Philippe Bouillet

Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death.

Elise Clayer, Destiny Dalseno, Andrew Kueh, Derek Lacey, Minhsuang Tsai, Elysa Carr, Verena C Wimmer, Philippe Bouillet

Journal article  |  2020  |  iScience

Post-transcriptional regulation mechanisms control mRNA stability or translational efficiency via ribosomes, and recent evidence i..

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2020  |  Cell Death and Differentiation

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3( ) regulatory T cells

Antonia Polichen, Keisuke Horikawa, Liz Milla, Jennifer Kofler, Philippe Bouillet, Gabrielle T Belz, Lorraine A O'Reilly, Christopher C Goodnow, Andreas Strasser, Daniel HD Gray

Journal article  |  2019  |  Immunology & Cell Biology

FOXP3+ regulatory T (Treg) cells are essential for immunological tolerance and immune homeostasis. Despite a great deal of interes..

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt

Journal article  |  2019  |  Immunity

Physiological role of linear ubiquitination: more to it than meets the eye

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Lucia Taraborrelli, Amanda Fisher, Tobias L Haas, Yutaka Shimizu, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Ciaran Hutchinson, Charlotta Boiers, Michael T Ashworth, Allison Beal, Tariq Enver, John Bertin, et al.

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia

Cyril Seillet, Elysa Carr, Derek Lacey, Michael D Stutz, Marc Pellegrini, Lachlan Whitehead, Joel Rimes, Edwin D Hawkins, Ben Roediger, Gabrielle T Belz, Philippe Bouillet

Journal article  |  2019  |  Immunology and Cell Biology

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  Nature Communications

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak

Journal article  |  2018  |  Nature Communications

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L Haas, Yutaka Shimizu, Charlotta Boiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T Ashworth, Allison Beal, et al.

Journal article  |  2018  |  Nature