparumPfSERA5pseudo-zymogen

Nicholas A Smith, Oliver B Clarke, Mihwa Lee, Anthony N Hodder, Brian J Smith

Journal article  |  2020  |  PROTEIN SCIENCE

PfSERA5, a significantly abundant protein present within the parasitophorous vacuole (PV) and essential for normal growth during t..

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article  |  2019  |  NATURE

Plasmodium falciparum causes the severe form of malaria that has high levels of mortality in humans. Blood-stage merozoites of P. ..

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBL beta Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

Sofonias K Tessem, Digjaya Utama, Olga Chesnokov, Anthony N Hodder, Clara S Lin, GL Abby Harrison, Jakob S Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S Hansen, Andrew Oleinikov, Ivo Mueller, Alyssa E Barry

Journal article  |  2018  |  INFECTION AND IMMUNITY

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via..

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics

William Nguyen, Anthony N Hodder, Richard Bestel de Lezongard, Peter E Czabotar, Kate E Jarman, Matthew T O'Neill, Jennifer K Thompson, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2018  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Plasmepsin V is an aspartyl protease that plays a critical role in the export of proteins bearing the Plasmodium export element (P..

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

Fiona J McCallum, Kristina EM Persson, Freya JI Fowkes, Linda Reiling, Cleopatra K Mugyenyi, Jack S Richards, Julie A Simpson, Thomas N Williams, Paul R Gilson, Anthony N Hodder, Paul R Sanders, Robin F Anders, David L Narum, Chetan Chitnis, Brendan S Crabb, Kevin Marsh, James G Beeson

Journal article  |  2017  |  JOURNAL OF LEUKOCYTE BIOLOGY

Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf) malaria and target merozoites to reduce or pre..

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

Damien R Drew, Danny W Wilson, Salenna R Elliott, Nadia Cross, Ulrich Terheggen, Anthony N Hodder, Peter M Siba, Kiprotich Chelimo, Arlene E Dent, James W Kazura, Ivo Mueller, James G Beeson

Journal article  |  2016  |  BMC MEDICINE

BACKGROUND: The polymorphic nature of many malaria vaccine candidates presents major challenges to achieving highly efficacious va..

Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2016  |  BIOORGANIC & MEDICINAL CHEMISTRY

The use of arginine isosteres is a known strategy to overcome poor membrane permeability commonly associated with peptides or pept..

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

Justin A Boddey, Matthew T O'Neill, Sash Lopaticki, Teresa G Carvalho, Anthony N Hodder, Thomas Nebl, Stephan Wawra, Pieter van West, Zeinab Ebrahimzadeh, Dave Richard, Sven Flemming, Tobias Spielmann, Jude Przyborski, Jeff J Babon, Alan F Cowman

Journal article  |  2016  |  NATURE COMMUNICATIONS

Plasmodium falciparum exports proteins into erythrocytes using the Plasmodium export element (PEXEL) motif, which is cleaved in th..