Anthony Hodder

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article  |  2019  |  Nature

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBL beta Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

Sofonias K Tessem, Digjaya Utama, Olga Chesnokov, Anthony N Hodder, Clara S Lin, GL Abby Harrison, Jakob S Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S Hansen, Andrew Oleinikov, Ivo Mueller, Alyssa E Barry

Journal article  |  2018  |  Infection and Immunity

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics

William Nguyen, Anthony N Hodder, Richard Bestel de Lezongard, Peter E Czabotar, Kate E Jarman, Matthew T O'Neill, Jennifer K Thompson, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2018  |  European Journal of Medicinal Chemistry

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

Fiona J McCallum, Kristina EM Persson, Freya JI Fowkes, Linda Reiling, Cleopatra K Mugyenyi, Jack S Richards, Julie A Simpson, Thomas N Williams, Paul R Gilson, Anthony N Hodder, Paul R Sanders, Robin F Anders, David L Narum, Chetan Chitnis, Brendan S Crabb, Kevin Marsh, James G Beeson

Journal article  |  2017  |  Journal of Leukocyte Biology

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

Damien R Drew, Danny W Wilson, Salenna R Elliott, Nadia Cross, Ulrich Terheggen, Anthony N Hodder, Peter M Siba, Kiprotich Chelimo, Arlene E Dent, James W Kazura, Ivo Mueller, James G Beeson

Journal article  |  2016  |  BMC Medicine

Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2016  |  Bioorganic & Medicinal Chemistry

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

Justin A Boddey, Matthew T O'Neill, Sash Lopaticki, Teresa G Carvalho, Anthony N Hodder, Thomas Nebl, Stephan Wawra, Pieter van West, Zeinab Ebrahimzadeh, Dave Richard, Sven Flemming, Tobias Spielmann, Jude Przyborski, Jeff J Babon, Alan F Cowman

Journal article  |  2016  |  Nature Communications

Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes

Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Matthew T O'Neill, Sash Lopaticki, Thomas Nebl, Tony Triglia, Brian J Smith, Kym Lowes, Justin A Boddey, Alan F Cowman

Journal article  |  2015  |  Nature Structural & Molecular Biology

Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria

Chris YH Chiu, Anthony N Hodder, Clara S Lin, Danika L Hill, Connie SN Li Wai Suen, Louis Schofield, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2015  |  Journal of Infectious Diseases

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines

Ulrich Terheggen, Damien R Drew, Anthony N Hodder, Nadia J Cross, Cleopatra K Mugyenyi, Alyssa E Barry, Robin F Anders, Sheetij Dutta, Faith HA Osier, Salenna R Elliott, Nicolas Senn, Danielle I Stanisic, Kevin Marsh, Peter M Siba, Ivo Mueller, Jack S Richards, James G Beeson

Journal article  |  2014  |  BMC Medicine

The Merozoite Surface Protein 1 Complex Is a Platform for Binding to Human Erythrocytes by Plasmodium falciparum

Clara S Lin, Alessandro D Uboldi, Danushka Marapana, Peter E Czabotar, Christian Epp, Hermann Bujard, Nicole L Taylor, Matthew A Perugini, Anthony N Hodder, Alan F Cowman

Journal article  |  2014  |  Journal of Biological Chemistry

Synthetic peptides derived from the C-terminal 6 kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development

Shivani Kanodia, Gautam Kumar, Luca Rizzi, Alessandro Pedretti, Anthony N Hodder, Sergio Romeo, Pawan Malhotra

Journal article  |  2014  |  Biochimica et Biophysica Acta - General Subjects

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Guenther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey

Journal article  |  2014  |  PLoS Biology

Sequential Processing of Merozoite Surface Proteins during and after Erythrocyte Invasion by Plasmodium falciparum

Michelle J Boyle, Christine Langer, Jo-Anne Chan, Anthony N Hodder, Ross L Coppel, Robin F Anders, James G Beeson

Journal article  |  2014  |  Infection and Immunity

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

Journal article  |  2013  |  PLoS One

Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

Jack S Richards, Thangavelu U Arumugam, Linda Reiling, Julie Healer, Anthony N Hodder, Freya JI Fowkes, Nadia Cross, Christine Langer, Satoru Takeo, Alex D Uboldi, Jennifer K Thompson, Paul R Gilson, Ross L Coppel, Peter M Siba, Christopher L King, Motomi Torii, Chetan E Chitnis, David L Narum, Ivo Mueller, Brendan S Crabb, et al.

Journal article  |  2013  |  Journal of Immunology

Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome

Justin A Boddey, Teresa G Carvalho, Anthony N Hodder, Tobias J Sargeant, Brad E Sleebs, Danushka Marapana, Sash Lopaticki, Thomas Nebl, Alan F Cowman

Journal article  |  2013  |  Traffic

Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria

Damien R Drew, Anthony N Hodder, Danny W Wilson, Michael Foley, Ivo Mueller, Peter M Siba, Arlene E Dent, Alan F Cowman, James G Beeson

Journal article  |  2012  |  PLoS ONE

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Anthony N Hodder, Peter E Czabotar, Alessandro D Uboldi, Oliver B Clarke, Clara S Lin, Julie Healer, Brian J Smith, Alan F Cowman

Journal article  |  2012  |  Journal of Biological Chemistry

Biochemical and Functional Analysis of Two Plasmodium falciparum Blood-Stage 6-Cys Proteins: P12 and P41

Tana Taechalertpaisarn, Cecile Crosnier, S Josefin Bartholdson, Anthony N Hodder, Jenny Thompson, Leyla Y Bustamante, Danny W Wilson, Paul R Sanders, Gavin J Wright, Julian C Rayner, Alan F Cowman, Paul R Gilson, Brendan S Crabb

Journal article  |  2012  |  PLoS One

Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains

Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman

Journal article  |  2011  |  PLoS Pathogens

An aspartyl protease directs malaria effector proteins to the host cell

Justin A Boddey, Anthony N Hodder, Svenja Guenther, Paul R Gilson, Heather Patsiouras, Eugene A Kapp, J Andrew Pearce, Tania F de Koning-Ward, Richard J Simpson, Brendan S Crabb, Alan F Cowman

Journal article  |  2010  |  Nature

Reticulocyte binding protein homologues are key adhesins during erythrocyte invasion by Plasmodium falciparum

Tony Triglia, Wai-Hong Tham, Anthony Hodder, Alan F Cowman

Journal article  |  2009  |  Cell. Microbiol.

Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine

Anthony N Hodder, Robyn L Malby, Oliver B Clarke, W Douglas Fairlie, Peter M Colman, Brendan S Crabb, Brian J Smith

Journal article  |  2009  |  Journal of Molecular Biology

Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils

Christopher G Adda, Vince J Murphy, Margaret Sunde, Lynne J Waddington, Jesse Schloegel, Gert H Talbo, Kleo Vingas, Vivian Kienzle, Rosella Masciantonio, Geoffrey J Howlett, Anthony N Hodder, Michael Foley, Robin F Anders

Journal article  |  2009  |  Molecular and Biochemical Parasitology

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

Anthony N Hodder, Alexander G Maier, Melanie Rug, Monica Brown, Mirja Hommel, Ivan Pantic, Marina Puig-de-Morales-Marinkovic, Brian Smith, Tony Triglia, James Beeson, Alan F Cowman

Journal article  |  2009  |  Mol. Microbiol.

Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5

W Douglas Fairlie, Tim P Spurck, Joanne E McCoubrie, Paul R Gilson, Susanne K Miller, Geoffrey I McFadden, Robyn Malby, Brendan S Crabb, Anthony N Hodder

Journal article  |  2008  |  Infection and Immunity

Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: Implications for vaccine and drug design

Joanne E McCoubrie, Susanne K Miller, Tobias Sargeant, Robert T Good, Anthony N Hodder, Terence P Speed, Tania F de Koning-Ward, Brendan S Crabb

Journal article  |  2007  |  Infection and Immunity

Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts

Paul R Sanders, Greg T Cantin, Doron C Greenbaum, Paul R Gilson, Thomas Nebl, Robert L Moritz, John R Yates, Anthony N Hodder, Brendan S Crabb

Journal article  |  2007  |  Mol. Biochem. Parasitol.

Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms

Lukasz Kedzierski, Robyn L Malby, Brian J Smith, Matthew A Perugini, Anthony N Hodder, Thomas Ilg, Peter M Colman, Emanuela Handman

Journal article  |  2006  |  Journal of Molecular Biology

Distinct protein classes including novel merozoite surface antigens in raft-like membranes of Plasmodium falciparum

PR Sanders, PR Gilson, GT Cantin, DC Greenbaum, T Nebl, DJ Carucci, MJ McConville, L Schofield, AN Hodder, JR Yates, BS Crabb

Journal article  |  2005  |  Journal of Biological Chemistry

Antigen delivery via two molecules on the CD8(-) dendritic cell subset induces humoral immunity in the absence of conventional "danger"

AJ Corbett, I Caminschi, BS McKenzie, JL Brady, MD Wright, PL Mottram, PM Hogarth, AN Hodder, YF Zhan, DM Tarlinton, K Shortman, AM Lew

Journal article  |  2005  |  European Journal of Immunology

A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvant

A Saul, G Lawrence, A Allworth, S Elliott, K Anderson, C Rzepczyk, LB Martin, D Taylor, DP Eisen, DO Irving, D Pye, PE Crewther, AN Hodder, VJ Murphy, RF Anders

Journal article  |  2005  |  Vaccine

Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains

J Healer, T Triglia, AN Hodder, AW Gemmill, AF Cowman

Journal article  |  2005  |  Infection and Immunity

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast

BJ Foth, LM Stimmler, E Handman, BS Crabb, AN Hodder, GI McFadden

Journal article  |  2005  |  Molecular Microbiology

The serine repeat antigen (SERA) gene family phylogeny in Plasmodium: The impact of GC content and reconciliation of gene and species trees

R Bourgon, M Delorenzi, T Sargeant, AN Hodder, BS Crabb, TP Speed

Journal article  |  2004  |  Mol. Biol. Evol.

The alanine-rich heptad repeats are intact in the processed form of Plasmodium falciparum MSP3

JA Pearce, AN Hodder, RF Anders

Journal article  |  2004  |  Exp. Parasitol.

Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum

J Healer, V Murphy, AN Hodder, R Masciantonio, AW Gemmill, RF Anders, AF Cowman, A Batchelor

Journal article  |  2004  |  Mol. Microbiol.

Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen

JA Pearce, T Triglia, AN Hodder, DC Jackson, AF Cowman, RF Anders

Journal article  |  2004  |  Infection and Immunity

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

AJ Davis, MA Perugini, BJ Smith, JD Stewart, T Ilg, AN Hodder, E Handman

Journal article  |  2004  |  Journal of Biological Chemistry

Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5

AN Hodder, DR Drew, VC Epa, M Delorenzi, R Bourgon, SK Miller, RL Moritz, DF Frecklington, RJ Simpson, TP Speed, RN Pike, BS Crabb

Journal article  |  2003  |  J. Biol. Chem.

A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle

SK Miller, RT Good, DR Drew, M Delorenzi, PR Sanders, AN Hodder, TP Speed, AF Cowman, TF de Koning-Ward, BS Crabb

Journal article  |  2002  |  Journal of Biological Chemistry

Identification of antigenically active tryptic fragments of apical membrane antigen-1 (AMA1) of Plasmodium chabaudi malaria: strategies for assembly of immunologically active peptides

D Salvatore, AN Hodder, WG Zeng, LE Brown, RF Anders, DC Jackson

Journal article  |  2002  |  Vaccine

Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)

M Nair, MG Hinds, AM Coley, AN Hodder, M Foley, RF Anders, RS Norton

Journal article  |  2002  |  J. Mol. Biol.

Specificity of the protective antibody response to apical membrane antigen 1

AN Hodder, PE Crewther, RF Anders

Journal article  |  2001  |  Infect. Immun.

Assignment of H-1, C-13 and N-15 resonances of domain III of the ectodomain of apical membrane antigen 1 from Plasmodium falciparum

M Nair, AN Hodder, MG Hinds, RF Anders, RS Norton

Journal article  |  2001  |  J. Biomol. NMR

Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species

T Triglia, J Healer, SR Caruana, AN Hodder, RF Anders, BS Crabb, AF Cowman

Journal article  |  2000  |  Molecular Microbiology

Identification of glycosaminoglycan binding domains in Plasmodium falciparum erythrocyte membrane protein 1 of a chondroitin sulfate A-adherent parasite

JC Reeder, AN Hodder, JG Beeson, GV Brown

Journal article  |  2000  |  Infection and Immunity

CD4 T cells acting independently of antibody contribute to protective immunity to Plasmodium chabaudi infection after apical membrane antigen 1 immunization.

H Xu, AN Hodder, H Yan, PE Crewther, RF Anders, MF Good

Journal article  |  2000  |  The Journal of Immunology

Apical membrane Ag 1 (AMA1) is a leading malaria vaccine candidate. Homologues of AMA1 can induce protection in mice and monkeys, ..

Idarubicin-145-2C11-F(ab ')2 promotes peripheral tolerance and reduces chronic vascular disease in mouse cardiac allografts

WR Han, LJ Murray-Segal, A Gershenzon, JG Zhang, AN Hodder, GA Pietersz, PL Mottram

Conference Proceedings  |  1999  |  Transplant Immunology

Pathotyping isolates of Newcastle disease virus using antipeptide antibodies to pathotype-specific regions of their fusion and hemagglutinin-neuraminidase proteins.

DB Scanlon, GL Corino, BJ Shiell, AJ Della-Porta, RJ Manvell, DJ Alexander, AN Hodder, JJ Gorman

Journal article  |  1999  |  Archives of Virology

Antipeptide antibodies have been evaluated for their abilities to predict the characteristics of the cleavage motifs of the fusion..

Apical membrane antigen 1: A leading malaria vaccine candidate

RF Anders, PE Crewther, AN Hodder

Journal article  |  1998  |  Australasian Biotechnology

The disulfide bond structure of Plasmodium apical membrane antigen-1

AN Hodder, PE Crewther, MLSM Matthew, GE Reid, RL Moritz, RJ Simpson, RF Anders

Journal article  |  1996  |  Journal of Biological Chemistry

Characterization of field isolates of Newcastle disease virus using antipeptide antibodies.

AN Hodder, ZY Liu, PW Selleck, GL Corino, BJ Shiell, DC Grix, CJ Morrow, JJ Gorman

Journal article  |  1994  |  Avian Diseases

A recent Australian field isolate of Newcastle disease virus (NDV) was analyzed with antipeptide antibodies capable of differentia..

Analysis of pathotype-specific structural features and cleavage activation of Newcastle disease virus membrane glycoproteins using antipeptide antibodies.

AN Hodder, PW Selleck, JR White, JJ Gorman

Journal article  |  1993  |  Journal of General Virology

Peptides were synthesized, that correspond to cleaved and trimmed carboxyl termini of the F2 polypeptide regions of fusion (F) pro..

Antipeptide antibodies for analysis of pathotype-specific variations in cleavage activation of the membrane glycoprotein precursors of Newcastle disease virus isolates in cultured cells.

JJ Gorman, AN Hodder, PW Selleck, E Hansson

Journal article  |  1992  |  Journal of Virological Methods

Antipeptide antibodies have been produced which target regions either side of the cleavage activation sites of Newcastle disease v..